• 제목/요약/키워드: Genetic Progress

검색결과 225건 처리시간 0.026초

Pathological Classification of Focal Cortical Dysplasia (FCD) : Personal Comments for Well Understanding FCD Classification

  • Kim, Se Hoon;Choi, Junjeong
    • Journal of Korean Neurosurgical Society
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    • 제62권3호
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    • pp.288-295
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    • 2019
  • In 2011, the International League against Epilepsy (ILAE) proposed a first international consensus of the classification of focal cortical dysplasia (FCD). This FCD classification had been widely used in worldwide. In this review paper, the authors would like to give helpful comments for better understanding of the current FCD classification. Especially, the basic concepts of FCD type I, such as "radial", "tangential" and "microcolumn" will be discussed with figures. In addition, the limitations, genetic progress and prospect of FCD will be suggested.

Phenotypic and genotypic screening of rice accessions for salt tolerance

  • Reddy, Inja Naga Bheema Lingeswar;Kim, Sung-Mi;Yoon, In Sun;Kim, Beom-Gi;Kwon, Taek-Ryoun
    • 한국작물학회:학술대회논문집
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    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
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    • pp.188-188
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    • 2017
  • Rice (Oryza sativa L.) is one of the major crops that is seriously impacted by global soil salinization. Rice is among those crops where most of the high-yielding cultivars are highly sensitive to salinity. The key to a plant survival under NaCl salt stress is by maintaining a high $K^+/Na^+$ ratio in its cells. Selection for salinity tolerance genotypes of rice based on phenotypic performance alone is less reliable and will delay in progress in breeding. Recent advent of molecular markers, microsatellites or simple sequence repeats (SSRs) were used to find out salt tolerant rice genotypes. In the current experiment phenotyping and genotyping studies were correlated to differentiate different rice accessions for salinity tolerance. Eight rice accessions along with check plant Dongjin were screened by physiological studies using Yoshida solution with 50mM NaCl stress condition. The physiology studies identified four tolerant and four susceptible accessions based on their potassium concentration, sodium concentration, $K^+/Na^+$ ratio and biomass. 17 SSR markers were used to evaluate these rice accessions for salt tolerance out of which five molecular markers were able to discriminate tolerant accessions from the susceptible accessions. Banding pattern of the accessions was scored comparing to the banding pattern of Dongjin. The study identifies accessions based on their association of $K^+/Na^+$ ratio with molecular markers which is very reliable. These markers identified can play a significant role in screening large set of rice accessions for salt tolerance; these markers can be utilized to improve salt tolerance of commercial rice varieties with marker-assisted selection (MAS) approach.

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Biological Constraints in Algal Biotechnology

  • Torzillo, Giuseppe;Pushparaj, Benjamin;Masojidek, Jiri;Vonshak, Avigad
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제8권6호
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    • pp.338-348
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    • 2003
  • In the past decade, considerable progress has been made in developing the appropriate biotechnology for microalgal mass cultivation aimed at establishing a new agro-industry. This review points out the main biological constraints affecting algal biotechnology outdoors and the requirements for making this biotechnology economically viable. One of them is the availability of a wide variety of algal species and improved strains that favorably respond to varying environmental conditions existing outdoors. It is thus just a matter of time and effort before a new methodology like genetic engineering can and will be applied in this field as well. The study of stress physiology and adaptation of microalgae has also an important application in further development of the biotechnology for mass culturing of microalgae. In outdoor cultures, cells are exposed to severe changes in light and temperature much faster than the time scale re-quired for the cells to acclimate. A better understanding of those parameters and the ability to rapidly monitor those conditions will provide the growers with a better knowledge on how to optimize growth and productivity. Induction of accumulation of high value products is associated with stress conditions. Understanding the physiological response may help in providing a better production system for the desired product and, at a later stage, give an insight of the potential for genetic modification of desired strains. The potential use of microalgae as part of a biological system for bioremediation/detoxification and wastewater treatment is also associated with growing the cells under stress conditions. Important developments in monitoring and feedback control of the culture behavior through application of on-line chlorophyll fluorescence technique are in progress. Understanding the process associated with those unique environmental conditions may help in choosing the right culture conditions as well as selecting strains in order to improve the efficiency of the biological process.

유전자 알고리즘과 나이브 베이지언 기법을 이용한 의료 노모그램 생성 방법 (A Clinical Nomogram Construction Method Using Genetic Algorithm and Naive Bayesian Technique)

  • 이건명;김원재;윤석중
    • 한국지능시스템학회논문지
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    • 제19권6호
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    • pp.796-801
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    • 2009
  • 복잡한 진단이나 예측 모델은 계산이 복잡하고 추론 과정을 해석하기 어렵기 때문에 임상현장에서 널리 사용되지 않고 있다. 의료 종사자들은 이러한 복잡한 모델 대신에, 복잡한 함수를 컴퓨터 등을 사용하지 않고도 쉽게 계산할 수 있도록 수치 관계를 그래픽으로 표현한 노모그램을 사용해 왔다. 의료분야에서 질병의 진단과 질병예후의 예측은 매우 주요한 관심사이다. 노모그램은 증상검사결과치료이력질병의 진단 결과 등의 속성을 포함한 임상 데이터들로부터 만들어진다. 노모그램을 만들 때는 가용한 여러 가지 속성 중에서 효과적인 것들을 찾아야 하고, 경우에 따라서는 속성에 대한 파라미터를 함께 결정해야 한다. 이 논문에서는 효과적인 속성과 파라미터를 선택하기 위해 유전자 알고리즘을 사용하고, 노모그램을 생성하기 위해 나이브 베이지언 기법을 사용하는 방법을 제안한다. 또한 제안한 방법을 실제 임상 데이터에 적용한 결과를 보인다.

Progress and Prospect of Rice Biotechnology in Korea

  • Tae Young, Chung
    • 한국잠사학회:학술대회논문집
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    • 한국잠사학회 1997년도 Progress and Future Development of Sericultural Science and Technology 40th Anniversary Commemoration Symposium
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    • pp.23-49
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    • 1997
  • This is a progress report of rice biotechnology including development of gene transformation system, gene cloning and molecular mapping in rice. The scope of the research was focused on the connection between conventional breeding and biotech-researches. Plant transformation via Agrobacterium or particle bombardment was developed to introduce one or several genes to recommended rice cultivars. Two chimeric genes containing a maize ribosome inactivating protein gene (RIP) and a gerbicide resistant gene (bar) were introduced to Nipponbare, a Japonica cultivar, and transmitted to Korean cultivars. The homozygous progenies of herbicide resistant transgenic plant showed good fertility and agronomic characters. To explore the genetic resourses in rice, over 8,000 cDNA clones from immature rice seed have been isolated and sequenced. About 13% of clones were identified as enzymes related to metabolic pathway. Among them, twenty clones have high homology with genes encoding enzymes in the photorespiratory carbon cycle reaction. Up to now about 100 clones were fully sequenced and registered at EMBL and GenBank. For the mapping of quantitative tarits loci (QTL) and eternal recombinant inbred population with 164 F13 lines (MGRI) was developed from a cross between Milyang 23 and Gihobyeo, Korean rice cultivars. After construction of fully saturated RFLP and AFLP map, quantitative traits using MGRI population were analyzed and integrated into the molecular map. Eighty seven loci were determined with 27 QTL characters including yield and yield components on rice chromosomes. Map based cloning was also tried to isolate semi-dwarf (sd-1) gene in rice. A DNA probe, RG 109, the most tightly linked to sd-1 gene was used to screen from bacterial artifical chromosome (BAC) libraries and five over lapping clones presumably containing sd-1 gene were isolated. Rice genetic database including results of biotech reasearch and classical genetics is provided at Korea Rice Genome Server which is accessible with world wide web (www) browser. The server provides rice cDNA sequences and map informations linked with phenotypic images.

Estimation of Genetic Parameters of Body Weight Traits in Ghezel Sheep

  • Baneh, Hasan;Hafezian, Seyed Hasan;Rashidi, Amir;Gholizadeh, Mohsen;Rahimi, Ghodrat
    • Asian-Australasian Journal of Animal Sciences
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    • 제23권2호
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    • pp.149-153
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    • 2010
  • The present study was carried out to estimate genetic parameters for body weight traits in Ghezel sheep. The data set used was records of 9,221 lambs from 180 sires and 5,060 dams for birth weight (BW), 7,206 lambs from 167 sires and 4,497 dams for weaning weight (WW) and 6,112 lambs from 157 sires and 3,841 dams for 6-months weight (6 MW), which were collected from 1999 to 2007 (9-years) at Ghezel sheep Breeding Station in west Azarbaijan. Variance components and corresponding genetic parameters were obtained with univariate analyses fitting animal models using restricted maximum likelihood (REML) methods. The most suitable model for each trait was determined based on log likelihood ratio tests. Birth year, lamb gender, type of birth, age of dam and herd were significant sources of variation on BW, WW and 6 MW (p<0.01). Direct estimate of heritability for BW, WW and 6 MW was 0.24, 0.29 and 0.37, respectively. The estimate of maternal permanent environmental variance as a proportion of phenotypic variance was 0.09 and 0.05 for BW and WW, respectively. The results of this study showed that genetic progress for growth traits is possible by selection.

수령간 상관을 이용한 잣나무 수고 생장의 조기선발 효율 추정 (Estimates of Early Selection Efficiency for Height Growth Using Age-Age Correlation in Pinus koraiensis)

  • 한상억;이재선
    • 한국산림과학회지
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    • 제84권3호
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    • pp.356-360
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    • 1995
  • 잣나무림에 있어서 목재 및 종자 생산이 중요 경영 목적이므로 이러한 형질을 개량하기 위한 선발육종이 진행중에 있다. 본 연구는 잣나무의 유전모수 및 조기선발 효율 등을 추정하여 1세대 채종원을 전진세대 채종원으로 유도하는데 필요한 자료와 정보를 얻기 위하여 수행하였다. 1986년 50가계로 된 풍매 차대검정림을 3곳에 조성하여 6년간(5~10년생) 수고 생장을 조사하여 분석한 결과, LAR에 대한 수령간 유전 및 표현형 상관의 단순직선회귀는 유의차가 있었으며($r^2=0.7862$, 0.8256), 성숙기를 20년으로 가정하였을 때 조림 후 3년생이 1.96으로 조기선발 효율이 가장 높은 수령으로 추정되어 조기선발이 가능하였다.

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Identification of New Source of Resistance to Powdery Mildew of Indian Mustard and Studying Its Inheritance

  • Nanjundan, Joghee;Manjunatha, Channappa;Radhamani, Jalli;Thakur, Ajay Kumar;Yadav, Rashmi;Kumar, Arun;Meena, Mohan Lal;Tyagi, Rishi Kumar;Yadava, Devender Kumar;Singh, Dhiraj
    • The Plant Pathology Journal
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    • 제36권2호
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    • pp.111-120
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    • 2020
  • Powdery mildew of Indian mustard (Brassica juncea), caused by Erysiphe cruciferarum, is emerging as major problem in India. All the Indian mustard cultivars presently grown in India are highly susceptible to powdery mildew and so far no resistance source has been reported. In this study, with an aim to identify resistant source, 1,020 Indian mustard accessions were evaluated against E. cruciferarum PMN isolate, at Wellington, The Nilgiris, Tamil Nadu, India under natural hot spot conditions. The study identified one accession (RDV 29) with complete resistance against E. cruciferarum PMN isolate for the first time, which was consistent in five independent evaluations. Genetic analysis of F1, F2 and backcross populations obtained from the cross RSEJ 775 (highly susceptible) × RDV 29 (highly resistant) for two season revealed that the resistance is governed by two genes with semi-dominant and gene dosage effect. Further, a new disease rating system using six scales (0, 1, 2, 3, 4, and 5) has also been proposed in this study to score powdery mildew based on progress of fungal growth in different plant parts of the F2 population. The outcome of this study viz. newly identified powdery mildew-resistant Indian mustard accession (RDV 29), information on inheritance of resistance and the newly developed disease rating scale will provide the base for development of powdery mildew-resistant cultivars of Indian mustard.

배추좀나방의 계절적 발생과 월동집단의 유전적 분화 감소 (Decrease in Genetic Variation of Overwintering Populations of the Diamondback Moth during Seasonal Occurrence)

  • 김은성;박아름;박영진;김주일;김용균
    • 한국응용곤충학회지
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    • 제54권4호
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    • pp.303-310
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    • 2015
  • 배추좀나방(Plutella xylostella)은 시설재배지를 중심으로 국내 자연 상태에서 월동한다. 안동지역에서 이른 봄부터 배추좀나방 성페로몬트랩을 이용하여 배추좀나방의 성충 발생 시기를 주기적으로 조사한 결과 연중 4 회의 성충 발생 피크를 보였다. 월동 집단을 대상으로 서로 다른 지역 집단 간 생물적 특성을 조사한 결과 내한성, 약제감수성 및 발육속도에서 뚜렷한 집단 특성을 나타냈다. 분자마커로 집단변이를 분석한 결과 월동세대의 높은 집단변이는 계절이 진행됨에 따라 낮아지는 양상을 나타냈다. 이 결과는 배추좀나방의 국내 월동 집단 사이의 생물적 특성 차이를 나타냈고, 이들의 높은 유전적 분화는 계절이 진행됨에 따라 감소하여 이들 집단 사이의 개체들의 이동에 따른 유전적 교환이 이뤄졌다는 것을 제시했다.

한국 전통공간디자인의 고고학적 접근에 관한 연구 - 푸코의 고고학적 언표를 중심으로 - (A Study on the Archaeological Approach in Korean Traditional Space Design - Focusing on the Archaeological Statement of Foucault -)

  • 박경애;박영목
    • 한국실내디자인학회논문집
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    • 제19권2호
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    • pp.99-106
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    • 2010
  • This study is about Foucault's conceptual and methodological relevance for structural analysis of Korean traditional space design history. By Foucault's Theory, regionalism is product of the instrumentality of space, power, knowledge and provide the basis for making the operation of power both spatial and temporal. The purpose of this study is to establish topographical map of historical progress and to shed new light on the forming of identity in Korean traditional space design on the poststructural-archaeological aspect. The process of this study is illustrated as follows: At first, it suggests Foucault's 'Theory of archaeology'. It mentions 'historical apriori' and archive, collateral space and general grammar as theoretical background of archaeological logic. Secondly, it clarifies 'statements' depending on the conditions that is 'episteme' in which they emerge and exist within a field of discourse. And it discuss Korean traditional space design concept as a social product on the situated character of interaction in time-space. Finally, it studies genetic variation process of Korean traditional space design based on the social progress in Korean society. And it analyses practical actions of 'Statements' in terms of general grammar and textuality.