• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.711-722
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• 2020

An optimization framework using genetic algorithms has been developed towards an automated parametric optimization of the Octabuoy semi-submersible design. Compared with deep draft production units, the design of the shallow draught Octabuoy semi-submersible provides a floating system with improved motion characteristics, being less susceptible to vortex induced motions in loop currents. The relatively large water plane area results in a decreased natural heave period, which locates the floater in the wave period range with more wave energy. Considering this, the hull design of Octabuoy semi-submersible has been optimized to improve the floater's motion performance. The optimization has been conducted with optimized parameters of the pontoon's rectangular cross section area, the cone shaped section's height and diameter. Through numerical evaluations of both the 1st-order and 2nd-order hydrodynamics, the optimization through genetic algorithms has been proven to provide improved hydrodynamic performance, in terms of heave and pitch motions. This work presents a meaningful framework as a reference in the process of floating system's design.

• Journal of Genetic Medicine
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• v.20 no.1
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• pp.15-24
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• 2023

Monogenic disorders are traditionally attributed to the presence of mutations in a single gene. However, recent advancements in genomics have revealed instances where the phenotypic expression of apparently monogenic disorders cannot be fully explained by mutations in a single gene alone. This review article aims to explore the emerging concept of digenic or oligogenic inheritance in seemingly monogenic disorders. We discuss the underlying mechanisms, clinical implications, and the challenges associated with deciphering the contribution of multiple genes in the development and manifestation of such disorders. We present relevant studies and highlight the importance of adopting a broader genetic approach in understanding the complex genetic architecture of these conditions.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.31-31
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• 2022

Rice contains a wealth of genetic diversity, both within Oryza sativa and in related A-genome species. Decades of genetic research into this diversity have identified dozens of major genes contributing to a wide variety of important traits, including disease resistance, abiotic stress tolerance (drought, salinity, submergence, heat, cold etc.), grain quality, flowering date and maturity and plant architecture. Yet despite these opportunities, very few of the major genes and QTLs known have been successfully applied through rice breeding programs to produce sustained changes in farmer's fields. This presentation will briefly examine some of the factors limiting application of major genes in the mainstream breeding programs, and steps that have been taken to alleviate those limitations. As a result of these interventions, dozens of major genes that were previously unavailable to breeders are now being used confidently in the variety development process. Case studies will be discussed of genes critical for blast resistance worldwide, rice yellow mottle virus for Africa, and new validated QTLs for salinity tolerance.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.2
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• pp.224-229
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• 2005

Generally, genetic algorithm (GA) has too much time and space complexity when it is running in the typical processor. Therefore, we are forced to use the high-performance and expensive processor by this reason. It also works as a barrier to implement real device, such a small mobile robot, which is required only simple rules. To solve this problem, this paper presents and proposes enhanced processor-architecture for the faster GA processing. A typical processor architecture can be enhanced and specialized by two approaches: one is a sorting network, the other is a residue number system (RNS). A sorting network can improve the time complexity of which needs to compare the populations' fitness. An RNS can reduce the magnitude of the largest bit that dictates the speed of arithmetic operation. Consequently, it can make the total logic size smaller and innovate arithmetic operation speed faster.

• International Journal of Naval Architecture and Ocean Engineering
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• v.7 no.4
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• pp.750-769
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• 2015

The geometry of engineering systems affects their performances. For this reason, the shape of engineering systems needs to be optimized in the initial design stage. However, engineering system design problems consist of multi-objective optimization and the performance analysis using commercial code or numerical analysis is generally time-consuming. To solve these problems, many engineers perform the optimization using the approximation model (response surface). The Response Surface Method (RSM) is generally used to predict the system performance in engineering research field, but RSM presents some prediction errors for highly nonlinear systems. The major objective of this research is to establish an optimal design method for multi-objective problems and confirm its applicability. The proposed process is composed of three parts: definition of geometry, generation of response surface, and optimization process. To reduce the time for performance analysis and minimize the prediction errors, the approximation model is generated using the Backpropagation Artificial Neural Network (BPANN) which is considered as Neuro-Response Surface Method (NRSM). The optimization is done for the generated response surface by non-dominated sorting genetic algorithm-II (NSGA-II). Through case studies of marine system and ship structure (substructure of floating offshore wind turbine considering hydrodynamics performances and bulk carrier bottom stiffened panels considering structure performance), we have confirmed the applicability of the proposed method for multi-objective side constraint optimization problems.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.1
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• pp.1-7
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• 2017

Objective: Three genome-wide association studies (GWAS) and a meta-analysis of GWAS were conducted to explore the genetic mechanisms underlying variation in pig teat number. Methods: We performed three GWAS and a meta-analysis for teat number on three pig populations, including a White Duroc${\times}$Erhualian $F_2$ resource population (n = 1,743), a Chinese Erhualian pig population (n = 320) and a Chinese Sutai pig population (n = 383). Results: We detected 24 single nucleotide polymorphisms (SNPs) that surpassed the genome-wide significant level on Sus Scrofa chromosomes (SSC) 1, 7, and 12 in the $F_2$ resource population, corresponding to four loci for pig teat number. We highlighted vertnin (VRTN) and lysine demethylase 6B (KDM6B) as two interesting candidate genes at the loci on SSC7 and SSC12. No significant associated SNPs were identified in the meta-analysis of GWAS. Conclusion: The results verified the complex genetic architecture of pig teat number. The causative variants for teat number may be different in the three populations

• Smart Structures and Systems
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• v.26 no.5
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• pp.545-558
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• 2020

A design method of a Multiple Tuned Mass Damper (MTMD) system is presented for wind induced vibration control of a cable-supported roof structure. Modal contribution analysis is carried out to determine the dominating modes of the structure for the MTMD design. Two MTMD systems are developed for two most dominating modes. Each MTMD system is composed of multiple TMDs with small masses spread at multiple locations with large responses in the corresponding mode. Frequencies of TMDs are distributed uniformly within a range around the dominating frequencies of the roof structure to enhance the robustness of the MTMD system against uncertainties of structural frequencies. Parameter optimizations are carried out by minimizing objective functions regarding the structural responses, TMD strokes, robustness and mass cost. Two optimization approaches are used: Single Objective Approach (SOA) using Sequential Quadratic Programming (SQP) with multi-start method and Multi-Objective Approach (MOA) using Non-dominated Sorting Genetic Algorithm-II (NSGA-II). The computation efficiency of the MOA is found to be superior to the SOA with consistent optimization results. A Pareto optimal front is obtained regarding the control performance and the total weight of the TMDs, from which several specific design options are proposed. The final design may be selected based on the Pareto optimal front and other engineering factors.

• Computers and Concrete
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• v.6 no.3
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• pp.253-268
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• 2009

This study aims to develop a cost-based high-performance concrete (HPC) mix optimization system based on an integrated approach using artificial neural networks (ANNs) and genetic algorithms (GA). ANNs are used to predict the three main properties of HPC, namely workability, strength and durability, which are used to evaluate fitness and constraint violations in the GA process. Multilayer back-propagation neural networks are trained using the results obtained from experiments and previous research. The correlation between concrete components and its properties is established. GA is employed to arrive at an optimal mix proportion of HPC by minimizing its total cost. A system prototype, called High Performance Concrete Mix-Design System using Genetic Algorithm and Neural Networks (HPCGANN), was developed in MATLAB. The architecture of the proposed system consists of three main parts: 1) User interface; 2) ANNs prediction models software; and 3) GA engine software. The validation of the proposed system is carried out by comparing the results obtained from the system with the trial batches. The results indicate that the proposed system can be used to enable the design of HPC mix which corresponds to its required performance. Furthermore, the proposed system takes into account the influence of the fluctuating unit price of materials in order to achieve the lowest cost of concrete, which cannot be easily obtained by traditional methods or trial-and-error techniques.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.4
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• pp.388-394
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• 1999

This paper is concerned with an application of Parallel Genetic Algorithms(PGA) to optimal econmic load dispatch(ELD) in power systems. The ELD problem is to minimize the total generation fuel cost of power outputs for all generating units while satisfying load balancing constraints. Genetic Algorithms(GA) is a good candidate for effective parallelization because of their inherent principle of evolving in parallel a population of individuals. Each individual of a population evaluates the fitness function without data exchanges between individuals. In application of the parallel processing to GA, it is possible to use Single Instruction stream, Multiple Data stream(SIMD), a kind of parallel system. The architecture of SIMD system need not data communications between processors assigned. The proposed ELD problem with C code is implemented by SIMSCRIPT language for parallel processing which is a powerfrul, free-from and versatile computer simulation programming language. The proposed algorithms has been tested for 38 units system and has been compared with Sequential Quadratic programming(SQP).

• International Journal of Control, Automation, and Systems
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• v.1 no.3
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• pp.321-331
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• 2003

Experimental software datasets describing software projects in terms of their complexity and development time have been the subject of intensive modeling. A number of various modeling methodologies and modeling designs have been proposed including such approaches as neural networks, fuzzy, and fuzzy neural network models. In this study, we introduce the concept of the Rule-based fuzzy polynomial neural networks (RFPNN) as a hybrid modeling architecture and discuss its comprehensive design methodology. The development of the RFPNN dwells on the technologies of Computational Intelligence (CI), namely fuzzy sets, neural networks, and genetic algorithms. The architecture of the RFPNN results from a synergistic usage of RFNN and PNN. RFNN contribute to the formation of the premise part of the rule-based structure of the RFPNN. The consequence part of the RFPNN is designed using PNN. We discuss two kinds of RFPNN architectures and propose a comprehensive learning algorithm. In particular, it is shown that this network exhibits a dynamic structure. The experimental results include well-known software data such as the NASA dataset concerning software cost estimation and the one describing software modules of the Medical Imaging System (MIS).