• 대한물리치료과학회지
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• 제15권2호
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• pp.1-13
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• 2008

Background: This study had been carried out with 18 ischemic stroke patients as its object for about eight months from October, 2006 to May, 2007 in order to observe the recovery of motor function and the change of important blood factors according to the different quantitative exercises. Methods: Subjects were assigned randomly either experimental group (n＝19) or the control group (n＝19), when the study began the halfway on this study dropout 20 patients, and final subjects remained experimental group's 9 patients and control group's 9 patients. Both groups received thermotherapy and functional electrical stimulation (FES), also taken different quantitative exercise therapy (experimental group 180 minutes, control group 80 minutes). Subjects were assessed for upper and lower extremities motor function Fugl－Meyer Scale; FMS), blood test (white blood count; WBC, low density lipoprotein －cholesterol; LDL-C, high density lipoprotein-cholesterol; HDL-C, Troponin) during pretest, after 2 months, after 3 months. Results: The results of this study were as follows; 1. FMS has no statistically significant difference with intergroup(p>.05). But there was a statistically significant difference with each groups (p<.05). 2. WBC has no statistically significant difference with intergroup (p>.05). But there was a statistically significant difference in control group (p<.05), without experimental group (p>.05). 3. LDL-C has no statistically significant difference with intergroup (p>.05). But there was a statistically significant difference in control group (p<.05), without experimental group (p>.05). 4. HDL-C has no statistically significant difference with intergroup (p<.05). But there was a statistically significant difference with each groups (p>.05). 5. Troponin Ⅰ has no statistically significant difference with intergroup (p>.05). Also there was no statistically significant difference with each groups (p>.05). Conclusion: These findings suggest that different quantitative exercises has no effect on FMS, LDL-C, HDL-C, WBC, Troponin Ⅰ with ischemic stroke patients. But the treatment period that there's less correlation between the recovery of motor function and the different quantitative exercise, also less correlation between the change of important blood factors and the different quantitative exercises with ischemic stroke patients.

• 한국임상수의학회지
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• 제29권4호
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• pp.277-282
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• 2012

본 연구는 건강한 개에서 혈장 homocysteine농도가 비만이나 비만 관련인자(예, 지방, 인슐린, 혈당, 글루카곤, fructosamine)들과 어떤 상관관계가 있는지를 확인하기 위해 실시되었다. 이를 위해, 절식시 혈당, 지방지수(예, total triglycerides [TG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C]과 low-density lipoprotein cholesterol [LDL-C]), fructosamine, insulin 및 glucagon 농도를 각각 측정하였다. 실험에 사용된 개들은 body condition score (BCS)에 따라 분류하였다. 평균 혈장 homocysteine 농도는 비만한 개 집단이 정상이나 마른 개 집단에 비해 상당히 높았다. 또한 혈장 homocysteine농도는 HDL-C농도 뿐아니라 TG, TC, 혈장 glucagon 및 fructosamine 농도와도 밀접한 상관관계를 가지고 있었다. 반대로 LDL-C 농도, 절식시 혈당농도 및 insulin농도는 아무런 상관관계가 확인되지 않았다. 본 연구 결과, homocysteine의 농도 상승이 비만견에서 생물학적으로 중요한 역할을 하는 것으로 추정된다.

• 한국산학기술학회논문지
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• 제12권7호
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• pp.3072-3081
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• 2011

본 연구는 일부 종합검진 수검자들을 대상으로 BMI와 혈압, 혈액학적 및 혈액생화학적 지표와의 관련성을 검토하고자 2007년 1월부터 2009년 12월까지의 기간에 한국건강관리협회 대전지부 건강검진센터에서 종합건강검진을 받았던 20세 이상의 지역주민 3,731명(남자 2,312명, 여자 1,419명)을 분석대상으로 하였다. 연구 결과 남녀 모두 BMI가 증가할수록 SBP, DBP, TG, TC, LDL-C, AST, GGT, ALP의 평균치는 유의하게 증가하였으며, HDL-C는 유의하게 감소하였다. BMI는 SBP, DBP, TG, TC, LDL-C 및 GGT와 유의한 양의 상관관계가 인정되었고, HDL-C와는 유의한 음의 상관관계가 인정되었다. 순서형 다변량 로지스틱 회귀분석 결과 BMI가 증가함에 따라 SBP, DBP, TG, ALT, GGT의 비정상치에 대한 위험비가 유의하게 증가하였다.

• Journal of Nutrition and Health
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• 제29권9호
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• pp.1035-1041
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• 1996

The study was undertaken to examine the levels of serum lipids and the correlations between serum lipid levels and other factors(nutrient intakes, anthrometric measurement, blood pressure, drinking, smoking). The participants in this study were healthy volunteers over the age of 40 residing in Whachon area, Kang-Wan Do. The level of serum TG was higher in males than in females, particularly in age of 40(209.8mg/dl$\pm$154.9, p<0.05). The HDL-c/total cholesterol ratio(HTR) in males was the lowest(0.23$\pm$0.07, p<0.05) in age of 40 and in females was the lowest(0.25$\pm$0.1) in age of 60 and over. LDL-c/HDL-c ratio(LHR) was the highest (males 3.64$\pm$6.29, females 3.28$\pm$3.03) in age of 40 in both sexes. In the age of 40-59, serum TG, total cholesterol and LDL-cholesterol and HDL-cholesterol tended to increase with BMI. Serum TG showed positive correlation with drinking (r=0.026, p<0.001) and BMI (r=0.2096, p<0.01). BMI was negatively correlated with HTR(r=-0.2242, p<0.01) and HDL-cholesterol (r=-0.2054, p<0.01).

• ETRI Journal
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• 제33권5호
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• pp.731-740
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• 2011

Reconfigurable computing using a field-programmable gate-array (FPGA) device has become a promising solution in system design because of its power efficiency and design flexibility. To bring the benefit of FPGA to many application programmers, there has been intensive research about automatic translation from high-level programming languages (HLL) such as C and C++ into hardware. However, the large gap of syntaxes and semantics between hardware and software programming makes the translation challenging. In this paper, we introduce a new approach for the translation by using the widely used GCC compiler. By simply adding a hardware description language (HDL) backend to the existing state-of- the-art compiler, we could minimize an effort to implement the translator while supporting full features of HLL in the HLL-to-HDL translation and providing high performance. Our translator, called GCC2Verilog, was implemented as the GCC's cross compiler targeting at FPGAs instead of microprocessor architectures. Our experiment shows that we could achieve a speedup of up to 34 times and 17 times on average with 4-port memory over PICO microprocessor execution in selected EEMBC benchmarks.

• 한방비만학회지
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• 제17권2호
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• pp.140-144
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• 2017

고도비만 여성환자 1명을 대상으로 감로수 절식요법과 더불어 절식기 동안 수용성 식이섬유를 함께 공급한 결과 절식 전보다 혈중 T-cholesterol -37.4%, LDL-C -39.7%, triglyceride -39.0%, HDL-C가 -27.0% 감소하였다. 향후 감로수 절식요법을 심혈관계 질환의 예방과 치료를 위한 방법으로 사용하기 위해서는 HDL-C 감소를 보완할 수 있는 추가 연구가 필요하리라 생각된다.

• BMB Reports
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• 제38권2호
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• pp.238-242
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• 2005

5-HT2A is one of major serotonin receptor that is involved in the action of serotonin-targeting drugs. Previous clinical studies have shown an unexpected association between lower cholesterol level and psychiatric diseases, in which T102C polymorphism of HTR2A, gene of 5-HT2A serotonin receptor, might be involved. Therefore, we hypothesized a potential association between lower cholesterol level and T102C polymorphism. The effect of the T102C polymorphism on the serum lipid profiles of 646 subjects without specific psychiatric disease was investigated. Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. There were significantly lower levels of total cholesterol ($193.6{\pm}35.0$ versus $202.1{\pm}45.5\;mg/dl$, p = 0.016) and HDL-cholesterol ($42.7{\pm}11.6$ versus $46.3{\pm}12.7\;mg/dl$, p = 0.004) in CC genotype than non-CC genotypes. Moreover, multivariate analysis showed that the CC genotype is a strong predictor of a lower HDL-cholesterol level (p < 0.001). In conclusion, this study shows that the CC genotype of the HTR2A gene is related to lower HDL-cholesterol level in Koreans. This is the first demonstration showing the potential genetic relationship between the serotonin receptor gene polymorphism and the HDL-cholesterol level.

• Clinical and Experimental Reproductive Medicine
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• 제41권1호
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• pp.15-20
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• 2014

Objective: Combined oral contraceptives (COCs) have some adverse effects on the serum lipid profile. Because hyperlipidemia is one of the risk factors in cardiovascular diseases, lipid abnormalities should be evaluated in women consuming COCs. Vitamins E and C are known to have beneficial effects on serum lipid profiles. Therefore, in this study, we evaluated the effects of vitamins E and C on serum lipids in women using COCs. Methods: The study compared changes in lipid parameters with and without vitamin therapy in women consuming COCs compared to those of a control group (40 non-contraceptive users or NCU) for 4 weeks. Total cholesterol and triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels along with HDL/LDL ratios were measured for all participants. Results: COC users experienced significantly higher increases in the levels of triglycerides and LDL than non-users (p<0.05). However, no significant differences were noted in the total cholesterol and HDL levels. In the treated COC group receiving vitamins E and C, the HDL level and the HDL/LDL ratio increased and the LDL and triglycerides levels decreased significantly compared with those of the other groups. Conclusion: The results of our study indicate that supplementation with antioxidant vitamins E and C restores a normal lipid profile in COC users.

• 한국자원식물학회지
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• 제27권4호
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• pp.271-278
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• 2014

고지혈증은 체내 지질대사에 이상이 생겨 혈중의 지질이 비정상적으로 높아진 상태로서, 지질이 필요 이상으로 혈액내 존재하게 되면 혈관벽에 쌓이고 굳어지게 되면서 동맥경화증, 고혈압, 뇌졸중 등의 심혈관계 질환을 일으키기도 한다. 본 연구에서는 고콜레스테롤 식이로 고지혈증을 유도한 생쥐의 동물모델에서 복분자 추출물의 유효성분인 protocatechuic acid(PCA)를 경구 투여하여 PCA의 간손상 보호 효과와 지질 대사함량 변화를 분석함으로써 PCA의 고지혈증 치료에 대한 유의적인 임상 효과를 제시하였다. PCA의 투여는 고콜레스테롤 식이에 의한 간무게 증가, 비장무게의 증가, 흉선의 위축, 신장의 위축 등 장기무게변화에 대하여 회복 효과를 보였고, 혈청 내 간세포 손상 마커 GPT 및 GOT의 회복 효과를 나타내었으며, 혈청 내 총콜레스테롤, 중성지방, HDL, LDL의 지질대사산물의 profile에서도 유의적인 회복효과를 보였다. 특히, PCA의 투여군에서는 혈중 HDL의 농도를 정상식이군 수준으로 높이고, LDL의 농도를 크게 낮추는 효과를 나타냄으로써 HDL/LDL의 균형유지에 역할을 나타내는 것으로 보이며 이러한 효과는 simvastatin의 HDL/LDL 조절 효과와는 다른 패턴을 보이고 있다. 따라서 PCA는 단독으로 고지혈증 치료의 기능성 소재로써의 개발 가능성뿐만 아니라, 합성의약품 simvastatin 등의 스타틴계 약물의 보조제로써의 개발 가능성을 제시한다.

• 생명과학회지
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• 제20권7호
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• pp.1100-1106
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• 2010

본 연구는 체지방률이 35% 이상인 폐경기 비만중년여성 26명을 대상으로 하타요가 운동이 체조성과 렙틴 및 대사증후군관련인자에 미치는 영향과 렙틴에 영향을 미치는 대사증후군인자들을 규명하기 위하여 하타요가 운동을 16주간 실시한 후 운동전과 후의 체조성, 렙틴 및 대사증후군인자를 측정하여 비교분석하였다. 본 연구의 결과 운동 후에 하타요가집단에서 체중, 체지방률, 체질량지수, 허리둘레, 허리엉덩이둘레비 및 내장지방면적이 유의하게 감소하였고, 골격근량(SMM)은 증가하였다. 고밀도지단백 콜레스테롤(HDL-C)은 유의하게 증가하였고, 렙틴, 총콜레스테롤(TC), 중성지방(TG), 저밀도지단백 콜레스테롤(LDL-C), 인슐린, 글루코스 및 인슐린저항성지수(HOMA-IR)는 유의하게 감소하였으며, 하타요가집단의 렙틴에 영향을 미치는 대사증후군인자는 HDL-C로 나타났다. 이상과 같이 하타요가운동으로 체지방의 감량이 렙틴저항성을 개선하여 렙틴의 감소와 대사증후군인자의 개선으로 생활습관병을 예방하는 데 효과가 있을 것으로 사료된다.