• 한국축산식품학회지
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• 제38권3호
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• pp.570-579
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• 2018

The study investigated antioxidative properties and rectal cancer cell inhibition effect of amaranth (Amaranthus cruentus L.) cauline leaves (ACL) to produce the sausage with ACL powder (ACLP). Antioxidative effects of ACLP prepared with different stem lengths (10-45 cm) were evaluated through DPPH, ABTS, reducing power, total phenol, and total flavonoid. Inhibition effect on rectal cancer cells growth was also examined with CT-26 cell. To determine appropriate ACL amounts in sausage formula, response surface methodology was used. The sausages without ACL (control) and the sausage with ACL (ACLP sausage) were the subjected to the examinations of antioxidation, growth inhibition on CT-26, and physicochemical properties (pH and water content). ACLP made from the leaf with 15 cm length stem generally showed the highest antioxidative effect through results of DPPH, ABTS, reducing power, total phenol, and total flavonoid. ACLP also showed inhibition effect on the proliferation of CT-26, depending on concentration of ACLP. The surface response model showed that 4.87 g of ACLP was optimized amount for sausage production. Physicochemical properties between optimized ACLP and control sausages were not significantly different. Higher antioxidative effect of optimized ACLP sausage extract was observed (p<0.05) in antioxidation tests than control sausage extract except for DPPH. Cell viability of CT-26 cells were higher (p<0.05) in ACLP than in control sausage extracts. These results indicate that ACLP has functional effects on antioxidation activity and growth inhibition on CT-26 cell, and thus, it should be useful as a supplement in sausage, which may some effect as ACLP itself.

• 대한조선학회논문집
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• 제34권4호
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• pp.12-20
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• 1997

자유표면상을 항주하는 고속쌍동선의 저항성능 추정을 위한 포텐설기저 패널법을 개발하였다. 물체표면에 법선 다이폴과 쏘오스를 자유표면에는 쏘오스를 분포하였고, 선형화된 자유표면조건을 고속으로 진행하는 쌍동선에 적용하였다. 쌍동선이 고속으로 진행할 때 dernihull 사이의 내부유동과 쌍동선 주위의 외부유동의 속도차이로 인해 발생하는 해의 불안정성을 해결하기 위해 선미에 Kutta 조건을 적용하였다. 수치계산결과의 검증과 화류수조에서 고속선형에 대한 저항시험 가능성을 확인하기 위한 목적으로 회류수조에서 모형시험을 수행하였다. 모형시험 및 수치계산결과는 동일한 실험을 수행한 Insel[l]의 실험결과와 비교하였다. 이를 통해 회류수조에서의 실험결과가 정성적으로 타당한 결과를 보이고 있음을 확인하였다. 수치계산결과는 Kutta 조건을 사용함으로써 고속에서도 안정된 계산결과를 얻을 수 있었다. 선형화된 사유표면조건을 고속선에 적용한 본 연구결과는 모형시험결과에 비해 작게 나타났으나, 정성적으로 티당한 결과를 주고 있어 고속쌍동선의 선형설계에 적용될 수 있음음 보였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.191-191
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• 1998

It has been hypothesized that formation of oxygen-derived free radicals may play an important part in ischemically induced tissue injury. In this study, the effects of vitamin C treatment on hepatic reperfusion model were investigated. Livers isolated from 18 hrs fasted rats were subjected to low flow hypoxia (1 $m\ell$/g liver/min, for 45min) followed by reoxygenation (for 30min). The perfusion medium used was Krebs-Henseleit bicarbonate buffer (KHBB, pH 7.4) and vitamin C (0.25, 0.5, 1.0 and 2.0 mM) was added to perfusate. 7-Ethoxycoumarin was used as substrate of phase and metbolism. After hypoxia oxygen consumption significantly dropped but vitamin C 0.25, 0.5 and 1.0 mM treatments restored oxygen consumption to the level of control group. LDH and lipid peroxidation were not changed in all experimental groups. Oxidation, phase metabolism, significantly decreased following hypoxia but improved during reoxygenation. Vitamin C 0.25 mM treatment significantly improved the oxidation of 7-ethoxycoumarin during hypoxia and reoxygenation, but the oxidation significantly decreased by vitamin C 2.0 mM treatment. Similarly, sulfate conjugation decreased in hypoxic group, but this decrease was inhibited by vitamin C 0.25, 0.5 and 1.0 mM treatments. Our findings suggest that hypoxia/reoxygenation diminishes hepatic drug metabolizing function, vitamin C at concentration of 0.25-1.0 mM ameliorates but at higher concentration aggravates these hypoxia/reoxygenation-induced changes.

• Biomolecules & Therapeutics
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• 제20권1호
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• pp.96-103
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• 2012

In the present study, the inhibitory effect of neem leaf extract (NLE) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) production was examined both in vitro and in vivo. In vitro study revealed that NLE treatment ($100{\mu}g/ml$) inhibits LPS (100 ng/ml)-induced NO production by 96% and TNF-${\alpha}$ production by 32%. The reduction in NO production is probably conferred by the complete suppression of inducible nitric oxide synthase (iNOS) expression. Interestingly, in vivo NLE significantly improved the survival rate of mice in an experimental sepsis model. Administration of NLE (100 mg/kg) 24 h before LPS treatment (20 mg/kg) improved the survival rate of mice by 60%. The inhibition of plasma NO and TNF-${\alpha}$ production by NLE is likely to account for the improved survival of mice. Our results suggest that NLE may present a promising avenue in the development of therapeutic agents for the treatment of inflammatory diseases.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 1999년도 Proceedings of Pre-symposium of the 10th ISWPC
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• pp.159-163
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• 1999

Model experiments were conducted to investigate the effect of different fillers on the removal of toner ink. Combinations of different papers (commercial photocopy paper and filler-free paper), fillers (calcium carbonate, kaolin clay, and talc), and chemicals(1-octadecanol, stearic acid, oleic acid, and TOFA) and stearic acid were found to be effective in detachment and agglomeration of toner ink. Furthermore, pH had little effect on toner detachment and agglomeration, indicating both protonated fatty acids and their anions are equally effective. In the presence of either kaolin clay or talc, all these agglomerating agents are equally effective, although a slightly higher dosage(1% for clay and 2% for talc as compared with control) is required, presumably due to the adsorption of chemical by the filler. Calcium carbonate filler, on the other hand, has a significant and adverse effect on the fatty acids used but has little effect on 1-octadecanol with the exception of possible adsorption. While stearic acid is not effective, a much higher level of oleic acid or TOFA is needed when calcium carbonate fillers are present as compared to the filler-free case. Fatty acids react with calcium carbonate to form calcium salts. The availability of fatty acid anion for toner detachment and agglomeration is determined by the solubility of calcium salt of a given fatty acid. Calcium oleate is 10 times more soluble in water than calcium stearate.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2006년도 가을 학술발표논문집 Vol.33 No.2 (D)
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• pp.750-753
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• 2006

e-Learning 분야는 정부, 기업, 학교 등 많은 조직에서 교육을 위한 수단으로 사용되어지고 있다. 이러한 e-Learning은 독립적인 운영플렛폼의 개발부터 웹 기반의 코스웨어(Courseware)까지 발전해왔다. 코스웨어는 컴퓨터 전달 체제를 통하여 교수-학습 과정을 촉진시켜 명시된 교수 목표 하에 학습자의 지식과 기능의 바람직한 변화를 목적으로 설계 및 개발된 교육용 소프트웨어와 데이터라고 할 수 있다. 또한 컴퓨터 언어 및 저작도구(Authoring Tools)를 이용하여 각 과목별 교육내용을 음성, 그림, 애니메이션, 동영상 등의 다양한 형태로 제시될 수 있도록 저작된 프로그램으로 주로 눈으로 보고 귀로 들으면서 학습하는 유형이다. 현재 코스웨어에서 제공되는 정보는 학습에 대한 정보와 교수정보 그리고 Client의 학습 진행 상황 등을 제공한다. 하지만 학습에 연관된 다른 학습이나 학습에 관련된 교수들의 전공정보, 또한 학습에 관련된 어플리케이션 등을 검색하려 할 때는 하나하나 따로 검색을 해야 하는 어려움이 따른다. 본 논문에서는 이러한 문제점을 해결하기 위하여 학습에 대한 목적과 관련학습, 관련교수, 관련연구, 관련 어플리케이션 등의 연관성을 토픽맵(TopicMap)을 이용하여 학습에 대한 더 정확한 정보를 쉽게 검색할 수 있게 한다. Client가 찾으려는 토픽을 중심으로 연관된 토픽과 카테고리를 나열하여 수작업으로 인한 검색시간과 잘못된 키워드 검색을 해결하였다.

• Restorative Dentistry and Endodontics
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• 제22권1호
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• pp.170-180
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• 1997

Cariogenicity of the bacteria is attributed to their binding capacity to the teeth. Bacterial attachment to oral surfaces is an essential step for colonization and subsequently infection. Therefore, it is conceivable that caries prevention can be achieved fundamentally by inhibition of bacterial attachment. The rationale for caries prevention through the use of sugar substitutes or limited use of sugar has been revealed. Among many sugar substitutes, xylitol has been shown to exhibit the most profound cariostatic effect, inhibiting glucose metabolism and possibly binding of mutans streptococci. The purpose of this study was to examine the effect of xylitol on binding of different species of oral bacteria. The effect of xylitol on binding of [$^3H$]-labeled oral bacteria to hydroxyapatite coated with human saliva(SHA) as a model for the pellicle-coated tooth surfaces was investigated. The strains of oral bacteria used in this study were A. viscosus T14V, A. viscosus WVU627, P. gingivaiis 2561, P. gingivalis A7Al-28, S. gordonii G9B, S. gordonii Challis, S. sobrinus 6715, S. mutans UA101, S. mutans KPSK -2, S. mutans T8, and S. mutans UA130. The obtained results were as follows: 1. P. gingivalis A7 Al-28, S. mutans UA130, S. mutans T8 grown with xylitol showed greater binding to SHA than the organism grown without xylitol. Among these, S. mutans T8 showed the greatest rate of increase in its binding to SHA ; 8-fold increase in its binding with xylitol. 2. S. mutans KPSK -2 grown with xylitol showed 2 times lesser binding to SHA than the organism grown without xylitol. 3. Binding ability of the remaining strains grown with xylitol to SHA was almost same as that of the organisms grown without xylitol. The overall results suggest that use of xylitol in the oral cavity may affect the complex oral bacterial ecosystem.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.396-401
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• 2004

In this paper, a 1MW HAWT(FIL-1000) rotor blade has been designed by BEMT(Blade Element Momentum Theory) with Prandtl's tip loss. Also, a 3-D flow and performance analysis on the FIL-1000 rotor blade has been carried out by using the 3-D Navier-Stokes commercial solver (CFX-5.7) to provide more efficient design techniques to the large-scale HAWT engineers. The rated power and itsapproaching wind velocity at design point (TSR=7.5) are 1MW and 9.99m/s respectively. The rotor diameter is 54.5m and the rotating speed is 26.28rpm. Airfoils such as FFA W-301, DU91-W-250, DU93-W-210, NACA 63418, NACA 63415 consist of the rotor blade from hub to tip. Recent CFX version, 5.7 was adopted to simulate 3-D flow field and to analyze the performance characteristics of the rotor blade. Entire mesh node number is about 730,000 and it is generated by ICEM-CFD to achieve better mesh quality The predicted maximum power occurringat the design tip speed ratio is 931.45kW. Approaching to the root, the inflow angle becomes large, which causesthe blade to be stalled in the region. Therefore, k-$\omega$ SST turbulence model was used to predict the quantitative flow information more accurately. Application of commercial CFD code to optimum blade design and performance analysis was proved to be more effective environment to HAWT blade designers.

• The Korean Journal of Physiology
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• 제17권1호
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• pp.29-35
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• 1983

The most popular way to get the animal to be co-operative for the animal experimentation is by using some kinds of general anesthetic agents. One of the most important point to take care of is, however, whether the agent(s) to be used is hinder the experimentation itself. There have been many contradictory reports of the general anesthetic agents on the renal function. Moreover, little information on the changes of the renal function by anesthesia has been available. We have done experiments to clarify and compare the effects of anesthesia induced by several general anesthetic agents on renal function in unanesthetized rabbits. Nembutal anesthesia(30 mg/kg, iv.) caused a decrease in free-water clearance, and increase in sodium and chloride excretion without significance. Thiopental anesthesia$(20{\sim}30\;mg/kg,\;iv.)$ suppressed all renal parameters tested. Chloralose(50 mg/kg, iv.) and chloral hydrate(75 mg/kg, iv.) did not change renal functions except for glomerular filtration rate, which parameter was suppressed only for a short period just after agent administration. Urethane(1 g/kg), administered by the route of either subcutaneously or intraperitoneally, suppressed renal functions lasted for the duration of experimental anesthesia. The above data suggest that it is very important to chose an appropriate anesthetic agents for a given experiment, especially experiment involved with renal function, and to interprete the data obtained from the anesthetized animal model for the expected results.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.75-75
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• 2003

We report here the results on N-acetyl-N'-dimethylamide of proline (Ac-Pro-NM $e_2$) calculated using the ab initio molecular orbital method with the self-consistent reaction field (SCRF) theory at the HF level with the 6-31+G(d) basis set to investigate the conformational preference of polyproline depending on the cis/trans peptide bonds and down/up puckerings along the backbone torsion angle $\square$ in the gas phase, chloroform, and water. In the gas phase, Ac-Pro-NM $e_2$ has seven local minima of tFd, tFu, cFd, cFu, cAu, tAu, and cAd conformations. In particular, polyproline conformations tFd, tFu, cFd, and cFu are found to be more stable than $\square$-helical conformations cAu, tAu, and cAd. In contrast, Ac-Pro-NHMe has seven local minima of tCd, tCu, cBd, cAu, tAu, cFd, and cFu conformations. Conformations tCd and tCu are found to be most stable, which is ascribed to the intramolecular hydrogen bond between C=O of acetyl group and $N^{~}$ H of N'-methyl amide group. The stability of the cFd conformation (i.e., the polyproline I structure) in chloroform is somewhat increased, relative to that in water, although tFd and tFu conformations (i.e., the polyproline II structure) are dominate both in chloroform and water. The population of backbone conformations feasible in chloroform and water is consistent with the experiments. This work is supported by a Korea Research Foundation Grant (KRF-2002-041-C00129).