• Journal of Periodontal and Implant Science
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• 제24권3호
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• pp.472-482
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• 1994

Cytokines expressed specifically in leukocytes subsets and in activated cells, which are involved in chemotaxis and activation of leukocytes, are recently defined as chemokines. Macrophage inflammatory $protein-1{\alpha}(MIP-1{\alpha})$ and $MIP-1{\beta}$ are members of C-C chemokine subfamily which produces wide immunomodulatory, proinflammatory, and hematopoietic modulatory actions. We have studied their gene expression by using Northern blot analysis in various blood cells such as cytolytic T lymphocyte(CTL), helper T lymphocyte(HTL), macrophage, and B lymphocyte. Resting CTL line CTLL-R8 expressed $MIP-1{\alpha}$ mRNA which was downregulated by ConA stimulation. Both of resting and ConA stimulated HTL line Hut78 and Jurkat did not express $MIP-1{\alpha}$ mRNA. There was detectable $MIP-1{\alpha}$ transcript in HTL hybridoma 2B4.11 which was a little upstimulated by ConA stimulation. B cell line 230, and macrophage cell line RAW264.7 and WR19M.1 showed distinct $MIP-1{\alpha}$ message which were induced after LPS stimulation. Expression pattern of $MIP-1{\beta}$ in all cell lines or cell were almost identical to that of $MIP-1{\alpha}$. Also strategies employed to identify and characterize the biological functions was preceded by receptor cloning to trace the shorcut to the final goal of cytokine research. For the cloning of $MIP-1{\alpha}$ receptor(R), we used synthetic oligonucleotides of transmembrane(T) conserved sequences of already cloned human(h) IL-8-R, and performed reverse transcription-polymerase chain reaction(RT-PCR) amplification using murine(m) macrophage cell line mRNA. Among 5RT-PCR products, we isolated a homologous cDNA with hIL-8-R which were shown to be putative mIL-8-R cDNA.

• 한국임상약학회지
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• 제12권1호
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• pp.29-38
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• 2002

Hypertension is an important public health problem because it increases the risk of stroke, angina, myocardial infarction, heart failure, and end-stage renal disease. If it is not actively treated, morbidity and mortality increase with hypertension-induced complications and quality of life decreases. This study was to evaluate the use of antihypertensive drugs and blood pressure changes and to compare algorithms chosen (or the 1st and 2nd line therapy of hypertension based on the JNC VI recommendations. The medical charts of 222 patients with essential hypertension at St. Vincent's Hospital in Suwon from January 1997 to January 2000 were reviewed retrospectively. Data collection and analysis included baseline BP underlying diseases and complications, administered antihypertensives, BP changes, changes of antihypertensive regimen, and adverse effects with treatments. As results, the higher BP the patients had, the more frequent they had target organ damages and clinical cardiovascular diseases. Mean duration to reduce blood pressure less than 140/90 mmHg was 8 weeks in $85.3\%$ of the patients. The rate of control in BP was $82.4\%$ at 6 months. The major antihypertensive drugs prescribed were calcium channel blockers $(61.8\%)$ , ACE inhibitors $(19.1\%),\;\beta-blockers\;(13.7\%)$ and diuretics $(5.3\%)$ as the 1st-line monotherapy. The methods of treatment used as the 1st-line therapy were monotherapy$(59\%)$ and combination therapy $(41\%)$. Blood pressure change was significantly greater for combination therapy than monotherapy$(-26.2\pm21.4\;vs.\;-18.56\pm16.7$ mmHg for systolic blood pressure; P<0.003, $-16.9\pm13.2\;vs.\;-9.2\pm12.8$ mmHg for diastolic blood pressure; p<0.001). When blood pressure was not completely controlled with the first antihypertensive selected, the 2nd line therapy had 4 options: addition of 2nd agent from different class; $66.2\%$, substitution with another drug, $21.9\%$ increase dose $11.9\%$ continue first regimen $27.9\%$ Calcium channel blockers were the most frequently prescribed agents. This was not comparable to the JNC VI guideline which recommended diuretics and $\beta-blockers$ for the 1st-line therapy. Most of patients achieved the goal BP and maintained it until 6 months, but the remaining patients should be controlled more tightly to improve their BP with combination of life style modification, patient education, and pharmacotherapy.

• 정보화연구
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• 제11권1호
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• pp.63-73
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• 2014

웹의 발달로 텍스트 등으로 이루어진 비정형 데이터의 활용에 대한 관심이 높아지고 있다. 웹상에서 사용자들이 작성한 대부분의 비정형 데이터는 사용자의 주관이 담겨져 있어 이를 적절히 분석할 경우 사용자의 취향이나 주관적인 관점 등의 아주 유용한 정보를 얻을 수 있다. 이 논문에서는 이러한 비정형 텍스트 문서를 다양한 차원으로 분석하기 하는데 OLAP(온라인 분석 처리)의 다차원 데이터 큐브 기술을 활용한다. 다차원 데이터 큐브는 간단한 문자나 숫자 형태의 정형적인 데이터에 대해 다차원 분석하는데 널리 사용되었지만, 텍스트 문장으로 이루어진 비정형 데이터에 대해서는 활용되지 않았다. 이러한 텍스트 데이터베이스에 포함된 정보를 다차원으로 분석하기 위한 방법으로 텍스트 큐브 모델이 최근에 제안되었는데, 이 텍스트 큐브는 정보 검색에서 널리 사용하는 용어 빈도수(Term Frequency)와 역 인덱스(Inverted Index)를 측정값으로 이용하여 텍스트 데이터베이스에 대한 다차원 분석을 지원한다. 이 논문에서는 이러한 다차원 텍스트 큐브를 활용하여 실제 서비스되고 있는 호텔 정보 공유 사이트의 리뷰 데이터 분석에 활용하였다. 이를 위해 호텔 리뷰 데이터에 대한 다차원 텍스트 큐브를 생성하였으며, 이를 이용하여 다차원 키워드 검색 기능을 제공하여 사용자 중심의 의미있는 정보 검색이 가능한 시스템을 설계 및 구현하였다. 또한, 본 논문에서 제안하는 시스템에 대해 다양한 실험을 수행하였으며 이를 통해 제안된 시스템의 실효성을 검증하였다.

• 디지털산업정보학회논문지
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• 제13권4호
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• pp.231-245
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• 2017

The purpose of this study is to analyze the trend line through scatter diagram analysis on correlation between SNS addiction tendencies and learning attitudes, figure out the knee point influencing learning attitudes negatively in detail, and examine influence among subareas. To address the goal, study questions are formulated as follows. First, this author did screening on the data of variables measured and analyzed descriptive statistics. Second, this researcher produced the trend line by drawing a scatter diagram in order to analyze correlation between SNS addiction tendencies, withdrawal symptoms, excessive communication, and excessive time wasting, and learning attitudes exploratorily. Third, to explore correlation between self-evaluation, learning participation, and developmental attitudes, the subfactors of learning attitudes related to SNS addiction tendencies, this author drew a scatter diagram and analyzed the threshold of positive and negative correlation. To verify the study questions, the SNS addiction tendency scale and learning attitude scale were applied to 301 university students in Chungcheong area. According to the study results, first, their learning attitudes are influenced by SNS addiction tendencies, excessive communication and excessive time wasting, and they are not influenced by withdrawal symptoms that much. Second, excessive communication, a factor of SNS addiction tendencies, and self-evaluation and developmental attitudes, factors of learning attitudes, show positive correlation to some extent and indicate negative correlation after the threshold. However, excessive communication and learning participation are found to show no correlation. Third, according to the results of examining correlation with learning attitudes by dividing them into excessive communication and excessive time wasting groups with the knee point of 1.40, as the symptom of excessive communication is found more, it influences self-evaluation, learning participation, developmental attitudes, and learning attitudes more negatively in general. The result of this study is expected to provide foundational material necessary to develop educational programs to prevent undergraduates' excessive SNS use and SNS addiction which can be used in the scenes of counseling or education.

• 한국실내디자인학회논문집
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• 제13호
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• pp.89-95
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• 1997

In line with the worldwide trend toward the protection of natural environment and economic concerns, the steel framed house is suggested for the next industrialized generatiov. In Korea, untrustworthiness of concrete structured apartment has led to the development of alternative building material and technology. POSCO has constructed the model steel house to assess the marketability of steel framed house in Korea. To collect basic data required to design the steel framed house suitable to Korean life pattern and housing needs, professional evaluation of model steel house was conducted. The goal of this study is to propose alternative plan and ideas on the interior space planning based upon the evaluation from women housing professionals. Our analysis reveals that the habitability of steel house is equal or superior to that of traditional houses. But in the interiior sapce planning, the certain aspects of steel houses is not suitable to Korean likfe style: the lack of storage space and utility space, inflexibility of plav. We conclude that given its cost efficiency and environmental concern, steel house has potential to take an important part in future Korean housing.

• The Journal of Asian Finance, Economics and Business
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• 제8권3호
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• pp.399-409
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• 2021

This study examines whether oil and gas companies comply with the requirements of the International Financial Reporting Standards (IFRS) 6 on Exploration and Evaluation (E&E) of Mineral Resources. For this purpose, a comprehensive checklist divided into eight different parameters was prepared by including every requirement of IFRS 6. While building on the previous studies, the annual reports of the top five Indian and top five Global companies engaged in this business have been investigated in detail against the checklist using content analysis as the research method. Results show that a majority of the companies (both Indian as well as global companies) have not been complying with the requirements of IFRS 6. In five out of eight parameters the companies have not complied with even half of the requirements. The overall compliance ratio is as low as 41.54 percent and 43.68 percent for Indian and Global companies respectively. While analyzing the non-compliance, it has been observed that despite having distinct accounting standards, different kinds of companies are reporting differently. Thus, it is not in line or consistent with the goal of IFRS i.e., to establish a universal language for the companies to prepare the accounting statements. The research findings identify the exact area of non-compliance while citing the relevant paragraph number of IFRS 6.

• 구강회복응용과학지
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• 제19권4호
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• pp.257-268
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• 2003

The purpose of this study was to assess the loading distributing characteristics of implant prosthesis according to position and direction of load, under vertical and inclined loading using FEA analysis. The finite element model was designed according to standard fixture (4.1mm restorative component x 11.5mm length). The crown for mandibular first molar was made using UCLA abutment. Each three-dimensional finite element model was created with the physical properties of the implant and surrounding bone. This study simulated loads of 200N at the central fossa in a vertical direction (loading condition A), 200N at the outside point of the central fossa with resin filling into screw hole in a vertical direction (loading condition B), 200N at the centric usp in a $15^{\circ}$ inward oblique direction (loading condition C), 200N at the in a $30^{\circ}$ inward oblique direction (loading condition D) or 200N at the centric cusp in a $30^{\circ}$ outward oblique direction (loading condition E) individually. Von Mises stresses were recorded and compared in the supporting bone, fixture, and abutment screw. The following results have been made based on this study: 1. Stresses were concentrated mainly at the ridge crest around implant in both vertical and oblique loading but stresses in the cancellous bone were low in both vertical and oblique loading. 2. Bending moments resulting from non-axial loading of dental implants caused stress concentrations on cortical bone. The magnitude of the stress was greater with the oblique loading than with the vertical loading. 3. An offset of the vertical occlusal force in the buccolingual direction relative to the implant axis gave rise to increased bending of the implant. 4. The relative positions of the resultant line of force from occlusal contact and the center of rotation seems to be more important. 5. The magnitude of the stress in the supporting bone, fixture and abutment screw was greater with the outward oblique loading than with the inward oblique loading and was the greatest under loading at the centric cusp in a $30^{\circ}$ outward oblique direction. Conclusively, this study provides evidence that bending moments resulting from non-axial loading of dental implants caused stress concentrations on cortical bone. But it seems to be more important that how long is the distance from center of rotation of the implant itself to the resultant line of force from occlusal contact(leverage). The goal of improving implants should be to avoid bending of the implant.

• 한국컴퓨터정보학회논문지
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• 제23권1호
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• pp.75-84
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• 2018

In this study, the researchers attempted to automate the process of painting the characters on the road surface, which is currently done by manual labor, by using the information and communication technology. Here are the descriptions of how we put in our efforts to achieve such a goal. First, we familiarized ourselves with the current regulations about painting letters or characters on the road, with reference to Road Mark Installation Management Manual of the National Police Agency. Regarding the graphemes, we adopted a new one using connection components, in Gothic print characters which was within the range of acceptance according to the aforementioned manual. We also made it possible for the automated program to recognize the graphemes by means of the feature dots of the isolated dots, end dots, 2-line gathering dots, and gathering dots of 3 lines or more. Regarding the database, we built graphemes database for plotting information, classified the characters by means of the arrangement information of the graphemes and the layers that the graphemes form within the characters, and last but not least, made the character shape information database for character plotting by using such data. We measured the layers and the arrangement information of the graphemes consisting the characters by using the information of: 1) the information of the position of the center of gravity, and 2) the information of the graphemes that was acquired through vertical exploration from the center of gravity in each grapheme. We identified and compared the group to which each character of the database belonged, and recognized the characters through the use of the information gathered using this method. We analyzed the input characters using the aforementioned analysis method and database, and then converted into plotting information. It was shown that the plotting was performed after the correction.

• Molecular & Cellular Toxicology
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• 제4권2호
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• pp.113-123
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• 2008

Microglia, which is the primary immune effector cells in the central nervous system, constitutes the first line of defense against infection and injury in the brain. The goal of this study was to determine the protective (anti-inflammation) mechanisms of forsythia suspense (FS) on LPS-induced activation of BV-2 microglial cells. The effects of FS on gene expression profiles in activated BV-2 microglial cells were evaluated using microarray analysis. BV-2 microglial cells were cultured in a 100mm dish $(1{\times}10^7/dish)$ for 24hr and then pretreated with $1{\mu}g/mL$ FS or left untreated for 30 min. Next, $1{\mu}g/mL$ LPS was added to the samples and the cells were reincubated at $37^{\circ}C$ for 30 min, 1hr, and 3hr. The gene expression profiles of the BV-2 microglial cells varied depending on the FS. The oligonucleotide microarray analysis revealed that MAPK pathway-related genes such as Mitogen activated protein kinase 1 (Mapk1), RAS protein activator like 2 (Rasal2), and G-protein coupled receptor 12 (Gpr12) and nitric oxide biosynthesis-related genes such as nitric oxide synthase 1 (neuronal) adaptor protein (Nos1ap), and dimethylarginine dimethylaminohydrolase 1 (Ddah1) were down regulated in FS-treated BV-2 microglial cells. FS can affect the MAPK pathway and nitric oxide biosynthesis in BV-2 microglial cells.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2355-2359
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• 2015

Background: Combination chemotherapy of 5 fluorouracil (5-FU) and leucovorin (LV) with oxaliplatin, mainly FOLFOX regimens, has shown considerable antitumor activity and a tolerable toxicity profile in gastric cancer. The goal of this study was to retrospectively compare the efficacy and toxicity of modified FOLFOX-6 (mFOLFOX6) regimen in advanced gastric cancer (AGC) patients with good and poor performance status (PS). Materials and Methods: AGC patients receiving the mFOLFOX6 regimen including oxaliplatin $85mg/m^2$, bolus of 5-FU $400mg/m^2$ and LV $400mg/m^2$ on the first day, followed by $2400mg/m^2$ of 5- FU as a continious infusion over 46 hour for first-line treatment were eligible for the study. Results: A total 58 patients with a median age of 59.5 (32-81) were included. The median follow up of the study was 9.2 months. Thirty patients (51.7%) with an ECOG PS 0-1 were assigned to the good PS arm, while 28 patients (48.3%) with ECOG PS 2 were in the poor PS arm. Overall response rates were 36.6 and 28.8%, respectively (p=0.91). Median PFS was 6.7 and 6.3 months in good PS and poor PS arms (p=0.50) and median OS was 9.6 and 10.4 months (p=0.55). As compared with good PS arm, poor PS arm was associated with more grade 3-4 neutropenia and anemia. Dose reduction and dose delays were also significantly higher. Conclusions: In this study, mFOLFOX6 was similarly effective in both arms. Although hematologic toxicity was significantly higher in patients with poor PS, it remained manageable. Our results suggest that this regimen may be an effective treatment option for AGC patients with poor PS.