• Transactions of Materials Processing
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• v.19 no.5
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• pp.305-310
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• 2010

Recently industry of motor vehicle is making a gradual progress of automotive electric components. According to this step, wire harness equipped at motor vehicle is also increased. The most important component at the wire harness is electric connector. At the manufacturing process of electric connector, exactly at the crimping process, design variables, such as clamping-height, clamping-width and clamping die shape are critical parameters to assure satisfactory harness shape in clamping process of electric connector. In this study we have performed FEM simulation for clamping process and clarified the effect of design variables on compression rate of wire.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.470-472
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• 1993

Nowadays, according to gradual progress of the information oriented society, it is being increase rapidly that social requirement for the high quality and stability of electric power supply. Therefore, for the sake of expansion of the various power system and reasonable operation and administration, there are some growing need for telecommunication system that will operate in high dependability performance and expansion by much. But beause of unestablished reliability analysis and evaluation methodology for power telecommunication system, it could not have a reasonable planning for the purpose of improving dependability performance on telecommunication system. The object of this study is to construct reasonable methodology of reliability evaluation fur the efficient power telecommunication facility administration.

• Osteoporosis and Sarcopenia
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• v.3 no.3
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• pp.117-122
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• 2017

Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.

• Journal of Pharmacopuncture
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• v.17 no.2
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• pp.7-17
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• 2014

Objectives: Condurango is widely used in various systems of complementary and alternative medicines (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats, in vivo to validate its use as traditional medicine. Methods: Fifteen male and 15 female Sprague-Dawley (SD) rats were treated with 0.28 mg/kg of Sweet Bee Venom (SBV) (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate reactive oxygen species (ROS), which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer cell-death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusion: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• Journal of Pharmacopuncture
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• v.18 no.2
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• pp.86-87
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• 2015

Objectives: Condurango is widely used in various systems of complementary and alternative medicine (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats in vivo to validate its use as a traditional medicine. Methods: After one month of scheduled BaP feeding (50 mg/kg body-weight), lung cancer developed after four months. BaP-intoxicated rats were then treated with Condurango (0.06 mL) twice daily starting at the end of the four months for an additional one, two and three months, respectively. Effects of Condurango were evaluated by analyzing lung histology, reactive oxygen species (ROS) and antioxidant biomarkers, DNA-fragmentation, RT-PCR (Reverese Transcriptase-Polymerase Chain Reaction), ELISA (Enzyme linked immunosorbent assay) and western blot of several apoptotic signalling markers and comparing the results against those obtained for controls. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate ROS, which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer-cell death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusions: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• Journal of The Korean Association For Science Education
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• v.2 no.1
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• pp.31-51
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• 1980

In order to research into the devel of the concept of movement and speed in our own way and compare with the Piaget's method, and then find out the formative period of such development, we have put the 192 primary school children as the model and obtained the following results. 1. As their grade upyards, all the experimental subjects showed the gradual progress generally regardless of sex or regions, while only the relative speed showed irregular progress. 2. There was no experimental subject which showed any remarkable sexual characteristics. But in the relative movement, the lower grade boys and higher grade girls made progress. In the subjects of circulation movement, intuition of speed, relative speed and speed of simultaneous movement, the boys marked better progress, whilst the girls were advanced a little in the speed of continuous movement with, different distance and time. 3. There was no conspicuous difference between the urban and rural areas, except a slight tendency that the urban children made better progress in the change of progressing direction, native continuous procedure of periodical movement, travelling road, and the speed of continuous movement with different distance and time whereas the rural children were more advanced in the relative movement, relative speed and intuition of speed. But it should be 'taken into consideration that the rural regions in our case were relatively developed in comparison with the traditional rural communities, which may explain about little regional difference. 4. Comparing our research results with the Piaget's theory, we have reached below results. Our research reports that the formative period of the conception of the problems of diverse progressing direction and a native continuous procedure of periodical movement was simultaneous, at the Piagetian level(at the fourth grade) which coincides with Piagetian theory. The travelling road should be made up a little lower at 2A/2B according' to Piagetian Level, whereas it was formed at the 4th grade as shown in our previous research. Intuition of speed should belong to the prior stage to concrete operation, but our research shows it was formed late at the 4th grade. Composition of displacement was made at the 6th grade, and it was almost equal to the first stage of formal operation(3A). But in the subjects of relative movement relative speed, the speed of continuous movement with different distance and time, relation and preservation of invariable speed, and accelerated motion, even 6th grade children marked a poor record. Summed up, the procedure conception as a basic movement conception coincides with the Piagetion level. But as for speed intuition, relative speed and speed fixation, it was Jar behind Piagetian level. Therefore it is required that we have to concentrate on the systematic training in these parts on the spot.

• Journal of Korean society of Dental Hygiene
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• v.6 no.2
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• pp.103-113
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• 2006

The purpose of this study was to examine and analyze motivation of entrance into the college, knowledge prior to the entrance, satisfaction with their major, and a sense of employment after graduation among students majoring in dental hygiene at some colleges and subdivide them by grades for comparative analysis to determine the progress of changes in general characteristics, department satisfaction, and a sense of employment among students majoring in dental hygiene for the recent three years and provide basic data for improving dental hygienic education. Questionnaires were distributed to 520 students majoring in dental hygiene at some college in South Chungcheong, South Jeolla, and North Jeolla Provinces, followed by explanation of the purport of the research and the content of the questionnaire; after completion, 513 copies were used for analysis with exception of 7 copies with insincere responses. The analysis of the data examined resulted in the following conclusions: First, Changes in Department Satisfaction among Students Majoring in Dental Hygiene As for motivation of entrance into a college, less and less students chose the department of dental hygiene through recommendation by parents or seniors while more and more students chose their major due to easy employment. Less and less students obtained information on the department from a college application guidebook while more and more students obtained it through Internet. There was also a gradual increase in prior knowledge about the department and in satisfaction with their major. More and more students had no will to change their course. Second, Changes in a Sense of Employment among Students Majoring in Dental Hygiene There was a gradual decrease in the number of students who would follow friends' or their own decision in selecting workplace but an increase in the number of those who would follow their professors' opinion. There was a gradual increase in the number of students who wanted to be employed in workplace with good social perception; many students wanted to be employed in a personal dental clinic, a general hospital, or a public health center; and more and more students also wanted to be employed in a school dental health center or to become a government official or an educator.

• Journal of Ocean Engineering and Technology
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• v.22 no.2
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• pp.28-33
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• 2008

From the 1997 to January, 2004, a groin 156m long was constructed at the mouth of the Heoya river-mouth as a protection and barrier. To understand the changes to Jinha beach from the blockade of the river mouth, several aerial photographs, etc., were compared, which showed that the changes were significant. Comparing these results to the state of the area before construction of the groin, the blockade of the river was relaxed, but the formation of the tombolo, in the middle groin area was accelerated and the total Jinha beach erosion and especially the erosion of the southern part of Jinha beach was developed. But according to statements by residents and some current documents, the blockade of the Heoya-river mouth is still underway at the surrounding areas of the groin and chronic dredged sand has been used for littoral nourishment at the northern part of the middle groin and on Jinha beach. The result of numerical simulation based on the present state shows that if this sort of dredging is stopped, the sand accumulation will progress near the river mouth groin and the existing tombolo at the middle groin will progress to the north and severe erosion will occur at the southern coastline near the middle groin and the farthest southern part of Jinha beach, and Jinha beach itself will experience a gradual erosion. The main reason for these erosions should be the typhoons that are happening during the summer season. To provide protection from these kinds of undesirable erosions, a total of 23 numerical simulations have been done. It has been shown that submerged breakwaters at the front area of the beach will be efficient to protect from main beach erosion, but there should be alternative proposals for the influence of the river mouth blockade.

• Progress in Superconductivity and Cryogenics
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• v.18 no.3
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• pp.6-9
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• 2016

The enhancement of mechanical properties of coated conductor (CC) tapes in practical application are usually achieved by reinforcing through lamination or electroplating metal layers on either sides of the CC tape. Mechanical or electromechanical properties of the CC tapes have been largely affected by the lamination structure under various loading modes such as tension, bending or even cyclic. In this study, the influence of brass laminate volume fraction on electromechanical properties of RCE-DR processed Gadolinium-barium-copper-oxide (GdBCO) CC tapes was investigated. The samples used were composed of single-side and both-side laminate of brass layer to the Cu-stabilized CC tape and their $I_c$ behaviors were compared to those of the Cu-stabilized CC tape without external lamination. The stress/strain dependences of $I_c$ in laminated CC tapes under uniaxial tension were analyzed and the irreversible stress/strain limits were determined. As a result, the increase of brass laminate volume fraction initially increased the irreversible strain limit and became gradual. The corresponding irreversible stress limit, however, showed no difference even though the brass laminate volume fraction increased to 3.4. But the irreversible load limit linearly increased with the brass laminate volume fraction.

• School Mathematics
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• v.15 no.2
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• pp.389-404
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• 2013

Researchers have suggested that students should be experienced in progress of geometric thinking set out in naive and intuitive level and deduced throughout gradual formalization rather than completed mathematics are conveyed to students for students' understanding. This study examined naive and intuitive thinking of students by investigating students' geometric problem solving without diagrams. The students showed these naive thinking: lack of recognition of relation between problem and conditions, use of intuitive judgement depending on diagrams, lacking in understanding of role of specific case, and use of unjustified assumption. This study suggests implication for instruction in geometry.