• Journal of Science and Technology Studies
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• v.3 no.2 s.6
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• pp.61-82
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• 2003

In a new paradigm of competition, firms face a multiple industry in a generation and compete with existing capabilities and resources in a new industry. Firms need to increase dynamic capabilities to adjust to a radical change in terms of technologies for survival and sustainable growth in a new industry. But we lack a clear conceptual model explaining evolutionary process of firms facing a emerging industry with different experiences in a prior industry and where heterogeneity in firms' technological portfolios come from. How we explaining firms' heterogeneity arising in a new industiy? In this article, I suggest hypothesis explaining firms' heterogeneity in a new industry with the concept of existent industry's technological trajectories, available assets, core processes and show the possibility of model to explain the heterogeneity of firms.

• STI Policy Review
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• v.5 no.2
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• pp.20-42
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• 2014

The Brazil, Russia, India China and South Africa (BRICS) group has emerged as a collection of large economies which are outside the traditional groups of industrialised "first world" economies and which have altered the global distribution of economic power. The basis of their emergence is a combination of their size and growth rates, and the fact that they lie outside the established centres of global economic power. As such, they have "diversified" the power base of the global economic order. The question which is asked in this paper is whether the phenomenon of the BRICS goes beyond this to mark the start of a possible challenge to the neoliberal orthodoxy which emerged as the globally dominant policy paradigm since the collapse of the Soviet Union. This paper develops and uses a "modes of innovation" approach to explore the potential of the BRICS to constitute a structural rupture in the current globally dominant neoliberal mode of innovation. This question is important since, in the absence of this rupture, the remarkable development trajectory of the BRICS will serve to reinforce the legitimacy of the global orthodoxy. The paper first articulates the modes of innovation concept and then proceeds to locate the BRICS systems of innovation within the current globally dominant mode. On this basis it then provides an appraisal of the possible impact of the BRICS on the evolutionary path of the global system of innovation.

• Journal of Distribution Science
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• v.19 no.10
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• pp.75-86
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• 2021

Purpose: The purpose of this study is to address policy preparation and amendments on regulations in accommodation sharing for resource distribution by fostering better adjustment in a society, since previous studies are rarely investigated in those issues. After conduct exploratory research about laws and regulations of accommodation sharing, this study investigates how effective policy instruments improve trust in accommodation sharing and potential growth by investigating the perceptions of individuals and by applying policymaking procedures. Research design, data and methodology: The data is collected via online survey. Structural equation modeling with confirmatory factor analysis and non-recursive model with multiple regression analysis were applied. Results: The results of this study found that among proposed policy instruments, individuals perceive local ordinances, government publicizing and campaign, trust marks, taxation, penalties, and government controls are effective to build trust in accommodation sharing. Policies geared toward the majority of the public are more effective, while governments should establish a strategic approach as to which policies are introduced in public and which role the government plays in the departments. Conclusions: The results provide policy and managerial implications how to enhance distributional values of accommodation sharing economy with proper preparations and amendments of laws and regulations.

• BMB Reports
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• v.57 no.9
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• pp.388-399
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• 2024

Immunotherapy represents a promising treatment strategy for targeting various tumor types. However, the overall response rate is low due to the tumor microenvironment (TME). In the TME, numerous distinct factors actively induce immunosuppression, restricting the efficacy of anticancer immune reactions. Recently, metabolic reprogramming of tumors has been recognized for its role in modulating the tumor microenvironment to enhance immune cell responses in the TME. Furthermore, recent elucidations underscore the critical role of metabolic limitations imposed by the tumor microenvironment on the effectiveness of antitumor immune cells, guiding the development of novel immunotherapeutic approaches. Hence, achieving a comprehensive understanding of the metabolic requirements of both cancer and immune cells within the TME is pivotal. This insight not only aids in acknowledging the current limitations of clinical practices but also significantly shapes the trajectory of future research endeavors in the domain of cancer immunotherapy. In addition, therapeutic interventions targeting metabolic limitations have exhibited promising potential as combinatory treatments across diverse cancer types. In this review, we first discuss the metabolic barriers in the TME. Second, we explore how the immune response is regulated by metabolites. Finally, we will review the current strategy for targeting metabolism to not simply inhibit tumor growth but also enhance antitumor immune responses. Thus, we could suggest potent combination therapy for improving immunotherapy with metabolic inhibitors.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1996.06a
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• pp.179-200
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• 1996

The intrinsic instabilities of fluid flow occurred in the melt of the Czochralski crystal growth system Czochralski method, asymmetric flow patterns and temperature profiles in the melt have been studied by many researchers. The idea that the non-symmetric structure of the growing equipment is responsible for the asymmetric profiles is usually accepted at the first time. However further researches revealed that some intrinsic instabilities not related to the non-symmetric equipment structure in the melt could also appear. Ristorcelli had pointed out that there are many possible causes of instabilities in the melt. The instabilities appears because of the coupling effects of fluid flow and temperature profiles in the melt. Among the instabilities, the B nard type instabilities with no or low crucible rotation rates are analyzed by the visualizing experiments using X-ray radiography and the 3-D numerical simulation in this study. The velocity profiles in the Silicon melt at different crucible rotation rates were measured using X-ray radiography method using tungsten tracers in the melt. The results showed that there exits two types of fluid flow mode. One is axisymmetric flow, the other is asymmetric flow. In the axisymmetric flow, the trajectory of the tracers show torus pattern. However, more exact measurement of the axisymmetrc case shows that this flow field has small non-axisymmetric components of the velocity. When fluid flow is asymmetric, the tracers show random motion from the fixed view point. On the other hand, when the observer rotates to the same velocity of the crucible, the trajectory of the tracer show a rotating motion, the center of the motion is not same the center of the melt. The temperature of a point in the melt were measured using thermocouples with different rotating rates. Measured temperatures oscillated. Such kind of oscillations are also measured by the other researchers. The behavior of temperature oscillations were quite different between at low rotations and at high rotations. Above experimental results means that the fluid flow and temperature profiles in the melt is not symmetric, and then the mode of the asymmetric is changed when rotation rates are changed. To compare with these experimental results, the fluid flow and temperature profiles at no rotation and 8 rpm of crucible rotation rates on the same size of crucible is calculated using a 3-dimensional numerical simulation. A finite different method is adopted for this simulation. 50×30×30 grids are used. The numerical simulation also showed that the velocity and flow profiles are changed when rotation rates change. Futhermore, the flow patterns and temperature profiles of both cases are not axisymmetric even though axisymmetric boundary conditions are used. Several cells appear at no rotation. The cells are formed by the unstable vertical temperature profiles (upper region is colder than lower part) beneath the free surface of the melt. When the temperature profile is combined with density difference (Rayleigh-B nard instability) or surface tension difference (Marangoni-B nard instability) on temperature, cell structures are naturally formed. Both sources of instabilities are coupled to the cell structures in the melt of the Czochralski process. With high rotation rates, the shape of the fluid field is changed to another type of asymmetric profile. Because of the velocity profile, isothermal lines on the plane vertical to the centerline change to elliptic. When the velocity profiles are plotted at the rotating view point, two vortices appear at the both sides of centerline. These vortices seem to be the main reason of the tracer behavior shown in the asymmetric velocity experiment. This profile is quite similar to the profiles created by the baroclinic instability on the rotating annulus. The temperature profiles obtained from the numerical calculations and Fourier transforms of it are quite similar to the results of the experiment. bove esults intend that at least two types of intrinsic instabilities can occur in the melt of Czochralski growing systems. Because the instabilities cause temperature fluctuations in the melt and near the crystal-melt interface, some defects may be generated by them. When the crucible size becomes large, the intensity of the instabilities should increase. Therefore, to produce large single crystals with good quality, the behavior of the intrinsic instabilities in the melt as well as the effects of the instabilities on the defects in the ingot should be studied. As one of the cause of the defects in the large diameter Silicon single crystal grown by the

• Management & Information Systems Review
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• v.38 no.1
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• pp.121-139
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• 2019

This study aims to identify the change of customer participation(CP) which is essential to the service industry as the relationship between the customer and the employee develops. The latent growth modeling analysis based on the longitudinal data is utilized to examine the pattern of the change. This is based on the fact that CP needs to be understood in the relationship and is to confirm the change in CP by the development of the relationship. Given the dynamics of the relationship, we intend to overcome the limitations of previous cross-sectional researches by revealing the trajectory of CP in the relationship through the longitudinal data. We also want to examine which variables in the relationship can facilitate changes of CP. Research has shown that CP is significantly changed with the development of the relationship when we analyzed it through latent growth modeling. This confirms that CP needs to be understood in the relationship. In addition, 'relationship proneness' variable and 'dependence to provider' variable have positive effects on the initial values of CP, but they have not been established to promote the changes of CP. Consequently, when considering the dynamics of relationships, it is important to recognize that CP is also dynamic. This study sought to get out of the cross-sectional and fragmented understanding of CP that is dynamic. Through this, we would like to propose the successful operation of the customer management program of service firms in relation to CP. This will lead to the success of service encounter where appropriate CP levels at each stage of relationship development can be achieved.

• Journal of Korean Home Economics Education Association
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• v.33 no.4
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• pp.31-48
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• 2021

The purpose of this study was to provide an understanding of the trajectories of multidimensional health among older adults, including depression, chronic diseases, and cognitive function. Data were drawn from the 1-6 waves of the Korean Longitudinal Study of Ageing(KLoSA), and a sample of 2,059 respondents aged 65 and older at baseline was used for the analyses. Latent growth curve models and growth mixture models were used to explore the changes in depression, chronic diseases, cognitive function, and heterogeneous trajectories among them. One-way ANOVAs with Scheffé post-hoc analysis and chi-square tests were used to find differences in sociodemographic characteristics, health behaviors, and life satisfaction across the latent trajectory classes. Latent growth curve models revealed that depressive symptoms and the number of chronic diseases increased over time, while cognitive function showed gradual decreases. Three heterogeneous patterns of multidimensional health trajectories were identified: normal aging, increase in chronic diseases, and chronic deterioration. Significant differences were observed in sociodemographic characteristics, health behaviors, and life satisfaction across the three latent classes. In particular, low educational attainment, household income, and life satisfaction were associated with the chronic deterioration class. Based on the findings, we discussed suggestions for health promotion education targeting older adults. This study also emphasizes the importance of home economics education in promoting health literacy across the life course.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.84-93
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• 2020

This study had two aims (1) to explore the trajectory of family functioning (flexibility and cohesion) in the mothers' perspective and classify it according to the development of their child, and (2) to examine the differences in children's self-esteem as well the internal and external behavioral problems based on the latent groups. A total of 1,348 mothers and their children who participated in the survey in 2013 through to 2017 were analyzed. The group was subdivided into low incremental, average incremental, average-above incremental, and high unchanged groups according to the flexibility, and into low incremental, average incremental, decremental, high incremental, and above-high unchanged groups in terms of cohesion. From 2015 to 2017, the self-esteem of elementary school-age children showed differences depending on the flexibility and cohesion of family functioning; children in the high-unchanged group of flexibility and the above-high unchanged group of cohesion showed high self-esteem. Behavior problems of early childhood and elementary school-age children varied according to the latent classes of flexibility and the cohesion of family functioning. Children in low incremental and average incremental groups of flexibility and low incremental, average incremental, and decremental groups of cohesion showed more internal and external behavioral problems. These findings suggest that family functioning has significant effects on the psychological aspects of children.

• Journal of the Economic Geographical Society of Korea
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• v.4 no.2
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• pp.57-77
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• 2001

The Honam region has been recognized as one of the most lagging regions in Korea. Drawing upon some decompositions oi Gross Regional Domestic Product(GRDP) per head and labor productivity, the overall trend of inequalities in Korea has been revealed and the trajectory of the Honam region's economic change has been identified by examining how the region's economic performance changed relative to that of Korea in the 1990s. There are some findings. First of all, Korea is characterized by strong divergence in the development of its region economies, in terms o\ulcorner per capita GRDP, which relies upon productivity differentials rather than differences in employment rates. Second, the Honam region has displayed poor economic performances in terms of GRDP per head except for Jeonnam. Third, the dramatic fall in cumulative population growth relative to the national average has been an important factor in the Jeonnam's overwhelming economic performance measured by per capita GRDP. Fourth, the decline in the relative productivity of the Honam region is mostly explained by falling relative regional productivity growth in construction, transport and manufacturing, although it should be noted that the latter sector has made positive contribution to raising relative regional productivity of Jeonnam. Fifth, overall the shift in employment to service sector, especially to social, personal, public, health, education, other services other than distribution, hotels, catering has tended to support relative regional productivities, along with the positive contribution being made oi agriculture, forestry and fishing to relative regional productivity growth in the Honam region.

• 한국노년학
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• v.37 no.1
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• pp.15-32
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• 2017

The current study aims to identify the heterogeneous changes of functional disabilities in old age rather than to identify an average longitudinal pattern and to explore the effect of health status and social status as risk factors in functional disability trajectories. The sample consisted of a representative sample of community dwellers aged 65 and older from the Korean Longitudinal Study of Ageing (2006 - 2012) was the focus of the study. Latent Class Growth Analysis was used to identify the functional disability trajectory groups. Variables regarding health status and social status changes by class were identified using multinomial logistic regression. The results showed various change patterns in functional disability, which include independent (78%), stable high (4.4%), steeply increasing (7.1%), slightly increasing (5.5%), and moderate to low (4.7%). Aggravation in depressive symptoms and cognitive functions as well as decline in social participations and social engagements were significant predictors of membership in increasing group of functional disability. The findings provide important initial empirical information to target clinical practice and have implications in the importance of conducting research on groups with different characteristics.