• Korean Journal of Acupuncture
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• v.20 no.1
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• pp.45-55
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• 2003

Backgrounds : It has been investigated about ageing theory. However, ageing mechanism still remains to be unknown. Since Harman proposes that ageing and ageing related diseases might be due to oxidative damage and these are modifiable by genetic and environmental factors. For designing an optimal nutritional countermeasure against ageing and ageing related disease, it is necessary to understand the ageing mechanism and other reactive species. Objectives : Schizandra Chinesis has been clinically used to treat brain disease, respiratory or inflammatory disease etc. in Oriental medicine. The purpose of this study is to investigate the scavenging effect of Schizandrae Fructus herbal-acupuncture solution(SFHA) on NO, DPPH and IL-4. Results : The results are summarized as follows; (1) There is a significant scavenging effect of SFHA on NO in 0.1, 1, 10mg/ml group after 24hrs. (2) There is a significant scavenging effect of SFHA on DPPH in 1, $10{\mu}g/ml$ group. (3) There is a significant inhibitory effect of SFHA on IL-4 in 1, 10, $100{\mu}g/ml$ group. Conclusions : These findings indicate that SFHA can be used as antioxidant or antiimflammatory drug. But further study is needed about the effect of SFHA.

• Journal of Computational Design and Engineering
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• v.2 no.3
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• pp.157-164
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• 2015

This paper discusses an optimization-based approach for the design of a product platform for industrial three-axis linear-type robots, which are widely used for handling objects in manufacturing lines. Since the operational specifications of these robots, such as operation speed, working distance and orientation, weight and shape of loads, etc., will vary for different applications, robotic system vendors must provide various types of robots efficiently and effectively to meet a range of market needs. A promising step toward this goal is the concept of a product platform, in which several key elements are commonly used across a series of products, which can then be customized for individual requirements. However the design of a product platform is more complicated than that of each product, due to the need to optimize the design across many products. This paper proposes an optimization-based fundamental framework toward the design of a product platform for industrial three-axis linear-type robots; this framework allows the solution of a complicated design problem and builds an optimal design method of fundamental features of robot frames that are commonly used for a wide range of robots. In this formulation, some key performance metrics of the robot are estimated by a reducedorder model which is configured with beam theory. A multi-objective optimization problem is formulated to represent the trade-offs among key design parameters using a weighted-sum form for a single product. This formulation is integrated into a mini-max type optimization problem across a series of robots as an optimal design formulation for the product platform. Some case studies of optimal platform design for industrial three-axis linear-type robots are presented to demonstrate the applications of a genetic algorithm to such mathematical models.

• The Transactions of the Korea Information Processing Society
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• v.6 no.4
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• pp.952-958
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• 1999

This paper presented the application of GAs as a means of finding optimal solutions over a parameter space in the controller design for a fuzzy control system. The performance can involve a weighted combination of various performance characteristics such as rise-time, settling-time, settling-time, overshoot. The results obtained here are compared with those for a traditional design obtained using the root-locus method. In contrast to traditional methods, the GA-based method does not require the usual mathematical processess or mathematical model of the system. In this paper, the Ga-based Fuzzy control system combining Fuzzy control theory with the GA, that is known to be very effective in the optimization problem, will be proposed The effectiveness of the proposed control system will be demonstrated by computer simulations using task tracking position system in stable and unstable linear systems. It is shown that the GA-based controller is better than the traditional controller used It stable and unstable linear systems.

• Journal of KIISE:Software and Applications
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• v.31 no.4
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• pp.525-536
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• 2004

Gene expression profile is numerical data of gene expression level from organism, measured on the microarray. Generally, each specific tissue indicates different expression levels in related genes, so that we can classify disease with gene expression profile. Because all genes are not related to disease, it is needed to select related genes that is called feature selection, and it is needed to classify selected genes properly. This paper Proposes GA based method for searching optimal ensemble of feature-classifier pairs that are composed with seven feature selection methods based on correlation, similarity, and information theory, and six representative classifiers. In experimental results with leave-one-out cross validation on two gene expression Profiles related to cancers, we can find ensembles that produce much superior to all individual feature-classifier fairs for Lymphoma dataset and Colon dataset.

• Economic and Environmental Geology
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• v.29 no.6
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• pp.665-676
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• 1996

Domestic metal mines have contributed to the national industrialization of Japan for over a century through their stable supply of raw materials. However, due to the changes which have taken place in the industries structure, mining industry has been shifted to downstream industries. At present, only three major mines are in production. In recent times, changing economic conditions have made it increasingly difficult to develop new base metal mines. Subsequently, the deposit type targeted has shifted from base metals to epithermal associated gold deposits which, if of sufficient grade and tonnage, can be economical. Accompanying the dramatic rise in the price of gold during the late 1970's, has been an increase in the geological information and our understanding of epithermal gold deposits around the Pacific rim region. In particular, the common acceptance of the plate tectonic theory and the correlation's between modem geothermal systems and fossil epithermal systems were most important developments. In 1988, the Mining Council authorized the domestic exploration of 19 districts, targeting epithermal gold mineralization. Since 1989 the Metal Mining Agency of Japan, semi-government organization, has been conducted gold exploration in such area. With new genetic concepts and new technologies, promising gold mineralization has been discovered. Two such areas which are at an advanced stage of exploration are Seta, in northern Hokkaido, and Noya, in central Kyushu.

• The Journal of the Korea Contents Association
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• v.20 no.12
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• pp.278-286
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• 2020

The prisoner's dilemma game which is a representative example of game theory is being studied with interest by many economists, social scientists, and computer scientists. In recent years, many researches on computational approaches that apply evolutionary computation techniques such as genetic algorithms and particle swarm optimization have been actively conducted to analyze prisoner dilemma games. In this study, we intend to evolve a strategy for a iterated prisoner dilemma game participating two or more players using three different binary particle swarm optimization techniques. As a result of experimenting by applying three kinds of binary particle swarm optimization to the iterated prisoner's dilemma game, it was confirmed that mutual cooperation can be established even among selfish participants to maximize their own gains. However, it was also confirmed that the more participants, the more difficult to establish a mutual cooperation relationship.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.191-191
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• 2022

Heterostyly continues to fascinate evolutionary biologists interested in heredity, evolution, breeding, and adaptive function. Polymorphism demonstrates how simply inherited developmental changes in the location of plant sexual associations can have important consequences for population pollination and mating biology. In contrast to homozygous self incompatibility, only a small number of mating phenotypes can be maintained in the population because insect pollinators have limitations in achieving multiple segregation sites for pollen deposition. Field studies of pollen tube growth have shown that reciprocal style-stamen polymorphisms function to increase the capacity of insect-mediated cross-pollination. The genetic pattern of style morphs is well established in various taxa, but despite recent advances, the identity, number, and structure of the genes controlling the heteromorphic syndrome have been poorly elucidated. The phenomenon of heterostyly in buckwheat has been controlled by gene complex concentrate to S-locus. Homomorphic autogamous buckwheat strains were established by the interspecific hybridization. Backcrossing of this line to the common buckwheat (pin) and selecting homostylar progenies made it possible to introduce the self-compatible gene into common buckwheat. In the result, we obtained the BC₉F₂ generation, and defined the strong linkage between flower type and self-incompatibility by microscopic observation of pollen tube growth. This finding suggests that self-incompatibility character is not controlled by one gene. Moreover, we defined the strong linkage between flower type and self-incompatibility. It strongly supports the S supergene theory. Therefore, we have plan to elucidate the heterostyly self-incompatibility by using molecular genetics, proteome analysis and apply to exploitation of buckwheat improvement. In near future, the expression of heterozygous syndromes in genus Fagopyrum with single isolated heterozygous species may provide clues to early stages of polymorphic assembly and shed light on evolutionary models of heterozygous strains.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.5 s.57
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• pp.109-120
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• 2009

This paper introduces a new method to estimate the loss of prestressing force for the externally prestressing tendon. The proposed method that combines of HGA and FEM is able to identify the lost tensile force of a externally prestressed tendon. The identification variables of the proposed method is a exteranlly prestressed tendon of tension, effective nominal diameter, mass per unit length and Rayleigh damping coefficients. First of all, a finite element model system is constructed to consider the effect of damping, and these variables are identified using inverse analysis technique - updating algorithm. Finally, throughout total 3 cases of numerical tests, the numerical propriety of the proposed method is verified. Here, it is seen that the errors in the estimated variables by the proposed method are about 1% except in the case of Rayleigh damping coefficients.

• Studies on Life and Culture
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• v.53
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• pp.3-28
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• 2019

Since the development of gene scissors 'CRISPR in 2012, CRISPR has been called the hope to lead the future of science and cure genetic diseases. But many indiscriminate experiments and destructions on human embryos have been made. For these reasons, ethical controversies and concerns have been amplified. At present, We have to make the law and the system step by step after reviewing and discussing the level of technology and social impact thoroughly. On the premise of this situation, in this study, I reviewed the patent dispute, interpretation of bioethics law, and the legislative theory. CRISPR could not have made the off-target effect zero. also, we just know only a few genes whose function is known in DNA networks. Therefore, it should be acknowledged that there are limits obviously to technical safety and knowledge of DNA . No means of gene editing on human embryo should be allowed. In order to carry out gene therapy on somatic cell , Diseases , dugs and treatment methods hat can be allowed by the law should be specified concretely in the positive form inEnforcement Decree of the Bioethics and Safety Act.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.6
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• pp.395-401
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• 2002

The combination of early heading time, maturing time and short grain-filling period is very important to develop early varieties in winter barley. The 4 parental half diallel crosses (parents, $F_1$s, $F_2$s) were cultivated at the field. The heading date was from April 3 to 26, maturing date from May 15 to 27 and grain-filling period from 31 days to 42 days, showing that the varietal differences about the 3 traits were remarkable. According to half diallel cross analyses, Dongbori 1 for heading time (late heading) was dominant, but Oweolbori (early heading) was recessive, showing partial dominance with high additive component of genetic variance. Dongbori 1 for maturing time was dominant, but Oweolbori was recessive, showing partial dominance with high additive variance. Reno for grain-filling period (short grain-filling period) was dominant, but Oweolbori (long grain-filling period) was recessive with additive, and partial dominance. There were highly significant mean squares for both GCA and SCA effects on the heading and maturing times, and GCA/SCA ratios for all traits were high, showing the additive gene effects more important. Sacheon 6 and Oweolbori had greater GCA effects for early heading and maturing times, and Dongbori 1 and Reno had greater GCA effects for late times. GCA effects were highly significant in $F_1$ and $F_2$ generations, showing high GCA/SCA ratios (7.02). The heading and maturing times in field were positively correlated with antifreeze proteins concentrations, accumulation, resistance to photoinhibition and winter survival, respectively) but the grain-filling period did negatively correlated with the trails.