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Effect of a Proton Pump Inhibitor on Tumor Bleeding Prevention in Unresectable Gastric Cancer Patients: a Double-Blind, Randomized, Placebo-Controlled Trial

  • Kim, Young-Il;Kim, Mi-Jung;Park, Sook Ryun;Kim, Hark Kyun;Cho, Soo-Jeong;Lee, Jong Yeul;Kim, Chan Gyoo;Kim, Gwang Ha;Park, Moo In;Nam, Byung-Ho;Park, Young Iee;Choi, Il Ju
    • Journal of Gastric Cancer
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    • v.17 no.2
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    • pp.120-131
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    • 2017
  • Purpose: Tumor bleeding is a major complication in inoperable gastric cancer. The study aim was to investigate the effects of proton pump inhibitor (PPI) treatment for the prevention of gastric tumor bleeding. Materials and Methods: This study was a prospective double-blind, randomized, placebo-controlled trial. Patients with inoperable gastric cancer were randomly assigned to receive oral lansoprazole (30 mg) or placebo daily. The primary endpoint was the occurrence of tumor bleeding, and the secondary endpoints were transfusion requirement and overall survival (OS). Results: This study initially planned to enroll 394 patients, but prematurely ended due to low recruitment rate. Overall, 127 patients were included in the analyses: 64 in the lansoprazole group and 63 in the placebo group. During the median follow-up of 6.4 months, tumor bleeding rates were 7.8% and 9.5%, in the lansoprazole and placebo groups, respectively, with the cumulative bleeding incidence not statistically different between the groups (P=0.515, Gray's test). However, during the initial 4 months, 4 placebo-treated patients developed tumor bleeding, whereas there were no bleeding events in the lansoprazole-treated patients (P=0.041, Gray's test). There was no difference in the proportion of patients who required transfusion between the groups. The OS between the lansoprazole (11.7 months) and the placebo (11.0 months) groups was not statistically different (P=0.610). Study drug-related serious adverse event or bleeding-related death did not occur. Conclusions: Treating patients with inoperable gastric cancer with lansoprazole did not significantly reduce the incidence of tumor bleeding. However, further studies are needed to evaluate whether lansoprazole can prevent tumor bleeding during earlier phases of chemotherapy (ClinicalTrial.gov, identifier No. NCT02150447).

Two Cases of Iatrogenic Pneumothorax after Intra-Muscular Stimulation (IMS) Therapy (근육 내 자극 요법 후 발생한 의인성 기흉 2예)

  • Son, Jun Gwang;Oh, In Jae;Jeong, Jong Pil;Kim, Soo Ok;Ju, Jin Yung;Lim, Jung Hwan;Cho, Gye Jung;Chae, Dong Ryeol;Kim, Kyu Sik;Kim, Yu Il;Lim, Sung Chul;Kim, Young Chul
    • Tuberculosis and Respiratory Diseases
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    • v.63 no.5
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    • pp.444-448
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    • 2007
  • Recently, intra-Muscular Stimulation (IMS) therapy is being increasingly used for musculoskeletal pain. This procedure is generally regarded as a safe procedure for the general public. Some cases of iatrogenic pneumothorax caused by acupuncture have been reported in the medical literature. However, a case of an IMS therapy associated pneumothorax has not reported. We experienced two cases of iatrogenic pneumothorax after IMS therapy. A 62 year-old man received IMS therapy on the right shoulder due to posterior neck pain. After IMS therapy, acute dyspnea and chest discomfort developed. The other patient was a 74 year-old woman who also received IMS therapy. This patient experienced a nonproductive cough and acute dyspnea after the treatment. As the popularity of this form of alternative medicine increases, we might expect to see more cases of iatrogenic pneumothorax. Physicians should be aware of the adverse events associated with IMS therapy.

A Case of Pheochromocytoma Accompanied with Alveolar Hemorrhage and Cardiogenic Pulmonary Edema (심인성 폐부종과 폐포성 출혈을 보인 갈색세포종 1예)

  • Jeong, Jong Pil;Ban, Hee Jung;Kim, Soo Ock;Son, Jun Gwang;Ju, Jin Yung;Kwon, Yong Soo;Oh, In Jae;Kim, Kyu Sik;Kim, Yu Il;Lim, Sung Chul;Kim, Young Chul
    • Tuberculosis and Respiratory Diseases
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    • v.64 no.3
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    • pp.219-223
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    • 2008
  • Pheochromocytoma is derived from the chromaffin tissue. The typical finding of pheochromocytoma is paroxysmal hypertension accompanied with various signs and symptoms that are due to the excess of catecholamines or other bioactive substances. Yet the diagnosis is sometimes difficult to make because its clinical presentation is quite variable. Especially, hemoptysis is a very rare symptom, so the diagnosis is often missed or delayed. Without making the correct diagnosis and then subsequently administering treatment, the condition may be fatal. We herein report on a 68 year-old woman who was admitted because of abdominal pain and hemoptysis. The initial radiologic findings suggested pulmonary edema with alveolar hemorrhage. The urine catecholamine levels were elevated and she developed catecholamine-induced cardiomyopathy. We performed bronchial arterial embolization and we administered alpha blocker medication for controlling the hemoptysis and hypertension. After the temporary symptomatic improvement, her clinical course was aggravated by pneumonia and pulmonary edema. In spite of performing definitive surgery for pheochromocytoma, she died of postoperative hemodynamic instability.

Quantitative Evaluation of Image Quality using Automatic Exposure Control (AEC 사용 유무에 따른 영상의 화질평가)

  • Kim, Gwang-ho;Yoo, Gwan-ju;Kang, Ji-won;Ko, Bong-joo;Kim, Kyoun-lan;Kim, Min-hee;Yoon, Young-woo;Ye, Soo-young;Choi, Seok-yoon
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.86-89
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    • 2015
  • Quantitative Evaluation of Image Quality using Automatic Exposure Control This it leads, the relationship of control and image between of photographing condition, DR proper use method proposing. Chest phantom acquires Chest PA images which it follows in conditional change, Image evaluation factor (SNR (Signal to Noise Ratio), CNR (Contrast to Noise Ratio), PSNR (Peak Signal to Ratio), RMS (Root Mean Square)). It excepted RMS price, SNR, CNR, PSNR the case which uses AEC it came out being high The fact that the quality of image is better there was a case which does not use AEC. but Price it was slight. Image qualitative it was deficient in AEC use presence. Through this, the overall situation and most efficient use of radiation workers is better suited. But Passive AEC use would be appropriate for use rather than proactive AEC.

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Assessing Water Quality of Siheung Stream in Shihwa Industrial Complex Using Both Principal Component Analysis and Multi-Dimensional Scaling Analysis of Korean Water Quality Index and Microbial Community Data (Principal Component Analysis와 Multi-Dimensional Scaling 분석을 이용한 시화공단 시흥천의 수질지표 및 미생물 군집 분포 연구)

  • Seo, Kyeong-Jin;Kim, Ju-Mi;Kim, Min-Jung;Kim, Seong-Keun;Lee, Ji-Eun;Kim, In-Young;Zoh, Kyung-Duk;Ko, Gwang-Pyo
    • Journal of Environmental Health Sciences
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    • v.35 no.6
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    • pp.517-525
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    • 2009
  • The water quality of Lake Shihwa had been rapidly deteriorating since 1994 due to wastewater input from the watersheds, limited water circulation and the lack of a wastewater treatment policy. In 2000, the government decided to open the tidal embankment and make a comprehensive management plan to improve the water quality, especially inflowing stream water around Shihwa and Banwol industrial complex. However, the water quality and microbial community have not as yet been fully evaluated. The purpose of this study is to investigate the influent water quality around the industrial area based on chemical and biological analysis, and collected surface water sample from the Siheung Stream, up-stream to down-stream through the industrial complex, Samples were collected in July 2009. The results show that the downstream site near the industrial complex had higher concentrations of heavy metals (Cu, Mn, Fe, Mg, and Zn) and organic matter than upstream sites. A combination of DGGE (Denaturing Gradient Gel Electrophoresis) gels, lists of K-WQI (Korean Water Quality Index), cluster analysis, MDS (Multi-Dimensional Scaling) and PCA (Principal Component Analysis) has demonstrated clear clustering between Siheung stream 3 and 4 and with a high similarity and detected metal reducing bacteria (Shewanella spp.) and biodegrading bacteria (Acinetobacter spp.). These results suggest that use of both chemical and microbiological marker would be useful to fully evaluate the water quality.

Lightweight design for windlass base frame using optimal design technique (최적 설계 기법을 적용한 Windlass base frame의 경량화 설계)

  • Songr, Ju-Han;Pack, Min-Hyuk;Kang, Han-Bin;Pack, In-Seok;Lee, Dong-Wook;Lee, Gye-Gwang;Lee, Seok-Soon
    • Journal of Advanced Marine Engineering and Technology
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    • v.37 no.5
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    • pp.477-483
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    • 2013
  • The widlass base frame which is currently used is designed by lots of volume and costs so as to obtain high rigidity in spite of the greatly external load. The purpose of this research is to draw conceptual design of optimal design which can satisfy high rigidity existing windlass base frame has and lessening the body at the same time. Therefore, it progressed conceptual design by applying Topology optimization and Size optimization based on the finite-element analysis for the early model and indicated the result by comparing the early model with optimized model. As the result of Topology optimization, its stress was increased by about 6MPa and weight was decreased by about 560kg in comparison with the early model. In addition, in case of Size optimization, its stress was increased by about 7MPa and weight was decreased by about 1,560kg in comparison with the early model.

Numerical Study on the Flow and Combustion Characteristics in Swirl-Premix Burners (스월 예혼합 버너의 유동 및 연소특성에 관한 수치적 연구)

  • Lim, Jun-Seok;Lee, Jong-Hyeok;Baek, Gwang-Min;Cho, Ju-Hyeong;Kim, Han-Seok;Sohn, Chae-Hoon
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.36 no.1
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    • pp.103-110
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    • 2012
  • The flow field, fuel-air mixing, and behaviors of turbulent flames have been investigated using the large eddy simulation (LES) numerical technique in a premixed swirl combustor equipped with EV double cone burners. Recirculation zones are generated by the swirl burner, and lean premixed flames are formed within a distance of 0.2 m from the tip of the burner. NOx emission of 0.46 ppm is predicted at 1 atm and an air/fuel ratio of 38.7. However, most of the CO generated in a flame front continues to be oxidized as it moves toward the exit, and CO emission of 5.45 ppm is predicted at the exit. The NOx emission can be reduced by decreasing the pressure and air/fuel ratio. The characteristics of NOx emission have been investigated through RANS simulations for various fuel injection types, and it is found thereby that five-lance-hole injection produces the lowest NOx emission rate.

Social work field training awareness on the impact of the research career (사회복지현장실습이 진로의식에 미치는 영향에 관한 연구)

  • Jeon, Seong-Nam
    • Journal of the Korea Society of Computer and Information
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    • v.19 no.6
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    • pp.119-128
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    • 2014
  • In this study, the social welfare field training course there is a growing awareness as professionals in order to verify the impact was conducted. G-local four-year university study social work majors by sampling 198 people were examined for the purpose, through self - survey was conducted. Materials and analytical methods in order to identify the characteristics of a variable frequency, and technical analysis, T-test, F-test, ANOVA, correlation (correlation), Regression (regression) was used for the SPSS 14.0. The results are as follows. First, the personal factors of the individual physician trainees reflect (${\beta}=.197$), and then the same about Social Welfare satisfaction (${\beta}=.205$) of the Social Welfare majors had significant impact on career identity. Second, the personal factors they chose what to major in social work satisfaction (${\beta}=-.291$), and if you feel you select a parent with a major in Social Work and Social Welfare major students feel the satisfaction of having a significant effect on the level of career decision crazy. Third, individual reflect personal physician factors (${\beta}=.156$) is significantly influenced the behavior of career preparation.

Evaluation of leaf morphology for distinguishing Prunus (Rosaceae) from Jeju, Korea (제주도산 벚나무속 잎 형질의 분류학적 검토)

  • Kim, Chan-Soo;Moon, Myung-Ok;Cheong, Eun Ju;Byun, Gwang Ok
    • Korean Journal of Plant Taxonomy
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    • v.35 no.2
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    • pp.81-98
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    • 2005
  • Leaf morphology was examined for Prunus species from Jeju Island. Analyzed were the leaf blade length, petiole length, width of blade, number of veins and angle of the base to the mid-vein as quantitative characters and the distribution of trichome, position of glandsand leaf features qualitative characters. A total of 25 OTU were phenetically analyzed by UPGMA. The resuling phenograms slightly differ from the currently recognized taxonomic system in two points. Prunus mume was clustered with P. padus and P. buergeriana. Prunu spendula and P. yedoensis were separated from the cluster of P. jaamasakura, P. speciosa, P. sargentii and P. jamasakura var. quelpaertensis. Except for the members of subgenus Cerasus, subgenera Padus (P. buergeriana and P. padus), Microcerasus (P. japonica) and Amygdalus were well defined. Some morphological characters of leaves such as the ratio of blade length to width, the length of blade to petiole, number of veins, the distance between the gland and base, the angle of base to mid-vein, and the distribution of trichome were useful as diagnostic features for Prunus from Jeju Island.

A Study on the Relationship of Job Satisfaction Factors, Job Satisfaction, Organizational Commitment and Turnover Intention of Call Center Agent (콜센터 상담사의 직무만족요인, 직무만족, 조직몰입과 이직의도 간의 상호관계에 관한 연구)

  • Park, Deuk
    • Journal of the Korea Society of Computer and Information
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    • v.16 no.11
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    • pp.209-217
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    • 2011
  • Recently, As it takes charge of the customer service in many enterprises, the importance of call center has been emphasized more and more. The growth of call center industry is leading lots of call center agents. But, Call center agent's frequent turnover deteriorates the labor productivity and quality. Also, This turnover increases training cost and recruit cost. For these reasons, management turnover in call center is emerging as an important issue. The purpose of this study is to analyze the relationship of job satisfaction factors, job satisfaction, organizational commitment and turnover intention of call center agent. To achieve these objective, as a conceptual model of the study, job satisfaction factors, job satisfaction, organizational commitment and turnover intention were reviewed and the model could be estimated through path analysis. According th the finding of this study, job satisfaction factors have positively impact on the job satisfaction, organizational commitment but have not directly impact on the turnover intention. Also job satisfaction and organizational commitment have negatively impact on the turnover intention. As a result, the meaningful implication of this study suggests that the increase of both job satisfaction and organizational commitment through the improvement of job satisfaction factors should be regard as important dimensions to decrease of turnover intention of call center agents.