• 한방재활의학과학회지
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• 제29권4호
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• pp.101-108
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• 2019

Objectives The purpose of this study is to evaluate the safety of Gunghatang tablet in healthy male volunteers. Methods Single center pharmacokinetics study was carried out in healthy male volunteers. Through the laboratory test, vital sign and adverse event data, safety evaluation was conducted. Total 15 of 16 subjects who met the inclusion criteria were enrolled and three subjects were allocated to waiting group. 12 subjects were allocated by serial number according to registration order. Subjects took the maximum daily dose of the tablet on the second day of hospitalization. For the evaluation of safety, blood samples were collected and vital sign were checked 4 times (screening, before administration, after administration and follow up period) during the trial. All adverse events were recorded and summarized as frequency and percentage. All continuous data were summarized as mean and standard deviation. For comparison of variables between before administration and after administration, data were analyzed by paired T-test or Wilcoxon signed rank test (p<0.05). Results As a result of all data related to vital sign and laboratory test in both group, there were no significant differences associated with the clinical trial drug between pre and post administration. And there was no adverse event associated with the clinical trial drug. Conclusions Gunghatang tablet were found to be safe for healthy male volunteers.

• 대한한방내과학회지
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• 제13권1호
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• pp.156-166
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• 1992

This study has been carried out to investigate the cause and symptom treatment of Dam-Hum (痰飮) by referring to 41 literatures. The results were as follows; 1. The factors causing Dam-Eum (痰飮) divided into 3 groups. The 1st outer factors are six dirty (六淫), 2nd week and yanghu (陽虛), 3rd mental. 2. The symptom of Dam-Eum (痰飮) is as follows. (1) dam(痰) : cough, retching, pain of sub-ribs, vomiting, crazy, coma, dizziness. (2) eum(飮) : edema, stimulus feeling in throat, cough with pain, cough, hemoptysis indigestion. 3. The treatment of Dam-Eum (痰飮) is as follows. gudam(祛痰), sungi(順氣), bobipaesin(補脾肺腎), chungyul(淸熱), jesep(除濕). 4. The drugs of Dam-Eum (痰飮) is as follows. gudam (祛痰): ejintang (二陳湯), dodamtang (導痰湯), gunghatang (芎夏湯). sungi (順氣) : chilgitang (七氣湯), gamisachiltang (加味四七湯). babi (補脾) : gwibitang (歸脾湯), sagunjatang (四君子湯). bopae (補肺) : bapaetang (補肺湯), yunpaeeum (潤肺湯), saeumjun (四飮煎). bosin (補腎) : yukmihwan (六味丸), palmihwan (八味丸), singihwan (腎氣丸).