• Journal of Yeungnam Medical Science
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• v.31 no.2
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• pp.127-130
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• 2014

Autoimmune thyroiditis is the most common cause of hypothyroidism in the world. It is characterized clinically by gradual thyroid failure, goiter formation, or both, because of the autoimmune-mediated destruction of the thyroid gland. Renal involvement presenting proteinuria in autoimmune thyroiditis is not uncommon, occurring in 10% to 30% of the cases. Glomerulonephropathy associated with autoimmune thyroiditis, however, is a rare disease. Most reports of autoimmune thyroiditis with glomerulonephropathy have demonstrated a mixed pathological morphology and have been predominantly associated with membranous glomerulopathy. The case of minimal-change disease associated with thyroiditis presenting acute kidney injury is a rare disease that has not been reported in South Korea. Reported herein is the case of a 16-year-old man diagnosed with Hashimoto's thyroiditis, with minimal-change disease presenting acute kidney injury. He revealed hypothyroidism, proteinuria, and impaired renal function. Renal biopsy showed minimal-change disease and minimal tubular atrophy. The patient was treated with thyroid hormone, and his renal function and proteinuria improved. Therefore, for patients with autoimmune thyroiditis presenting unexplained proteinuria, glomer-ulonephropathy should be ruled out. Conversely, for patients with glomerulonephropathy and persistent proteinuria despite proper treatment, thyroid function and antibody tests should be performed.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.6
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• pp.533-543
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• 2021

Myocardial fibrosis (MF) is the result of persistent and repeated aggravation of myocardial ischemia and hypoxia, leading to the gradual development of heart failure of chronic ischemic heart disease. Triptolide (TPL) is identified to be involved in the treatment for MF. This study aims to explore the mechanism of TPL in the treatment of MF. The MF rat model was established, subcutaneously injected with isoproterenol and treated by subcutaneous injection of TPL. The cardiac function of each group was evaluated, including LVEF, LVFS, LVES, and LVED. The expressions of ANP, BNP, inflammatory related factors (IL-1β, IL-18, TNF-α, MCP-1, VCAM1), NLRP3 inflammasome factors (NLRP3, ASC) and fibrosis related factors (TGF-β1, COL1, and COL3) in rats were dete cted. H&E staining and Masson staining were used to observe myocardial cell inflammation and fibrosis of rats. Western blot was used to detect the p-P65 and t-P65 levels in nucleoprotein of rat myocardial tissues. LVED and LVES of MF group were significantly upregulated, LVEF and LVFS were significantly downregulated, while TPL treatment reversed these trends; TPL treatment downregulated the tissue injury and improved the pathological damage of MF rats. TPL treatment downregulated the levels of inflammatory factors and fibrosis factors, and inhibited the activation of NLRP3 inflammasome. Activation of NLRP3 inflammasome or NF-κB pathway reversed the effect of TPL on MF. Collectively, TPL inhibited the activation of NLRP3 inflammasome by inhibiting NF-κB pathway, and improved MF in MF rats.

• Korea Science and Art Forum
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• v.24
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• pp.1-13
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• 2016

The aim of this study is to find the reasons of success and failure of digital animations in terms of 'immersion.' For the purpose, the causes of immersion were analyzed through complex comparison about concepts and stories of two animation films with similar size of budget: 'Shrek 2' which ranked number 1 in the box-office of animation and 'Mars Needs Moms' which ranked number 172 in the same category. The complex results showed that immersion becomes bigger with creativity and popularity of the characters' outer concept, diversity and organic of the characters' inner concept, and diversity and consistency of the background. Moreover, gradual arrangement of characters' appearance in the story and increasing number of the characters, and visual changes around the plot heightening with a well-organized passage increase immersion. After all, immersion of digital animation requires developing creative, diverse, and popular concept and arranging and strengthening strategic well-organized plot of parts and the whole. This is the key to convergence it.

• Journal of the Korean GEO-environmental Society
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• v.13 no.1
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• pp.21-29
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• 2012

Ground failure by liquefaction can occur not only during shaking but also as the result of the post-liquefaction process after an earthquake. During the process of ground deformation and failure, excess pore water pressure in soil is redistributed, which can then lead to changes in the effective stress of soils. Therefore, in order to provide a further understanding of the phenomenon, we have to estimate the properties of effective stress during the recompression process in post-liquefaction as well, not only the total amount of pore water drained. The primary objectives of this study are to determine and compare the recompression properties in the post-liquefaction process in terms of the relationship between volumetric strains and mean effective stresses under the various conditions of relative density and shear stress history. In all experimental cases, the volumetric strains increase greatly in the low effective stress level, almost to the zero zone, and granite soil, which has fine grains, undergoes gradual changes in the relationship between volumetric strains and mean effective stresses compared with fine sand. And, we can also find that recompression properties in the post-liquefaction process by cyclic loading depend highly on the dissipation energy and maximum shear strain, and this fact can be obtained in all cases regardless of the existence of fine content, relative density, and loading history. Especially, granite soil having fine grains can be defined uniformly in the relationship between dissipation energy and maximum volumetric strain, while fine sand cannot be so uniformly defined.

• Korean Business Review
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• v.4
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• pp.355-383
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• 1991

1. The Purpose of This study research: The focus of marketing until recently has simply been on sales which means the transfer of goods from the producer to the consumer and on profits therefrom. However, the excess supply of goods due to the expansion of the economy and the resulting fierce competition between companies have changed the nature of marketing. Maximizing consumers' satisfaction and establishing marketing mix strategies for market subdivision and penetration into the target market are now significant roles of the marketing manager. In addition, with regard to company management, information within the company which had been collected, managed and processed sporadically indegrated manner. The purpose of this research on marketing information systems in connection with the above will be to seek ways enabling us to create an efficient and integrated information system for an entire company. 2. The Method and Scop of This Stdudy: Marketing information systems, as a part of management information systems, shall be examined based on relevant theoretical literature. The research process shall be generally developed as follows: 1) The basic structure of the marketing information systems, including its fundamental purpose and necessity, shall be examined. 2) The method for a specific plan shall be presented through fundamental marketing strategy concepts and marketing decision-making. 3) A general model shall be presented based on examinations of various mod els used for marketing information systems and on research of the models' relationship with management information systems. 4) The direction of development shall be presented as the basis for gradual development following examination of the scope, pertinent issues, and means of improvement of the marketing information systems. 3. Summary and Conclusion: As the competition among the enterprises has become keen and thus the management of the contemporary enterprises shows the tendencies of uncertainty as well as complexity, all the managers must make the correct and prompt decision of their mind. Otherwise, the danger which will lead to and failure in the failure in the business may befall to the enterprise. Though computer system and information related techniques have the endless potentiality for the improvement of the enterprise, those are granted only to the enterprise which will be able to manage the computer system and information related techniques. In the contemporary industrial society, the need to a managerial information system has been increasing because all the complicated information can be stored, disposed and managed by the efficient method. And the marketing information system is also the integrated system which has been formed and developed through the efficient mixture of all the constituent elements including the definition of marketing research as the definition of the information system has been enlarged due to the reason shown above. The common point of the two systems is the man machine system functioning to help the efficient decision of the mind by introducing the computer system on the basis of user manager centered thought in order to provide informations to be useful in operation and management of the organization and the function of the mind decision. The purpose for the marketing information system lies in making the utmost use of marketing information available in the course of the mind decision. The reason why the contemporary enterprises necessitate the marketing information system are as follows: 1) The stages of the business operation are expanded wide to the world. 2) As the living standards of the consumers have been on the rise, the enter prise has to satisfy the consumer's "wants" than simple "needs".

• Journal of Yeungnam Medical Science
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• v.14 no.1
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• pp.245-261
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• 1997

Slipped capital femoral epiphysis(SCFE) is a disorder in which there is a gradual or acute disruption through the capital physeal plate. The physiolysis is through a widened zone of hypertrophy, which is weakened due to altered chondrocytic maturation and endochondral ossification. The cause or causes of SCFE remain uncertain. The association of obesity and adolescent age with growth rate are predisposing factors. The possibility that most patients with subclinical hormonal abnormality were proved. The goal of treatment of slipped capital femoral epiphysis is to restore the function of the hip and delay the development of degenerative osteoarthrosis by prevention of additional displacement of the epiphysis. We report 10 patients(12hips) with SCFE who were treated by surgical means and followed along for more than one year, at Yeungnam University Hospital, from 1989 to 1996. There were six boys and four girls. The average age at operation was 11.8 years. Seven cases occurred in the left hip, one case in the right and 2 cases had bilateral involvement, five cases had a history of minor trauma on affected hip. Among hormonally studied six patients, panhypopituitarism patient was one case; decreased testosterone, two; decreased growth hormone, two; and decreased thyroid hormone, one. According to clinical stage, two cases were the acute type; five cases, acute on chronic type; and three cases, chronic type. On the radiological grades of slipping, mild slippage were nine hips; moderate, one; and severe, two. The eleven hips were treated by pin fixation in situ, and one, by cuneiform osteotomy. On the average follow-up of 2.6 years, ten hips were excellent or good functional results, two hips were failure.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.3
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• pp.147-160
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• 2020

A stochastic probabilistic model for harbor structures such as rubble-mound breakwater has been formulated by using the generalized Wiener process considering the nonlinearity of damage drift and its nonlinear uncertainty, by which the damage path with real-time can be tracked, the residual useful lifetime at some age can also be analyzed properly. The formulated stochastic model can easily calculate the probability of failure with the passage of time through the probability density function of cumulative damage. In particular, the probability density functions of residual useful lifetime of the existing harbor structures can be derived, which can take into account the current age, its present damage state and the future damage process to be occurred. By using the maximum likelihood method and the least square method together, the involved parameters in the stochastic model can be estimated. In the calibration of the stochastic model presented in this paper, the present results are very well similar with the results of MCS about tracking of the damage paths as well as evaluating of the density functions of the cumulative damage and the residual useful lifetime. MTTF and MRL are also evaluated exactly. Meanwhile, the stochastic probabilistic model has been applied to the rubble-mound breakwater. The related parameters can be estimated by using the experimental data of the cumulative damages of armor units measured as a function of time. The theoretical results about the probability density function of cumulative damage and the probability of failure are very well agreed with MCS results such that the density functions of the cumulative damage tend to move to rightward and the amounts of its uncertainty are increased as the elapsed time goes on. Thus, the probabilities of failure with the elapsed time are also increased sharply. Finally, the behaviors of residual useful lifetime have been investigated with the elapsed age. It is concluded for rubble-mound breakwaters that the probability density functions of residual useful lifetime tends to have a longer tail in the right side rather than the left side because of the gradual increases of cumulative damage of armor units. Therefore, its MRLs are sharply decreased after some age. In this paper, the special attentions are paid to the relationship of MTTF and MRL and the elapsed age of the existing structure. In spite of that the sum of the elapsed age and MRL must be equal to MTTF deterministically, the large difference has been shown as the elapsed age is increased which is due to the uncertainty of cumulative damage to be occurred in the future.

• The Journal of Korean Academy of Prosthodontics
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• v.52 no.4
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• pp.312-316
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• 2014

Purpose: The aim of this study was to compare the fracture toughness of currently available resin cements for zirconia restorations and evaluate the effect of water storage on fracture toughness of those resin cements. Materials and methods: Single-edge notched specimens ($3mm{\times}6mm{\times}25mm$) were prepared from three currently available dual cure resin cements for zirconia restorations (Panavia F 2.0, Clearfil SA luting and Zirconite). Each resin cement was divided into four groups: immersed in distilled water at $37^{\circ}C$ for 1 (Control group), 30, 90, or 180 days (n=5). Specimens were loaded in three point bending at a cross-head speed of 0.1 mm/s. The maximum load at specimen failure was recorded and the fracture toughness ($K_{IC}$) was calculated. Data were analyzed using one-way ANOVA and multiple comparison $Scheff{\acute{e}}$ test (${\alpha}$=.05). Results: In control group, the mean $K_{IC}$ was $3.41{\pm}0.64MN{\cdot}m^{-1.5}$ for Panavia F, 2.0, $3.07{\pm}0.41MN{\cdot}m^{-1.5}$ for Zirconite, $2.58{\pm}0.30MN{\cdot}m^{-1.5}$ for Clearfil SA luting respectively, but statistical analysis revealed no significant difference between them. Although a gradual decrease of $K_{IC}$ in Panavia F 2.0 and gradual increases of KIC in Clearfil SA luting and Zirconite were observed with storage time, there were no significant differences between immersion time for each cement. Conclusion: The resin cements for zirconia restorations exhibit much higher $K_{IC}$ values than conventional resin cements. The fracture toughness of resin cement for zirconia restoration would not be affected by water storage.

• Korean Journal of Environmental Agriculture
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• v.15 no.4
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• pp.406-418
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• 1996

Tomatoes are water logged differently 0, 5, 10 and 15 cm, according to the developing stages such as germination and seedling stage under the condition of greenhouse. Along with this, they are treated according to the time condition such as 6, 12, 24, 48 and 120 hours. The results obtained are summarized as follows. 1. The result at germination stage Remarkable germination failure was observed when tomatoes were water-logged for 25 to 27 hours in the depth of 0 to 5 cm. Plant height recovered within 24 hours regardless of the water-logging depths. In the case of leaves, the recoverable time limit became shorter gradually in accordance with the increase of the water-logging depth. The decrease of the fresh weight showed acute response in the shoot rather than the root. It recovered with the 24 hours of water logging. Significant correlation was observed in all characteristics of plant height, number of leaves, fresh weight and germination rates according to the depth of water-logging. 2. The result at seedling stage Plant height recovered within the 24 hours of water-logging in the depth of 0 cm. On the deeper level, there was significant decrease regardless of time. With regard to the number of leaves, there was recovery up to 120 hours in the depth of 0 cm, up to 24 hours in the depth of 5 cm. There was, however, significant decrease when done for more than 6 hours on the deeper level. Growth of the shoot displayed the same tendency as in plant height and number of leave. The length of the longest root could be maintained by 80% in the water-logging of 0 cm compared with control. However in depth of 5 cm or more, it could not be maintained by the 120 hours water-logging. Root activity became conspicuously diminished with the logging over 0 cm. Respiration showed conspicuous decrease by the depth of 5 cm as a turning point. On the other hand, photosynthesis became decreased linearly by the depth of water-logging. Chlorophyll content displayed gradual decrease up to 48 hours, but conspicuously decreased up to 120 hours according to the varying depth of water-logging. Dieases tended to increase according to the depth and hours of water-logging. Diseases would be prevented by dint of insecticide, but there was no effect of fertilization. Weight and number of fruit per plant displayed gradual decrease as the depth and hours of water-logging became increased. Average weight of a fruit became increased. There was no statisticaly reciprocal effects between the depth and hours of water-logging. There was significant positive correlation among all the investigated characteristics, such as traits of growth and yield.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.5
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• pp.163-169
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• 2017

Although the strength of polyethylene terephthalate (PET) fibers which are generally used to make plastic bottles is low, the deformability of PET fibers is substantially high. Due to these material characteristics, a PET fiber can be used as a reliable strengthening material to resist a large deformation caused by earthquake and research pertinent to application of PET fibers is actively conducted in Japan. Therefore, in this study, experiments have been carried out to investigate the lateral confinement effect of PET fibers and to assess the applicability of PET fibers to construction fields by comparing the strengthening effect of PET fibers to that of carbon and glass fiber sheets. For this purpose, concrete cylinder specimens with parameters of different concrete strength and strengthening layers of carbon fiber sheets, glass fiber sheets, and PET fibers were respectively tested using two sets of cylinders for each parameter. As a result, specimens strengthened with carbon fiber sheets and glass fiber sheets failed due to sudden decrease of strength as with existing studies. However, specimens with PET fibers reached their maximum strength and then failed after gradual decrease strength without failure of PET fibers. In addition, although the strength of specimens with PET fibers did not significantly increase in comparison with that of specimens with carbon fiber sheets and glass fiber sheets, specimens with PET fibers indicated considerable deformability. Thus, a PET fiber can be considered as an effective strengthening material.