• Archives of Pharmacal Research
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• v.27 no.7
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• pp.763-768
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• 2004

To investigate the feasibility of developing a new quercetin transdermal system, a preformulation study was carried out. Therefore, the effects of vehicles and pressure-sensitive adhesives (PSA) on the in vitro permeation of quercetin across dorsal hairless mouse skin were studied. Among vehicles used, propylene glycol monocaprylate (PGMC) and propylene glycol mono-laurate were found to have relatively high permeation flux from solution formulation (i.e., the permeation fluxes were 17.25$\pm$1.96 and 9.60$\pm$3.87 $\mu\textrm{g}$/$\textrm{cm}^2$/h, respectively). The release rate from PSA formulations followed a matrix-controlled diffusion model and was mainly affected by the amount of PSA and drug loaded. The overall permeation fluxes from PSA formulations were less than 0.30 $\mu\textrm{g}$/$\textrm{cm}^2$/h, which were significantly lower compared to those obtained from solution formulations. The lower permeation fluxes may be due to the decrease of solubility and diffusivity of quercetin in the PSA layer, considering the fact that the highest flux of 0.26 $\mu\textrm{g}$/$\textrm{cm}^2$/h was obtained with the addition of 0.2％ butylated hydroxyanisole in PGMC-diethyl-ene glycol monoethyl ether co-solvents (80-85 ： 15-20, v/v). Taken together, these observations indicate that improvement in the solubility and diffusivity of quercetin is necessary to realize fully the clinically applicable transdermal delivery system for the drug.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.644-648
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• 2003

To investigate the feasibility of developing a new ondansetron transdermal system, the effects of vehicles and penetration enhancers on the in vitro permeation of ondansetron hydrochloride (OS) from a pressure-sensitive adhesive (PSA) matrices across dorsal hairless mouse skin were studied. Vehicles employed in this study consisted of various ratios of propylene glycol monocaprylate (PGMC)-diethylene glycol monoethyl ether (DGME) co-solvents and PGMC-propylene glycol (PG) co-solvents with 3% oleic acid. $Duro-Tak^\circledR$ 87-2100 and $Duro-Tak^\circledR$ 87-2196 were used as PSAs. The concentration of DGME in PGMC-DGME co-solvent system affected the release rate; as the concentration of DGME increased, the release rate decreased. The cumulative release amount of OS increased as the ratio of PSA to drug solution decreased. The permeation flux was also primarily affected by the amount of PSAs; as the amount decreased, the permeation flux increased. The overall fluxes from matrix formulations were significantly lower when compared to those obtained from solution formulations. The ratio of PG to PGMC did not affect permeation flux, while the lag time decreased significantly from $5.14\pm3.31 to 0.31\pm0.12$ h as the PG increased from 40% to 60%.

• Membrane Journal
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• v.23 no.2
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• pp.144-150
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• 2013

In order to increase the permeabilities of $N_2$, $O_2$, $CH_4$, $CO_2$, $SO_2$, Poly (ether block amides) (PEBAX) 3533 and its blended membranes with Poly (ethylene glycol) (PEG) of molecular weight 400 were prepared. The contents of PEG400 were 20%, 40%, and 50% and this membranes were characterized in terms of permeability for $N_2$, $O_2$, $CH_4$, $CO_2$, $SO_2$ gases and also diffusivity and solubility as well by using the time-lag gas separation apparatus. As expected, the permeabilities incerased as the contents of PEG400 increased. For the ideal selectivity, there is no big difference in values of between PEBAX 3533 and PEBAX/PEG400 membranes. The increase of permeabilities is due to the increases of solubilities of gases in question and this will be explained in more detail.

• Journal of the Korean Society of Clothing and Textiles
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• v.18 no.3
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• pp.348-354
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• 1994

The changes of surface activities in the aquaous solutions of mixed surfactants composed of linear sodium dodecylbenznesulfoate (LAS), polyoxyethylene nonyl phenylether (PE, EO=10) and polyethylene glycol monolauryl ether (LE, EO=25) have been studied. Addition of nonionic surfactants to LAS reduces the surface tension, especially at the lower concentration than cmc. The interfacial tension of olive oil/LAS was lower than the other surfactant solutions. The removal of triolein from cotton fabrics by nonionic surfactants and mixtures is higher than by LAS. The addition of NaCI to surfactant solutions even though reduces surface tension smaller but enthances oil removal more than that of $CaCl_2$.

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.61-65
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• 1998

Epoxy resins are currently one of the most widely used thermoset polymers. Applications on epoxy-based materials range from common to structural adhesives as well as to matrix materials for high performance composites. The outstanding versatility of this resin can be related to the reactivity of the epoxy group, which can be opened by a large number of different chemical compounds, such a aliphatic and aromatic amines, anhydrides and poly-amides. (omitted)

• Proceedings of the Korean Fiber Society Conference
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• 1995.04a
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• pp.15-15
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• 1995

• Applied Chemistry for Engineering
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• v.4 no.4
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• pp.760-769
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• 1993

Solvent-free low foaming scouring agents(LFSA) were prepared by blending of polyoxyethylene(30) octadecylbenzylammonium chloride(POAC), block copolymer of propylene oxide-ethylene oxide[p(PO-b-EO) glycol], Sedlan FF-200(FF-200) and sulfonic acid-amine condensate of polyoxyethylene(10) nonylphenyl ether(PSAC). In consequence of several tests, FF-200/POAC/p(PO-b-EO) glycol/PSAC/water (20g/10g/5g/5g/60g) mixture (LFSA-5) showed good cleaning power, penetrating ability, emulsifiability and stability to alkali, and gave less problem in water pollution. Scouring effect of LFSA-5 was investigated by the change of percentage of exhaustion before and after scouring at various dyeing temperatures. The percentage of exhaustion of the unscoured PET fabric was 4.5% at $70^{\circ}C$, while that scoured with LFSA-5 was 1.3% at the same temperature, which proved LFSA-5 to be a good scouring agent. Moreover, the foaming power of LFSA-5 measured by Ross and Miles method was 6mm foam height immediately after foaming, and that measured by Ross and Clark method was less than 300mm foam height at $30^{\circ}C$, and 20mm at $80^{\circ}C$. As a result, LFSA-5 proved a good low foaming scouring agent.

• Clean Technology
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• v.16 no.2
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• pp.103-116
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• 2010

It has been reported that the LCD panel market in the FPD industry is become growing and its panel size and production capacity are increasing, and its manufacturing technique is improved every year. FPD manufacturing process requires high cleanliness in its overall process. Especially, FPD cleaning process which accounts for 30~40% of total manufacturing process is very important in its technological and productivity aspects. It is difficult to remove residual liquid-crystal in the fine gap after liquid-crystal injection process in the cell. In this study, aqueous cleaning agents with excellent cleaning, rinsing, and penetrating abilities, but minimum ion content for LCD panel were formulated through mixing glycol ether-type and glycol dimethyl ether-type solvents and nonionic surfactants which are widely used as raw materials for alternative cleaning agents because of environmental regulation at home and abroad. And the formulated cleaning agents were applied to clean FPD liquid crystal after its injection in the cell. Physical properties, cleaning efficiencies, and rinsabilities of the formulated cleaning agents with different combination ratios of solvents, surfactants and additives were measured. As experimental results, the formulated cleaning agents showed higher wetting indices and cloud point than the traditional commercial cleaning agent. And it was found that cleaning efficiencies of the formulated cleaning agents were influenced by the structure of main solvents in them and the types of liquid crystal as soil for cleaning. The best cleaning agents among the formulated cleaning agents showed similar cleaning efficiencies and better rinsabilities compared to the conventional cleaning agent.

• Membrane Journal
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• v.25 no.4
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• pp.332-342
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• 2015

In this study, to solve the major problem of reverse osmosis (RO) membrane, surface of reverse osmosis membrane was modified by silane-epoxy multi layer. Octyltrimethoxysilane (OcTES) was polymerized to membrane surface via cross-linking by Sol-gel method. n = 8 alkylgroup of OcTES formed the branch structure by self assembly. And for improve fouling resistance of RO membrane, Ether group of ethylene glycol diglycidyl ether (EGDE) was given to improve hydrophilicity of RO membrane surface by ring-opening. To analyze structure of RO membrane surface with FE-TEM and AFM. Membrane surface of the ridge and valley structure and the bridge structure was confirmed due to the multi-layer surface modification of OcTES and EGDE. And through the increase of the roughness, the branch structure was formed well on membrane surface. Through the XPS analysis was identified chemical structure of membrane surface. And confirmed that the hydrophilic surface modification is given to the surface of the film through a Contact angle analysis. In optimization of EGDE surface modification condition, was suitable 0.5 wt% EGDE concentraion and $70^{\circ}C$ ring-opening temperature. In result of fouling resistance test and MFI is SUL-H10, $PA-OcTES_{1.0}$, $PA-OcTES_{1.0}-EGDE_{0.5}$ 68.7, 60.4, 5.4 ($10E-8hr/mL^2$), multi-layer surface modified membrane improved fouling resistance.

• Journal of the Korean Electrochemical Society
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• v.3 no.1
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• pp.11-14
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• 2000

Transparent conducting ITO thin films have been studied and developed for the solar cell substrate or LCD substrate. ITO thin film has been mostly fabricated by high cost sputtering method. In this research, sol-gel method is applied to fabricate ITO thin film at lower cost. The research is focused on the establishment of process condition and development of precursor. Organic sol was made of indium tri-isopropoxide dissolved in ethylene glycol monoethyl ether. The hydrolysis was controled by addition of acetyl acetone. Tin(IV) chloride was added as dopant. Inorganic sol was made of indium acetate dissolve din normal propanol. Spin coating technique was applied to coat ITO on borosilicate glass. The resistivity of ITO thin film was approximately $0.01\Omega{\cdot}cm$ and the transmittance is higher than $90\%$ in a visible range.