• Journal of Life Science
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• v.18 no.8
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• pp.1053-1058
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• 2008

Glutathione is a well known chemotherapeutic agent for liver disease and is a popular nutritional supplement in the United States. Previous our studies reported the suppressive effects of glutathione-enriched Saccharomyces cerevisiae FF-8 strain (FF-8GY) on carbon tetrachloride- and alcohol-induced hepatotoxicity. The primary objective of this study was to investigate the comparative effects of FF-8GY and commercially available glutathione-enriched yeast extract (GYE) against the oxidative stress in alcohol-induced fatty liver of rats. The lipid peroxidative index (thiobarbituric acid-reactive substances, TBARS) and antioxidant status (reduced glutathione level) were used to monitor those protective roles of FF-8GY or GYE treatment. When the rat was treated alcohol, the TBARS levels in the whole liver and the subfractions of microsomal and mitochondria were significantly increased but these were significantly decreased by FF-8GY treatment and tended to be lowered by GYE treatment. The concentration of hepatic glutathione is known to be closely associated with antioxidant system and this was slightly deplete in the alcohol-induced rats, but this was recovered by treating with FF-8GY. However, the glutathione concentration was more significantly decreased in the GYE supplementation in alcohol feeding rats. Alcohol treatment also negatively affected the serum total protein and albumin, but these were significantly increased near normal levels in FF-8GY coadministered rats. These results suggest that glutathione-enriched Saccharomyces cerevisiae FF-8 strain may have positively mediate the alcohol-induced oxidative stress, and this effect was more pronounced in FF-8GY compared to GYE.

• 대한한약
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• s.7
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• pp.19-20
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• 2003

• 대한한약
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• s.6
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• pp.19-19
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• 2002

• 대한한약
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• s.1
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• pp.258-260
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• 1997

• 대한한약
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• s.9
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• pp.27-28
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• 2005

• 대한한약
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• s.8
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• pp.24-25
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• 2004

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3C
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• pp.187-196
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• 2008

An earthquake of magnitude 5.0 occurred at Ssang-gye-sa, a Buddhist temple in Jirisan, located near the southern border of the Korean peninsula on 4 July 1936. It resulted in severe damage of several buildings and structures in Ssang-gye-sa. Particularly, the top component of a five-story stone pagoda in the temple was tipped over and fell down during the earthquake. This earthquake damage case would be usefully applied to estimating the intensity of ground motion in the Korean peninsula, a moderate seismicity region, where strong motion has never been recorded with the exception of historic seismic events. In order to estimate the local site effects and the corresponding ground motion at Ssang-gye-sa site, intensive site investigations including borehole drilling and in-situ seismic tests such as crosshole and SASW tests were performed in the temple area. Based on the site characteristics, site-specific seismic response analyses using various input motions were conducted for a representative Ssang-gye-sa site by means of both one-dimensional equivalent-linear and nonlinear methods with six input rock outcrop acceleration levels ranging from 0.044g to 0.220g. The resultant site-specific seismic responses indicated the amplified ground motions in the short-period range near the site period of Ssang-gye-sa. Furthermore, the intensity on rock outcrop of the 1936 Jirisan earthquake was estimated by making a comparison between the site responses analysis results in this study and the full-scaled seismic test of pagoda model in the prior study.

• Korea Petroleum Association Journal
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• no.12 s.22
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• pp.34-37
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• 1982

• 베이커리
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• no.10 s.315
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• pp.88-91
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• 1994

• The Monthly Technology and Standards
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• s.15
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• pp.11-12
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• 2003