• The Journal of Asian Finance, Economics and Business
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• v.7 no.6
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• pp.457-464
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• 2020

This study aims to recognize customers' real sentiment and then discover the data-driven insights for strategic decision-making in the financial sector of Saudi Arabia. The data was collected from the social media (Facebook and Twitter) from start till October 2018 in financial companies (NCB, Al Rajhi, and Bupa) selected in the Kingdom of Saudi Arabia according to criteria. Then, it was analyzed using a sentiment analysis, one of data mining techniques. All three companies have similar likes and followers as they serve customers as B2B and B2C companies. In addition, for Al Rajhi no negative sentiment was detected in English posts, while it can be seen that Internet penetration of both banks are higher than BUPA, rarely mentioned in few hours. This study helps to predict the overall popularity as well as the perception or real mood of people by identifying the positive and negative feelings or emotions behind customers' social media posts or messages. This research presents meaningful insights in data-driven approaches using a specific data mining technique as a tool for corporate decision-making and forecasting. Understanding what the key issues are from customers' perspective, it becomes possible to develop a better data-based global strategies to create a sustainable competitive advantage.

• Journal of Microbiology and Biotechnology
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• v.23 no.6
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• pp.779-784
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• 2013

Leptospirosis is a worldwide zoonosis of global concern caused by Leptospira interrogans. The availability of ligand libraries has facilitated the search for novel drug targets using chemogenomics approaches, compared with the traditional method of drug discovery, which is time consuming and yields few leads with little intracellular information for guiding target selection. Recent subtractive genomics studies have revealed the putative drug targets in peptidoglycan biosynthesis pathways in Leptospira interrogans. Aligand library for the murD ligase enzyme in the peptidoglycan pathway has also been identified. Our approach in this research involves screening of the pre-existing ligand library of murD with related protein family members in the putative drug target assembly in the peptidoglycan biosynthesis pathway. A chemogenomics approach has been implemented here, which involves screening of known ligands of a protein family having analogous domain architecture for identification of leads for existing druggable protein family members. By means of this approach, one murC and one murF inhibitor were identified, providing a platform for developing an anti-leptospirosis drug targeting the peptidoglycan biosynthesis pathway. Given that the peptidoglycan biosynthesis pathway is exclusive to bacteria, the in silico identified mur ligase inhibitors are expected to be broad-spectrum Gram-negative inhibitors if synthesized and tested in in vitro and in vivo assays.

• The KIPS Transactions:PartD
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• v.14D no.3 s.113
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• pp.293-302
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• 2007

The study of the web graph yields valuable insight into web algorithms for crawling, searching and community discovery, and the sociological phenomena which characterize its evolution, also it is useful for understanding the evolution process of web graph and predicting the scale of the Web. In this paper, we report experimental results on properties of the Korea web graph with over 116 million pages and 2.7 billion links. We indicate to study the Korea web properties such as the power law phenomenon and then to analyze the similarity and difference between the global and Korea web graph. Our analysis reveals the Korea web graph have different properties compared with the global web graph from the structure to the evolution of the Web. Finally, a number of measurements of the evolution of the Korea web graph ill be represented.

• Genomics & Informatics
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• v.21 no.2
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• pp.16.1-16.14
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• 2023

Coronavirus disease 2019 (COVID-19) is a viral infection produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus epidemic, which was declared a global pandemic in March 2020. The World Health Organization has recorded around 43.3 billion cases and 59.4 million casualties to date, posing a severe threat to global health. Severe COVID-19 indicates viral pneumonia caused by the SARS-CoV-2 infections, which can induce fatal consequences, including acute respiratory distress syndrome (ARDS). The purpose of this research is to better understand the COVID-19 and ARDS pathways, as well as to find targeted single nucleotide polymorphism. To accomplish this, we retrieved over 100 patients' samples from the Sequence Read Archive, National Center for Biotechnology Information. These sequences were processed through the Galaxy server next generation sequencing pipeline for variant analysis and then visualized in the Integrative Genomics Viewer, and performed statistical analysis using t-tests and Bonferroni correction, where six major genes were identified as DNAH7, CLUAP1, PPA2, PAPSS1, TLR4, and IFITM3. Furthermore, a complete understanding of the genomes of COVID-19-related ARDS will aid in the early identification and treatment of target proteins. Finally, the discovery of novel therapeutics based on discovered proteins can assist to slow the progression of ARDS and lower fatality rates.

• Journal of KIISE:Information Networking
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• v.29 no.3
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• pp.224-232
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• 2002

The routing protocols designed for wired networks can hardly be used for mobile ad-hoc networks due to limited bandwidth of wireless transmission and unpredictable topological change. Recently, several routing protocols for mobile ad-hoc networks have been proposed. However, when these protocols are applied to support real time services like multimedia transmission, they still have problems in ad-hoe networks, where the topology changes drastically. In this paper, we propose a new route selection algorithm which selects the most reliable rouse that is impervious to route failures by topological changes by mobile hosts. For reliable route selection, the concept of virtual zone (stable lone and caution zone) is proposed. The lone is located in a mobile node's transmission range and determined by mobile node's mobility information received by Global Positioning System (GPS). The proposed algorithm is applied to the route discovery procedure of the existing on-demand routing protocol, AODV, and evaluated by simulation in various traffic conditions and mobility patterns.

• Journal of Korea Society of Industrial Information Systems
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• v.22 no.6
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• pp.71-84
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• 2017

Over the past decade, we have witnessed Serious Debates in MISQ and Other Journals Between Two Camps that have Differing Views on the use of Causal Indicators to Measure Constructs. There is the Camp that advocates Causal Indicators (ADVOCATE) and the Camp that opposes Their Usage (OPPONENT). The Debates have been primarily centered on the OPPONENT's Argument that the Meaning of a Latent Variable is determined by its Outcome Variables. However, Little Effort has been made to Validate the ADVOCATE's Dispute (Against the OPPONENT's Arguments) that the Meaning of a Latent Variable is decided by its Causal Indicators if there is no Misspecification. Our Study precisely examines the Integrity of the Argument. For this, we empirically examine how the two Primary Psychometric Properties-Comprehensiveness and Interrelationship-of Causal Indicators Influence Theory Testing between Latent Variables through Three Different Tests (i.e., Comprehensive Test, Interrelationship Test, and Mixed Test). Conducted on Two Different Datasets, Our Analysis Consistently Reveals that Structural Path Coefficients are Hardly Sensitive to the Changes (i.e., Misspecification) in the Properties of Causal Indicators. The Discovery offers Important Evidence that the Sound Theoretical Logic of a Causal Model is not in Sync with the Empirical Mechanism of Parameter Estimation. This Underscores that a Latent Variable Formed by Causal Indicators is empirically an elusive notion that is Difficult to Operationalize. As Our Results have Significant Implications on the Integrity of Numerous IS studies which have conducted Theory or Hypothesis Testing Using Causal Indicators, we strongly advocate Open Discussions among Methodologists regarding Our Findings and Their Implications for Both Published IS Research and Future Practices.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.1-1
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• 2016

Many of the world's large ecosystems are severely stressed due to population growth, water quality and quantity problems, vulnerability to flood and drought, and the loss of native species and cultural resources. Consequences of climate change further increase uncertainties about the future. These major societal challenges must be addressed through innovations in governance, policy, and ways of implementing management strategies. Science and engineering play a critical role in helping define possible alternative futures that could be achieved and the possible consequences to economic development, quality of life, and sustainability of ecosystem services. Science has advanced rapidly during the past decade with the emergence of science communities coalescing around 'Grand Challenges' and the maturation of how these communities function has resulted in large interdisciplinary research networks. An example is the River Experiment Center of KICT that engages researchers from throughout Korea and the world. This trend has been complemented by major advances in sensor technologies and data synthesis to accelerate knowledge discovery. These factors combine to allow scientific debate to occur in a more open and transparent manner. The availability of information and improved communication of scientific and engineering issues is raising the level of dialogue at the science-policy interface. However, severe challenges persist since scientific discovery does not occur on the same timeframe as management actions, policy decisions or at the pace sometimes expected by elected officials. Common challenges include the need to make decisions in the face of considerable uncertainty, ensuring research results are actionable and preventing science being used by special interests to delay or obsfucate decisions. These challenges are explored in the context of examples from the United States, including the California Bay-Delta system. California transfers water from the wetter northern part of the state to the drier southern part of the state through the Central Valley Project since 1940 and this was supplemented by the State Water Project in 1973. The scale of these activities is remarkable: approximately two thirds of the population of Californians rely on water from the Delta, these waters also irrigate up to 45% of the fruits & vegetables produced in the US, and about 80% of California's commercial fishery species live in or migrate through the Bay-Delta. This Delta region is a global hotspot for biodiversity that provides habitat for over 700 species, but is also a hotspot for the loss of biodiversity with more than 25 species currently listed by the Endangered Species Act. Understanding the decline of the fragile ecosystem of the Bay-Delta system and the potential consequences to economic growth if water transfers are reduced for the environment, the California State Legislature passed landmark legislation in 2009 (CA Water Code SS 85054) that established "Coequal goals of providing a more reliable water supply for California and protecting, restoring, and enhancing the Delta ecosystem". The legislation also stated that "The coequal goals shall be achieved in a manner that protects and enhances the unique cultural, recreational, natural resource, and agricultural values of the Delta as an evolving place." The challenges of integrating policy, management and scientific research will be described through this and other international examples.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.5
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• pp.2375-2382
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• 2011

The user clustering for web navigation pattern discovery is very useful to get preference and behavior pattern of users for web pages. In addition, the information by the user clustering is very essential for web personalization or customer grouping. In this paper, an algorithm for clustering the web navigation path of users is proposed and then some special navigation patterns can be recognized by the algorithm. The proposed algorithm has two clustering phases. In the first phase, all paths are classified into k-groups on the bases of the their similarities. The initial solution obtained in the first phase is not global optimum but it gives a good and feasible initial solution for the second phase. In the second phase, the first phase solution is improved by revising the k-means algorithm. In the revised K-means algorithm, grouping the paths is performed by the hyperplane instead of the distance between a path and a group center. Experimental results show that the proposed method is more efficient.

• IE interfaces
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• v.24 no.2
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• pp.139-150
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• 2011

The EPCglobal Network is a computer network used to share product data among trading partners. It provides the supply chain with improved visibility and traceability by using Electronic Product Code (EPC), which is stored on an RFID tag. Although this network model is widely accepted as a global standard and the growth of EPCglobal-subscriber base is considerable, the EPC technology adoption process is still in its infancy. This is because some of the critical issues on this model still remain to be verified such as scalability, data management, security, privacy and the economic value of data sharing. In this paper, we focus on scalability issue among the challenges to overcome and we regard performance of the EPCglobal Network only as a track and trace query-processing cost in the network. We developed performance models consisting of three elements of the EPCglobal Network : Discovery Services (DS), EPC Information Services (EPCIS), Object Naming Services (ONS). Then we abstracted out the track and trace query execution model to evaluate performance of the overall EPCglobal Network. Finally using the proposed models, we carried out simulation analysis based on an RFID-based inbound logistics process of automobile parts. This work is an important step towards the EPC technology diffusion and provides guidelines for businesses looking to buy or build the EPCglobal Network-based systems.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2489-2493
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• 2015

Background: Loss of heterozygosity (LOH) on chromosomal regions is crucial in tumor progression and this study aimed to identify genome-wide LOH in pancreatic cancer. Materials and Methods: Single-nucleotide polymorphism (SNP) profiling data GSE32682 of human pancreatic samples snap-frozen during surgery were downloaded from Gene Expression Omnibus database. Genotype console software was used to perform data processing. Candidate genes with LOH were screened based on the genotype calls, SNP loci of LOH and dbSNP database. Gene annotation was performed to identify the functions of candidate genes using NCBI (the National Center for Biotechnology Information) database, followed by Gene Ontology, INTERPRO, PFAM and SMART annotation and UCSC Genome Browser track to the unannotated genes using DAVID (the Database for Annotation, Visualization and Integration Discovery). Results: The candidate genes with LOH identified in this study were MCU, MICU1 and OIT3 on chromosome 10. MCU was found to encode a calcium transporter and MICU1 could encode an essential regulator of mitochondrial $Ca^{2+}$ uptake. OIT3 possibly correlated with calcium binding revealed by the annotation analyses and was regulated by a large number of transcription factors including STAT, SOX9, CREB, NF-kB, PPARG and p53. Conclusions: Global genomic analysis of SNPs identified MICU1, MCU and OIT3 with LOH on chromosome 10, implying involvement of these genes in progression of pancreatic cancer.