• The Journal of Internal Korean Medicine
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• v.40 no.6
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• pp.1081-1100
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• 2019

Objectives: This study is an overview of the meta-analysis and systematic review of randomized controlled trials investigating the clinical effectiveness and safety of pharmacopuncture for patients with stroke. Methods: Core electronic databases were searched from their inception to 21 May 2019. A measurement tool to assess systematic reviews (AMSTAR 2) was applied to screen high-quality studies. The results of these studies were summarized, and additional meta-analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the certainty of evidence. Results: Sixteen studies met eligibility criteria. Four were excluded owing to insufficiency of AMSTAR 2 or low data reliability. The finally selected 12 studies were about pharmacopuncture using either a single herb extract, such as Dengzhan xixin, Sanch, Ginkgo biloba, or Acanthopanax, or a mixture of herbs, such as Compound danshen, Shenxiong, Xingnaojing, or Mailuoning. Most of the patients were from China, with acute ischemic stroke. All the studies using a pharmacopuncture versus a non-pharmacopuncture design reported the significant superiority of pharmacopuncture on every outcome measure. On the other hand, in a few studies, pharmacopuncture was inferior to active control in improving neurological deficit. Few studies reported adverse events. Conclusions: It is difficult to apply the results of this study directly to Korea, because the level of evidence is generally low and the clinical settings and social acceptance of pharmacopuncture therapy differ in Korea and China. Further studies are warranted to confirm the domestic applicability of evidence generated in China and to create evidence that supports the domestic situation.

• Herbal Formula Science
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• v.17 no.2
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• pp.111-121
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• 2009

Objectives : This study was performed to evaluate the efficacy of ampule containing herbal extract(Ulmus davidiana, Ginkgo biloba, Perilla ocymoides, Morus alba, Glycyrrhiza uralensis (licorice), and Angelica gigas) on skin wrinkles in adult women with facial wrinkles. Methods : A total of 12 women, 30 to 46 years of age, with wrinkles in the corner of eyes, applied ampule containing herbal extract twice daily for up to 12 weeks. Silicon replicas of right crow's feet area and antecubital fossa were taken before use of test product and at 4, 8 and 12 weeks. The replicas were analyzed by optical profilometry with Skin Visiometer SV600. The wrinkle and roughness parameters, R1, R2, R3, R4 and R5 were calculated and statistically analyzed. In addition, a subjective evaluation of product efficacy was conducted by patient's assessment. Results : The mean values of all the skin roughness parameters were decreased at 4-week, and decreased significantly at 8 and 12-week except R4 at 12-week after test product use. The subjective evaluation of wrinkle by patient's assessment was also improved. However, one patient noted stiffness of face after use of test product. Conclusions : These study suggested that the application of ampule containing herbal extract twice daily for 12 weeks may effectively improve the facial wrinkles without severe side effect.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.6 no.2
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• pp.27-38
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• 2003

This study aimed to provide basic data for future management of roadside trees by analyzing problems associated with plantation and management of roadside trees through categorization of functions and organizational structure, plantation and management, and management regulations and generating improvement opportunities based on the result of a survey on the awareness of government officials who are directly in charge of managing roadside trees in 31 cities & counties within Kyonggi province. The summary of key results of this study is as follows. First, "roadside tree-related function" is still not considered to be independent. About a half of government officials in charge did not majored in this field and they spent only about "2.09hours", in average, in the roadside tree-related function out of 8 working hours per day. Second, regarding problems and improvement opportunities in roadside tree-related function, lack of time was considered to be the biggest problem in overall management of roadside trees. As for improvement opportunities, "increase of dedicated manpower" and "system development" to facilitate efficient processing were suggested. Third, an annual budget for roadside tree-related affairs was merely 92 million won per city/county. A registry for management of roadside trees was kept manually. As for the roles of roadside trees, improvement of landscape and securing of green area itself were valued highly. Fourth, Ginkgo biloba, Zelkova serrata, and Prunus yedoensis were suggested to be the most appropriate species for roadside tree and Platanus occidentalis, Populus albaglandulosa, Populus euramericana, and Robinia pseudo-acacia were mentioned to be the least appropriate species.

• Journal of Fashion Business
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• v.15 no.2
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• pp.107-119
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• 2011

The rate of disposable diaper usage has been increased continuously from convenience of disposable diapers and increment of women's entry in workforce. However, a new perspective toward disposable diapers has been come to the fore in various sides like babies' health, environment, and cost. Furthermore, cloth diaper has started to attract more attention. Since parents and grandparents pay more attention to children as birth rate dropped, they tend to purchase expensive goods if the quality or design of the goods is worthy enough. Therefore, this study has the purpose in presenting the basic data for developing functional and pleasant cloth diaper with analyzing the consuming patterns (convergence in nature, health and technology) and cloth diaper characteristics. The research on the actual condition about children cloth diapers and environmental-friendly materials is as follows. Firstly, as a result of analyzing pros and cons about disposable diapers and cloth diapers, the cloth diapers are estimated to have better health, environment, and cost factors than disposable diapers, only excluding convenience. Secondly, as a result of examining patent registered diapers, the disposable diapers have been improved from shape-centered development to well-being material development, and the cloth diapers have mainly developed functional shape-centered. Thirdly, as a result of analyzing children's goods made with environmental-friendly materials, the children's clothes already use organics and natural resources like beans, bamboo trees, ginkgo, and chitosan. Recently, the diaper industry starts to pay attention to environmental-friendly because the skin ailment from environmental pollution has been an issue. To conclude, children's cloth diaper should be appropriate to their body shape and optimized to have convenient form and functional materials. If environmental-friendly materials are used, quality, functionality, various demands from customers and vitalization of goods industry will be all satisfied.

• Korean Journal of Pharmacognosy
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• v.39 no.1
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• pp.68-73
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• 2008

The present study represents the screening of the protective effects of herbal methanolic extracts from Baekdu mountain against tacrine-induced cytotoxicity in HepG2 cells. Tacrine is an acetylcholinesterase inhibitor, and used for the treatment of Alzheimer's disease. However, administration of tacrine for the treatment of Alzheimer's disease results in a reversible hepatotoxicity in 30-50% of patients, consequently limiting clinical use. Therefore, studies for natural products with protective effect on the tacrine-induced hepatotoxicity would be valuable as providing potential therapeutic use. 109 plant sources were collected in Baekdu mountain, and extracted with methanol. These extracts had been screened the protective effects against tacrine-induced cytotoxicity in HepG2 cells at the 100 and 300 ${\mu}g/ml$. Of these, ten methanolic extracts, roots of Ampelosis japonica, aerial parts of Berberis amurensis, aerial parts of Sedum aizoon, aerial parts of Lespedeza tomentosa, aerial parts of Lespedeza juncea, aerial parts of Hypenricum ascyron, stem barks of Syringa reticulata, fruits of Gleditsia japonica, aerial parts of Chamaenerion angustifolium, branches of Ginkgo biloba, showed significant protective effects against tacrine-induced cytotoxicity in HepG2 cells.

• Journal of the Korean Society of Tobacco Science
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• v.22 no.1
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• pp.51-57
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• 2000

The feeding preference of cigarette beetles, Lasioderma serricorne F., was tested using various leaf litters. The number of the trapped L. serricome was 45.25$\pm$10.44 at flue-cured leaf tobacco, Nicotiana tabacum L., 23.50$\pm$6.0 at chinese juniper, Juniperus chinensis L., 1l.75$\pm$4.99 at oak, Qqercus acutissiuma C., and 1l.50$\pm$2.52 at rice-straw, (Oryza. sativa L.). The response of oviposition was 93.20$\pm$26.22 at flue-cured leaf tobacco, 53.60$\pm$11.82 at chinese juniper, 48.20$\pm$20.90 at oriental arborvitae, Thuja orientalis L., 31.80$\pm$18.10 at cherry-tree, Prunus serrulata var. spontanea M., and 29.40$\pm$13.7 at rice-straw. However, the oviposition was respectively low at gingko, Ginkgo biloba L.,(5.40$\pm$2.97), turf grass, Zoysia japonica S., (5.20$\pm$13.7), and oak (3.00$\pm$l.41). The augmentation was maximum at chinese juniper (27.33$\pm$19.44 of emerged adults) followed by Magnolia obovata (8.50$\pm$9.33). Fifty percent of the tested species leaf litters including cherry-tree did not show any augmentation. The adult activities after hibernation were primarily found in May and June at Kwangju and Suwon, and in April at Chungju. The field activity of L. serricome at Suwon was mostly lower than that at other places, except in August at Chungju. The first appearance of L. serricome was observed earlier at Chungju and Kwangju than at Suwon, and the frequency of insect appearance was high in July, August, and September. L. serricome could hibernate by feeding on many kinds of plant leaf litters and it's population could be maintained in the open field in Korea.

• Biomolecules & Therapeutics
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• v.24 no.1
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• pp.40-48
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• 2016

The pregnane X receptor (PXR), a liver and intestine specific receptor,, has been reported to be related with the repression of inflammation as well as activation of cytochromosome P450 3A (CYP3A) expression. We examined the effect of PXR on tetrachloromethane (CCl4)-induced mouse liver inflammation in this work. Ginkgolide A, one main component of Ginkgo biloba extracts (GBE), activated PXR and enhanced PXR expression level, displayed both significant therapeutic effect and preventive effect against $CCl_4$-induced mouse hepatitis. siRNA-mediated decrease of PXR expression significantly reduced the efficacy of Ginkgolide A in treating $CCl_4$-induced inflammation in mice. Flavonoids, another important components of GBE, were shown anti-inflammatory effect in a different way from Ginkgolide A which might be independent on PXR because flavonoids significantly inhibited CYP3A11 activities in mice. The results indicated that anti-inflammatory effect of PXR might be mediated by enhancing transcription level of $I{\kappa}B{\alpha}$ through binding of $I{\kappa}B{\alpha}$. Inhibition of NF-${\kappa}B$ activity by NF-${\kappa}B$-specific suppressor $I{\kappa}B{\alpha}$ is one of the potential mechanisms of Ginkgolide A against CCl4-induced liver inflammation.

• Journal of the Korean Wood Science and Technology
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• v.24 no.2
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• pp.46-54
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• 1996

This study was carried out to investigate the vacuum drying characteristics of 50mm- and 75mm- thick tree disks of some domestic softwoods for substituting the conventional hardwoods as the materials for wood crafts. Though the elapsed drying times from green to in-use moisture content(MC) were largely shortened by vacuum drying, the tree disks treated by EWS couldn't be dried to in-use MC, and so sapwood stains also were occurred severely. We suggest EWS treatment is undesirable for the species with very high sapwood portion or vacuum drying with hot water circulation heating system. Heart checks were slight, but sapwood checks, which have never been trouble in drying process of tree disks, were severe. For the reasonable explanation it is suggested MC differences between sapwood and heartwood were large and most of tree disks had already no barks before drying test. Ginkgo was vacuum-dried with very slight drying defects such as heart checks, sapwood checks. V-cracks and sapwood stains. In Korean red pine and pitch pine V-cracks were severely occurred. And it was found the special feature that most of these defected tree disks contained several V-cracks within one tree disk. It can be considered as the causes that the region of sapwood was defected by the several checks at the early drying stage because of the steep MC gradient along the radial direction, and then at the later drying stage the drying stresses due to differential shrinkage were concentrated on these brittle spots.

• Journal of Haehwa Medicine
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• v.5 no.1
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• pp.185-198
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• 1996

After evaluation of antithrombotic effect of 40 herbs on platelet aggregation induced by ADP(Adenosine diphosphate), these results were obtained as follows: 1. Crude drugs exerting over 30 % of in Chinemys reevesii (Gray)hibition on platelet aggregation induced by ADP were Ganoderma japonicum (Fr.) Lloyd., Panax ginseng C. A. Mey., Gastrodia elata Bl., Thea sinensis, Chinemys reevesii (Gray), Cuscuta chinensis Lam., Cervus nippon Temminck., Biota orientalis (L.) Endl., Coriolus versicolor, Cinnamomum cassia Presl., Sophora flavescens Ait., Amomum villosum Lour., Carthamus tinctorius L., Rubus chingii Hu., Poria cocos (Schw.) Wolf., Laminana japonica Aresch., Ligustrum lucidum Ait., Angelica sineusis (Oliv.), Cyperus rotundas L., Ginkgo biloba L., Zingiber officinale Rosc., Prunus persica (L.) Batsch., Schizandra chinensis (Turcz.) Baill. and Plantago asiatica L.. 2. Of crude drugs having showed over 50% of inhibitory effect on platelet aggregation, at the concentration of $100{\mu}g/m{\ell}$, the inhibitory rates were 82.2% in Ganoderma japonicum (Fr.) Lloyd., 55% in Panax ginseng C. A. Mey., 50.8% in Gastrodia elata Bl., while at the concentration of $200{\mu}g/m{\ell}$, antithrombotic rates were 89.4% in Ganoderma japonicum (Fr.) Lloyd., 59.2% in Panax ginseng C. A. Mey., 57.9% in Thea sinensis, 52.7% in Gastrodia elata Bl.. These results suggest that the study sholuld be necessary on antithrombotic effect of solvent fractions of Ganoderma japonicum (Fr.) Lloyd., Panax ginseng C. A. Mey., Gastrodia elaha B1. and Thea sinensis and isolation of effective compound from above drugs.

• Journal of Environmental Science International
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• v.15 no.10
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• pp.983-988
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• 2006

The textile remains have been affected largely by environmental factors including microorganisms because they were composed of organic compounds to be easy to damage. So, we selected 8 strains of the 131 isolated strains from museum environments and textile remains by high pretense activity, and identified them for measuring the antibacterial activity of Gingko biloba extracts. They were identified Genus Arthrobacter spp. 3 strains (Arthrobacter nicotiannae A12, Arthrobacter sp B12, Arthrobacter oxidans B13), Cenus Bacillus spp. 2 strains (Bacillus licheniformis D9, Bacillus cereus D33), Genus Pseudomonas spp. 2 strains (Pseudomonas putida A24, Pseufomonas fluorescene C21) and a Genus Staphylococcus sp. 1 strain (Staphylococcus pasteuri D3) as closest strains through the blast search of NCBI. Though antibacterial activity of the extracts of Gingko biloba leaves as MIC was lower than that of other pharmaceutical antibiotics. However the extracts was crude extracts, the extracts might have good antibacterial against most of the isolates from museum. Especially, the antifungal activity of Gingko biloba is known previously, the extracts of Gingko biloba leaves has possibility of usage as a good natural material for conservation of remains.