• 한국산학기술학회논문지
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• 제10권5호
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• pp.985-991
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• 2009

문법 기반의 테스트 케이스 자동 생성(GBTG) 알고리즘은 문법 G를 기반으로 G에 의해 수용되는 문장들의 집합 L(G), 즉 소프트웨어 테스트를 위한 테스트 케이스를 생성한다. 문맥 자유 문법으로 기술되는 대부분의 언어들은 순환적 성격을 가지며, 일반적으로 G에 의해 생성되는 집합 L(G)는 너무 커서 생성된 케이스들을 모두 실행시킬 테스트 대상으로 삼는다는 것은 현실석이지 못하다. 본 논문에서는 CFG에 의해 자동 생성되는 테스트 케이스의 집합의 크기를 통제하면서도 테스트의 주요 범위를 커버하기 위하여 문맥 자유 문법을 보강하는 문법외적 요소인 태그들을 개발하고 실험하였다.

• 동의생리병리학회지
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• 제24권6호
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• pp.921-923
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• 2010

Although Bi(脾 Spleen) is a major organ which controls digestion and absorption in Korean medicine, there also introduced another function of bi, which is called 'bitonghyul(脾統血)' that means the spleen controls(holdings) the blood. While the spleen is involved in the function of blood generation through the digestion and absorption of food, 'bitonghyul' is another expression regarding function of the spleen. The meaning of 'bitonghyul' is related with the function of keeping the blood flowing within the blood vessels, hemostasis. Comparing the function of the spleen with the mechanisms of hemostais, it is concluded that 'bitonghyul' is a physiological effects which affect hemostatic mechanisms via absorption of vitamin K.

• Biomolecules & Therapeutics
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• 제30권5호
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• pp.399-408
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• 2022

Diabetic cardiomyopathy (DCM) is described as abnormalities of myocardial structure and function in diabetic patients without other well-established cardiovascular factors. Although multiple pathological mechanisms involving in this unique myocardial disorder, mitochondrial dysfunction may play an important role in its development of DCM. Recently, considerable progresses have suggested that mitochondrial biogenesis is a tightly controlled process initiating mitochondrial generation and maintaining mitochondrial function, appears to be associated with DCM. Nonetheless, an outlook on the mechanisms and clinical relevance of dysfunction in mitochondrial biogenesis among patients with DCM is not completely understood. In this review, hence, we will summarize the role of mitochondrial biogenesis dysfunction in the development of DCM, especially the molecular underlying mechanism concerning the signaling pathways beyond the stimulation and inhibition of mitochondrial biogenesis. Additionally, the evaluations and potential therapeutic strategies regarding mitochondrial biogenesis dysfunction in DCM is also presented.

• 말소리와 음성과학
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• 제1권1호
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• pp.9-22
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• 2009

This paper first presents the author's personal view on the importance of modeling in scientific research in general, and then describes two of his works toward modeling certain aspects of human speech communication. The first work is concerned with the physiological and physical mechanisms of controlling the voice fundamental frequency of speech, which is an important parameter for expressing information on tone, accent, and intonation. The second work is concerned with the cognitive processes involved in a discrimination test of speech stimuli, which gives rise to the phenomenon of so-called categorical perception. They are meant to illustrate the power of models based on deep understanding and precise formulation of the functions of the mechanisms/processes that underlie observed phenomena. Finally, it also presents the author's view on some models that are yet to be developed.

• IMMUNE NETWORK
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• 제23권5호
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• pp.38.1-38.14
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• 2023

Neutrophils are professional phagocytes that provide defense against invading pathogens through phagocytosis, degranulation, generation of ROS, and the formation of neutrophil extracellular traps (NETs). Although long been considered as short-lived effector cells with limited biosynthetic activity, recent studies have revealed that neutrophils actively communicate with other immune cells. Neutrophils employ various types of soluble mediators, including granules, cytokines, and chemokines, for crosstalk with immune cells. Additionally, ROS and NETs, major arsenals of neutrophils, are utilized for intercellular communication. Furthermore, extracellular vesicles play a crucial role as mediators of neutrophil crosstalk. In this review, we highlight the extracellular mechanisms of neutrophils and their roles in crosstalk with other cells.

• BMB Reports
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• 제43권2호
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• pp.69-78
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• 2010

Asymmetric cell division is a fundamental mechanism for the generation of body axes and cell diversity during early embryogenesis in many organisms. During intrinsically asymmetric divisions, an axis of polarity is established within the cell and the division plane is oriented to ensure the differential segregation of developmental determinants to the daughter cells. Studies in the nematode Caenorhabditis elegans have contributed greatly to our understanding of the regulatory mechanisms underlying cell polarity and asymmetric division. However, much remains to be elucidated about the molecular machinery controlling the spatiotemporal distribution of key components. In this review we discuss recent findings that reveal intricate interactions between translational control and targeted proteolysis. These two mechanisms of regulation serve to carefully modulate protein levels and reinforce asymmetries, or to eliminate proteins from certain cells.

• 한국소음진동공학회논문집
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• 제14권8호
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• pp.675-683
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• 2004

The motor current signature provides an important source of the information for the faults diagnosis of three-phase induction motor. The theoretical principles behind the generation of unique signal characteristics, which are indicative of failure mechanisms, are Presented. The fault detection techniques that can be used to diagnose mechanical Problems, stator and rotor winding failure mechanisms, and air-gap eccentricity are described. A theoretical analysis is presented which predicts the presence of unique signature patterns in the current that are only characteristics of the fault. The predictions are verified by experimental results from a special fault Producing test rig and on-site tests in a steel company. And this study have made new diagnostic algorithm for the operating induction motors with the test results. These developments are including the use of monitoring and analysis of electric current to diagnose mechanical and electrical problems and gave the precise test results automatically.

• International Journal of Oral Biology
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• 제47권2호
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• pp.17-24
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• 2022

Preserving intact genetic material and delivering it to the next generation are the most significant tasks of living organisms. The integrity of DNA sequences is under constant threat from endogenous and exogenous factors. The accumulation of damaged or incompletely-repaired DNA can cause serious problems in cells, including cell death or cancer development. Various DNA damage detection systems and repair mechanisms have evolved at the cellular level. Although the mechanisms of these responses have been extensively studied, the global RNA expression profiles associated with genomic instability are not well-known. To detect global gene expression changes under different DNA damage and hypoxic conditions, we performed RNA-seq after treating human cervical cancer cells with ionizing radiation (IR), hydroxyurea, mitomycin C (MMC), or 1% O₂ (hypoxia). Results showed that the expression of 184-1037 genes was altered by each stimulus. We found that the expression of 51 genes changed under IR, MMC, and hypoxia. These findings revealed damage-specific genes that varied differently according to each stimulus and common genes that are universally altered in genetic instability.

• 한국항공우주학회지
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• 제37권8호
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• pp.729-736
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• 2009

벌새(Selasphorus rufus)의 날갯짓 운동에 의한 양력발생 및 추력발생 메커니즘을 이해하고자 2차원 수치해석을 수행하였다. 날갯짓 운동의 궤적은 풍동 실험에서 관찰된 결과를 모델링하여 해석하였다. 비행속도에 따라 날갯짓 운동 궤적이 달라지고, 그 결과 양력 및 추력의 발생 메커니즘이 변화하는 것을 알 수 있었다. 본 연구에서는 이를 통하여 비행속도를 저속비행과 고속비행으로 구분하여 물리적인 이해를 하고자 하였다. 양력발생의 경우에는 기존의 날갯짓 비행의 주된 양력발생 메커니즘인 앞전와류효과(Leading Edge Vortex Effect), 실속지연(Delayed Stall), 후류포착(Wake capture)등의 메커니즘을 확인하였으며, 벌새에서 유일하게 관찰되는 Upstroke에서의 양력발생 메커니즘을 유동특성 분석을 통하여 확인하였다. 추력발생의 경우에는 벌새의 골격 구조, 와류형성 및 압력구배에 따른 합력 성분의 분해를 통하여 이해할 수 있었다.

• Archives of Plastic Surgery
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• 제47권3호
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• pp.203-208
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• 2020

Vascular anomalies are congenital localized abnormalities that result from improper development and maintenance of the vasculature. The lesions of vascular anomalies vary in location, type, and clinical severity of the phenotype, and the current treatment options are often unsatisfactory. Most vascular anomalies are sporadic, but patterns of inheritance have been noted in some cases, making genetic analysis relevant. Developments in the field of genomics, including next-generation sequencing, have provided novel insights into the genetic and molecular pathophysiological mechanisms underlying vascular anomalies. These insights may pave the way for new approaches to molecular diagnosis and potential disease-specific therapies. This article provides an introduction to genetic testing for vascular anomalies and presents a brief summary of the etiology and genetics of vascular anomalies.