• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.77-85
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• 2011

Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathway studio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.

• Journal of the Korea Concrete Institute
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• v.18 no.3 s.93
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• pp.389-395
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• 2006

For the assessment of exsiting concrete structures, it is important to get the real strength of concrete. The load test or core test has many problems due to cost time, easiness, structural damage, and reliability and so on. Thus, various non-destructive test and statistical analysis techniques for strength assessment have been developed. As a result the real strength of concrete can be obtained by both direct and indirect test. In this study, a series of experimental tests of core strength and Schmidt hammer tests on 3, 7, 14, 28, 90, 180, 365, and 730 days' were done for predicting the compressive strength of high strength concrete with 65.0MPa of 28-days' strength. Each experimental results was analyzed by simple regression analysis. Then, reliability level and error rate between the proposed equations and the existing ones was examined. However, the application of the exsisting equations was inadequate to high strength concrete, because they were conducted under normal strength concrete. Therefore, the following compressive strength equations were proposed for predicting the compressive strength of high strength concrete by Schmidt hammer test. The proposed equations by Schmidt hammer test are as follows.

• Journal of Nutrition and Health
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• v.54 no.6
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• pp.573-583
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• 2021

Energy requirement is defined as energy expenditure in an energy equilibrium state. The doubly labeled water (DLW) method is considered the gold standard for measuring total energy expenditure (TEE). In 2002, the Institute of Medicine (IOM) of the National Academies established dietary reference intakes (DRIs) for Americans and Canadians, and the equations for estimated energy requirement (EER) were developed by using pooled data from studies that had applied the DLW method. Since 2005, these equations have been used for establishing EER in the DRI for Koreans. These equations based on age group include the physical activity (PA) coefficient determined by the PA level (PAL; sedentary, low active, active and very active) as well as body weight and height. The PAL values of Koreans calculated using the DLW method and PA diaries were determined to fall in the low active category (1.40~1.59). Therefore, the PA coefficient corresponding to 'low active' was applied to the EER equations. In recent years, with increasing number of people regularly engaging in various physical activities in Korea, EER is now separately presented for people with 'active' and 'very active' PALs. In the future, like the United States and Japan, Korea needs to expand the DLW research for developing EER predictive equations for Koreans. In addition, standardized guidelines should be prepared to accurately evaluate the PAL using the physical activity diary and the new PA classification table for Koreans.

• Journal of Advanced Research in Ocean Engineering
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• v.1 no.3
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• pp.157-167
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• 2015

In order to provide simple and accurate wave theory in design of offshore structure, an analytical approximation is introduced in this paper. The solution is limited to flat bottom having a constant water depth. Water is considered as inviscid, incompressible and irrotational. The solution satisfies the continuity equation, bottom boundary condition and non-linear kinematic free surface boundary condition exactly. Error for dynamic condition is quite small. The solution is suitable in description of breaking waves. The solution is presented with closed form and dispersion relation is also presented with closed form. In the last century, there have been two main approaches to the nonlinear problems. One of these is perturbation method. Stokes wave and Cnoidal wave are based on the method. The other is numerical method. Dean's stream function theory is based on the method. In this paper, power series method was considered. The power series method can be applied to certain nonlinear differential equations (initial value problems). The series coefficients are specified by a nonlinear recurrence inherited from the differential equation. Because the non-linear wave problem is a boundary value problem, the power series method cannot be applied to the problem in general. But finite number of coefficients is necessary to describe the wave profile, truncated power series is enough. Therefore the power series method can be applied to the problem. In this case, the series coefficients are specified by a set of equations instead of recurrence. By using the set of equations, the nonlinear wave problem has been solved in this paper.

• Journal of the Society of Naval Architects of Korea
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• v.50 no.3
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• pp.175-181
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• 2013

This paper presents a simulation for passenger ship evacuation considering the inclination of a ship. In order to describe a passenger's behavior in an evacuation situation, a passenger is modeled as a rigid body which translates in the horizontal plane and rotates along the vertical axis. The position and rotation angle of a passenger are calculated by solving the dynamic equations of motions at each time step. To calculate inclined angle of damaged ship, static equilibrium equations of damaged ship are derived using "added weight method". Using these equations, physical external forces due to the inclination of a ship act on the body of each passenger. The crowd behavior of the passenger is considered as the flock behavior, a form of collective behavior of a large number of interacting passengers with a common group objective. Passengers can also avoid an obstacle due to penalty forces acting on their body. With the passenger model and forces acting on its body, the test problems in International Maritime Organization, Maritime Safety Committee/Circulation 1238(IMO MSC/Circ.1238) are implemented and the effects of ship's inclination on the evacuation time are confirmed.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.24 no.1
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• pp.10-15
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• 2012

Wave characteristics in the presence of energy damping are investigated using the linear shallow water equations. To get the phase and energy velocities, geometric optics approach is used and then these values are validated through numerical experiments. Energy damping affects wave height, phase and energy velocities which result in wave transformation. When the complex wavenumber is used by the Eulerian approach, it is found that the phase velocity decreases as the damping increases while the energy velocity increases showing higher values than the phase velocity. When the complex angular frequency is used by the Lagrangian approach, the energy-damping wave group is found to propagate in the energy velocity. The energy velocity is found to affect shoaling and refraction coefficient which is verified through numerical experiments for waves on a plane slope.

• Korean Journal of Optics and Photonics
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• v.18 no.6
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• pp.410-420
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• 2007

We theoretically derive the set of utilizable paraxial zoom locus equations for all complicated zoom lens systems with infinite object distance, such as a camera zoom lens, by using the Gaussian bracket method and the matrix representation of paraxial ray tracing. And we make the zoom locus program according to these equations in Visual Basic. Since we have applied the paraxial ray tracing equations into Gaussian bracket representation, the resultant program systematically simplifies various constraints of the zoom loci of various N group types. Consequently, the solutions of this method can be consistently used in all types of zoom lens in the step of initial design about zoom loci. Finally, in order to verify the usefulness of this method, we show that one example among 4 groups and that among 5 groups, which are very complex zoom lens systems, can be rapidly and with versatility traced through various interpolations by using this program.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.4
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• pp.11-20
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• 2004

This paper suggests the site-dependent ductility factor which is a key component of response modification factor(R). To compute the ductility factor, a group of 1,860 ground motions recorded from 47 earthquake was considered. Based on the local site conditions at the recording station, ground motions were classified into four groups according to average shear wave velocity. This site classification was consistent with site categories of the UBC(1997), NEHRP(1997) and IBC 2000(1997). Based on the results of regression analysis, a simplified equations were proposed to compute site-dependent ductility factors. The proposed equations were relatively simple and provide a good estimation of mean ductility factors. Based on the proposed equation, ductility factors considering the site conditions can be evaluated in accordance with the present building codes.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.38 no.11
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• pp.861-869
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• 1989

The optimization problems, based on Pontryagin's Maximum Principle, for minimizing (damping) Xenon spatial oscillations in Load Following operations of Pressurized Water Reactor (PWR) is presented. The optimization model is formulated as an optimal tracking problem with quadratic objective functional. The oen-group diffusion equations and Xe-I dynamic equations are defined as equality constraints. By applying the maximum principle, the original problem is decomposed into a single time problem with no constraints. The resultant subproblems are optimized by using the conjugate Gradient Method. The computational results show that the Xenon spatial oscillation is minimized, and the reactor follows the load demand of the electrical power systems while maintaining the desired power distribution.

• Structural Engineering and Mechanics
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• v.73 no.5
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• pp.555-563
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• 2020

The objective of present paper is assessment of dynamic buckling behavior of an embedded sandwich microplates in thermal environment in which the layers are reinforced through functionally graded carbon nanotubes (FG-CNTs). Therefore, mixture rule is taken into consideration for obtaining effective material characteristics. In order to model this structure much more realistic, Kelvin-Voigt model is presumed and the sandwich structure is rested on visco-Pasternak medium. Exponential shear deformation theory (ESDT) in addition to Eringen's nonlocal theory are utilized to obtain motion equations. Further, differential cubature method (DCM) as well as Bolotin's procedure are used to solve governing equations and achieve dynamic instability region (DIR) related to sandwich structure. Different parameters focusing on volume percent of CNTs, dispersion kinds of CNTs, thermal environment, small scale effect and structural damping and their influences upon the dynamic behavior of sandwich structure are investigated. So as to indicate the accuracy of applied theories as well as methods, the results are collated with another paper. According to results, presence of CNTs and their dispersion kind can alter system's dynamic response as well.