• The Korean Journal of Nuclear Medicine
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• v.39 no.1
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• pp.44-48
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• 2005

Purpose: Ethylenediamine-tetramethylenephosphonic acid (EDTMP) has widely used chelator for the labeling of bone seeking radiopharmaceuticals complexed with radiometals. $^{153}Sm$ can be produced by the HANARO reactor at the Korea Atomic Energy Research Institute, Taejon, Korea. $^{153}Sm$ has favourable radiation characteristics $T1/2=46.7\;h,\;{\beta}_{max}=0.81\;MeV\;(20%),\;0.71\;MeV\;(49%),\;0.64\;MeV\;(30%)\;and\;{\gamma}=103\;keV\;(30%)$ emission which is suitable for imaging purposes during therapy. We investigated the labeling condition of $^{153}Sm$-EDTMP and imaging of $^{153}Sm$-EDTMP in normal rats. Materials and methods: EDTMP 20 mg was solved in 0.1 mL 2 M NaOH. $^{153}SmCl^3$ was added to EDTMP solution and pH of the reaction mixtures was adjusted to 3 and 12, respectively. Radiochemical purity was determined with paper chromatography. After 30 min. reaction, reaction mixtures were neutralized to pH 7.4, and the stability was estimated upto 120 hrs. Imaging studies of each reaction were perfomed in normal rats (37 MBq/0.1 mL). Results: The labeling yield of $^{153}Sm$-EDTMP was 99%. The stability of pH 8 reaction at 60, 96 and 120 hr was 99%, 95%, 89% and that of pH 12 at 36, 60, 96 and 120 hr was 99%, 95%, 88%, 66%, respectively. The $^{153}Sm$-EDTMP showed constantly higher bone uptake from 2 to 48 hr after injection. Conclusion: $^{153}Sm$-EDTMP, labeled at pH 8 reaction condition, has been stably maintained. Image of $^{153}Sm$-EDTMP at 2, 24, 48 hr after injection, demonstrate that $^{153}Sm$-EDTMP is a good bone seeking radiopharmaceuticals.

• Progress in Medical Physics
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• v.10 no.3
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• pp.151-157
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• 1999

The GafChromic film was used for the dosimetry of a balloon angio catheter filled with the radioisotope HO-166 for endovascular irradiation. The balloon angio catheter was 2 cm long and 3 mm in diameter when inflated. The isotope, Ho-166, was produced by the neutron bombardment using the research reactor in Korea Atomic Energy Research Insititute. Co-60 teletherapy beam was used for making H-D curve for the Gaf-Chromic film. The film dosimetry was measured with a videodensitometer. The radial dose distribution indicated that the absorbed dose dropped to about 20% of the surface dose at the 1 mm away from the balloon surface and at 5 mm position the dose decreased to below 1% of the surface dose. The result also shows that with the specific activity of Ho-l66, 250 mCi/ml it takes 230 seconds to deliver 1200 cGy to the region where is 1mm away from the balloon surface. The concentric isodose curves were also presented. The Ho-166 is an another alternative for endovascualr irradiation to prevent restenosis after PTCA (Percutaneous Trans Coronary Angioplasty)

• Journal of the Korean Applied Science and Technology
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• v.31 no.4
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• pp.642-652
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• 2014

The synthesis of octenyl succinyl ${\beta}$-gucan (OSA-${\beta}$-glucan) was carried out and its interfacial properties at the oil-water interface and in emulsion systems were investigated. An aqueous ethanol system as a reaction media was used to facilitate the synthesis process; 10% (w/w) ethanol found to be the best as it showed a maximum degree of substitution (DS: 0.0132). FT-IR showed a characteristic absorption spectrum at $1736cm^{-1}$, indicating the esterification of octenyl succinyl groups to ${\beta}$-glucan backbone. As for interfacial tension measurements, it was decreased with increasing concentration of OSA-${\beta}$-glucan in the aqueous phase and when NaCl was added to aqueous OSA-${\beta}$-glucan solution in the range of 0.01 M to 0.1 M and also when pH was raised (pH 3 ~ pH 9). In systems of emulsion stabilized with OSA-${\beta}$-glucan, fat globule size found to decrease with increasing concentration of OSA-${\beta}$-glucan, showing a critical value of about $0.32{\mu}m$ at 0.5 wt%. When the OSA-${\beta}$-glucan emulsions were stored, it was found that fat globule size was increased with storage time and particularly pronounced increase was observed in emulsion with 1% OSA-${\beta}$-glucan, possibly due to depletion flocculation. Results of creaming stability evaluated by light scattering technique showed that it was more stable in emulsions containing smaller fat globule size. Surface load of OSA-${\beta}$-glucan in emulsions increased with increasing concentration of OSA-${\beta}$-glucan, suggesting a multilayer adsorption.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.884-888
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• 2005

An agar-degrading bacterium was isolated from north-eastern sea of Jeju island and cultured in marine agar 2216 media. Biochemical and morphologicl characteristics and 165 rRNA gene revealed that isolated strain was member of Agarivorans genus, and named Agarivorans sp. JA-1. Agarase was produced as growth-related and expressed regardless of agar presence. Optimal pH was 8 at 50 mM Clycine-NaOH buffer, and activity was maximum at $40^{\circ}C$E Enzymatic activity was maintained over $80\%$ at $60^{\circ}C$t and $70\%$ at $80^{\circ}C$ which is thermotolerant. Hence isolated novel Agarivorans sp. JA-1 strain and its beta-agarase could be used for the production of functional oligosaccharide from agar in solution state.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.9
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• pp.1584-1587
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• 2004

The betaine content of Saliconia herbacea L. was determined by reverse-phase high performance chromatog-raphy on a C_(18) column. A 50% methanol extract was passed through a anion exchanger Ambelite IRA 400 (quaternary ammonium type, OH-) column and a strong cation exchanger Ambelite IR 120 (sulfonic acid type, $H^+$) column to remove amino acids, zwitter ions which are interfere with betaine analysis. The betaine extract was derivatized with 18-crown-6-ether and 4-bromophenacyl bromide (PBPB) for UV-labelling. Betaine in Saliconia herbacea L. was analysed on a mobile phase contained 13 mM sodium heptane sulfonic acid and 5 mM $Na_2SO_4$ in deionized water by isocratic elution for 30 min. The recovery ratio of betaine from Saliconia herbacea L. extract was 83.6%. The mean betaine value for Saliconia herbacea L. determined by the described method is 4.85 mg/mL with a standard deviation of 0.127.

• Journal of the Korean Applied Science and Technology
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• v.32 no.3
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• pp.394-404
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• 2015

This study investigated the pharmacodynamics of betaine on the blood profile and short chain fatty acid levels in meat ducks exposed to heat wave. 400 heads of Cherry valley (Anasplatyrhynchos) meat ducks were completely randomized to 5 treatments (4 repetitions each), and were raised for 42 days. They were grouped into T1 (heat wave control group without betaine), T2 (betaine 400 ppm), T3 (betaine 800 ppm), T4 (betaine 1200 ppm), and T5 (normal control group without betaine). Compared to T1, the betaine addition groups showed higher body weight gain at shipment, with T3 showing the highest significant difference. For hematological indictors measured (red blood cells and platelets), the betaine addition groups showed significantly higher values than the heat wave control group. The pH of the former was lower but their electrolytes ($K^+$, $P^+$, and $Cl^-$) were significantly higher compared to the latter. For blood gas concentration, the former showed a significantly higher value than the latter. For the total short chain fatty acids, acetic acid, and propionic acid, the betaine addition groups and group fed broiler-high temperature diet showed higher values than the heat wave control group. On the other hand, the former showed significantly lower values in butyric acid, isobutyric acid, valeric acid, and isovaleric acid than the latter group. These results suggest that betaine has the pharmacodynamics that mediate heat stress, via the maintenance and control of the blood profile, osmotic pressure, gas concentration, and short chain fatty acid, of meat ducks under heat wave.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.46 no.4
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• pp.393-398
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• 2013

The purpose of this study was to determine how an ornamental fish, such as the fighting fish, Betta splendens would respond to the use of freshwater live-prey, such as rotifers Brachionus calyciflorus and water fleas Moina macrocopa. Ingested quantity, digestive velocity and somatic growth were compared between larvae fed a freshwater rotifer and those fed boiled yolk. Food efficiency and somatic growth were compared between larvae that were fed freshwater water fleas and those fed a micro-diet developed for flounder ($250{\mu}m$, I-hwa Ltd.). The number of rotifers ingested by larvae reached a maximum of 191 per day. However, based on the number ingested per hour and the digestive velocity of consumed rotifers, the maximum ingestible and digestible number of rotifers was calculated to be 272 per day. A maximum of 67 individuals (mean, 49.8 individuals) could be completely digested within the 1-h period from 90 to 180 min after feeding. Somatic growth was enhanced in larvae that were fed rotifers compared to those fed boiled yolk. Larvae exhibited greater growth at rotifer densities of 30 and 40 per mL than at lower densities. Among the water-flea (M. macrocopa and Bosmina sp.) and micro-particle diets, feeding with M. macrocopa resulted in the greatest somatic growth of larvae during the water-flea feeding stage.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.232-233
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• 2013

본 발표에서 2012년 나노융합산업원천기술개발사업 꼭지로 연구개발을 수행하고 있는 "외부 충전없이 반영구적으로 사용이 가능한 10 mWh/cm2급 동위원소기반 전고상(全固相) 하이브리드 전지 원천기술 개발" 사업의 핵심내용을 간략히 소개하고자 한다. 본 과제의 핵심내용은 국내 유일의 원자로인 하나로의 중성자 빔라인을 이용하여 ${\beta}$-선을 방출하는 동위원소파우더를 생산하고, 방출되는 ${\beta}$-선을 효율적으로 흡수할 수 있는 PN-접합 전지구조에 노출시켜 2차적인 e-h 쌍을 생성시키고, 분리시키고 전극으로 포집하여 전력을 생산하는 한국형 동위원소전지 개발에 있다. 더하여 실시간으로 생성되는 미세한 출력전력을 증폭시켜 저장할 수 있는 고효율 전고상 이차전지와 전력제어회로를 포함하는 한국형 하이브리드전지관련 원천기술 개발관련 세부 사업내용을 소개함으로 관련분야 연구에 대한 국내관심을 환기시켜 관련기술개발을 촉진하고자 한다.

• Korean Journal of Food Science and Technology
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• v.48 no.1
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• pp.54-58
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• 2016

Physicochemical and sensory characteristics of persimmon jelly products with different levels (3, 5, and 7% w/w) of Daebong ripened persimmon puree was investigated. The moisture content of all jelly products used in this experiments was maintained within $8{\pm}2%$ of the products. Levels of crude chemical composition (moisture, crude protein, crude lipid, and crude ashes), texture, soluble materials, vitamin C, dietary fiber and ${\beta}$-carotene were increased as amount of puree addition increased in the products. Color values, $L^*$, $a^*$, and $b^*$ of the persimmon jelly products were 33.08-42.04, 0.93-1.31 and 8.85-11.21, respectively. There was no significant difference in pH (5.51-5.61) as the levels of Daebong ripened persimmon puree increased. Sensory evaluation in terms of appearance, color, taste, flavor, chewiness, and overall acceptance resulted in the highest score in the persimmon jelly product with 5% level of Daebong ripened persimmon puree. In conclusion, level of Daebong ripened persimmon puree affected color value, texture and vitamin C, dietary fiber, and ${\beta}$-carotene content of the persimmon jelly products. In addition, optimum level of Daebong ripened persimmon puree would be 5% for manufacturing the persimmon jelly product.

• Horticultural Science & Technology
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• v.16 no.2
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• pp.226-228
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• 1998

The objective of this study was to observe the effects of potassium-cyanoethylstarch (K-CES), which is a natural polymer derivate,. and polyacrylamide (PAM), which is a synthetic polymer, on the growth of spinach under environment-controlled biotron. K-CES was made from tapioca starch, and introductions of acrylonitrile was confirmed by FT-IR. Water absorbing capacities (WAC) of K-CES and PAM were 37.6 and 47.8 times, respectively. WAC of PAM was slightly higher than K-CES, WAC of PAM m saline solutions were more reduced than those of K-CES. It was introduced that K-CES treatment was more effective than PAM in higher salinity of water and soil. Dry super absorptive polymers were put into solution, and the solution was applied to soil as an soil conditioner. Both amendments, K-CES and PAM, increased the vegetative growth of the spinach when applied at 0.1% of soil weight. In general, the most favorable results for early vegetative growth of the spinach came from the PAM treatment, followed by the K-CES treatment.