• 과학교육연구지
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• 제34권2호
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• pp.185-192
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• 2010

이 연구의 목적은 생물분류탐구과정에서 나타나는 부정감성을 호르몬 변화로 예측할 수 있는 부정감성 예측모델을 개발하는 것이다. 이를 위해 통합적인 과학 탐구가 가능하도록 깃털 분류 탐구 활동을 개발하였다. 연구대상은 호르몬 변화 측정에 문제가 없는 서울, 안산, 청주 소재 중학교 2학년 47명(남 18, 여 29)으로 하였다. 피험자들은 개인별로 깃털 분류 탐구 활동을 수행하였다. 깃털 분류 탐구 활동 전과 후에 형용사 이모티콘 척도법을 이용하여 부정감성 검사를 하였고, 타액 시료를 채취하여 코르티솔 호르몬 변화를 분석하였다. 연구결과 부정감성 변화량과 타액 코르티솔 변화량 사이에서 유의미한 정적 상관관계(R=0.39, P<0.001)가 나타났으며, 회귀분석을 이용하여 생물분류탐구에서 나타나는 타액 코르티솔 변화량을 이용한 부정감성 예측모델을 개발하였다.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.608-618
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• 2021

Objective : The endoscopic endonasal transsphenoidal approach is a widely-used method for the surgical treatment of pituitary adenomas. We aimed to evaluate the results of endoscopic surgery by comparing preoperative classification methods and investigating their relationship with postoperative resection and remission rates and complications. Methods : We retrospectively reviewed the medical records of 236 patients (118 males) who underwent surgery for pituitary adenomas. Preoperative Knosp classification, tumor size (TS), suprasellar extension (SSE), postoperative resection and remission rates, and complications were evaluated. Results : The follow-up period was 3 months to 6 years. The patients' ages ranged between 16 and 84 years. Endocrinologically, 114 patients (48.3%) had functional adenoma (FA), and 122 patients (51.7%) had non-functional adenoma (NFA). Among the FA group, 92 (80.7%) showed remission. A statistically significant difference was found between patients with and without remission in terms of the Knosp, TS, and SSE classifications (p<0.01). Knosp, TS, and SSE classification grades were found to be correlated with the resection rates (p<0.01). Meningitis was seen in seven patients (3.0%), diabetes insipidus in 16 (6.9%; permanently in two [0.9%]), and rhinorrhea in 19 (8.1%). Thirty-six patients (15.3%) developed pituitary insufficiency and received hormone replacement therapy. Conclusion : The resection categories and remission rates of FAs were directly proportional to the adenoma sizes and Knosp grades, while the degree of suprasellar growth further complicated resection and remission rates. Adenoma sizes less than 2 cm and SSEs less than 1 cm are associated with favorable remission and resection rates.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5137-5142
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• 2012

UHRF2 is a member of the ubiquitin plant homeo domain RING finger family, which has been proven to be frequently up-regulated in colorectal cancer cells and play a role as an oncogene in breast cancer cells. However, the role of UHRF2 in glioma cells remains unclear. In this study, we performed real-time quantitative PCR on 32 pathologically confirmed glioma samples (grade I, 4 cases; grade II, 11 cases; grade III, 10 cases; and grade IV, 7 cases; according to the 2007 WHO classification system) and four glioma cell lines (A172, U251, U373, and U87). The expression of UHRF2 mRNA was significantly lower in the grade III and grade IV groups compared with the noncancerous brain tissue group, whereas its expression was high in A172, U251, and U373 glioma cell lines. An in vitro assay was performed to investigate the functions of UHRF2. Using a lentivirus-based RNA interference (RNAi) approach, we down-regulated UHRF2 expression in the U251 glioma cell line. This down-regulation led to the inhibition of cell proliferation, an increase in cell apoptosis, and a change of cell cycle distribution, in which S stage cells decreased and G2/M stage cells increased. Our results suggest that UHRF2 may be closely related to tumorigenesis and the development of gliomas.

• Asian Spine Journal
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• 제12권6호
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• pp.1060-1068
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• 2018

Study Design: Retrospective study. Purpose: Lumbar intervertebral disc degeneration is an important cause of low back pain. Overview of Literature: Spinal fusion is often reported to have a good course for adolescent idiopathic scoliosis (AIS). However, many studies have reported that adjacent segment degeneration is accelerated after lumbar spinal fusion. Radiography is a simple method used to evaluate the orientation of the vertebral column. magnetic resonance imaging (MRI) is the method most often used to specifically evaluate intervertebral disc degeneration. The Pfirrmann classification is a well-known method used to evaluate degenerative lumbar disease. After spinal fusion, an increase in stress, excess mobility, increased intra-disc pressure, and posterior displacement of the axis of motion have been observed in the adjacent segments. Methods: we retrospectively secured and analyzed the data of 15 patients (four boys and 11 girls) with AIS who underwent a spinal fusion surgery. We studied the full-length view of the spine (anterior-posterior and lateral) from the X-ray and MRI obtained from all patients before surgery. Postoperatively, another full-length spine X-ray and lumbosacral MRI were obtained from all participants. Then, pelvic tilt, sacral slope, curve correction, and fused and free segments before and after surgery were calculated based on X-ray studies. MRI images were used to estimate the degree to which intervertebral discs were degenerated using Pfirrmann grading system. Pfirrmann grade before and after surgery were compared with Wilcoxon signed rank test. While analyzing the contribution of potential risk factors for the post-spinal fusion Pfirrmann grade of disc degeneration, we used generalized linear models with robust standard error estimates to account for intraclass correlation that may have been present between discs of the same patient. Results: The mean age of the participant was 14 years, and the mean curvature before and after surgery were 67.8 and 23.8, respectively (p<0.05). During the median follow-up of 5 years, the mean degree of the disc degeneration significantly increased in all patients after surgery (p<0.05) with a Pfirrmann grade of 1 and 2.8 in the L2-L3 before and after surgery, respectively. The corresponding figures at L3-L4, L4-L5, and L5-S1 levels were 1.28 and 2.43, 1.07 and 2.35, and 1 and 2.33, respectively. The lower was the number of free discs below the fusion level, the higher was the Pfirrmann grade of degeneration (p<0.001). Conversely, the higher was the number of the discs fused together, the higher was the Pfirrmann grade. Conclusions: we observed that the disc degeneration aggravated after spinal fusion for scoliosis. While the degree of degeneration as measured by Pfirrmann grade was directly correlated by the number of fused segments, it was negatively correlated with the number of discs that remained free below the lowermost level of the fusion.

• 한국항공운항학회지
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• 제18권1호
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• pp.83-88
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• 2010

The study is intended to help to select the pilot candidates with exceptional flight aptitude ability and to investigate the relationship between the results of the scholastic aptitude test and the flight aptitude. It is intended that the research will help to draw recommendations on the relevant fields of the scholastic aptitude test that is to be used to select the high caliber candidates with exceptional flight aptitude ability, to gauge the resulting effectiveness of its application and helping to revise the university's syllabus accordingly. From the study, korean, mathematics, english grade and the flight aptitude test results have all shown to hold mutual relationship and through simple correlation analysis, it was discovered that mathematics and English are the two factors that affect the results of the flight aptitude test, with the extent of its impact graded in descending order of English, mathematics and Korean. Lastly, the logistic regression analysis have discovered that the mathematics grade has significant effect on the classification of the flight aptitude and non aptitude category groups, and English also has significant influence close to the 0.05 p-values. It is believed that should the findings of this study be considered as part of the selection process of the university applicants of the department of aeronautical science, making discovery of candidates of higher quality is expected.

• 대한물리의학회지
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• 제14권4호
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• pp.1-8
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• 2019

PURPOSE: The purpose of this study was to compare the maximum knee strength and endurance of elderly Korean women with Kellgren-Lawrence grade (K-L II) by age. METHODS: In this study, the total number of participants was 50, divided into five groups of 10 by age. Maximum knee muscle strength was measured at a low speed of 60°/sec using Biodex, an isokinetic device for comparison of maximum knee muscle strength, whereas muscle endurance was measured by muscle contraction at a high speed of 180°/sec. The peak torque values of the extensor and flexor muscles in the muscle strength and muscle endurance tests were collected according to each classification. RESULTS: The results of the experiment show that maximum muscle strength and muscle endurance decreased significantly at 60°/sec and 180°/sec during flexion and extension according to age (p<.05). In particular, the age group of 71 to 75 years showed the most significant correlation with other age groups (p<.05). CONCLUSION: The results of this study can be used as basic data for increasing physical activity and muscle strength in women with knee osteoarthritis.

• 한국초등과학교육학회지:초등과학교육
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• 제33권1호
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• pp.30-43
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• 2014

'Basic Inquiry' unit was newly included in the grade 3~4 science textbook developed for 2009 revised national curriculum. The unit deals with six basic inquiry skills such as 'observation', 'measurement', 'classification', 'prediction', 'inference', and 'communication'. This study investigated elementary school teachers' perceptions on the effects of 'Basic Inquiry' unit by questionnaires (N=104 for pre-survey, N=90 for post-survey). The results showed that how the teachers have taught basic inquiry skills before this new textbook and how they perceived the educational effects of the unit after experimental teaching period in three aspects; development of basic inquiry skills, facilitating science learning in other units, and implementation of open inquiry. The reasons of positive perceptions as well as negative perceptions were analyzed and discussed with the suggestions for further study.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 The 6th International Symposium of East Asian Resources Recycling Technology
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• pp.759-764
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• 2001

The separation performance of zigzag air classifier with angle of 90 degrees was studied using narrow size fractions of thin square samples and granular samples. The simulation results of air velocity inside the classifier indicated that the zigzag geometry induces a new pattern consisting of an upward flow and a circulation flow, Experimental results showed that overflow product recovery was described as an integral calculus of normal distribution as a function of dimensionless air velocity ( $V_{A}$ $V_{A50}$), where $V_{A}$ is superficial air velocity and $V_{A50}$ is the $V_{A}$ at the fifty percent recovery. The $V_{A}$ values were predicted using the equations derived from dynamics for a particle dropping in air. A monitoring system that utilizes changes in acoustic signals emitted during the process of air classification was developed to separate PET with desired recovery or grade. The technical feasibility of the on-line monitoring of the PET recovery and grade was demonstrated by measuring relative energy of the signals.signals.als.

• Agricultural and Biosystems Engineering
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• 제1권2호
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• pp.100-105
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• 2000

Quality sorting of cut flowers is very essential to increase the value of products. There are many factors that determine the quality of cut flowers such as length, thickness, and straightness of stem, and color and maturity of bud. Among these factors, the straightness of stem and the maturity of bud are generally considered to be more difficult to evaluate. A prototype grading and sorting machine for cut flowers was developed and tested for a rose variety. The machine consisted of a chain-drive feed mechanism, a pneumatic discharge system, and a grading system utilizing color image processing and neural network. Artificial neural network algorithm was utilized to grade cut roses based on the straightness of stem and maturity of bud. Test results showed 89% agreement with human expert for the straightness of stem and 90% agreement for the maturity of bud. Average processing time for evaluating straightness of the stem and maturity of the bud were 1.01 and 0.44 second, respectively. Application of neural network eliminated difficulties in determining criteria of each grade category while maintaining similar level of classification error.

• 국제물리치료학회지
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• 제8권1호
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• pp.1122-1127
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• 2017

The purpose of this case study was to identify the effects of posteroanterior (PA) mobilization on the cervical spine in a patient with chronic whiplash-associated disorder (WAD). The subject of this study was a 58-year-old woman who sustained a chronic WAD as a result of a motor vehicle accident two years prior. The subject has progressively worsening neck pain and stiffness. The subject was determined to have a grade IIb WAD the use of the Modified Quebec Classification. The intervention was central and unilateral PA mobilization on the spinous process of C4 and C5. The PA mobilizations were performed at the end of range to Maitland grade IV. The PA mobilization was conducted once daily for a total of eight days. Two sets of measurements were done one before and one after the intervention. Neck pain, cervical stiffness, range of motion and lordosis of the cervical spine were measured. Experimental intervention decreased the neck pain, and increased the neck stiffness and cervical ROM (range of motion) such as flexion, extension, lateral flexion and rotation. X-ray photographs also represented that cervical curvature increased from $35^{\circ}$ to $40^{\circ}$. This study suggested that PA cervical mobilization applied to hronic WAD is effective in decreasing pain, increasing cervical ROM and cervical curvature.