• STI Policy Review
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• v.3 no.1
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• pp.46-62
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• 2012

This study investigates the effects of the two most important indicators of a nation's state of scientific infrastructure: R&D investment and the number of R&D researchers engaged in high-tech product export competitiveness for a panel of 11 countries/economies from East Asia from 1994 to 2010. A GMM panel estimation method was employed to account for the dynamic effect of trade and to control for un-observed country specific effects that may arise due to an inter-country differences and intra-country dynamics. Accordingly, the empirical results reveal that (once controlled for the influence of per capita income) physical capital and infrastructure, a 1% increase in a country's expenditure on the ratio of R&D to GDP may increase high-tech product export performance by approximately $397 million per year. Other factors constant, a 1% increase in the number of R&D researchers is expected to increase the ability to export high-tech products by approximately $67 million. The East Asian development experience demonstrates how latecomers can follow systematic industrialization and join the handful of economies that have come a long way toward closing the knowledge gap with the global technological leaders. However, this does not mean that the policy approaches and overall commitments pursued by each East Asian economy in relation to R&D investment and acquisition of an adequate pool of researchers, and their ultimate achievements in high-tech product export competitiveness were uniform. As a result, there is still a significant variation among countries/economies in terms of performance. This study recommended a number of potential tools and policy instruments that may assist policy makers to foster R&D as an engine to enhance the high-tech product export competitiveness.

• International Journal of Knowledge Content Development & Technology
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• v.8 no.2
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• pp.49-65
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• 2018

Are the benefits derived from ICT based reference and information service worth the financial and other commitments devoted to it? In an attempt to answer this, this study delved into finding out the perceived benefits; the rational for ICT based reference services in Nigerian university libraries. The main objectives were to find out the purposes for using ICT facilities in reference services delivery and the perceived benefits derived from using ICT resources in reference and information services. Being a survey, questionnaire was used to collect data from the librarians of twelve (12) universities; two (2) each sampled from the six geopolitical zones of Nigeria. Data was analyzed using frequencies, mean scores and standard deviations. ANOVA statistical analysis was used to test the hypothesis of no significance difference in the benefits derived from ICT based reference services using p-value of 0.05 to calculate the level of significance. Findings showed that librarians and library users made use of ICT facilities for different reference purposes especially to obtain information they need using the internet. Other reference needs for which patrons used the ICT facilities included: - access to current e-books and e - journals, user education and access to global information in other libraries. Provision of current awareness services (CAS) and selective dissemination of information services (SDI), on-line searching using workstations in the library, provision of on-line public access catalogue (OPAC) services, keeping statistics of users of the reference section and compilation of bibliographies. Further findings showed that the librarians and library users derive a lot of benefits from their use of ICT facilities in reference services. The results showed that easy retrieval and dissemination of information to patrons were ranked highest by the librarians amongst others.

• Journal of Marine Bioscience and Biotechnology
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• v.6 no.2
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• pp.84-101
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• 2014

The aim of this project is to develop an adaptive and collective National Marine Biotechnology Plan for the next decade(2014~2023) which is able to reflect current and future changing environment. This effective strategy targets to foster marine-derived active bio-materials, marine bioenergy production technology and many promising technologies in order to promote marine biotechnology industry as a next-generation growth engine. Marine biotechnology industry based on R&D activities since 1980 has been growing as an emerging industry. This new field enables to secure exclusive patent rights and to find new potential bio-active materials from the ocean that requires long-term aggressive R&D investments. The current policy direction is to raise appropriate level of R&D investment because the current Korea's national marine biotechnology R&D fund ratio is less than 2% of the total national biotechnology R&D budget. The result shows three major strategies. First, it recommended a research implementation system and supporting policy that includes establishment of open innovation framework for the 'Industry-Academia-Research Institute Collaborations', strategic research planning and enhanced policy making process. Second, it derived state-of-the-art or new technology in many areas. Third, it formulated more detailed execution plans for successful R&D support and set up performance indicator system in related R&D program.

• Molecules and Cells
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• v.39 no.6
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• pp.495-500
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• 2016

We have solved the crystal structure of a predicted fructose-specific enzyme $IIB^{fruc}$ from Escherichia coli ($EcEIIB^{fruc}$) involved in the phosphoenolpyruvate-carbohydrate phosphotransferase system transferring carbohydrates across the cytoplasmic membrane. $EcEIIB^{fruc}$ belongs to a sequence family with more than 5,000 sequence homologues with 25-99% amino-acid sequence identity. It reveals a conventional Rossmann-like ${\alpha}-{\beta}-{\alpha}$ sandwich fold with a unique ${\beta}$-sheet topology. Its C-terminus is longer than its closest relatives and forms an additional ${\beta}$-strand whereas the shorter C-terminus is random coil in the relatives. Interestingly, its core structure is similar to that of enzyme $IIB^{cellobiose}$ from E. coli ($EcIIB^{cel}$) transferring a phosphate moiety. In the active site of the closest $EcEIIB^{fruc}$ homologues, a unique motif CXXGXAHT comprising a P-loop like architecture including a histidine residue is found. The conserved cysteine on this loop may be deprotonated to act as a nucleophile similar to that of $EcIIB^{cel}$. The conserved histidine residue is presumed to bind the negatively charged phosphate. Therefore, we propose that the catalytic mechanism of $EcEIIB^{fruc}$ is similar to that of $EcIIB^{cel}$ transferring phosphoryl moiety to a specific carbohydrate.

• Journal of the Korea Convergence Society
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• v.8 no.4
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• pp.167-182
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• 2017

This study aims to examine the impacts of service quality (SQ) on consumer-brand relationship quality (BRQ), the mediation effects of brand trust (BT) in those relationships and the moderated mediation effects of BT by the level of perceived product quality (PQ). A 376 valid sample was obtained from the consumers who have visited the service centers of automotive brands. The findings demonstrate the direct effects of SQ of the service centers in automotive brands on BRQ are not significant, while the mediation effects of BT between SQ and BRQ are significant. Moreover, the findings reveal that the mediation effects of BT in the lower perception group of PQ are stronger than those in the higher group. Based on these findings, not only the necessary roles of a service center to improve BRQ but also the transferring process from service centers' SQ to building a strong brand are discussed.

• KSBB Journal
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• v.22 no.6
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• pp.393-400
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• 2007

Analysis of protein interactions/functions in a microarray format has been of great potential in drug discovery, diagnostics, and cell biology, because it is amenable to large-scale and high-throughput biological assays in a rapid and economical way. In recent years, the protein microarray have broaden their utility towards the global analysis of protein interactions on a proteome scale, the functional activity analysis based on protein interactions and post-translational modifications (PTMs), and the discovery of biomarkers through profiling of protein expression between sample and reference pool. As a promising tool for proteomics, the protein microarray technology has advanced outstandingly over the past decade in terms of surface chemistry, acquisition of relevant proteins on a proteomic level, and detection methods. In this article, we briefly describe various techniques for development of protein microarray, and introduce developmental state of protein microarray and its applications.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.3
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• pp.591-605
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• 2017

The right to informational self-determination refers to the constitutional right for an individual, which is approved by the constitutional court, to decide what contents the collected information comprises and to control the circulation of information relation to oneself. It contains claim for inspection of personal information(The right to informational self-access) as a right for individual to review information of current state and processing history which information holders have. To assure the right to informational self-access, individual must be notified of the processing history of information by information holders regardless of individual's request(The unconditional right to informational self-access). This study will analyse current status of domestic and foreign legislation and global regulation which are related to the unconditional right to informational self-access. In addition, the action of domestic corporations will be introduced. Finally, it will be concluded with relevant problems and solutions to solve the problems.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.5
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• pp.1102-1112
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• 2012

The policy of the United States is a Korean Peninsula free of all nuclear weapons. The United States government was considering the possibility of military action to eliminate the North Korean nuclear threat. Talk of military action peaked from mid-1993 through mid-1994. Such an attack might have led directly to a Korean war. At that time the nuclear crisis solutioned by North Korea-United States negotiation and ROK-United States alliance. PSI's purpose is to prevent or at least inhibit the spread of weapons of mass destruction, their delivery systems, and related materials to and from states and non-state actors whose possession would be a serious threat to global or regional security. The most controversial activity of PSI is interdiction. North Korea has expressed grave concern over the initiative, stating that it has a sovereign right to develop, deploy, and export weapons, and that it would view any interdiction of its ships as a declaration of war. If South Korea is to execute interdiction North Korean ships expect tensions to increase dramatically on the peninsula with North Korea doing something quite provacative in response. South Korea cannot help approaching PSI with great caution, since it has to consider the ROK-United States alliance, and inter-Korean relations.

• Korean Journal of Oriental Medicine
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• v.12 no.1
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• pp.13-22
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• 2006

Background and Aims: Herbal drugs and traditional medicines have lately attracted considerable attention by global pharmaceutical corporations because the conventional chemical drugs didn't work well for many chronic diseases or intractable diseases. The government of Korea is also supporting to develop the new drug which is high value added product, and the natural medicine including herbal medicine(or Traditional Korean Medicine) have a significant presence in this field. non-clinical pharmacology/toxicology study and clinical trial are the two major criteria which estimate efficacy and safety for registration of new drugs. All of the pharmaceutical companies producing herbal medicine and the academic and the academic world of Tradition Korean Medicine have the will to develop new herbal drugs, but there are obstacles that they have neither experience nor guideline about clinical trial. Therefore for developing new herbal drugs, it is necessary to research the present conditions and comprehensive systems about clinical trial in Northeast Asian countries China, Taiwan and Japan because they have the common background with Korea in traditional medicine fields. Methods : The present state of clinical trial for herbal medicine in Korea was investigated. And then, those in China, Taiwan, Japan was also investigated. Results and conclusions : There are significant differences among 4 Southeast Asian countries Korea, China, Taiwan and Japan each in present condition, purpose, involved comprehensive system including legislation, and actual operation of clinical trial for traditional medicine.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.12B
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• pp.1066-1080
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• 2003

In this paper a scalable QoS routing scheme for distributed multimedia applications in a hierarchical wide area network is proposed. The problem of QoS routing is formulated as a multicriteria shortest path problem, known as NP-complete. The proposed hierarchical routing scheme consists of two phases. In Phase 1, every border node periodically pre-computes the QoS distance for the paths between every pair of border nodes in any level of domain hierarchy. This phase is independet of the QoS request from an application. In Phase II, distributed graph construction algorithm is performed to model the network as a graph by retrieving pre-computed QoS distances. The graph is constructed by the on-demand algorithm and contains a part of the network topology which is completely neglected or partially considered by existing routing schemes, thus maintaining more accurate topology information. By using retrieval approach rather than advertising one, no global QoS state information exchange among nodes is needed. In this Phase, distributed partition algorithm for QoS routing problem is also performed, thus eliminating virtual links on the hierarchically complete path.