• Journal of Microbiology and Biotechnology
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• 제22권4호
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• pp.494-500
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• 2012

Silk fibroin (SF) peptide has been traditionally used as a treatment for flatulence, spasms, and phlegm. In this study, we examined whether SF peptide enhanced the anti-inflammatory effect of PEP-1-FK506 binding protein (PEP-1-FK506BP) through comparing the anti-inflammatory activities of SF peptide and/or PEP-1-FK506BP. In the presence or absence of SF peptide, transduction levels of PEP-1-FK506BP into HaCaT cells and mice skin and anti-inflammatory activities of PEP-1-FK506BP were identified by Western blot and histological analyses. SF peptide alone effectively reduced both mice ear edema and the elevated levels of cyclooxygenase-2, interleukin-6 and $-1{\beta}$, and tumor necrosis factor-${\alpha}$, showing similar anti-inflammatory effect to that of PEP-1-FK506BP. Furthermore, co-treatment with SF peptide and PEP-1-FK506BP exhibited more enhanced anti-inflammatory effects than the samples treated with SF peptides or PEP-1-FK506BP alone, suggesting the possibility that SF peptide and PEP-1-FK506BP might interact with each other. Moreover, the transduction data demonstrated that SF peptide did not affect the transduction of PEP-1-FK506BP into HaCaT cells and mice skin, indicating that the improvement of anti-inflammatory effect of PEP-1-FK506BP was not caused by enhanced transduction of PEP-1-FK506BP. Thus, these results suggest the possibility that co-treatment with SF peptide and PEP-1-FK506BP may be exploited as a useful therapy for various inflammation-related diseases.

• The Journal of the Korea Contents Association
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• 제19권11호
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• pp.111-121
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• 2019

Recently, through the services that use drones at fire sites to deliver on-site and road conditions into the situation room and life-saving activities or the deliveries of first aid outfits at the accident scenes that are inaccessible to humans, there are more and more cases of dealing with emergency situations. Therefore, by studying the service design using drones in the initial stage of response to fires in dense residential areas, this study was intended to reify the service design area of the response stage, including the dispatch of fire sites and the fire suppression. To do this, through literature researches, research directions were explored by examining the concept and process review of service design, and by analyzing the application cases using service design. In order examine the validity of this study, a one-on-one interview was conducted to identify the use and problems of drones among incumbent firefighters, and identified the applicability of drones to fire sites by targeting drone experts. Field research was conducted to identify the location and distance of road conditions, site conditions, and 119 safety centers, by making Yongsan-gu, the most vulnerable area to fire in Seoul, as a research sample. And, among the methodologies of service design, Persona and Customer Journey Map were prepared and Insight was derived, by using virtual scenarios for the experience values and behavior analyses of the interested parties. Through these processes, this researcher intended to present the fire-response service design and help establish the direction of service design in the initial stages of fire in Korea.

• Quality Improvement in Health Care
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• 제10권1호
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• pp.28-41
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• 2003

Background : Because unplanned readmissions to intensive care unit(ICU)might be related with undesirable patient outcomes, we investigated the pattern of and reason for unplanned ICU readmission to provide baseline data for reducing unplanned returns to ICU. Methods : The subjects included all patients who readmitted to ICU during the same hospitalization at a tertiary referral hospital between January 1st and June 30th 2002. Quality improvement(QI) nurse collected the data through medical records and a medical director reviewed the data collected. Results : 1) The average unplanned ICU readmission rate was 5.6%(gastroenterology 14.6%, pediatrics 12.7%, pulmonology 11.9%, neurosurgery 6.3%, general surgery 5.3%, chest surgery 3.9%, and cardiology 3.3%). 2) Among the unplanned readmissions, more than 50% of cases were from patients older than 60 years, and the main categories of diagnose at hospital admission were neurologic disease(29.9%) and cardiovascular disease(27.6%). 3) Of unplanned ICU readmissions, 41.8% had recurrence of the initial problems, 44.8% had occurrence of new problems. And 9.7% required post-operative care after unplanned operations. 4) The most common cause responsible for unplanned ICU readmission were respiratory problem(38.3%) and cardiovascular problem(14.3%). 5) About 40% of unplanned ICU readmission occurred within 3 days after ICU discharge. 6) Average length of stay of the readmitted patients to ICUs were much longer than that of non-readmitted patients. 7) Hospital mortality rate was much higher for unplanned ICU readmitted patients(23.6%) than for non-readmitted patients(1.5%) (P<0.001). Conclusions : This study showed that the unplanned ICU readmitted patients had poor outcomes(high morality and increased length of stay). In addition study results suggest that more attention should be paid to patients in ICU with poor respiratory function or elderly patients, and careful clinical decisions are required at discharged from ICU to general ward.

• The Journal of Engineering Geology
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• 제20권1호
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• pp.101-109
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• 2010

There are many slopes generally developed by excavation and cut slope with small steps on massive slopes of roads. Especially these cut slopes which excavating around fault fracture zone need a reinforcement technology in order to ensure safety. In the case of slope excavation, it is difficult to use the existing slope support at fracture zone because of geological characteristics. Especially the factor of safety decreases significantly due to the movement of blocks in bed rocks and the expansion of interspace of discontinuous planes in fractured zones caused by excavation. Thus an efficient reinforcement technique in accordance with geological properties of fracture zones needs to be developed because the existing slope support has a restricted application. Therefore it is necessary to develop the specialized rock bolt technique in order to ensure an efficient factor of safety for anomalous fracture zones in slopes and tunnels. The purpose of this study is to develop newly improved rock bolt to increase a supporting effect of the swellex bolt method used recently as a friction type in fracture zones.

• The Journal of Engineering Geology
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• 제24권4호
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• pp.487-499
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• 2014

While the vertical open type of heat exchanger is more effective in areas of abundant groundwater, and is becoming more widely used, the heat exchanger most commonly used in geothermal heating and cooling systems in Korea is the vertical closed loop type. In this study, we performed numerical simulations of the optimal utilization of geothermal energy based on the hydrogeological and thermal properties to evaluate the efficiency of the vertical open type in areas of abundant groundwater supply. The first simulation indicated that the vertical open type using groundwater directly is more efficient than the vertical closed loop type in areas of abundant groundwater. Furthermore, a doublet system with separated injection and extraction wells was more efficient because the temperature difference (${\Delta}$) between the injection and extraction water generated by heat exchange with the ground is large. In the second simulation, we performed additional numerical simulations of the optimal utilization of geothermal energy that incorporated heat transfer, distance, flow rate, and groundwater hydraulic gradient targeting a single well, SCW (standing column well), and doublet. We present a flow diagram that can be used to select the optimal type of heat exchanger based on these simulation results. The results of this study indicate that it is necessary to examine the adequacy of the geothermal energy utilization system based on the hydrogeological and thermal properties of the area concerned, and also on a review of the COP (coefficient of performance) of the geothermal heating and cooling system.

• The Journal of Engineering Geology
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• 제23권3호
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• pp.293-304
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• 2013

Because the present groundwater law broadly regulates a simple and impractical guideline ignoring aquifer characters and geology, general purpose facilities for protection of groundwater contamination is still considered unsatisfactory to ensure groundwater resources. In recent, there have been growing attempts in the packer development as crucial techniques and devices for groundwater protection. This study investigated the application of packer grouting techniques to contaminated groundwaters of two well sites in the Andong and Yeongi areas, both of which revealed a satisfactory effect with improved water quality: 94% decrease in turbidity at the Andong area and 60% decrease in $NO_3$-N, respectively. Based on aquifer characters including geology, weathering depth, fracture pattern, hydraulic gradient, and the flow path of contaminants, the integrated properties of groundwater contamination should be evaluated and treated with the help of accurate analyses such as bore hole imaging and monitoring data. Packer grouting and casing on well to ensure the useful aquifer free of contaminant are expected to play important role in inhibiting the inflow of contaminants when adequately applied. Therefore it is concluded that these can serve as reliable tools in remediation and protection of contaminated groundwater as well as efficient utilization of groundwater.

• Journal of Korean Society on Water Environment
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• 제28권6호
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• pp.923-932
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• 2012

The purpose of this study was to determine parameters of surface cover materials and evaluation the effects on runoff and sediment reductions with rice straw mat with PAM at watershed scale using the SWAT model. In this study, 1) regression equation of CN for rice straw mat + PAM using SCS curve number method was developed, 2) the USLE P factor, being able to reflect simulation of rice straw mat + PAM in the agricultural field, was estimated for various slope scenarios with VFSMOD-w. Then regression equation for CN and USLE P factor were used as input data in the SWAT model. Assuming rice straw mat + PAM is applied to radish and potato fields, occupying 24% of agricultural fields at the study watershed. Result of direct runoff without rice straw mat + PAM was $65,964,368\;m^3,$ with rice straw mat + PAM, direct runoff was $65,637,336\;m^3$, $327,031.8\;m^3$ reductions compared without it. Also, result of sediment without rice straw mat + PAM was 163,531 ton, with rice straw mat + PAM, sediment was 84,779 ton, 78,752 ton reduction compared without it. This analysis showed that about 48% sediment reductions would be expected with rice straw mat + PAM. As shown in this study, rice straw mat + PAM would be used as an efficient site-specific BMPs to reduce runoff and sediment discharge from field.

• Food Science of Animal Resources
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• 제32권5호
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• pp.604-611
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• 2012

The purpose of this study was to explore the effect of fermented persimmon diet on the meat quality of fattening pigs. Pigs (75 kg) were grouped and housed as 15 animals per pen and 3 replications per treatment. The basal diet (C) was substituted with 3% (T1), 5% (T2) and 10% (T3) of fermented diet. The 180 pigs were fed experimental diet for 42 d and 10 longissimus dorsi (LD) per treatment were collected when each swine reached 105.6 kg of body weight. The crude fat concentration of LD was lower (p<0.05) in treatments, but the pH value of T3 and the shear force values of T2 and T3 were higher (p<0.05) than those of C. The CIE $L^*$ value (lightness) was significantly (p<0.05) higher in T2 and T3 than C, but the CIE $b^*$ (yellowness) of T2 and T3 was significantly (p<0.05) lower than C. The composition of myristic acid and oleic acid was significantly (p<0.05) higher in treatments than in C, while the composition of palmitic acid and stearic acid of treatments were significantly (p<0.05) lower than C in LD. Sensory evaluation of cooked meat as scores of aroma, taste, juiciness and overall acceptability showed higher (p<0.05) in treatments than in C. In conclusion, the dietary of fermented persimmon diet decreased the crude fat concentration, improved the fatty acids composition (increased composition of unsaturated fatty acid and decreased composition of saturated fatty acid) and improved the sensory evaluation of pork meat from fattening pigs.

• The Korean Journal of Mycology
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• 제40권1호
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• pp.7-10
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• 2012

Endophytic fungi were isolated from the roots of halophytes, Suaeda japonica and Carex scabrifolia in the Suncheonbay. The ITS region in rDNA of 15 endophytic fungal strains were amplified using PCR with universal primers ITS1 and ITS4, and those amplified fragments were sequenced. Based on ITS sequence, five fungal genera were identified in S. japonica and seven fungal genera were identified in C. scabrifolia. The Shannon's diversity index (H') of endophytic fungi isolated from S. japonica and C. scabrifolia was 1.561 and 1.889, respectively. In phylogenetic analysis, it was shown that Ascomycota and Pezizomycotina was widely distributed both in S. japonica and C. scabrifolia. Also, Sordariomycetes, Dothideomycetes and Eurotiomycetes were shown to be distributed in these halophytes used in this experiment.

• Archives of Plastic Surgery
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• 제38권2호
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• pp.155-160
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• 2011

Purpose: Fibrillar collagens like type I collagen, are the major constituent of the extracellular matrix and structural protein of bone. Also, it can be a scaffold for osteoblast migration. The purpose of this study is to estimate the effects of absorbable atelo-collagen sponge (Teruplug$^{(R)}$, Terumo biomaterials Co., Tokyo, Japan) insertion in tooth extraction sites on periodontal healing of the second molar, healing of the fractured mandibular bone and new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Methods: In our study of six cases of mandibular angle fractures, all of them underwent the extraction of the third molar tooth & absorbable atelo-collagen sponge insertion in tooth extraction site. Three of them had a intraoral infection & oral opening to fracture site, two of the six had dental caries, and only one had reduction problem due to third molar position. Six consecutive patients with noncomminuted fractures of the mandibular angle were treated by open reduction and internal fixation using one noncompression miniplates and screws placed through a transoral incision. Results: All of the patients have showed good postoperative functions and have not experienced complications requiring second surgical intervention. There was well healing of the mandibular bone and the most new bone formation of third molar socket after the extraction of the impacted third molar with mandibular angle fracture. Conclusion: The results of this study suggest that absorbable atelo-collagen sponge is relatively favorable bone void filler with prevention of tissue collapse, food packing, and enhance periodontal healing. Thus, the use of atelo-collagen sponge and one noncompression miniplate seems to be relatively easy, safe, and effective for the treatment of fractures of the mandibular angle and third molar extraction.