• Korean Journal of Biological Psychiatry
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• v.20 no.3
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• pp.111-117
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• 2013

Objectives We investigated the effectiveness and safety when treated in schizophrenics with paliperidone palmitate, a long acting injectable antipsychotic. Methods This was a 24-week open-label study, performed at one center in Korea. The eligible patients with schizophrenia diagnosed by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria were enrolled. Patients received long-acting paliperidone palmitate injection (234 mg, baseline; 156 mg, week 1 ; then once 4 weeks flexible dosing). Effectiveness assessments were measured by the Positive and Negative Syndrome Scale (PANSS), The Clinical Global Impression Severity Scale (CGI-S), The Personal and Social Performance (PSP) at baseline, week 1, every 4 weeks untill 24 weeks or endpoint. Safety assessments were measured by The Extrapyramidal Symptom Rating Scale (ESRS), body weight (BW) and incidence of adverse events. Oral antipsychotics were stopped or tapered off within next 14 days. Results Of 20 patients recruited, 9 patients (45%) completed the study. Paliperidone palmitate produced a significant improvement in PANSS total score from baseline to endpoint. The response rate was 75% [mean change (${\pm}SD$) $-25.9{\pm}14.4$, all p < 0.001]. The CGI-S and PSP total scores significantly improved during 24 weeks (All p < 0.001). Eighty percent of patients reported adverse events and most common adverse events (${\geq}10%$) in paliperidone palmitate were anticholinergic adverse event, extrapyramidal symptoms, weight gain, akathisia, insomnia, headache, agitation, anxiety and GI trouble. ESRS score is not statistically significant, but tends to get better at the end of the study when compared to baseline. Conclusions Our study results demonstrated maintained effectiveness and safety of paliperidone palmitate treatment in schizophrenics. And provides both clinicians and patients with a new choice of treatment that can improve the outcome of long term therapy. Their potential effectiveness and safety should be better addressed by future randomized-controlled trials.

• Journal of Korean Society for Geospatial Information Science
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• v.23 no.4
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• pp.25-33
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• 2015

The study of ecosystem assessment(ES) is based on land cover information, and primarily it is performed at the global scale. However, these results as data for decision making have a limitation at the aspects of range and scale to solve the regional issue. Although the Ministry of Environment provides available land cover data at the regional scale, it is also restricted in use due to the intrinsic limitation of on screen digitizing method and temporal and spatial difference. This study of objective is to generate UAV land cover map. In order to classify the imagery, we have performed resampling at 5m resolution using UAV imagery. The results of object-based image segmentation showed that scale 20 and merge 34 were the optimum weight values for UAV imagery. In the case of RapidEye imagery;we found that the weight values;scale 30 and merge 30 were the most appropriate at the level of land cover classes for sub-category. We generated land cover imagery using example-based classification method and analyzed the accuracy using stratified random sampling. The results show that the overall accuracies of RapidEye and UAV classification imagery are each 90% and 91%.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.2
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• pp.105-112
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• 2018

To determine the position of receiver, the GPS (Global Positioning System) uses position information of satellites and pseudo ranges based on signals. These are reflected by surrounding structures and multipath errors occur. This paper proposes a method for multipath error reduction using digital images to enhance the accuracy. The goal of the study is to calculate the shielding environment of receiver using image processing and apply it to GPS positioning. The proposed method, firstly, performs a preprocessing to reduce the effect of noise on images. Next, it uses hough transform to detect the outline of building roofs and determines mask angles and permissible azimuth range. Then, it classifies the satellites according to the condition using the image processing results. Finally, base on point positioning, it computes the receiver position by applying a weight model that assigns different weights to the classified satellites. We confirmed that the RMSE (Root Mean Square Error) was reduced by 2.29m in the horizontal direction and by 15.62m in the vertical direction. This paper showed the potential for the hybrid of GPS positioning and image processing technology.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.14 no.6
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• pp.97-109
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• 2011

Korea introduced the cooperation charge on conservation of ecosystem for minimizing damage of ecosystem due to development projects and their effects and for preparing resources for natural environment conservation projects. Advanced countries have made efforts by expanding investment in natural environment conservation and restoring projects to promote prevention of global warming and improvement of biological diversity, are establishing nationwide strategies and plans. To examine the reality of projects by returns of the cooperation charge on conservation of ecosystem, microsite projects in schools and public facilities take the largest share while their project budgets are only about 100~300 KRW, relatively small, which might be attributable to budget restrictions in accordance with the calculating method of levying cooperation charge on conservation of ecosystem and problems of project proceeding in the system of returning fund for projects in general. The conclusion which this study suggests on invigoration of cooperation charge on conservation of ecosystem and its operation are as followings. First, although the cooperation charge on conservation of ecosystem has been introduced in 2001, the amount of imposition per unit area remains unchanged. It is desirable to increase the amount into $1,400KRW/m^2$ as of August, 2011 as the price index has been continuously rising for the past 10 years and the upward adjustment of imposition per unit area should be notified by the decree of the Ministry of Environment every January. Second, the ceiling amount of the cooperation charge on conservation of ecosystem should be abolished. Now the ceiling amount is defined as 1 billion KRW but it was found that there was not any ceiling amount specified according to the comparative analysis of similar systems with the Korean environmental improvement fund. The ceiling should be abolished so that medium level businesses are carried out and ecosystem recovering projects in the true sense of the word can be made smoothly. Third, weight should be introduced in calculating amounts in accordance with ecologic and economic values. Harmony between development and environment can be achieved by applying differentiated weights of constant regional coefficient by use zone and ecologic and economic values. Continuous efforts of improving cooperation charge on conservation of ecosystem should be made more than anything else so that projects by returns of cooperation charge on conservation of ecosystem get effectiveness.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.265-278
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• 2011

Objectives : This trial were conducted to evaluate the efficacy and adverse events of Bofutsusho-san(BTS) and Boiogiot-tang(BOT) by oriental obesity pattern identification on obese subjects, as compared to placebo. Methods : 166 subjects(body mass index ${\geq}25kg/m^2$) were recruited and randomized to receive BT(n=55), FH(n=55) or placebo(n=56) for 8 weeks. Anthropometric factors, serum lipid, glucose, blood pressure(BP), pulse rate, resting metabolic rate and oriental obesity pattern identification questionnaire were measured at baseline and 8 weeks. Adverse events and safety outcome variables were also checked during trials. Results : The frequency of top-scored oriental obesity pattern was ordered by indigestion(食積) > stagnation of the liver qi(肝鬱) > yang deficiency(陽虛) > spleen deficiency(脾虛) > phlegm(痰飮) > blood stasis(瘀血) in subjects. BTS group significantly decreased body weight, body mass index(BMI), waist circumference(WC), body fat mass, total cholesterol and HDL-cholesterol in stagnation of the liver qi(肝鬱) and WC in indigestion(食積). BOT group showed significant decrease of body weight, BMI, WC, and body fat mass in indigestion(食積) not in deficiency(虛症). Adverse events were reported most frequently in yang deficiency(陽虛) by BT group and stagnation of the liver qi(肝鬱) by BOT group. Conclusions : Bofu-tsusho-san was effective in treating obesity with stagnation of the liver qi(肝鬱). Obesity pattern identification could be a useful diagnostic tool predicting treatment effects and adverse events.

• Journal of the Korean Chemical Society
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• v.60 no.3
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• pp.187-193
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• 2016

In this study, preparation of positively and negatively charged carbon nanotube (CNT)-collagen (CG) hydrogels with pH sensitive characteristic was reported. The positive and negative characteristics of the prepared hydrogels were created by introduction of positively functionalized CNT-NH₂ and negatively functionalized CNT-COOH, respectively, into the collagen hydrogel. The surface charge of CNTs (CNT-NH₂ and CNT-COOH), CG and CNTs/CG hydrogels was measured by Zetasizer. The swelling ratios of CNT-NH₂/CG and CNT-COOH/CG hydrogels in aqueous solution were checked by measuring of weight changes of the hydrogels in the range of pH 2~10. In detail, the positively charged CNT-NH₂/CG hydrogel swelled up to 5% at pH 4 in comparison to the weight at pH 7, while the negatively charged CNT-COOH/CG hydrogel swelled up to 10% at pH 10. The prepared CNT-NH₂/CG and CNT-COOH/CG hydrogels will be very useful as pH sensitive oral drug-delivering systems for gastrointestine (pH ~2) and small intestine (pH ~9), respectively.

• Journal of the Korean GEO-environmental Society
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• v.16 no.8
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• pp.13-20
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• 2015

Due to the population growth and exhaustion of resource, the development on the harsh environment such as cold weather is emerging as an alternative for new resource development. The permafrost area covers about 14 percent of the world's land area and the global construction market for such area is rapidly expanded. Whereas the developed countries have already recognition of the need for research of coldest place and invested heavily in technology development, the domestic technology for the coldest place development is less developed and related research has rarely been performed. There is not a detailed national specification standard for the strength and deformation properties of the earthworks at sub-zero temperature but simple field directions. Therefore, the D compaction tests were conducted on the sand with fine contents of 0%, 5%, 10% and 15% at room temperature ($18^{\circ}C$), $-3^{\circ}C$ and $-8^{\circ}C$ to investigate the effect of the compaction energy on the compacted soils at sub-zero temperatures. Based on the test results, the larger compaction energy, the larger maximum dry unit weight under sub-zero temperature and D type compaction at $-3^{\circ}C$ show similar max. dry unit weights as those obtained from the compaction at the room temperature. However, compaction at $-8^{\circ}C$ showed significant performance degradation regardless of the compaction energy.

• Nutrition Research and Practice
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• v.10 no.1
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• pp.33-41
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• 2016

BACKGROUND/OBJECTIVES: Diabetes mellitus (DM) is a major chronic disease which increases global health problems. Diabetes-induced renal damage is associated with inflammation and fibrosis. Alpha (AT) and gamma-tocopherols (GT) have shown antioxidant and anti-inflammatory effects in inflammation-mediated injuries. The primary aim of this study was to investigate effects of AT and GT supplementations on hyperglycemia induced acute kidney inflammation in alloxan induced diabetic mice with different levels of fasting blood glucose (FBG). MATERIALS/METHODS: Diabetes was induced by injection of alloxan monohydrate (150 mg/kg, i.p) in ICR mice (5.5-week-old, male) and mice were subdivided according to their FBG levels and treated with different diets for 2 weeks; CON: non-diabetic mice, m-DMC: diabetic control mice with mild FBG levels (250 mg/dl ${\leq}$ FBG ${\leq}$ 450 mg/dl), m-AT: m-DM mice fed AT supplementation (35 mg/kg diet), m-GT: m-DM mice with GT supplementation (35 mg/kg diet), s-DMC: diabetic control mice with severe FBG levels (450 mg/dl < FBG), s-AT: s-DM mice with AT supplementation, s-GT: s-DM mice with GT supplementation. RESULTS: Both AT and GT supplementations showed similar beneficial effects on $NF{\kappa}B$ associated inflammatory response (phosphorylated inhibitory kappa B-${\alpha}$, interleukin-$1{\beta}$, C-reactive protein, monocyte chemotactic protein-1) and pre-fibrosis (tumor growth factor ${\beta}$-1 and protein kinase C-II) as well as an antioxidant emzyme, heme oxygenase-1 (HO-1) in diabetic mice. On the other hands, AT and GT showed different beneficial effects on kidney weight, FBG, and oxidative stress associated makers (malondialdehyde, glutathione peroxidase, and catalase) except HO-1. In particular, GT significantly preserved kidney weight in m-DM and improved FBG levels in s-DM and malondialdehyde and catalase in m- and s-DM, while AT significantly attenuated FBG levels in m-DM and improved glutathione peroxidase in m- and s-DM. CONCLUSIONS: the results suggest that AT and GT with similarities and differences would be considered as beneficial nutrients to modulate hyperglycemia induced acute renal inflammation. Further research with careful approach is needed to confirm beneficial effects of tocopherols in diabetes with different FBG levels for clinical applications.

• Korean Journal of Organic Agriculture
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• v.27 no.1
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• pp.45-56
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• 2019

The study I was initiated in six private 'Campbell Early' vineyards in parts of Jeollanam-do province to relieve symptom of fruit blight mostly due to a high temperature occurred in Summer. High percentage of fruit blight was observed for medium growth of grape trees non-irrigated. In the study II, grape trees treated with 0%, 30% and 60% shade films were investigated for the tree responses, including fruit blight symptom in the research plots. Harvesting time was advanced approximately two weeks by the 30% shade treatment. High percentage of shades increased total shoot length per tree and decreased shoot diameter, with the greatest number of shoots observed for the 30% shade-treated grapes. Light intensity in the tree canopy was approximately 26% decreased by 30% shade treatment. Marketable harvested fruits per tree were 50.6 of 30% shade treatment, 33.6 of 0% shade, and 42.8 of 60% shade. The 30% shade treatment decreased to 11.8% of cluster blight per tree and to 11.2% of berry blight per cluster. The 30% shade treatment increased cluster weight, berry weight, soluble solid contents, and anthocyanin contents.

• Journal of the Korean earth science society
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• v.40 no.3
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• pp.259-271
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• 2019

A statistical downscaling method was adopted in order to establish the high-resolution wave prediction system in the East Sea coastal area. This system used forecast data from the Global Wave Watch (GWW) model, and the East Sea and Busan Coastal Wave Watch (CWW) model operated by the Korea Meteorological Administration (KMA). We used the CWW forecast data until three days and the GWW forecast data from three to seven days to implement the statistical downscaling method (inverse distance weight interpolation and conditional merge). The two-dimensional and station wave heights as well as sea surface wind speed from the high-resolution coastal prediction system were verified with statistical analysis, using an initial analysis field and oceanic observation with buoys carried out by the KMA and the Korea Hydrographic and Oceanographic Agency (KHOA). Similar to the predictive performance of the GWW and the CWW data, the system has a high predictive performance at the initial stages that decreased gradually with forecast time. As a result, during the entire prediction period, the correlation coefficient and root mean square error of the predicted wave heights improved from 0.46 and 0.34 m to 0.6 and 0.28 m before and after applying the statistical downscaling method.