• Proceedings of the KIPE Conference
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• 2011.07a
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• pp.269-270
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• 2011

본 논문에서는 점차 증대되는 신재생 에너지 비율에 따라 계통 연계형 태양광 발전 시스템에 엄격하게 요구되고 있는 규정들에 대해 독일 연방 에너지 수자원 관리 협회(BDEW: Bundesverbands der Energie und Wasserwirtschaft)의 규정을 근간으로 그에 따른 인증 시험 항목에 대해 기술하기로 한다. 또한 실제 (주)카코 뉴 에너지의 BDEW 인증 시험 자료의 일부분을 바탕으로 시험의 중요성 및 필요성에 대해 그 타당성을 입증한다.

• Proceedings of the KIPE Conference
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• 2010.07a
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• pp.307-308
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• 2010

본 논문에서는 신재생에너지 발전 설비 증가에 따른 계통의 불안정성을 극복하기 위하여, 독일 BDEW(German Association of Energy and Water Industries)가 제정한 특고압(Medium Voltage) 계통 연계 신재생 에너지 발전 시스템에 대한 계통 연계 규정에 대해서 기술한다. 특히, 태양광 인버터 관점에서 독일의 새로운 계통연계 규정이 요구하고 있는 내용에 대해서 설명한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8550-8555
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• 2015

The research goal of this paper is to find the cluster policies for the federal and provincial governments through German Cluster Politics. This paper consists of five chapters. In the first chapter the theoretical background for the Cluster is examined. The next chapter details the research method for the federal and state German Cluster Policy study. The results of this paper show that the federal and state German Governments may co-operate or compete in cluster politics. Additionally, this research falls under EU Political Research under the umbrella of the EU. This cluster policy research also provides implications for the Korean Government in the long term.

• Molecules and Cells
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• v.37 no.11
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• pp.819-826
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• 2014

Protein modifications of recombinant pharmaceuticals have been observed both in vitro and in vivo. These modifications may result in lower efficacy, as well as bioavailability changes and antigenicity among the protein pharmaceuticals. Therefore, the contents of modification should be monitored for the quality and efficacy of protein pharmaceuticals. The interface of EPO and its receptor was visualized, and potential amino acids interacting on the interface were also listed. Two different types of modifications on the interface were identified in the preparation of rHu-EPO BRP. A UPLC/Q-TOF MS method was used to evaluate the modification at those variants. The modification of the oxidized variant was localized on the Met54 and the deamidated variants were localized on the Asn47 and Asn147. The extent of oxidation at Met54 was 3.0% and those of deamidation at Asn47 and Asn147 were 2.9% and 4.8%, respectively.

• Molecules and Cells
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• v.38 no.6
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• pp.496-505
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• 2015

A variant peak was detected in the analysis of RP-HPLC of rHu-EPO, which has about 7% relative content. Fractions of the main and the variant peaks were pooled separately and further analyzed to identify the molecular structure of the variant peak. Total mass analysis for each peak fraction using ESI-TOF MS shows differences in molecular mass. The fraction of the main peak tends to result in higher molecular masses than the fraction of the variant. The detected masses for the variant are about 600-1000 Da smaller than those for the main peak. Peptide mapping analysis for each peak fraction using Asp-N and Glu-C shows differences in O-glycopeptide profiles at Ser126. The O-glycopeptides were not detected in the fraction of the variant. It is concluded that the variant peak is non-O-glycosylated rHu-EPO and the main peak is fully O-glycosylated rHu-EPO at Ser126.

• STI Policy Review
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• v.3 no.2
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• pp.130-151
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• 2012

Fraunhofer was founded in 1949 and grew into Europe's largest application-oriented research organization. Fraunhofer currently employs over 20,000 members in Germany, is internationally networked, and manages an R&D budget of over 1,8 Billion Euros per year. An important step for Fraunhofer to become an integral component of the German innovation system was the introduction of the Fraunhofer Model of financing based on a performance-related system of financial management. The underlying model of the allocation and distribution of public funding to Fraunhofer that is subsequently allotted to specific research groups is one of the success factors of Fraunhofer. Fraunhofer is proud of its decentralized organizational model. Fraunhofer is comprised of 60 Institutes in Germany working in different fields, under one legal framework, and with a strong brand value. Every Fraunhofer Institute is affiliated with a German University and every institute director simultaneously holds a chair at the affiliated university. It is a challenge for the headquarter organization to balance the intended competition of individual Fraunhofer Institutes with complementarity cooperation in science among Fraunhofer-Institutes, especially when coming from different knowledge domains; however, this goal results in a significant advantage. The unique strengths of Fraunhofer offer system solutions in a world with increasingly complex R&D challenges. While growing to become the largest organization on Europe to focus on applied research it is the challenge to remain an agile organization that is flexible in organizational structure. Fraunhofer has reached a well-recognized position in the European innovation landscape. It is often referred to by science and governments as a role model for innovation policy and a key element of the latest successes in the German economy that has recovered quicker from the latest economic crisis than most other western economies. The paper explains Fraunhofer as an organizational paradigm and its underlying management model to elaborate on the challenges of managing a research organization. We wish to show how it is possible to transfer the management model and philosophy of Fraunhofer to innovation systems with different framework conditions and challenges. A universal conclusion may be drawn based on the description of Fraunhofer; however, changes in existing structures and innovation systems cannot be implemented over night.

• Journal of Korea Technology Innovation Society
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• v.4 no.2
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• pp.127-142
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• 2001

This paper presents an econometric model for measuring basic research capacity index(BRCI) of each OECD countries and analyses the gap in terms of time lag measured and forecasted in connection with factor analysis and BRCI progress function. Based on the analysis, gross domestic expenditure on R&D(GERD), total R&D personnel higher education expenditure on R&D(HERD) and number of science and technical papers based on SCI are more effective than other factors to BRCI. Also, BRCI progress function shows that 29 years is needed for Korea to catch up the level of German's BRCI of year 1998. But, it's impossible for Korea to catch up US and Japan. Therefore, with restricted scientific resources, Korea's own strategy for strengthening basic research capacity is going to be more important in 21st century.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2001.05a
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• pp.473-492
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• 2001

This paper presents an econometric model for measuring basic research capacity index(BRCI) of each OECD countries and analyses the gap in terms of time lag measured and forecasted in connection with factor analysis and BRCI progress function. Based on the analysis, gross domestic expenditure on R&D(GERD), total R&D personnel, higher education expenditure on R&D(HERD) and number of science and technical papers based on SCI are more effective than other factors to BRCI. Also, BRCI progress function shows that 29 years is needed for Korea to catch up the level of German's BRCI of year 1998. But, it's impossible for Korea to catch up US and Japan. Therefore, with restricted scientific resources, Korea's own strategy for strengthening basic research capacity is going to be more important in 21st century.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.3
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• pp.333-341
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• 2014

The purpose of this study is to forecast the penetration rate of renewable energy and a reasonable scale for the R&D investment plan in Korea based on the relationship between the diffusion and R&D investments drawn by analogy from empirical cases of advanced countries. Among numerous candidate developed countries, the German market was chosen based on the similarity of the diffusion patterns to those of the Korean plan. We then figured out how the investment triggers the growth of technology from the selected benchmark, and applied the technology S-curve relation formula to derive the desirable investment plan for Korea. The present paper is a pioneering attempt to forecast the diffusion process of renewable energy technology in Korea using the comparative analogy from cases of advanced countries.

• Toxicological Research
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• v.20 no.2
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• pp.89-100
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• 2004

The comet assay (also called the single-cell gel electrophoresis assay) has been widely used for detecting DNA damage and repair in individual cells. Since the conventional methods of evaluating comet assay data using frequency statistics are unsatisfactory we developed a new quantitative measure of DNA damage/repair that is based on all information residing in the dose/time-response curves of a comet experiment. Blood samples were taken from 25 breast cancer patients before undergoing radiotherapy. The comet assay was performed under alkaline conditions using isolated lymphocytes. Tail DNA, tail length, tail moment and tail inertia of the comet were measured for each patient at four doses of $\gamma$-rays (0, 2, 4 and 8 Gy) and at four time points after irradiation (0, 10, 20 and 30 min) using 100 cells each. The resulting three-dimensional dose-time response surface was modeled by multiple regression, and the second derivative, termed 2D, on dose and time was determined. A software module was programmed in SAS/AF to compute 2D values. We applied the new method successfully to data obtained from cancer patients to be assessed for their radiation sensitivity. We computed the 2D values for the four damage measures, i.e., tail moment, tail length, tail DNA and tail inertia, and examined the pairwise correlation coefficients of 2D both on the log scale and the unlogged scale. 2D values based on tail moment and tail DNA showed a high correlation and, therefore, these two damage measures can be used interchangeably as far as DNA repair is concerned. 2D values based on tail inertia have a correlation profile different from the other 2D values which may reflect different facets of DNA damage/repair. Using the dose-time response surface, other statistical models, e.g., the proportional hazards model, become applicable for data analysis. The 2D approach can be applied to all DNA repair measures, Le., tail moment, tail length, tail DNA and tail inertia, and appears to be superior to conventional evaluation methods as it integrates all data of the dose/time-response curves of a comet assay.