• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1974년도 학술대회지
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• pp.45-48
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• 1974

[ $\beta$-Sitosterol and oleanolic acid were isolated in a pure form from Radix Panax Ginseng, the genuine Ginseng drug, by column chromatography on Silicagel and aluminium oxide (Woelm). TLC indicates the presence of at least three other triterpene sapogenins.

• 대한본초학회지
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• 제22권1호
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• pp.41-48
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• 2007

Objectives : This research was investigated the effect of the Ginseng Radix plus Chaenomelis Fructus on Alzheimer's disease. Methods : Specifically, the effects of the Ginseng Radix plus Chaenomelis Fructus extract on $IL-1{\beta}$, $TNF-{\alpha}$ of BV2 microglia cell line treated with lipopolysacchride. Results : The Ginseng Radix plus Chaenomclis Fructus extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}$ amyloid peptide. Conclusion: These results suggest that the Ginseng Radix plus Chaenomelis Fructus extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Ginseng Radix plus Chaenomelis Fructus extract for Alzheimer's disease is suggested for future research.

• Journal of Ginseng Research
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• 제24권2호
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• pp.99-105
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• 2000

본 논문은 인삼의 한의학적 응용과 현재 각국별 인삼의 복용기준 및 그 동안 수행된 임상실험을 중심으로 인삼의 응용과 복용량에 대한 문헌적 고찰을 하였다. 인삼분말 기준 복용량은 특별히 처방에 기술되어 있지 않은 한 1회 3~4 g정도 복용하는 것이 보편적 복용량으로 간주되며, 인삼제품도 이에 상당하는 인삼량으로 복용하면 될 것으로 사료된다. 다만 서구권의 경우는 인삼을 의약품으로 분류하여 복용량을 하루 1-2정도로 규정하고 있고 임상실험에서 사용된 인삼투여용량은 대부분 1g 이하로 되어 있다 서구에서의 인삼복용량 설정은 그 동안 인삼의 안전성(부작용과 역작용 등)과 관련된 사례보고 등에 근거하여 그 복용기준을 설정한 것으로 이해된다. 그러나 동서양간 인삼복용량의 차이점에 대해서는 동양인과 서구인들 간의 식생활 차이 또는 인종적 차이에 기인한 인삼의 복용 반응의 차이인지에 대해서 추후 검토되어야 할 사항이다. 아울러 인삼의 투여용량별 효과의 차별성이 있는지, 금후 인삼의 적정 투여용량 설정과 관련하여 인체실험을 통한 활성성분의 체내동태(Pharmacokinetics)와 자생체내 이용효율(Bioavailability)에 대한 연구가 이루어져야할 것이다.

• 대한본초학회지
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• 제27권2호
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• pp.47-51
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• 2012

Objectives : The purpose of this study was to investigate the reproductive effect of Ginseng radix on male mice. Methods : Male C57BL/6J mice were divided into four groups ; normal group (vehicle-treated, n=8), Ginseng radix treatment group (100, 500, 1000 mg/kg, n=8). Ginseng radix extract was treated for 5 weeks. After treatment each group was examined for assessment of sperm count and CatSper protein expression using computer assisted semen analysis (CASA) system and the immunofluorescence. Results : Sperm count of normal and Ginseng radix extract treated group were 287.57 vs. 371.62, 364.83, $343.29{\times}10^6$, respectively. The CatSper3, 4 proteins expression of Ginseng radix treated group were significantly increased than that of normal group. Conclusions : These findings suggest that the Ginseng radix improves male reproductive function by increasing sperm count and CatSper protein expression.

• 동의생리병리학회지
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• 제21권5호
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• pp.1057-1064
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• 2007

Traditionlly Radix Ginseng has been known to Qi-tonic medicine. Practically Radix Ginseng is listed in Shinnongbonchokyeong as the medicine for replenishing the Primordial-Qi, tranquilizing the mind and improving mental power. However, when we consider the text of prescriptions that contained Radix Ginseng in Jangjoongkyeong's Sanghanlon, Radix Ginseng had not been conjugated to replenish the Primordial-Qi. On the other hand, Yoshimasu todo had been taken up the position that Radix Ginseng in Sanghanlon was conjugated to treat Shimhabikyeong. Accordingly, author studied about practical use of Radix Ginseng in Sanghanlon based on Yakjing and Yoochuibang that Yoshimasu todo's writing. The result of study are summurized as follows. Jangjoongkyeong conjugated ginseng to treat Shimhabikyeong in Sanghanlon. The prescription that Shimhabikyeong was not mentioned is thought as it was omitted from the text. Jangjoongkyeong conjugated the bitter taste ginseng to treat Shimhabikyeong. Shimhabikyeong is abdominal diagnosis that the patient feel a subjectively blocked sensation and below the Kumi becomes hard as solid.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1980년도 학술대회지
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• pp.37-38
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• 1980

• 인삼문화
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• 제3권
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• pp.38-53
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• 2021

이 연구는 세계적으로 가장 유명한 박물관으로 꼽히는 대영박물관이 개관 당시부터 인삼을 주요 전시품으로 취급하고 있었음을 학술적으로 규명했다. 대영박물관은 영국의 저명한 의사이자 과학자, 수집가인 한스 슬론(Hans Sloane, 1660-1753)의 유언에 따라 그의 컬렉션을 토대로 건립된 것으로, 인삼을 비롯한 '식물성 물질 표본(Vegetable Substances specimens)'이 그 핵심에 놓여 있었다. 이 글에서는 먼저 슬론이 방대한 컬렉션을 모으는 과정을 재구성하면서 영국의 초기 제국주의와 본초학, 수집과의 관계를 밝혔다. 대영박물관에 전시되었던 인삼 표본 4개--Radix Ginseng or ninzin from China (VS 532)/ Ginseng. Id (VS 8,198)/ Roots & seeds of Gin-seng (VS 7,825)/ Ginseng root (VS 12,140)--의 출처와 입수 경로를 추적하였다. 이들은 각각 중국, 일본, 북아메리카에서 온 것으로, 각각 고려인삼, 죽절삼, 화기삼으로 추정된다. 당시의 영향력 있던 인쇄물을 통해 인삼이 대영박물관의 주목할 만한 전시품으로 대중들에게 홍보되었으며, 영국에서는 화기삼이 고려인삼에 비해 열등한 평가를 받고 있었다.

• 동의신경정신과학회지
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• 제15권1호
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• pp.101-119
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• 2004

Ginseng Radix Alba and Cyperi Rhizoma were investigated for their anti-depressant effects. For this purpose, forced-swimming test, tail suspension test, hot plate test, reserpine-induced hypothermia, aggressive behavior test were performed. In addition, the brain content of 5-hydroxyindoleacetic acid(a metabolite of serotonin), the monoamine oxidase activity, anticonvulsant effect, sleep enhancement effect were determined. The results are as follows: In the forced swimming test, Ginseng Radix diminished the duration of immobility by 45.5% compared to the control group, while Cyperi Rhizoma showed weaker effect (12.4% reduction) at 2g/kg. In the tail suspension test, the effect of Ginseng Radix(43.7% reduction) are also better than that of Cyperi Rhizoma(15.6% reduction) at 2g/kg. In the hot plate test, Ginseng Radix showed no difference as compared to control, while Cyperi Rhizoma increased the jump latency time by about 25% after administration for 10 days. In the reserpine-induced hypothermia test, both drugs slowly dropped the body temperature compared to the control group, especially the rate of hypothermia of Ginseng Radix was 24.0% at 1g/kg. In the aggressive behavior test, both drugs delayed the onset time, decreased the duration and frequency, of which effects were better in Cyperi Rhizoma. The content of 5-hydroxyindoleacetic acid in mice brain was slightly increased in Ginseng Radix, while Cyperi Rhizoma increased its level almost to the control group. Both drugs inhibited the monoamine oxidase activity in a dose-dependent manner, but the effect(51.2%) of Cyperi Rhizoma was more potent than the effect(11.8%) of Ginseng Radix. In the pentobarbital-induced sleep test, Cyperi Rhizoma exhibited no significant difference against the control group, while Ginseng Radix showed about two-fold enhancement at 2g/kg. The anticonvulsant effect of both drugs delayed the onset time, shortened the duration of convulsion and diminished the lethality, but Ginseng Radix were better than Cyperi Rhizoma.

• 대한한방부인과학회지
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• 제19권2호
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• pp.49-61
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• 2006

Purpose : This study was undertaken to evaluate the effects of the different administration duration of Ginseng Radix Alba extract solution on the spermatogenic abilities. Methods : We used the 2-month-old mice and administered Ginseng Radix Alba extract solution 0.3mg/g/day for 30, 60, 90 and 120 days. The control group was administered the normal saline in the same way. We examined the number of total, motile and normal sperm from the cauda epididymis, the activities of sperm hyaluronidase. Also we observed changes of isolated testis before and after administration of Ginseng Radix Alba extract solutions in the mice. And we compared to the testicular tissue especially seminiferous tubules between control and treated group by histochemical methods. Results : The significant differences were observed in the concentration of total sperm and normality of spermatozoa of the Ginseng Radix Alba extract solution administered groups compared to the control group in 60, 90 and 120days groups. The significant differences were observed the motility of the Ginseng Radix Alba extract solution administered groups compared to the control group in 90 days group respectively. In the histological analysis of the testicular tissues, the enlargement of testicular lobe diameter and apparent vasculogenesis between testicular lobes were observed in the Ginseng Radix Alba extract solution administered groups compared to the control group, respectively. but the activity of hyaluronidase was not significantly increased in the Ginseng Radix Alba extract solution administered groups Conclusion : This study shows that Ginseng Radix Alba has the beneficial effect on the concentration, morphology and motility of sperm especially in 90 days administration group. We can suggest that Ginseng Radix Alba extract solution be useful for the treatment of male sexual dysfunctions and infertility.

• 대한한의학방제학회지
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• 제19권2호
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• pp.135-149
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• 2011

Objectives : This study was performed to investigate the applications of 47 prescriptions containing Ginseng Radix and Aconiti Lateralis Preparata Radix in Dongeuibogam. Methods : 47 prescriptions containing Ginseng Radix and Aconiti Lateralis Preparata Radix which have been used separately or concurrently in Oriental Medicine for a long time as a treatment for various disease in Dongeuibogam were studied through order of frequency, symptoms, dosages, etc. Results : 1. 17.02 % prescriptions are used in cold chapter with the 8 frequency, 14.89% in fatigue chapter with the 7 frequency, 10.64% in stool and wind chapter each with the 5 frequency, and 6.38% in children chapter with the 3 frequency. 2. Cold-diarrhea, Yang deficiency treating herbs, General fatigue treating herbs are most used chapters and articulation pain, severe cold, convulsion chapters are following frequency among 38 symptoms in prescriptions including Ginseng Radix and Aconiti Iateralis Preparata Radix. 3. In the prescriptons which has used more Ginseng Radix than Aconiti Lateralis Preparata Radix, the dosage ratio between Ginseng Radix and Aconiti Lateralis Preparata is ranged from 2.5 puns:1.5 puns ~ 1 jeon:7 puns. Among the range, 1 jeon:5 puns is recorded 2 times(33.33%), the rests are 1 time(16.67%). 4. In the prescriptons which has used same amount Ginseng Radix and Aconiti Lateralis Preparata Radix, the dosage ratio Ginseng Radix and Aconiti Lateralis Preparata is ranged from 2 puns ~ 1 nyangs each. Among the range, 1 jeon is recorded 12 times(41.38%), 1.25 jeon and 5 jeons are 3 times(10.34%) each, 0.5 jeon, 0.7 jeons and 3 jeons each are recorded 2 times (6.90%), the rests are 1 time(3.45%). 5. In the prescriptons which has used less Ginseng Radix than Aconiti Lateralis Preparata Radix, the dosage ratio between Ginseng Radix and Aconiti Lateralis Preparata is ranged from 3 puns:1 jeon ~ 1 nyang:3 nyangs. Among the range, 5 jeons:1 nyang is recorded 2 times(25.00%), the rests are 1 time(12.50%). 6. 5 jeons:1 piece are used 2 times(50.00%), the rests are 1 time(25.00%) each used among 3 prescriptions including Ginseng Radix and Aconiti Lateralis Preparata Radix. Conclusions : The 47 prescriptions including Ginseng Radix and Aconiti Iateralis Preparata Radix in Dongeuibogam are mainly composed of Samboo-tang, Sayeok-tang, Eejoong-tang, Samool-tang, Sagoonja-tang and Gobangpoong-tang, Bowon-tang, etc.