• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.217-223
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• 2013

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the outcomes for patients are still poor. It is important to determine the original type of synchronous multinodular HCC for preoperative assessment and the choice of treatment therapy as well as for the prediction of prognosis after treatment. Aims: To analyze clinicopathologic characteristics and prognoses in patients with multicentric occurrence (MO) and intrahepatic metastasis (IM) of synchronous multinodular hepatocellular carcinoma (HCC). Methods: The study group comprised 42 multinodular HCC patients with a total of 112 nodules. The control group comprised 20 HCC patients with 16 single nodular HCC cases and 4 HCC cases with a portal vein tumor emboli. The mitochondrial DNA (mtDNA) D-loop region was sequenced, and the patients of the study group were categorized as MO or IM based on the sequence variations. Univariate and multivariate analyses were used to determine the important clinicopathologic characteristics in the two groups. Results: In the study group, 20 cases were categorized as MO, and 22 as IM, whereas all 20 cases in the control group were characterized as IM. Several factors significantly differed between the IM and MO patients, including hepatitis B e antigen (HBeAg), cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and the histological grade of the primary nodule. Multivariate analysis further demonstrated that cirrhosis and portal vein and/or microvascular tumor thrombus were independent factors differentiating between IM and MO patients. The tumor-free survival time of the MO subjects was significantly longer than that of the IM subjects ($25.7{\pm}4.8$ months vs. $8.9{\pm}3.1$ months, p=0.017). Similarly, the overall survival time of the MO subjects was longer ($31.6{\pm}5.3$ months vs. $15.4{\pm}3.4$ months, p=0.024). The multivariate analysis further demonstrated that the original type (p=0.035) and Child-Pugh grade (p<0.001) were independent predictors of tumor-free survival time. Cirrhosis (p=0.011), original type (p=0.034) and Child-Pugh grade (p<0.001) were independent predictors of overall survival time. Conclusions: HBeAg, cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and histological grade of the primary nodule are important factors for differentiating IM and MO. MO HCC patients might have a favorable outcome compared with IM patients.

• The Journal of Korean Association of Computer Education
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• v.4 no.2
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• pp.31-39
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• 2001

In this paper, we investigate the effects of group composition according to the personality type of learner on the content of discussion in web-based synchronous online discussion. The experiment for this study was conducted with high school students. First, we conducted the MBTI(Myers Briggs Type Indicator) test and based upon the result, we classified learners into 3 groups; introverts group, extroverts group, and introverts/extroverts mixed group. After the online discussion, the content of discussion were analyzed by the units of meaning, based on the four dimensions which were proposed in the 'content analysis model' by Henri(l992). Among four dimensions, 'social' and 'interactive' dimension belonged to category of inter-dependence, and 'cognitive' and 'metacognitive' dimension belonged to category of subject-relevance. The introverts/extroverts mixed group, which was heterogeneously composed, had the most positive effects on the total numbers of the units of meaning, the inter-dependence, and the subject-relevance of the contents of discussion.

• Physical Therapy Korea
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• v.29 no.3
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• pp.187-193
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• 2022

Background: Neuromuscular electrical stimulation (NMES) is a physical modality used to activate skeletal muscles for strengthening. While voluntary muscle contraction (VMC) follows the progressive recruitment of motor units in order of size from small to large, NMES-induced muscle contraction occurs in a nonselective and synchronous pattern. Therefore, the outcome of muscle strengthening training using NMES-induced versus voluntary contraction might be different, which might affect balance performance. Objects: We examined how the NMES training affected balance and proprioception. Methods: Forty-four young adults were randomly assigned to NMES and VMC group. All participants performed one-leg standing on a force plate and sat on the Biodex (Biodex R Corp.) to measure balance and ankle proprioception, respectively. All measures were conducted before and after a training session. In NMES group, electric pads were placed on the tibialis anterior, gastrocnemius, and soleus muscles for 20 minutes. In VMC group, co-contraction of the three muscles was conducted. Outcome variables included mean distance, root mean square distance, total excursion, mean velocity, 95% confidence circle area acquired from the center of pressure data, and absolute error of dorsi/plantarflexion. Results: None of outcome variables were associated with group (p > 0.35). However, all but plantarflexion error was associated with time (p < 0.02), and the area and mean velocity were 37.0% and 18.6% lower in post than pre in NMES group, respectively, and 48.9% and 16.7% lower in post than pre in VMC group, respectively. Conclusion: Despite different physiology underlying the NMES-induced versus VMC, both training methods improved balance and ankle joint proprioception.

• Journal of Marine Life Science
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• v.7 no.1
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• pp.37-44
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• 2022

This study was performed to obtain information on the sex ratio, size at sexual group maturity, and main spawning period of Glyptocephalus stelleri. The sex ratio (female: male) was 1:0.54 (n=189:103, 64.7% female), and the frequency of females in the population tended to increase with total length. The oocyte development pattern was group synchronous development, in which oocyte groups at different stages were identified within the same ovary. The total length at 50% sexual group maturity was analyzed using a logistic regression model, and was determined to be 28.51 (female) and 30.49 cm (male). The gonadosomatic index (GSI) displayed the highest values in April (female) and March (male), and the main spawning period being in April to May.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.4
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• pp.85-94
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• 2003

The asynchronous design methods proved to have the higher performance in power consumption and execution speed than synchronous ones because it just needs to activate the required module without feeding clock in the system. Despite the advantage of CISC machine providing the variable addressing modes and instructions, its execution scheme is hardly suited for a synchronous Pipeline architecture and incurs a lot of overhead. This paper proposes a novel asynchronous pipeline architecture, A80sl, whose instruction set is fully compatible with that of Intel 80C51, an embedded micro controller. We classify the instructions into the group keeping the same execution scheme for the asynchronous pipeline and optimize it eliminating the bubble stage that comes from the overhead of the multi-cycle execution. The new methodologies for branch and various instruction lengths are suggested to minimize the number of states required for instructions execution and to increase its parallelism. The proposed A80C51 architecture is synthesized with 0.35${\mu}{\textrm}{m}$ CMOS standard cell library. The simulation results show higher speed than that of Intel 80C51 with 36 MHz and other asynchronous counterparts by 24 times.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.1945-1955
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• 2018

High frequency signal injection (HFI) is an alternative method for estimating rotor position of interior permanent magnet synchronous motor (IPMSM). The general method of frequency and amplitude selection is based on error tolerance and experiments, and is usually set with only one group of HF parameters, which is not efficient for different working modes. This paper proposes a novel rotor position estimation scheme by HFI with optimized frequency and amplitude, based on the mathematic model of IPMSM. The requirements for standstill and low-speed operational modes are met by applying this novel scheme. Additionally, the effects of the frequency and amplitude of the injected HF signal on the position estimation results under different operating conditions are analyzed. Furthermore, an optimization method for HF parameter selection is proposed to make the estimation process more efficient under different working conditions according to error tolerance. The effectiveness of the propose scheme is verified by the experiments on an IPMSM motor prototype.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.6
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• pp.121-126
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• 2018

IEEE 802.1 TSN TG is developing standards for end-to-end delay bounds and zero packet loss based on Ethernet technology. We focus on packet forwarding techniques. TSN packet forwarding techniques can be classified into Synchronous and Asynchronous framework. Synchronous approach allocates fixed time period for a class, yet is complex for large networks. Asynchronous approach provides delay guarantee by regulator-scheduler pair, yet is unnecessarily complex, too. We propose network components for TSN Asynchronous architecture, which remove the complexity of maintaining flow state for regulation decisions. Despite such a simplicity, the proposed architecture satisfies the TSN's delay requirements provided the limited high priority traffic's maximum packet length.

• Journal of Power Electronics
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• v.10 no.5
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• pp.485-490
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• 2010

Sensorless control methods are generally used in motor control for home-appliances because of the material cost and manufactureing standard restrictions. The current model-based control algorithm is mainly used for PMSM sensorless control in the home-appliance industry. In this control method, the rotor position is estimated by using the d-axis and q-axis current errors between the real system and a motor model of the position estimator. As a result, the accuracy of the motor model parameters are critical in this control method. A mismatch of the PMSM parameters affects the speed and torque in low speed, steadystate responses. Rotor position errors are mainly caused by a mismatch of the stator resistance. In this paper, a stator resistance compensation algorithm is proposed to improve sensorless control performance. This algorithm is easy to implement and does not require a modification of the motor model or any special interruptions of the controller. The effectiveness of the proposed algorithm is verified through experimental results.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1231-1233
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• 2012

Objective: The aim of this study was to explore the expression of DLC-l in breast carcinoma and any association with tumor metastasis. Methods: 51 surgical specimens of human breast carcinoma, divided into high invasive and low invasive groups according to their clinicopathological features, 30 cases of adjacent normal tissue and 28 benign breast lesions were examined by qRT-PCR for expression of DLC-1. Results: Expression level of DLC-1 in adjacent normal tissue and benign breast lesion specimens was higher than that in breast carcinoma (P<0.0001); the values in the high invasive group with synchronous metastases were also lower than in the low invasive group (P=0.0275). The correlation between DLC-1 expression level and tumor progression and metastasis of breast cancer was negative. Conclusion: As an anti-oncogene, DLC-1 could play an important part in breast carcinoma occurrence, progression, invasiveness and metastasis. Detecting the changes of the expression of DLC-1 in the breast carcinoma may contribute to earlier auxiliary diagnosis of invasiveness, metastasis and recrudescence.

• Korean Journal of Computational Design and Engineering
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• v.20 no.4
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• pp.337-347
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• 2015

This paper presents a dynamic association and natural interaction method for multi-displays composed of smart devices. Users can intuitively associate relations among smart devices by shake gestures, flexibly modify the layout of the display by tilt gestures, and naturally interact with the multi-display by multi-touch interactions. First of all, users shake their smart devices to create and bind a group for a multi-display with a matrix configuration in an ad-hoc and collaborative situation. After the creation of the group, if needed, their display layout can be flexibly changed by tilt gestures that move the tilted device to the nearest vacant cell in the matrix configuration. During the tilt gestures, the system automatically modifies the relation, view, and configuration of the multi-display. Finally, users can interact with the multi-display through multi-touch interactions just as they interact with a single large display. Furthermore, depending on the context or role, synchronous or asynchronous mode is available to them for providing a split view or another UI. We will show the effectiveness and advantages of the proposed approach by demonstrating implementation results and evaluating the method by the usability study.