• Journal of Nutrition and Health
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• 제31권4호
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• pp.739-746
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• 1998

This study was designed to investigated the antitumor effect and change chemosensitivity of chitosan in 2 kinds of humen lung cancer cell lines(NCI-H522, NCI-H596). To evaluate the antitumor effect and synergistic effectof chomosensitivity, MTT assay was used in vitro. then anticancer drugs used were 챤-platin , ectoposide, and adrimycin. The results of this study were as follows; Chitosan shwoed in antitumor effect on both NCI-H522 and NCI-H596. The lung cancer viability percent for NCI-H522 and NCL-H596 showed at the lowest levels of 5.31 and 5.33% when the concentration of chitosan was 25mg/$m\ell$ media and the exposure time of chitosan was 72 hours. ID50 value of chitosan on both NCI-H522 and NCI-H596 showed at the lowest levels of 14.07, 11.68 mg/$m\ell$ media when the exposure time of chitosan was 72 hours. the synergistic effect of chomosensitivity was better in NCI-H596 than in NCI0H522 . When the synergistic effect of chomosensitivity was shown according to the kind of the anticancer drugs, in case of NCI-H522 , in the concentration of 100$\mu\textrm{g}$/$m\ell$, ectoposide showed the highest synergistic effect of chomosensitivity and then was adrimycin In case of NCI-H596, in the concentration of 100$\mu\textrm{g}$/$m\ell$,, the order of the synergistic effect of chomosensitivity was ectoposide>adrimycin>cis-platin and in the concentration of 10$\mu\textrm{g}$/$m\ell$, ectoposide>cis-platin >adrimycin. It is concluded that chitosan is an active antitumor agent and is increased chomosensitivity though there is difference according to the kind and the concentration of anticancer drugs. But to be sued to lung cancer theraphy, further studies on toxicity, the mechanism of action, animal experiment are wanted.

• Clinical and Experimental Reproductive Medicine
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• 제20권1호
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• pp.65-70
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• 1993

To maintain a good sperm motility is one of the key factors for the successful artificial insemination in retrograde ejaculation, and the sperm motility has been shown to be affected by various environmental factors, including change in pH and osmolarity. Herein we have analyzed the effect of change in pH and osmolarity in urine and normal saline on sperm motility by Sperm Quality Analyzer and Makler counting chamber. Semen, which sampled by masturbation from a 28 year old male and showed normal finding on semen analysis, was used for this study. The results were as follows: 1. When osmolarity was fixed to 300mOsm, pH did not show a definite effect on the sperm moility. However, the motility was generally a bit better in alkaline urine and saline than in acid, particularly than in pH 5.0. 2. When pH was fixed to 7.5, sperm motility was best in urine and saline of 300mOsm. Hyperosmolarity had more adverse.effect on the motility than hypoosmolarity. 3. The sperm motility was worse in the urine than in saline under the same pH and osmolarity. In conclusion, osmolarity has a definite effect on sperm motility, where as pH has relatively little effect. And certain components of urine other than pH and osmolarity might affect the sperm motility.

• International Journal of Oral Biology
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• 제41권1호
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• pp.33-38
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• 2016

One of functions of Galla Rhois (GR) is reportedly an anti-inflammatory effect on the several inflammatory diseases. However, an effect of GR related to periodontitis has not been investigated. In the present study, we examined the effect of the hexane extract of Galla Rhois (GR-H) on periodontitis. Cytotoxicity was assessed by MTS analysis using human gingival fibroblast (hGF) cells. Experimental periodontitis was induced by injecting E.coli LPS into the palatal gingiva maxillary molar thrice weekly for 3 weeks (LPS group). GR-H diluted in 1xPBS was orally administrated using a syringe at 30 mg/kg body weight and 100 mg/kg body weight once a day (GR-H group). GR-H effect on the alveolar bone loss (ABL) was digitized with a micro-CT. GR-H treatment at concentrations exceeding 0.5 mg/ml showed cytotoxic effect in hGF cells. The micro-CT among groups were presented for the different distances from cemento-enamel junction (CEJ) to alveolar bone crest (ABC). The results indicated an inhibitory effect on alveolar bone loss for orally administered GR-H in a model of LPS-induced periodontitis.

• Geomechanics and Engineering
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• 제31권4호
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• pp.385-393
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• 2022

Previous studies postulated insignificant capillary rise (h_c) effect above the water table (H_w) for unsaturated soils. In addition, these studies utilised dry unit weight above H_w. This paper, therefore, addresses the effect of these postulations on strength where the influence of h_c using a modified upper bound approach, Discontinuity Layout Optimization (UNSAT-DLO) for a simulated soil was predicted. Two different parametric studies to model passive earth pressure and bearing capacity problems are carried out to provide an insight into the effect of capillary rise on strength. Significant increase in strength, owing to unsaturated conditions, was obtained where the maximum increase was when suction slightly less or greater than the air entry suction. On the other hand, the results showed a negative effect of h_c. For example, up to 8.24% decrease in passive thrust (P_p) was obtained at H_w=0 m when h_c rose 1 m from 0 m. To put this into perspective, this was equivalent to a decrease of about 2° in 𝜙 at H_w=0 m and h_c =0 m in order to obtain the same result at h_c =1 m. For the bearing capacity problem, the effect was seen to be higher, up to 18.4% decrease in N_𝛾 was obtained when h_c rose from 0 m to 2.5 m at H_w =0 m. In addition, the results revealed a negative influence of assigning dry unit weight above H_w or h_c.. However, considerable increase in strength was obtained when unsaturated unit weight above h_c was assigned.

• 사상체질의학회지
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• 제1권1호
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• pp.153-170
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• 1989

We have studied some effects of the SOEUMIN-HYANGSAYANGYUI-TANG (S.H.Y.) on the C.N.S. and on the intestines. Several empirical remarks, depending on the different treatments, are investigated throughout this study as follows; 1) The treatment, using atropine bromide, represses the effect of the S.H.Y. on the contractive force of intestines. 2) The treatment, using pheniramine maleate, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 3) The treatment, using cyproheptadine, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 4) The analgesic effect as well as the antipyretic effect are remarked while the acetic acid is applied. 5) The suppressive action on the convulsion, induced by strychine, is not observed. However the significant effect on the convulsion induced by picrotoxin is remarked. 6) The sedactive effect of the S.H.Y., using the Rotor rod test, is not obviously observed.

• 대한화장품학회지
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• 제42권4호
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• pp.413-420
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• 2016

하이드록시 산(hydroxy acid, HA)은 피부 각질층에 대한 박리효과로 노화방지와 피부 보습을 높이는데 효과를 보여, 피부 외용제와 화장품으로서 많은 활용을 하고 있다. 그 중에서 가장 효과적으로 빠른 시간 내에 나타나는 각질 박리는 화장품 제형 pH에 의해 효과를 보이는 것으로 많은 보고가 있다. 그러나 pH에 의한 자극, 부작용에 의한 염려로 인해 사용에 많은 어려움이 있다. 본 연구의 목적은 피부 각질층에 (1) 하이드록시 산의 농도와 (2) 종류, (3) pH를 변화시킨 화장품을 인체 피부에 도포하여 각질 박리 효과에 대한 영향을 측정하는 데에 있다. 건강한 성인 22명을 대상으로 하박 내측에 DHA (dihydroxyacetone), DC (dansyl chloride)로 피부 표면 각질을 염색하여, 시험제품을 도포한 뒤 각질박리 효과를 측정하였다. (1) GA (glycolic acid)의 농도에 따라 각질 박리 효과는 농도 의존적으로 증가하는 것으로 나타났다. (2 )하이드록시 산의 종류에 따라 pH를 산성과 중성으로 제조한 제품을 대상으로 각질 박리 효과를 측정한 결과, 중성 pH의 GA는 각질 박리 효과가 나타나지 않았다. 이에 반해 SA (salicylic acid)는 산성 pH와 중성 pH에서 모두 통계적으로 유의한 각질 박리 효과가 나타났다. (3) 중성 pH의 SA는 DHA와 DC로 염색한 피부 표면에서 모두 우수한 각질 박리 효과를 나타내었다. 이러한 결과는 pH에 민감한 사람들에게 각질 박리 효과를 기대하는 화장품을 사용할 수 있는 기회를 제공하며, 피부 장벽의 손상 없이 안전한 화장품을 제조할 수 있을 것이라 사료된다.

• Applied Biological Chemistry
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• 제6권
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• pp.57-59
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• 1965

According to the result of the observations on the effect of the reagents, $CuSO_4{\cdot}5H_2O$, $ZnSO_4{\cdot}7H_2O$ $MnSO_4{\cdot}4H_2O$, $HgCl_2$, upon the mycelial growth of psalliota campestris $HgCl_2$ showed the strongest effect on checking the mycelial growth $(,.008{\sim}0.01%)$ $CuSO_4{\cdot}5H_2O(0.030%)$, $ZnSO_4{\cdot}7H_2O(0.080%)$, came next and the $MnSO_4{\cdot}4H_2O(0.100%)$ was the weakest. Writer also found that showed the promoting effect of the mycelial growth in appropriate Concentration (at $0.015%\;CuSO_4{\cdot}5H_2O$, $0.030%ZnSO_4{\cdot}7H_2O$).

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.2180-2185
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• 2003

Numerical simulations of freely propagating flames burning $H_2/HCl/Air$ mixtures are performed at atmospheric pressure in order to understand the effect of HCl on the NOx reduction. A chemical kinetic mechanism is developed, which involves 26 gas-phase species and 99 reactions. Under several equivalence ratios the flame speeds are calculated and compared with those obtained from the experiments, the results of which is in good agreement. As HCl is added into $H_2/Air$ flame as additive, its chemical effect causes the reduction of radicals (H, OH, and O), and then the decrease of the net rate of NO production. It is found that the chemical effect of additive has much more influence on the reduction of EINO than its physical effect.

• 동의생리병리학회지
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• 제17권2호
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• pp.447-450
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• 2003

To clerify the cytotoxicity of reactive oxygen species in cultured hippocampal neurons of neonatal mouse, toxic effect was measured by MTT assay after cultured cells were incubated for 3 hours in the media containing 1～40 μM concentrations of H₂O₂. In addition, the protective effect of vitamin E was determined in these cultrures. Cell viability was significantly decreased in a dose-dependent manner after exposure of 10 μM H₂O₂ to cultured mouse hippocampal neurons for 5 hours. In the protective effect of vitamin E, vitamin E prevented the H₂O₂-induced cytotoxicity in these cultures. From these results, it suggests that H₂O₂ has toxic effect in cultured mouse hippocampal neurons and vitamin E has protective effect on the cytotoxicity induced by H₂O₂.

• 한국환경과학회지
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• 제13권7호
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• pp.667-674
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• 2004

The objective of this study was to investigate the effects of pH and temperature on the formation of bromate, which is ozonation by-products, during ozonation. In this experiment, the operating parameters including pH 3 ～ 10 and temperature 15 ～ $30^{\circ}C$ were studied. Through the study for the bromate formation, reaction rate constant, and ozonation effect index on pH and temperature, the results obtained are as follows. At the same initial pH condition, the increase of pH shown similar trends even if the reaction variables such as temperature and reaction time of ozonation were exchanged. As pH and temperature were increasing, the bromate concentration was increased but bromine(HOBr+OBr) was decreased with increasing pH from 3 to 10. The activation energy(J/mol) for bromate formation decreased with increasing pH. The rate constants of bromate formation for the reaction of ozone and bromide, and ozone dosage coefficient$(K_{0})$ increased with temperature and pH. Ozonation effect index(OI) decreased with increasing temperature and pH.