• Journal of Sasang Constitutional Medicine
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• v.23 no.4
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• pp.445-457
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• 2011

1. Purpose Lee Je-Ma had continued to revise "Donguisusebowon" by adding the contents of the Symptomatic-pharmacology(病證藥理論) on Soeumin, Soyangin and Taeeumin to it from the first establishment of the old version in 1894 to 1900.(new version). This paper tries to find out the contents and meaning of the Discourse on the Constitutional Symptoms and Diseases(病證論) between the old version and new version and what the Discourse on the Constitutional Symptoms and Diseases affected the Theory of Eight Constitution created in subsequent years. 2. Methods I classified the Discourse on the Constitutional Symptoms and Diseases in "DongYiSuseBowon" into old version and new version and tried to find out the Theory of Eight morbidities(8病證論) which is the predecessor of the Theory of Eight Constitution, before reviewing their relation. 3. Conclusions 1) The Discourse on the Constitutional Symptoms and Diseases in the old version specify that the externally sensed diseases are caused by the deep sediment of nature(性) and that the internally touched diseases are caused by the violent activities of emotion(情). In addition, it said that all diseases are caused by the specific characteristics of patient's smaller internal organs(偏小之臟). But in new version, the diseases were understood through the concept Exterior, Interior, Heat and cold(表裏寒熱). The new version said that the diseases may be caused not only the specific characteristics of patient's smaller organs but also by bigger organs(偏大之臟). 2) The Theory of Eight Constitution was derived from the Theory of Eight morbidities, in which all kinds of human diseases are caused by 8 disease-orgin organ and that the diseases therefore can be classified into 8 morbidities. The Theory of Eight morbidities reorganized the Discourse on the Constitutional Symptoms and Diseases in "DongYiSuseBowon" by classifying them into first morbidity and second morbidity. 3) The Discourse on the Constitutional Symptoms and Diseases in "DongYiSuseBowon" has decisively affected the creation of the Theory of Eight morbidities which is the predecessor of the Theory of Eight Constitution. The Theory of Eight morbidities may be deemed another interpretation of the Discourse on the Constitutional Symptoms and Diseases in "DongYiSuseBowon". As the Theory of Eight morbidities put emphasis on the genetic characteristics, the Theory of Eight Constitution stating that Eight morbidities are caused by different specific constitution was derived.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1154-1161
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• 2005

Yin Yang theory is the first and the last one to interpret diseases apply to treatment in oriental medicine. So it is regarded as the way of heaven and earth, the discipline of all things, the origin of change, the beginning of giving birth and death, the source of spirit. These regulatory passages are needed to compare with western medical physiology and analyzed whether it has scientific bases or not. The Yin Yang theory of traditional oriental medicine are summerized from the descriptions of Scripture of Documents, Ying Wei theory of Huangdi Neijing. Meanwhile up-to-date neurobiological and molecular genetic theories on circadian physiology are reviewed in western medicine. Sunshine is transferred through RGC to SCN, herein the central circadian rhythm is made by zeitgeber and interaction of melatonin secreted from pineal body and orexin from mp pan of hypothalamus. So HPA axis is activated and controlled under the circadian rhythm and affects peripheral tissues and cells of whole body through glucocorticoid hormones. First of all, the circadian rhythm makes the basic patterns of human life in biological and sociological meaning. It is almost same context with the record of the Scripture of Documents. Also the Ying Qi and Wei Qi is basically same with the sleep-awake mechanism, that is melatonin/orexin signal or per/clk/bmal/cry genes with circadian activation and activity of each organ's physiological function. Conclusively it can be said that Yin Yang is a priori principle of living things and the beginning of giving birth and death for activation of them biologically, as is described in Huangdi Neijing.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.04a
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• pp.317-324
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• 2004

Shape design optimization of shell structure is implemented on a basis of integrated framework of geometric modeling and finite element analysis which is constructed on the geometrically exact shell theory. This shell theory enables more accurate and robust analysis for complicated shell structures, and it fits for the nature of B-spline function which Is popular modeling scheme in CAD field. Shape of laminated composite shells is optimized through genetic algorithm and sequential linear programming, because there ire numerous optima for various configurations, constraints, and searching paths. Sequential adaptation of global and local optimization makes the process more efficient. Two different optimized results of laminated composite shell structures to minimize strain energy are shown for different layup sequence.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.1854-1855
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• 2006

In this paper, the Takagi-Sugeno (TS) fuzzy state estimation scheme, which is suggested for a steady state estimator using standard Kalman filter theory with uncertainties. In that case, the steady state with uncertain can be represented by the TS fuzzy model structure, which is further rearranged to give a set of uncertain linear model using standard Kalman filter theory. And then the unknown uncertainty is regarded as an additive process noise. To optimize fuzzy system, we utilize the genetic algorithm. The steady state solutions can be found for proposed linear model then the linear combination is used to derive a global model. The proposed state estimator is demonstrated on a truck-trailer.

• Advances in Computational Design
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• v.5 no.3
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• pp.209-231
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• 2020

In order to evaluate the performance of three heuristic optimization algorithms, namely, simulated annealing (SA), genetic algorithm (GA) and particle swarm optimization (PSO) for optimal stacking sequence of laminated composite plates with respect to critical buckling load and non-dimensional natural frequencies, a multi-objective optimization procedure is developed using the weighted summation method. Classical lamination theory and first order shear deformation theory are employed for critical buckling load and natural frequency computations respectively. The analytical critical buckling load and finite element calculation schemes for natural frequencies are validated through the results obtained from literature. The comparative study takes into consideration solution and computational time parameters of the three algorithms in the statistical evaluation scheme. The results indicate that particle swarm optimization (PSO) considerably outperforms the remaining two methods for the special problem considered in the study.

• BMB Reports
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• v.54 no.5
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• pp.253-259
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• 2021

Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2007.11a
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• pp.108-111
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• 2007

속성선택(Feature Selection)은 패턴분류 문제에서 분류기들의 성능을 향상시킬 수 있는 중요한 부분으로 다양한 기법들이 연구되어지고 있다. 특히, 많은 변수와 속성들을 가지는 데이터를 패턴분류 하는 과정에서 주요 속성부분집합을 추출하여 이용함으로써 분류기의 연산속도 및 정확도를 향상시킬 수 있다. 본 논문에서는 유전자 알고리즘과 정보이론의 상호정보량을 이용하여 속성선택을 하는 기법을 제안하였다. 제안된 기법의 성능을 평가하기 위하여 패턴분류 문제에 적용하고 그 성능이 우수함을 확인하였다.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2003.04a
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• pp.127-133
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• 2003

In this study, a problem formulation and solution for design optimization of laminate composite cylindrical beam section is presented. The objective of this research is to determine the optimal dimension of the laminated composite cylindrical beam sections which has the equivalent flexural rigidities to those of the steel cylindrical beam sections. The analytical model is based on the laminate theory and accounts for the material coupling for arbitrary laminate stacking sequence configuration. The outer diameter and thickness of the beam are design variables. The solutions described are found using a global search algorithm, Genetic Algorithms (GA).

• Proceedings of the Korean Society of Plant Pathology Conference
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• 1994.06a
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• pp.62-74
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• 1994

The current status of the development of commercial products for the biological control of plant-parasitic nematodes is discussed. an example is given of problems encountered by our program in patenting biocontrol agents in the United Stats. Two hypothetical approaches to the control of plant nematodes are considered. First recent experimental results relating to the theory on intervention with host-finding by plant nematodes are reviewed. Second, a newer hypothesis considering the possibilities for genetic approaches to modifying molecular signals between nematodes and their parasites is described.

• Journal of the military operations research society of Korea
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• v.32 no.2
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• pp.114-130
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• 2006

This paper deals with complexity theory to describe amphibious warfare situation using EINSTein (Enhanced ISAAC Neural Simulation Tool) simulation model. EINSTein model is an agent-based artificial "laboratory" for exploring self-organized emergent behavior in land combat. Many studies have shown that existing Lanchester equations used in most war simulation models does not describe changes of combat. Future warfare will be information warfare with various weapon system and complex combat units. We have compared and tested combat results with Lanchester models and EINSTein model. Furthermore, the EINSTein model has been applied and analyzed to amphibious warfare model such as amphibious assault and amphibious sudden attack. The results show that the EINSTein model has a possibility to apply and analyze amphibious warfare more properly than Lanchester models.