• Journal of Pharmaceutical Investigation
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• 제13권3호
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• pp.100-103
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• 1983

Coprecipitates of sulpiride and polyethylene glycol (PEG) decrease the dissolution rate of sulpiride and the degree of decrease is reversely proportional to molecular size of PEG and proportional to increase of PEG ratios in coprecipitates. The physical mixtures of sulpiride and PEG increase the dissolution rate of sulpiride.

• Fibers and Polymers
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• 제3권2호
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• pp.49-54
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• 2002

Radical copolymerization behavior of 4'-vinylbenzo-15-crown-5, a vinyl monomer having a pendant 15-membared crown ether unit (VCE) with di(ethylene glycol) ethyl ether acrylate (DEGEEA) was carried out in toluene solution using 2,2-azobisisobutyronitrile (AIBN) as an initiator. The copolymers were characterized by means of FT-IR, $^1{H-NMR}$, and $^{13}{C-NMR}$ . The reactivity ratio of VCE and DEGEEA, determined by Fineman-Ross and Kelen-Tudos method, gave values 0.55 for VCE, and 0.11 for DEGEEA respectively.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.234.1-234.1
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• 2003

The effects of vehicles and penetration enhancers on the in vitro permeation of ketorolac tromethamine (KT) across excised hairless mouse skins were investigated. Among pure vehicles examined, propylene glycol monolaurate (PGML) showed the highest permeation flux, which was 94.3${\pm}$17.3 mg/cm$^2$/hr. Even though propylene glycol monocaprylate (PGMC) alone did not show high permeation rate, the skin permeability of DT was markedly increased by the addition of diethylene glycol monoethyl ether (DGME); the enhancement factors were 19.0 and 17.1 at 20 and 40% of DGME, respectively. (omitted)

• KSBB Journal
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• 제13권5호
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• pp.518-523
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• 1998

A large quantity of ethylene glycol(EG) is remained in the effluent after pretreating polyester weight-loss wastewater physicochemically in the fist stage and must be treated biologically in the second stage. Therefore, an excellent EG-utilizing bacteria strain was isolated from the natural system and the optimal culture conditions of the strain were investigated. The optimal culture conditions of temperature, pH, and nitrogen source were found to be 35$^{\circ}C$, 7.5 and ammonium chloride, respectively, when CODCr removal efficiency was more than 90%. The growth of stains and EG removal efficiency was slightly improved by adding elements such as niacin and biotin. With increasing inoculation size in a batch culture, the removal efficiency of EG was conspicuously increased. Growth rate was inhibited when the initial concentration of EG was more then 30g/L. The strain was identified as Pseudomonas sp. based on morphological and biological characteristics and named as Pseudomonas sp. EG1.

• KSBB Journal
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• 제11권3호
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• pp.311-316
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• 1996

Polyethylene glycolCPEG)의 재조합 효모 배양 에서의 세포성장과 glucoamylase 생산에 대한 영향에 대하여 조사하였다. PEG 첨가에 의하여 세포성 장은 영향을 받지 않았으나 재조합 glucoamylase의 생산은 증가되었다. 최척의 PEG 분자량은 6000이었으며 최척의 농도는 1g/L이었다. 이러한 최척의 값을 이용하여 PEG 첨가배지에서 첨가하지 않은 배지보다 약 23%의 세포외 glucoamylase 활성의 증가를 보였다.

• 한국동물위생학회지
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• 제28권1호
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• pp.23-30
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• 2005

Ethylene glycol (EG) intoxication in dogs can pose a diagnostic challenge. We investigated the effect of a lethal dose of EG to the Shepherd on blood, urine test, and histopathologic observation. Shepherds were treated orally with EG at $10\;m{\ell}/kg$ body weight. Clinically, EG caused the vomition, depression of central brain. Anion gap was increased, which was decreased pH of blood, The blood osmorality was increased at 3 hours, and BUN and creatinine was increased at 24 hour significantly. The pH of urine decreased. The crystal of calcium oxalate appeared at 6 hours. The amount of crystals increased at 12 and 24 hours. Microscopically, the degeneration of proximal tubules were shown at 1 hour and finally progressed as acute tubular nephrosis at 24 hours. These results suggest that the blood and urine test accompanied with histopathological examination be helpful to investigate the EG intoxication.

• 한국미생물생명공학회:학술대회논문집
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• 한국미생물생명공학회 1986년도 추계학술대회
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• pp.510.1-510
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• 1986

Many enzymes require the participation of readily dissociable coenzymes as NAD for thir catalytic activities. The continuous utilization of the enzymes requires the retention and regeneration of the coenzymes. For this purpose, several kinds of macromolecular NAD derivatives have been prepared by covalently attaching NAD to watersoluble polymers. We have prepared poly (ethylene glycol)-bound NAD (PEG-NAD) by coupling N$\^$6/-(2-carboxyethyl)-NAD to one terminal of ${\gamma}$ $\omega$-diaminoly (ethylene glycol) (Mr 3000) with water-soluble carbodiimide. PED-NAD thus obtained has one NAD moiety located at a terminal of the linear, flexible and hydrophilic chain of poly (ethylene glycol). PED-NAD has good coenzyme activity for various dehydrogenases and is applicable in a continuous enzyme reactor. To use these macromolecular NAD derivatives in an enzyme reactor, it si necessary to understand the behavior of the system in which the reactions of dehydrogenases are coupled by the recycling of the NAD derivative. We investigated the kinetic properties of a continuous enzyme reactor containing lactate dehydrogenase, alcohol dehydrogenase and PEG-NAD. The steady-state behavior of the enzyme reactor is explained by a simple kinetic model.

• 한국응용과학기술학회지
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• 제20권3호
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• pp.204-211
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• 2003

Poly(oxypropylene-oxyethylene glycol) block copolymer(PBC) oil dispersant, which has low toxicity, high biodegradability, and an excellent dispersion efficiency to crude oils and weathered W/O emulsion was prepared by blending PBC, poly(oxyethylene) oleate, and sorbitan monooleate. The dispersing efficiency was measured by swirling flask method. The PBC oil dispersant had an excellent dispersing efficiency to weathered oil products formed as stable W/O emulsion, and the low toxicity, such as 4000 ppm to Oryzias Latipes(24 hr, TLM), Brine Shrimp Artemia(24 hr, TLM).

• Fibers and Polymers
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• 제4권4호
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• pp.156-160
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• 2003

Poly(ethylene 2,6-naphthalate) (PEN)/Poly(ethylene glycol) (PEG) copolymers were synthesized by two step reaction during the melt copolymerization process. The first step was the esterification reaction of dimethyl-2,6-naphthalenedicarbox-ylate (2,6-NDC) and ethylene glycol (EG). The second step was the condensation polymerization of bishydroxyethylnaphthalate (BHEN) and PEG. The copolymers contained 10 mol% of PEG units with different molecular weights. Structures and thermal properties of the copolymers were studied by using $^1{H-NMR}$, DSC, TGA, etc. Especially, while the intrinsic viscosities of PEN/PEG copolymers increased with increasing molecular weights of PEG, but the glass transition temperature, the cold crystallization temperature, and the weight loss temperature of the copolymers decreased with increasing molecular weights of PEG. Consequently, the hydrophilicities by means of contact angle measurement and moisture content of the copolymer films were found to be significantly improved with increasing molecular weights of PEG.

• 한국전기전자재료학회논문지
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• 제18권2호
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• pp.142-147
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• 2005

In this work, a gel polymer electrolyte (GPE) was prepared using polyoxyalkylene glycol acrylate (POAGA) as a macromonomer LiCoO$_2$/GPE/graphite cells were prepared and their electrochemical properties were evaluated at various current densities and temperatures. The ionic conductivity of the GPE was more than 6.2${\times}$10$^{-3}$ S$.$$cm^{-1}$ / at room temperature. The GPE had good electrochemical stability up to 4.5 V vs. Li/Li$^{+}$. POAGA-based cells were showed good electrochemical performances such as rate capability, low-temperature performance, and cycleability. The cells, also, passed a safety test such as the overcharge and nail-penetration test.t.