• Translational and Clinical Pharmacology
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• v.25 no.3
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• pp.153-156
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• 2017

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties of sildenafil citrate chewable tablets (UI14SDF100CW) and conventional sildenafil citrate film-coated tablets ($Viagra^{(R)}$, Pfizer). A randomized, open-label, single dose, two-treatment, two-period, two-way crossover study was conducted in 60 healthy male volunteers. In each period, the subjects received a single oral dose of UI14SDF100CW or $Viagra^{(R)}$ (both tablets contain 140.45 mg of sildenafil citrate, which is equivalent to 100 mg of sildenafil). Serial blood samples were collected up to 24 h post-dose for PK analysis. The plasma concentration of sildenafil was determined using a validated HPLC-MS/MS assay. PK parameters of sildenafil were calculated using non-compartmental methods. The plasma concentration-time profiles of sildenafil in both formulations were similar. For UI14SDF100CW, the $C_{max}$ and $AUC_{last}$ of sildenafil were $1068.69{\pm}458.25$ (mean${\pm}$standard deviation) mg/L and $3580.59{\pm}1680.29h{\cdot}mg/L$, and the corresponding values for $Viagra^{(R)}$ were $1146.84{\pm}501.70mg/L$ and $3406.35{\pm}1452.31h{\cdot}mg/L$, respectively. The geometric mean ratios (90% confidence intervals) of UI14SDF100CW to $Viagra^{(R)}$ for $C_{max}$ and $AUC_{last}$ were 0.933 (0.853-1.021) and 1.034 (0.969-1.108), respectively, which met the bioequivalence criteria of Korean regulatory agency. In conclusion, UI14SDF100CW and $Viagra^{(R)}$ showed similar PK properties. Therefore, UI14SDF100CW can be an alternative to sildenafil for the treatment of erectile dysfunction, providing better compliance.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.6
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• pp.623-633
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• 2020

As the time spent in indoor space has increased, the demand for services targeting indoor spaces also continues to increase. To provide indoor spatial information services, the construction of indoor spatial information should be done first. In the study, a method of generation IndoorGML, which is the international standard data format for Indoor space, from existing BIM data. The characteristics of IFC objects were investigated, and objects that need to be converted to IndoorGML were selected and classified into objects that restrict the expression of Indoor space and internal passages. Using the proposed method, a part of data set provided by the BIMserver github and the IFC model of the 21st Century Building in University of Seoul were used to perform experiments to generate PrimalSpaceFeatures of IndoorGML. As a result of the experiments, the geometric information of IFC objects was represented completely as IndoorGML, and it was shown that NavigableBoundary, one of major features of PrimalSpaceFeatures in IndoorGML, was accurately generated. In the future, the proposed method will improve to generate various types of objects such as IfcStair, and additional method for automatically generating MultiLayeredGraph of IndoorGML using PrimalSpaceFeatures should be developed to be sure of completeness of IndoorGML.

• Journal of the Korean GEO-environmental Society
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• v.23 no.2
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• pp.25-36
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• 2022

In this study, seepage control effect of relief well was evaluated quantitatively on embankment of small fill dam and levee. Seepage analysis of dam and levee were carried out according to the permeability of fill material and foundation and to analyze behaviour characteristics of seepage. The up-lift pressure at toe of embankment was analyzed which is generated by seepage according to relief well installation condition. The relief well could reduce pore water pressure which is to cause piping or up-lift pressure at foundation ground of embankment and it does not be influenced on geometric condition such as dam height and slope incline. In case of relative low permeable ground, the pore water pressure reduction effect of relief well was decreased compare with high permeable ground but it shows pore water pressure reduction effect compare with no relief well condition. The reduction effect of relief well shows relative gap according to diameter and penetration length of relief well and the installation length of relief well is the most effective factor for seepage control.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.4
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• pp.215-226
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• 2022

Significant efforts have been devoted to developing high-performance composite materials by emulating the structure of biological creatures with superior mechanical characteristics. Nacre has been one of the most sought-after natural structures due to its exceptional fracture toughness compared with the constituent materials. However, the effect of manipulating the nacre-like geometry on the impact performance has not been fully investigated thus far. In this study, composites of randomly manipulated nacreous geometry are numerically developed and the impact performance is analyzed. We develop an algorithm by which the planar area of platelets in the nacre-like design is randomly resized. Thereafter, the numerical models of nonuniform nacre-patterned multi-layer structures are developed and the drop-weight impact simulation is performed. The impact behaviors of the model are evaluated by using the ratio of absorbed energy, the von Mises stress distribution, and the impact force-time curve. Therefore, the effect of the geometric irregularity on the nacre-patterned design is elucidated. This insight can be efficiently utilized in establishing the optimum design of the nacre-patterned structure.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.39 no.6
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• pp.563-569
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• 2021

With the launch of Compact Advanced Satellite 500 series of various characteristics and the operation of KOMPSAT-3/3A, uses of high-resolution satellite images have been continuously increased. Especially, in order to provide satellite images in the form of ARD (Analysis Ready Data), various pre-processing such as geometric correction and radiometric correction have been developed. For pre-processing of high spatial satellite imagery, auxiliary information, such as solar zenith, solar azimuth and offnadir angle, should be required. However, most of the high-resolution satellite images provide the solar zenith and nadir angle for the entire image as a single variable. In this paper, the solar zenith and offnadir angle corresponding to each pixel of the image were calculated using RFM (Rational Function Model) and auxiliary information of the image, and the quality of extracted information were evaluated. In particular, for the utilization of pixel-based solar zenith and offnadir angle, pixel-based auxiliary data were applied in calculating the top of atmospheric reflectance, and comparative evaluation with a single constant-based top of atmospheric reflectance was performed. In the experiments using various satellite imagery, the pixel-based solar zenith and offnadir angle information showed a similar tendency to the auxiliary information of satellite sensor, and it was confirmed that the distortion was reduced in the calculated reflectance in the top of atmospheric reflectance.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.281-289
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• 2022

As the aging of our society gradually deepens, the quality of the elderly care environment based on the elderly care model of the Silver Town space is gradually becoming the focus of everyone's attention. This study mainly studies and discusses the visual and behavioral characteristics of the elderly. In order to pay more attention to the special needs of the elderly in order to optimize the spatial environment, the design of visual experience design in the living environment of the elderly in Silver Town is designed. explore in depth Through this, the environment of the space is optimized so that the elderly can enjoy their old age in a comfortable environment. This study is based on visual psychology, environmental psychology, gerontology and other theories. Through the collection of related literature and field research on the elderly, the function and overall combination of the living environment of the elderly in Silver Town is studied, and the environment is organized. Based on the behavioral and visual needs of middle-aged and older people, a design method was proposed to strengthen the visual connection in space. In terms of visual experience, the lighting, colors, and materials of the environment are studied. Through a combination of theory and research and experiments, it is concluded that the elderly prefer plants with warm colors, high brightness colors, and geometric patterns. The design principle and design method of the visual experience in the Silver Town space are summarized.

• Journal of Platform Technology
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• v.10 no.3
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• pp.60-68
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• 2022

As AI-technology develops, interest in the safety of autonomous driving is increasing. Recently, autonomous vehicles have been increasing, but efforts to solve side effects have been sluggish. In particular, night autonomous vehicles have more problems. This is because the probability of accidents is higher in the night driving environment than in the day environment. There are more factors to consider for self-driving at night. Among these factors, reflection of light or reflected light of lighting may be a fundamental cause of night accidents. Therefore, this study proposes method to reduce accidents and improve safety by reducing reflected light generated by the headlights of opposite vehicles or various surrounding light that appear as an important problem in night autonomous vehicles. Therefore, first, in an image obtained by a sensor of a night autonomous vehicle, illumination reflected light is extracted using reflected light characteristic information, and a color of each pixel using a reflection coefficient is found to reduce a special area generated by geometric characteristics. In addition, we find a new area using only the brightness component of the specular area, define it as Illuminated Reflection Light (IRL), and finally present a method to reduce it. Although the illumination reflection light could not be completely reduce, generally satisfactory results could be obtained. Therefore, it is believed that the proposed study can reduce casualties by solving the problems of night autonomous driving and improving safety.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.3
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• pp.371-381
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• 2017

This paper presents a methodology for creating abstract animation based on the human movement theories originating from the work of dance theorist Rudolf von Laban. Laban Movement Analysis is a method and language for describing, visualizing, interpreting and documenting all varieties of human movement, and Choreutics is based on universal patterns of nature and of human as part of a universal design. Laban defines the space of movements in a profoundly dualistic way. Outwardly, his objective and scientific definitions provide a concrete base for generating human movements in computer graphics in terms of geometric and motion primitives such as points, lines, planes, polygons, linear and nonlinear movements. On the other hand, he also offers a system for understanding the subtle characteristics about the way a movement is dynamically done with respect to inner intention. Laban's interpretations of human motion can be utilized potentially in plastic arts and computer arts. Our work was inspired by those physical and psychological analyses and computer algorithms have been developed for creating abstract animation. We presented our computer animation works entitled "Choreography" in the exhibitions: a special section in "2015 Craft Trend Fair" and "Make Your Movement" held in the Korean Cultural Centre in UK, 2016. In this paper, we describe our ideas and methods for creating abstract object movements based on the Laban's motion representations.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.2D
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• pp.127-134
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• 2010

Tunnel sections on the highway are different from rest of sections on the highway in terms of velocity, the number of passing cars, and vehicle density which, in particular, affect drivers' behavior before and after drivers pass through the tunnel. However, literature review reveals that former studies are too focused on quantitative indicator to consider qualitative aspects. Therefore, this paper conducts survey questionnaire and IPA (Importance Performance Analysis) to find out qualitative improvements on velocity drop on the tunnel sections. The results show as follows: First, drivers require improvements of tunnel form (length and curved form inside tunnel) which is derived from long distance tunnel. Second, experts primarily ask for amendment of geometric characteristics. With comparison of requirements of both drivers and experts, there are many differences in length of tunnel and form of curved tunnel. This also presents that drivers don't satisfy with both length of tunnel and form of curved tunnel that are provided as a part of highway design factors.

• The Journal of Engineering Geology
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• v.14 no.1
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• pp.29-46
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• 2004

It is important to identify geometries of fracture that act as a conduit of fluid flow for characterization of ground water flow in fractured rock. Fracture geometries control hydraulic conductivity and stream lines in a rock mass. However, we have difficulties to acquire whole geometric data of fractures in a field scale because of discontinuous distribution of outcrops and impossibility of continuous collecting of subsurface data. Therefore, it is needed to develop a method to describe whole feature of a target fracture geometry. This study suggests a new approach to develop a method to characterize on the whole feature of a target fracture geometry based on the Fourier transform. After sampling of specimens along a target fracture from borehole cores, effective frequencies among roughness components were selected by the Fourier transform on each specimen. Then, the selected effective frequencies were averaged on each frequency. Because the averaged spectrum includes all the frequency profiles of each specimen, it shows the representative components of the fracture roughness of the target fracture. The inverse Fourier transform is conducted to reconstruct an averaged whole roughness feature after low pass filtering. The reconstructed roughness feature also shows the representative roughness of the target subsurface fracture including the geometrical characteristics of each specimen. It also means that overall roughness feature by scaling up of a fracture. In order to identify the characteristics of permeability coefficients along the target fracture, fracture models were constructed based on the reconstructed roughness feature. The computation of permeability coefficient was performed by the homogenization analysis that can calculate accurate permeability coefficients with full consideration of fracture geometry. The results show a range between $10^{-4}{\;}and{\;}10^{-3}{\;}cm/sec$, indicating reasonable values of permeability coefficient along a large fracture. This approach will be effectively applied to the analysis of permeability characteristics along a large fracture as well as identification of the whole feature of a fracture in a field scale.