Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The Efficacy of Ampule Containing Herbal Extract for Improving Skin Wrinkles in Women

한약재 추출물 함유 앰플의 주름개선 효능에 관한 기초 임상연구

  • Do, Eun-Ju (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Lee, Jin-Sang (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Park, Hyun-Jin (Clinical Research Support Team, Oriental Medicine, Industry Support Center) ;
  • Ha, Il-Do (Jeahan Oriental Medical Academy, Daegu Haany University) ;
  • Kim, Young-Chul (Department of Public Health, College of Natural Sciences, Keimyung University) ;
  • Kim, Mi-Ryeo (Clinical Research Support Team, Oriental Medicine, Industry Support Center)
  • 도은주 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 이진상 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 박현진 ((재)테크노파크 한방산업지원센터 임상시험지원팀) ;
  • 하일도 (대구한의대학교 제한동의학술원) ;
  • 김영철 (계명대학교 자연과학대학 공중보건학과) ;
  • 김미려 ((재)테크노파크 한방산업지원센터 임상시험지원팀)
  • Published : 2009.12.30
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Abstract

Objectives : This study was performed to evaluate the efficacy of ampule containing herbal extract(Ulmus davidiana, Ginkgo biloba, Perilla ocymoides, Morus alba, Glycyrrhiza uralensis (licorice), and Angelica gigas) on skin wrinkles in adult women with facial wrinkles. Methods : A total of 12 women, 30 to 46 years of age, with wrinkles in the corner of eyes, applied ampule containing herbal extract twice daily for up to 12 weeks. Silicon replicas of right crow's feet area and antecubital fossa were taken before use of test product and at 4, 8 and 12 weeks. The replicas were analyzed by optical profilometry with Skin Visiometer SV600. The wrinkle and roughness parameters, R1, R2, R3, R4 and R5 were calculated and statistically analyzed. In addition, a subjective evaluation of product efficacy was conducted by patient's assessment. Results : The mean values of all the skin roughness parameters were decreased at 4-week, and decreased significantly at 8 and 12-week except R4 at 12-week after test product use. The subjective evaluation of wrinkle by patient's assessment was also improved. However, one patient noted stiffness of face after use of test product. Conclusions : These study suggested that the application of ampule containing herbal extract twice daily for 12 weeks may effectively improve the facial wrinkles without severe side effect.

Keywords

References

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