• Title/Summary/Keyword: H-G model

Search Result 1,727, Processing Time 0.032 seconds

The Effects of Methanol Extract from Cheonggukjang in T98G Cells and Early Stage of Focal Ischemia Rodent Models (청국장 메탄올 추출물이 T98G 세포와 허혈성 뇌졸중 백서에 미치는 영향)

  • Han, Kyung-Hoon;Kim, Doh-Hee;Song, Kwan-Young;Lee, Seog-Won;Han, Sung-Hee
    • The Korean Journal of Food And Nutrition
    • /
    • v.28 no.6
    • /
    • pp.965-972
    • /
    • 2015
  • This study was conducted to evaluate the neuroprotective effects of Cheonggukjang extract in in-vitro and in-vivo models. T98G-human glioblastoma cells were pretreated with various concentrations (1~10 mg/mL) of Cheonggukjang extract for 24 h and then exposed to $H_2O_2$ (1 mM) for 3 h. The neuroprotective effects of Cheonggukjang extract were measured using a CCK-8 kit assay, total antioxidant capacity (TAC) assay, reactive oxygen species (ROS) assay, and lactate dehydrogenase (LDH) release assay. The early stage focal ischemia rodent model was used as the in-vivo neurotoxicity model. Various concentrations (10~200 mg) of Cheonggukjang extract were administered to the animal models for 1 week. Peripheral blood was analyzed for glutathione peroxidase (GPx) expression by ELISA, and infarct volume reduction was analyzed by TTC staining. Cheonggukjang extract significantly (p<0.05) increased cell viability in T98G cells against $H_2O_2$ as well as against the induced neurotoxicity. Indeed, treatment with the Cheonggukjang extract induced a decrease in ROS and LDH expression and increased TAC significantly (p<0.05). However, Cheonggukjang extract did not induce a decrease in infarct volume or an increase in GPx expression in the in-vivo model. Despite the limitation in neuroprotection, Cheonggukjang extract may be useful for treating ROS injury.

Adsorption Characterization of Cd by Coal Fly Ash Using Response Surface Methodology (RSM) (반응표면분석법을 이용한 석탄회에서의 Cd 흡착특성에 관한 연구)

  • An, Sangwoo;Choi, Jaeyoung;Cha, Minwhan;Park, Jaewoo
    • Journal of the Korean GEO-environmental Society
    • /
    • v.11 no.1
    • /
    • pp.19-26
    • /
    • 2010
  • The batch experiments and response surface methodology (RSM) have been applied to the investigation of the cadmium (Cd) adsorption by coal fly ash (CFA). CFA having maximum Cd removal mass of 8.51 mg/g were calculated from Langmuir model. Cd removal reaction with different initial pH ranged from 4 to 9. When the initial pH was higher, Cd was removed more by adsorption and precipitation. These results suggest that the lower pH cause an increase of $H^+$ ion concentration which competed with Cd ions for exchange sites in CFA. Also, The Cd adsorption was mathematically described as a function of parameters initial Cd concentration ($X_1$), initial pH ($X_2$), and initial CFA mass ($X_3$) being modeled by use of the Box-Behnken methods. Empirical models were developed to describe relationship between the experimental variables and response. Statistical analysis indicates that tree factors ($X_1$, $X_2$, and $X_3$) on the linear term (main effects), and tree factors ($X_1X_2$, $X_1X_3$, and $X_2X_3$) on the non-linear term (Interaction effect; cross-product) had significant effects, respectively. In this case, the value of the adjusted determination coefficient (adjusted $R^2=0.9280$) was closed to 1, showing a high significance of the model. Statistical results showed the order of Cd removal at experimental factors to be initial initial pH > initial Cd concentration > initial CFA mass.

Utilization of Chemical Blends to Increase Nitrogen and Decrease Pathogens in Duck Litter

  • Choi, In-Hag
    • Journal of Environmental Science International
    • /
    • v.26 no.10
    • /
    • pp.1181-1184
    • /
    • 2017
  • This study examined the effects of chemical blends (a combination of alum and aluminum chloride) on pH, N, and pathogens in duck litter during a six-week experiment. In total, 240 Pekin ducks (160 males and 80 females) were individually distributed into 16 pens, in a randomized experimental design consisting of four treatments and four replicate pens per treatment. Our treatments included a control, T1 (75 g alum + 75 g aluminum chloride/kg duck litter), T2 (100 g alum + 100 g aluminum chloride/kg duck litter), and T3 (150 g alum + 150 g aluminum chloride/kg duck litter). There was no difference among treatments in pH and Total N (TN) at weeks 2, 4, and 6 and weeks 1, 4, 5, and 6, respectively. However, there were significant differences in both pH and TN among treatments at weeks 1, 3, and 5 and weeks 2 and 3, respectively. Regarding pathogens, we found small differences in all treatments in Escherichia coli populations from weeks 1 to 5 and in Salmonella enterica populations from weeks 1 to 3. In conclusion, the addition of chemical blends to duck litter increased TN, which resulted in a lower litter pH, but did not significantly affect pathogen populations.

Bearing Capacity of Shallow Foundation on a Finite Layer of Sandy Ground Underlain by a Rigid Base (강성저면위 유한한 두께의 모래지반에 놓인 얕은기초의 지지력)

  • Jun, Sang-Hyun;Yoo, Nam-Jae;Yoo, Kun-Sun
    • Journal of the Korean Geotechnical Society
    • /
    • v.27 no.6
    • /
    • pp.39-48
    • /
    • 2011
  • In this paper the method of estimating the bearing capacity of shallow foundation on a finite layer of sandy ground underlain by a rigid base was proposed by assessing results of the model test and the numerical analyses. For model experiments, the centrifuge tests under 1g and 20 g of gravitational levels were performed with sandy soils sampled from the field, changing the relative density of sandy soil and the ratio of thickness of sand layer (H) to the width of strip footing (B). As results of tests, bearing capacity tends to increase with the value of H/B while settlement for a given load intensity decreases. Bearing capacity also increases with relative density of the soil. In order to propose the method of estimating the bearing capacity of thin sandy layer underlain by a rigid base, values of bearing capacity factors from test results were compared with the values of modified bearing capacity factor by Mandel & Salencon (1972) considering the effect of H/B value on bearing capacity. The relation of bearing capacity factor ratio, normalizing friction angle of sandy soil, with the value of H/B was suggested so that this relation could be applied to design in the safe side. The results of numerical analyses obrained by changing the layout of footing, relative density of sandy soil and the value of H/B, were in good agreements with the suggested relation.

Adsorption Properties of Oxidized NO by Plasma Using Hybrid Anion-Exchange Fibers (복합음이온 교환섬유의 플라스마 산화 처리한 NO의 흡착특성)

  • Cho In-Hee;Kang Kyung-Seok;Hwang Taek-Sung
    • Polymer(Korea)
    • /
    • v.30 no.4
    • /
    • pp.291-297
    • /
    • 2006
  • In this study, adsorption properties of oxidized NO by plasma using aminated polyolefin-g-GMA hybrid anion exchange fibers were investigated. The maximum conversion of $NO_2$ by plasma was 49% at the conditions of 200 ppm NO, 10% $O_2$ and 30 L/min of flow rate. The adsorption content for N02 of hybrid anion exchange fibers increased with increasing the swelling ratio and the highest value was 1.5 g $H_2O/g$ IEF. The adsorption of $NO_2$ by hybrid anion exchange fibers were very fast until 10 min and reached its maximum value of 80% at 120 min. Ion exchange capacity of hybrid anion exchange fibers increased with increasing the swelling ratio and it showed the highest 0.6 mmol/g IEF values at L/D=5. The adsorption isotherm model for hybrid anion exchange fibers were closer to Freundlich than Langmuir adsorption isotherm model. It was shown that adsorption of the multi-molecular layer was dominant.

Analysis of Active Characteristic the Low-voltage Circuit Breaker for Harmonics (고조파에 의한 저압용 차단기의 동작특성 해석)

  • Choi, M.G.;Jeong, B.H.;Park, J.C.;Kim, H.G.;Mok, H.S.;Choe, G.H.
    • Proceedings of the KIEE Conference
    • /
    • 2005.07b
    • /
    • pp.1474-1476
    • /
    • 2005
  • Because MCCB, ELB, etc. discharge both technical and economical duty, it is important that the study of circuit breaker guarantee high-performance and realize the power distribution system with reliability. Because of complexity electrical equipment, the accident with imbalance and flicker occur often according to technical improvement. However, study of accident with harmonics remains. In this paper, the essential characteristic of circuit breaker is introduced. To analysis operation of circuit breaker, theoretical model and several simulations have been performed.

  • PDF