• 한국항공우주학회지
• /
• 제49권10호
• /
• pp.849-858
• /
• 2021

항공기 내 장비의 장착 위치 결정은 환경조건, 감항성, 정비성 등 고려해야 할 사항이 많아 정량적인 기준을 세우기 힘들다. 또한 장비의 숫자 증가에 따라 설계안은 기하급수적으로 늘어나기 때문에 제한된 일정 내에 검토하기 위하여 설계자의 경험에 많이 의존하여 설계가 진행되고 있다. 본 논문에서는 설계안을 비교할 수 있는 정량적인 기준을 만들기 위하여 장비의 위치에 따른 와이어링 하네스 길이 및 중량을 계산하는 방법과 유전 알고리즘을 이용하여 와이어링 하네스의 중량과 장비들의 CG를 최적화하는 방법을 제안하였다. 그리고 최적설계와 실제설계를 비교하여 최적화 결과가 유용함을 확인하였다.

• Journal of Genetic Medicine
• /
• 제18권2호
• /
• pp.117-120
• /
• 2021

We experienced a case of Xq deletion -- 46,X,del(X)(q22.3) -- detected by abnormal noninvasive prenatal screening, subsequently diagnosed by amniocentesis. Genetic counseling was a challenge because there are few reports of prenatal diagnosis of Xq deletion. In each female cell, one X chromosome is inactivated at random early in development, and there may be a preferential inactivation of the abnormal X chromosome. But some proportions of genes escape inactivation. The most common manifestation in women with Xq deletion is primary or secondary ovarian failure. Critical regions for ovarian function may be located at the long arm of the X chromosome. But, the onset and the severity of ovarian failure may vary with diverse, intricate factors. We anticipate that noninvasive prenatal screening can identify the broader range of chromosomal or genetic abnormalities with the advances in technology and analytic methods. We report our case with a brief review of the literature.

• Steel and Composite Structures
• /
• 제43권3호
• /
• pp.293-309
• /
• 2022

Accurate design models for predicting the shear resistance of headed studs in solid concrete slabs are essential for obtaining economical and safe steel-concrete composite structures. In this study, symbolic regression with genetic programming (GPSR) was applied to experimental data to formulate new descriptive equations for predicting the shear resistance of studs in solid slabs using both normal and lightweight concrete. The obtained GPSR-based nominal resistance equations demonstrated good agreement with the test results. The equations indicate that the stud shear resistance is insensitive to the secant modulus of elasticity of concrete, which has been included in many international standards following the pioneering work of Ollgaard et al. In contrast, it increases when the stud height-to-diameter ratio increases, which is not reflected by the design models in the current international standards. The nominal resistance equations were subsequently refined for use in design from reliability analyses to ensure that the target reliability index required by the Eurocodes was achieved. Resistance factors for the developed equations were also determined following US design practice. The stud shear resistance predicted by the proposed models was compared with the predictions from 13 existing models. The accuracy of the developed models exceeds the accuracy of the existing equations. The proposed models produce predictions that can be used with confidence in design, while providing significantly higher stud resistances for certain combinations of variables than those computed with the existing equations given by many standards.

• 대한유전성대사질환학회지
• /
• 제22권1호
• /
• pp.15-20
• /
• 2022

The most common urea cycle disorder is ornithine transcarbamylase deficiency. More than 80 percent of patients with symptomatic ornithine transcarbamylase deficiency are late-onset, which can present various phenotypes from infancy to adulthood. With no regards to the severity of the disease, characteristic fluctuating courses due to hyperammonemia may develop unexpectedly, and can be precipitated by various metabolic stressors. Late-onset ornithine transcarbamylase deficiency is not merely related to a type of genetic variation, but also to the complex relationship between genetic and environmental factors that result in hyperammonemia; therefore, it is difficult to predict the prevalence of neurological symptoms in late-onset ornithine transcarbamylase deficiency. Most common acute neurological manifestations include psychological changes, seizures, cerebral edema, and death; subacute neurological manifestations include developmental delays, learning disabilities, intellectual disabilities, attention-deficit/hyperactivity disorder, executive function deficits, and emotional and behavioral problems. This review aims to increase awareness of late-onset ornithine transcarbamylase deficiency, allowing for an efficient use of biochemical and genetic tests available for diagnosis, ultimately leading to earlier treatment of patients.

• 대한의생명과학회지
• /
• 제29권3호
• /
• pp.95-102
• /
• 2023

The inner ear constitutes a complex organ responsible for auditory perception and equilibrium. It comprises diverse cellular entities operating collaboratively to perceive and transmit sensory information to the brain. Inner ear disease is a sophisticated and multifactorial scenario substantially impacting the quality of life of affected individuals. Gaining insights into the developmental process of the inner ear is crucial for diagnosing and treating inner ear diseases, which can lead to hearing loss and impaired balance. Recent research in inner ear development and associated pathophysiology has focused on several pivotal domains, including identifying new genes and signaling pathways involved in inner ear development, using stem cells for inner ear regeneration, and developing novel therapies for inner ear diseases. Recent advances in genetics research have shed new light on the fundamental etiologies of inner ear diseases, with a growing body of evidence suggesting that genetic mutations might exert a pivotal influence on the development and progression of this condition. In this review, we have delved into certain common genetic mutations linked to inner ear disorders. We also discussed ongoing research endeavors and future directions for understanding the genetic mechanisms underlying this condition and potential therapeutic avenues.

• 한국환경보건학회지
• /
• 제42권6호
• /
• pp.396-408
• /
• 2016

Objectives: The purposes of this study were to determine the relationship between the prevalence of allergic diseases and urinary cadmium concentration among children from six to 12 years of age, and to evaluate the association between cadmium in urine and other immunologically related factors in two elementary schools with different environmental conditions. Methods: Data on physician-diagnosed prevalence over the past 12 months and potential risk factors for allergic disease were collected from survey results drawn from 236 children living in different regions (central urban vs. suburban) from April to July in 2014 by an ISAAC questionnaire. We analyzed cytokine levels in serum through enzyme-linked immunosorbent assay and urinary cadmium concentration by use of inductively coupled plasma mass spectrometry. Results: Concentrations of urinary cadmium in suburban and central urban children were $0.11{\pm}0.11ug/L$, $0.14{\pm}0.17ug/L$, respectively (p>0.05). Results from the analysis of the t-test and chi-square test showed that urinary cadmium levels were positively associated with environmental factors (paternal smoking status, passive smoking, traffic volume and experiences of outdoor odors) and individual genetic factors (parental allergic disease). Cadmium concentrations in urine were also positively associated with the prevalence of allergic disease and immune-related cytokines (eosinophils, IgE, IL-5, IL-33, IL-17). Conclusion: This study suggests that genetic factors (parental history of allergic diseases), environmental factors, and regional status (suburban and central urban) should be considered as probable factors increasing the concentration of urinary cadmium, which has the potential to influence the allergic disease prevalence of school-age children.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권12호
• /
• pp.7595-7600
• /
• 2013

Cervical cancer is a serious public health problem in developing countries. We investigated possible risk factors for cervical cancer in rural areas of Wuhan China using a matched case-control study with 33 women diagnosed with cervical cancer and 132 healthy women selected from the same area as matched controls. A questionnaire, which included questions about general demography conditions, environmental and genetic factors, the first sexual intercourse, first marriage age, age at first pregnancy, pregnancy first child's age, female personal health history, social psychological factors, dietary habits, smoking and alcohol status and other living habits was presented to all participants. At the same time, HPV infection of every participant was examined in laboratory testing. Results showed HPV infection (P<0.000, OR=23.4) and pregnancy first child's age (P<0.000, OR=13.1) to be risk factors for cervical cancer. Menopause (P=0.003, OR=0.073) was a protective factor against cervical cancer. However, there was no indication of associations of environmental (drinking water, insecticide, disinfectant) genetic (cancer family history), or life-style factors (smoking status, alcohol status, physical training, sleep quality), including dietary habits (intake of fruit and vegetable, meat, fried food, bean products and pickled food) or social psychological factors with cervical cancer. The results suggest that the risk of cervical cancer in Chinese rural women may be associated with HPV infection, menopause and the pregnancy first child's age.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
• /
• 제4B권4호
• /
• pp.211-216
• /
• 2004

Inductance characteristics, torque variations and ripple according to current, and position of multi-layer buried magnet synchronous machines with field-weakening operations are presented. The rotor structure optimal design of a buried magnet synchronous machine with high performance is investigated, and optimization results and comparison among design candidates are shown. For the fast and accurate search of multiple optima, the auto-tuning niching genetic algorithm is used and a final solution is selected considering various design factors.

• Clinical and Experimental Pediatrics
• /
• 제50권11호
• /
• pp.1049-1054
• /
• 2007

Myocarditis represent an important condition encountered by general pediatricians & general practitioners. Its presentation is varied, and therefore a high index of suspicion must be maintained when the possibility of myocarditis is raised. A progression from viral myocarditis to dilated cardiomyopathy has long been hypothesized. Treatment is initially aimed at achieving hemodynamic stability and is largely supportive. There is currently little evidence to support the immunomodulatory or specific antiviral therapies. Pediatric cardiomyopathies are a heterogeneous group of disorders with diverse genetic, infectious, mitochodrial and metabolic etiologies. The timing and severity of presentation vary according to cardiomyopathy type as well as genetic and ethnic factors. The behavior of specific cardiomyopathies can be predicted by morphological and functional attributes, as well as underlying patient characteristics.

• 생물정신의학
• /
• 제3권2호
• /
• pp.211-215
• /
• 1996

The present study investigated the associations between CT measures and obstetric complications and family history of major mental illnesses. We had the hypothesis of diosthesis-stress model in the etiology of schizophrenia. We had the following findings. 1) Family history of major mental illnesses is inversely related to obstetric complications. 2) Prefrontal sulcal widening and family history of schizophrenia. are inversely related. 3) In female but not in male patients those with family history of schizophrenia tended to have less prefrontal sulcal widening and ventricular brain ratio. These results suggest that more genetic factors contribute to structural brain abnormalities in female than in male patients.