• Archives of Pharmacal Research
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• 제26권8호
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• pp.597-600
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• 2003

Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1 ,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제6권9호
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• pp.445-456
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• 2017

본 논문에서는 트레이닝 데이터가 제한된 환경에서 n-gram 사전을 이용하여 불건전 정보를 포함하는 스팸 트윗을 탐지하는 방법을 제안한다. 불건전 정보를 포함하는 스팸 트윗은 유사한 단어와 문장을 사용하는 경향이 있다. 이러한 특성을 이용하여 스팸 트윗과 정상 트윗에 대한 n-gram 사전을 구축하고 나이브 베이스 분류기를 적용하여 효과적으로 스팸 트윗을 탐지할 수 있음을 보인다. 반면에, 실시간으로 대용량의 데이터가 유입되는 트위터의 특성은 초기 트레이닝 집합 구성에 매우 큰 비용을 요구 한다. 따라서, 초기 트레이닝 집합이 매우 작거나 존재하지 않는 환경에서 적용할 수 있는 스팸 트윗 탐지 방법이 필요하다. 이를 위해 트위터의 리트윗 기능을 활용하여 의사 라벨을 생성하고 초기 트레이닝 집합의 구성과 n-gram 사전 업데이트에 활용하는 방법을 제안한다. 2016년 12월 1일부터 2016년 12월 7일까지 수집된 한국어 트윗 130만 건을 사용한 다양한 실험 결과는 비교 방법들보다 제안하는 방법의 성능이 우수함을 입증한다.

• 정보보호학회논문지
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• 제30권6호
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• pp.1043-1052
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• 2020

시그니처 기반 악성코드 탐지는 제로데이 취약점을 이용하거나 변형된 악성코드를 탐지하지 못하는 한계가 있다. 이를 극복하기 위해 N-gram을 이용하여 악성코드를 분류하는 연구들이 활발히 수행되고 있다. 기존 연구들은 높은 정확도로 악성코드를 분류할 수 있지만, Spectre와 같이 짧은 코드로 동작하는 악성코드는 식별하기 어렵다. 따라서 본 논문에서는 Spectre 공격 바이너리를 효과적으로 식별할 수 있도록 함수 단위 N-gram 비교 알고리즘을 제안한다. 본 알고리즘의 유효성을 판단하기 위해 165개의 정상 바이너리와 25개의 악성 바이너리에서 추출한 N-gram 데이터셋을 Random Forest 모델로 학습했다. 모델 성능 실험 결과, 25개의 Spectre 악성 함수의 바이너리를 99.99% 정확도로 식별했으며, f1-score는 92%로 나타났다.

• 한국통신학회논문지
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• 제33권7C호
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• pp.562-568
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• 2008

본 논문에서는 Gram-Schmidt 알고리즘에서 TDL(Tapped Delay Line) 필터의 계수를 구하는 방법과 등가의 Wiener-Hopf 방식의 해를 구하는 방법 중 정규화 알고리즘 두 가지를 제안한다. 이론적 해석에서 기존의 NLMS(Normalized Least Mean Square) 알고리즘이 입력의 파워의 합으로 정규화 하는 것에 비해 제안한 정규화 알고리즘들은 고유값들의 합으로 정규화 한다. 컴퓨터 모의실험에서 두 개의 pole이 단위원 밖의 근접한 위치를 가지는 불안정한 환경에서 시스템 식별을 수행하였다. 결과적으로, 제안한 두 개의 알고리즘은 Gram-Schmidt 알고리즘에서 TDL 필터의 계수를 회귀적으로 구할 수 있었고 기존의 NLMS 알고리즘에 비하여 우수한 수렴 성능을 나타냄을 알 수 있었다.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2006년도 제18회 한글 및 한국어 정보처리 학술대회
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• pp.125-132
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• 2006

한국어의 자연어처리 및 정보검색분야에서 자동 띄어쓰기는 매우 중요한 문제이다. 신문기사에서조차 잘못된 띄어쓰기를 발견할 수 있을 정도로 띄어쓰기가 어려운 경우가 많다. 본 논문에서는 자기 조직화 n-gram모델을 이용해 자동 띄어쓰기의 정확도를 높이는 방법을 제안한다. 본 논문에서 제안하는 방법은 문맥의 길이를 바꿀 수 있는 가변길이 n-gram모델을 기본으로 하여 모델이 자동으로 문맥의 길이를 결정하도록 한 것으로, 일반적인 n-gram모델에 비해 더욱 높은 성능을 얻을 수 있다. 자기조직화 n-gram모델은 최적의 문맥의 길이를 찾기 위해 문맥의 길이를 늘였을 때 나타나는 확률분포와 문맥의 길이를 늘이지 않았을 태의 확률분포를 비교하여 그 차이가 크다면 문맥의 길이를 늘이고, 그렇지 않다면 문맥의 길이를 자동으로 줄인다. 즉, 더 많은 정보가 필요한 경우는 데이터의 차원을 높여 정확도를 올리며, 이로 인해 증가된 계산량은 필요 없는 데이터의 양을 줄임으로써 줄일 수 있다. 본 논문에서는 실험을 통해 n-gram모델의 자기 조직화 구조가 기본적인 모델보다 성능이 뛰어나다는 것을 확인하였다.

• 미생물학회지
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• 제9권2호
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• pp.47-54
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• 1971

This study is concerned to the microbial population and its effects in the fish paste products. Experimental results were summarized as following orders ; 1) The number of bacteria in accordance with raw materials and coocking site waas known to as ; Wheat flor - $7.0{\times}10^8$/gram , Brayed fish meat - $2.0{\times}10^7$/gram, Cooking table - $6.1{\times}10^6$/$1.54cm^2$Chopped fish meat -$4.1{\times}10^6$/gram, Wooden plate - $5.5{\times}10^5$/218.32cm, Sodium chloride - $8.8{\times}10^4$/gram, Wheat starch - $4.5{\times}10^4$/gram, Fish meat - $2.3{\times}10^4$/gram. However, there were a few bacterial numbers less than 300 per gram of raw materials, such as monosodium glutamate, tap water, sugar, saccharine and eggs. 2) Bacterial population in the raw materials might be changed according to the conditions of preservation. 3) When the heat tratment is used for the preservation, the thermal effects were rarely found at the interior part of fish paste products. Conduction of heat into the interior part dose not rise about $84^{\circ}C$ and the survival of bacteria could be possible under the condition. Therefore, cooking being used requires further studies. 4) Number of bacteria in the fish paste products sold in the market was higher on April and May than those on June. Especially on June, the number of bacteriz in the interior part were found higher than those in the exterior part of the products.

• 약학회지
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• 제30권5호
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• pp.232-237
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• 1986

A series of modified poly(acrylic acid)'s containing different levels of 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and 6-[D-(-)-$\alpha$-aminophenyl acetamido] penicillanic acid (ampicillin) as pendant groups were prepared. Antibiotic activities of the newly prepared drugs were examined against the various gram-positive and gram-negative bacteria. It was found that ampicillin modified composition posses antibiotic activities against the gram-negative as well as the gram-positive bacteria.

• Asian-Australasian Journal of Animal Sciences
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• 제30권2호
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• pp.187-191
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• 2017

Objective: An experiment was conducted to examine the effect of dietary supplementation of dried and ground foliage of black gram (Vigna mungo L.) on feed intake and utilization, and production performance of crossbred lactating cows. Methods: Eighteen lactating crossbred (Bos taurus${\times}$Bos indicus) cows (body weight $330.93{\pm}10.82kg$) at their second and mid lactation (milk yield $6.77{\pm}0.54kg/d$) were randomly divided into three groups of six each in a completely randomized block design. Three supplements were formulated by quantitatively replacing 0, 50, and 100 per cent of dietary wheat bran of concentrate mixture with dried and ground foliage of black gram. The designated supplement was fed to each group with basal diet of rice straw (ad libitum) to meet the requirements for maintenance and milk production. Daily feed intake and milk yield was recorded. A digestion trial was conducted to determine the total tract digestibility of various nutrients. Results: The daily feed intake was increased (p<0.05) with the supplementation of black gram foliage. Although the digestibility of dry matter, organic matter, crude protein, and ether extract did not vary (p>0.05), the fibre digestibility was increased (p<0.05), which ultimately improved (p<0.05) the total digestible nutrients content of composite diet. Although, the average milk yield (kg/animal/d) and composition did not differ (p>0.05) among the groups, milk yield was increased by 10 per cent with total replacement of wheat bran in concentrate mixture with of black gram foliage. The economics of milk production calculated as feed cost per kg milk yield (INR 10.61 vs 7.98) was reduced by complete replacement of wheat bran with black gram foliage. Conclusion: Black gram foliage could be used as complete replacement for wheat bran in concentrate mixture of dairy cows in formulating least cost ration for economic milk production in small holders' animal production.

• 대한약침학회지
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• 제16권2호
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• pp.15-22
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• 2013

Objective: Evaluations of the in-vitro anti-bacterial activities of aqueous extracts of Acacia catechu (L.F.)Willd, Castanea sativa, Ephedra sinica stapf and Shilajita mumiyo against gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumonia) and gram-negative bacteria (Escherichia coli, klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa) are reasonable since these ethnomedicinal plants have been used in Persian folk medicine for treating skin diseases, venereal diseases, respiratory problems and nervous disorders for ages. Methods: The well diffusion method (KB testing) with a concentration of $250{\mu}g/disc$ was used for evaluating the minimal inhibitory concentrations (MIC). Maximum synergistic effects of different combinations of components were also observed. Results: A particular combination of Acacia catechu (L.F.) Willd, Castanea sativa, Ephedra sinica stapf and shilajita mumiyo extracts possesses an outstanding anti-bacterial activity. It's inhibiting effect on microorganisms is significant when compared to the control group (P<0.05). Staphylococcus aureus was the most sensitive microorganism. The highest anti-bacterial activity against gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumonia) or gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, and Pseudomonas aeruginosa) was exerted by formula number 2 (table 1). Conclusion: The results reveal the presence of anti-bacterial activities of Acacia catechu, Castanea sativa husk, Ephedra sp. and Mumiyo against gram-positive and gram-negative bacteria. Synergistic effects in a combined formula, especially in formula number 2 (ASLAN$^{(R)}$) can lead to potential sources of new antiseptic agents for treatment of acute or chronic skin ulcers. These results considering the significant anti-bacterial effect of the present formulation, support ethnopharmacological uses against diarrheal and venereal diseases and demonstrate use of these plants to treat infectious diseases.

• 한국임상수의학회지
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• 제21권2호
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• pp.133-139
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• 2004

Bacterial pathogens were isolated from 36 dogs with respiratory signs, that were submitted to Veterinary Clinics in Jeju, including Veterinary Medical Teaching Hospital in Cheju National University. Of 36 isolates, 16 (44.4%) bacterial pathogens were Gram-positive and 20 (55.6%) were Gram-negative. Gram-positive bacteria identified with API Staph were 12 S. intermedius (33.3%), 2 S. aureus (5.6%), 1 S. haemolyticum (2.8%), and 1 S. xylosus (2.8%). Gram-negative organisms identified with API 20E or API NE included 8 Bordetella bronchiseptica (22.2%), 6 Escherichia coli (16.7%), 4 Pasteurella spp. (11.1%), 1 Enterobacter intermedius (2.8%), and 1 Oligella ureolytica (2.8%). Both Staphylococcus spp. isolates and Gram-negative pathogens were resistant to one or more antibiotics, including ampicillin (AM), amoxicillin/clavulanic acid (AMC), chloramphenicol (C), cefazolin (CZ), erythromycin (E), gentamicin (GM), kanamycin (K), lincomycin (L), oxacillin (OX), trimethoprim/sulfamethoxazole (SXT), and tetracycline (TE). All Staphylococcus spp. were susceptible to AMC, OX and VA, while many isolates were highly resistant to L (87.5%), E (68.8%), P (62.5%), and AM (56.3%). Antibiotic-resistant patterns of staphylococcal isolates were shown ranges from single to 9-resistant patterns. Resistant rates to antibiotics of Gram-negative bacteria were usually higher than those of Staphylococcus spp. in this study. Most Gram-negative bacteria were highly resistant to L (90.0%), AM (85.0%), E (85.0%), P (85.0%), OX (80.0%), and CZ (75.0%). B. bronchiseptica isolates showed 5 to 8 antibiotics-resistant patterns and Pasteurella spp., 2 to 8-resistant patterns. In particular, all 6 E. coli isolates were resistant to more than 9 different kinds of antibiotics, including one strain resistant to all antibiotics tested.