• 한국분말재료학회지
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• 제31권1호
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• pp.30-36
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• 2024

The aerospace and power generation industries have an increasing demand for high-temperature, high-strength materials. However, conventional materials typically lack sufficient fracture toughness and oxidation resistance at high temperatures. This study aims to enhance the high-temperature properties of Nb-Si-Ti alloys through ball milling. To analyze the effects of milling time, the progression of alloying is evaluated on the basis of XRD patterns and the microstructure of alloy powders. Spark plasma sintering (SPS) is employed to produce compacts, with thermodynamic modeling assisting in predicting phase fractions and sintering temperature ranges. The changes in the microstructure and variation in the mechanical properties due to the adjustment of the sintering temperature provide insights into the influence of Nb solid solution, Nb5Si3, and crystallite size within the compacts. By investigating the changes in the mechanical properties through strengthening mechanisms, such as precipitation strengthening, solid solution strengthening, and crystallite refinement, this study aims to verify the applicability of Nb-Si-Ti alloys in advanced material systems.

• The Korean Journal of Physiology and Pharmacology
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• 제13권1호
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• pp.15-22
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• 2009

This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide(KCN)/0.1 mM iodoacetic acid(IAA), and membrane transport function and cell viability were evaluated by measuring $Na^+$-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in $Na^+$-dependent phosphate uptake and cell viability in a time-dependent manner. ATP depletion inhibited $Na^+$-dependent phosphate uptake in cells, when treated with 2 mM ouabain, a $Na^+$ pump-specific inhibitor, suggesting that ATP depletion impairs membrane transport functional integrity. Alterations in $Na^+$-dependent phosphate uptake and cell viability induced by ATP depletion were prevented by the hydrogen peroxide scavenger such as catalase and the hydroxyl radical scavengers(dimethylthiourea and thiourea), and amino acids(glycine and alanine). ATP depletion caused arachidonic acid release and increased mRNA levels of cytosolic phospholipase $A_2(cPLA_2)$. The ATP depletion-dependent arachidonic acid release was inhibited by $cPLA_2$ specific inhibitor $AACOCF_3$. ATP depletion-induced alterations in $Na^+$-dependent phosphate uptake and cell viability were prevented by $AACOCF_3$. Inhibition of $Na^+$-dependent phosphate uptake by ATP depletion was prevented by antipain and leupetin, serine/cysteine protease inhibitors, whereas ATP depletion-induced cell death was not altered by these agents. These results indicate that ATP depletion-induced alterations in membrane transport function and cell viability are due to reactive oxygen species generation and $cPLA_2$ activation in renal proximal tubular cells. In addition, the present data suggest that serine/cysteine proteases play an important role in membrane transport dysfunction, but not cell death, induced by ATP depletion.

• 한국음향학회지
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• 제41권4호
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• pp.389-396
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• 2022

본 논문은 냉장고 수축팽창 소음의 원인 및 메커니즘을 파악하고 소음 감소 방법을 제안한다. 냉장고에서 발생하는 수축팽창 소음은 주로 내부부품 사이의 접촉면에서 발생하는 스틱슬립 현상에 의한 것이다. 스틱슬립 현상을 일으키는 요인을 규명하기 위해 마찰실험이 수행되었다. 또한 내부부품의 진동레벨을 측정하여 수축팽창 소음의 특성 및 위치를 규명하였다. 실험 결과를 바탕으로 요인별 소음 특성을 검증하는 실험이 진행되었다. 이를 통해 마찰실험과 냉장고 수축팽창 소음 발생 위치와 빈도가 동일한 것을 확인하였다. 하중적재로 수직력이 증가하면 진동레벨도 증가하였다. 또한 표면거칠기를 증가하였을 때 수축팽창 소음이 저감되는 것으로 확인되었다. 따라서, 마찰실험 결과와 동일하게 접촉면의 표면거칠기를 증가하는 것이 수축팽창 소음저감 방법이라는 결론을 도출하였다.

• BMB Reports
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• 제48권1호
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• pp.13-18
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• 2015

Alzheimer's disease severely compromises cognitive function. One of the mechanisms to explain the pathology of Alzheimer's disease has been the hypotheses of amyloid-pore/channel formation by complex $A{\beta}$-aggregates. Clinical studies suggested the moderate alcohol consumption can reduces probability developing neurodegenerative pathologies. A recent report explored the ability of ethanol to disrupt the generation of complex $A{\beta}$ in vitro and reduce the toxicity in two cell lines. Molecular dynamics simulations were applied to understand how ethanol blocks the aggregation of amyloid. On the other hand, the in silico modeling showed ethanol effect over the dynamics assembling for complex $A{\beta}$-aggregates mediated by break the hydrosaline bridges between Asp 23 and Lys 28, was are key element for amyloid dimerization. The amyloid pore/ channel hypothesis has been explored only in neuronal models, however recently experiments suggested the frog oocytes such an excellent model to explore the mechanism of the amyloid pore/channel hypothesis. So, the used of frog oocytes to explored the mechanism of amyloid aggregates is new, mainly for amyloid/pore hypothesis. Therefore, this experimental model is a powerful tool to explore the mechanism implicates in the Alzheimer's disease pathology and also suggests a model to prevent the Alzheimer's disease pathology.

• Environmental Analysis Health and Toxicology
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• 제19권4호
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• pp.335-344
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• 2004

Diesel exhaust particle (<2.5 ${\mu}{\textrm}{m}$, DEP$_{2.5}$) is known to be probarbly carcinogenic (IARC group 2A). DEP$_{2.5}$ contains organic compounds such as polycyclicaromatic hydrocarbon (PAH), heterocyclic compounds, phenols, and nitroarenes. Reactive oxygen species (ROS) are generated by DEP$_{2.5}$ without any biological activation system. Therefore, an alternative mechanism by which DEP$_{2.5}$ could be carcinogenic is known by the generation of oxidative DNA damage. The aim of this study was to investigate genotoxic effects of DEP$_{2.5}$ using single cell gel electrophoresis. In order to evaluate the mechanisms of DEP$_{2.5}$ genotoxicity, the rat micro-some mediated and DNA repair enzyme treated comet assays together with routine comet assay were performed. DEP$_{2.5}$ was collected from diesel engine bus and dichloromethane extract was obtained. The organic extract of DEP$_{2.5}$ revealed DNA damage itself in NIH/3T3 cells. And it showed both oxidative and microsome mediated DNA damages. Vitamin C as an model antioxidant reduced DNA damage in endonuclase III treated comet assay. One of flavonoid, galangin as a CYP1A1 inhibitor reduced DNA damage in the presence of S-9 mixture. Our results show that DEP$_{2.5}$ are genotoxic and a great source of oxidative stress, but antioxidants can significantly reduce oxidative DNA damages. And DEP$_{2.5}$ may contain indirect mutagens which can be inhibited by CYP inhibitors.d by CYP inhibitors.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 추계학술대회 논문집(제1권)
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• pp.181-186
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• 2006

본 논문에서는 Freak Wave의 생성원인에 대하여 간략히 논의하였으며, 이 중 파랑-조류 비선형 상호작용에 대한 이론 및 수치적 해석기법의 역사와 장단점 등을 기술한다. 본 연구에서는 파랑-조류 상호작용에 대한 수치모델링 및 해석 기법을 개발하고 있다. 개발 중인 수치해석 기법은 공간적으로 불균일한 조류와 파랑의 비선형 상호작용을 해석하기 위하여 Navier-Stokes 방정식을 이용하여 유동현상을 모델링하였으며, 이산화를 위하여 스펙트랄요소법(Spectral Element Method; SEM)을 이용하였다. 또한 자유표면의 운동을 효과적으로 기술하기 위하여 ALE(Arbitrary Lagrangian-Eulerian)기법을 사용하였다. 본 연구의 유동 모델과 수치해석기법의 과정과 특성, 그리고 장점 등에 대하여 논의하였으며, 초기적인 수치해석 결과를 제시하였다. 이를 바탕으로 개발된 수치해석기법의 정확성 및 수렴성을 확인할 수 있다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권11호
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• pp.3182-3203
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• 2023

With the growing adoption of cloud-based technologies, maintaining the privacy and security of cloud data has become a pressing issue. Privacy-preserving encryption schemes are a promising approach for achieving cloud data security, but they require careful design and implementation to be effective. The integrated approach to cloud data security that we suggest in this work uses CogniGate: the orchestrated permissions protocol, index trees, blockchain key management, and unique Opacus encryption. Opacus encryption is a novel homomorphic encryption scheme that enables computation on encrypted data, making it a powerful tool for cloud data security. CogniGate Protocol enables more flexibility and control over access to cloud data by allowing for fine-grained limitations on access depending on user parameters. Index trees provide an efficient data structure for storing and retrieving encrypted data, while blockchain key management ensures the secure and decentralized storage of encryption keys. Performance evaluation focuses on key aspects, including computation cost for the data owner, computation cost for data sharers, the average time cost of index construction, query consumption for data providers, and time cost in key generation. The results highlight that the integrated approach safeguards cloud data while preserving privacy, maintaining usability, and demonstrating high performance. In addition, we explore the role of differential privacy in our integrated approach, showing how it can be used to further enhance privacy protection without compromising performance. We also discuss the key management challenges associated with our approach and propose a novel blockchain-based key management system that leverages smart contracts and consensus mechanisms to ensure the secure and decentralized storage of encryption keys.

• 한국게임학회 논문지
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• 제11권5호
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• pp.3-11
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• 2011

게임세대를 위한 효과적인 교육방법으로 게임을 통한 학습이 주목을 받고 있다. 기존 교육용 게임의 설계방법은 필요한 모든 학습요소들과 게임요소들을 동시에 한 게임 안에 수용하도록 설계하는 것이다. 그래서 동기유발과 학습효과를 동시에 달성해야 하는 교육용 게임을 설계하는 것은 일반적으로 어렵다. 교육용게임을 설계하기 어려움의 문제를 해결하기 위해, 본 논문에서는 동기유발기제를 사용하여 게임플레이와 학습플레이를 연동하는 G러닝 모델인 IGLM을 제안하였다. 제안하는 모델 IGLM은 게임레벨들과 학습레벨들을 따로 독립적으로 구성하고 있고 동기유발기제의 연동 메커니즘으로 게임레벨들과 학습레벨들이 서로 연동되어 진행된다. 제안하는 IGLM의 설계방법의 설계 어려움에 대하여 기존 설계방법들과 비교분석하였다. 분석결과에 의하면, 제안하는 IGLM은 기존 방법들의 설계 어려움을 해결할 수 있을 뿐 아니라 구성요소들의 설계의 난이도, 자유도, 그리고 수용범위가 가장 우수한 방법임을 알 수 있었다.

• Tribology and Lubricants
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• 제31권2호
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• pp.42-49
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• 2015

Because of the growing need for high-speed transport options such as trains and aircraft, there is increasing demand for technology related to high-speed trains. Among them, braking systems are important in high-speed trains in terms of reliability. Especially, the disk brake system, in use in most high-speed trains, transforms kinetic energy into thermal energy and noise. Therefore, the material properties of both the friction materials and disks are expected to influence the tribological characteristics. In this paper, the tribological characteristics depend on the hardness of the brake disks between the Cu-based sintered metallic friction material and the heat-treated heat-resisting steel disks. A lab-scale dynamometer used to perform braking tests at a variety of braking speeds using dry conditions. The test results revealed that the hardness of the disks affects the friction coefficients, friction stabilities, and wear rates. Thus, the brake system using the heat-resisting steel disk requires proper heat-treatment. These differences are considered to be caused by the change in tribological mechanisms and the generation of an oxide layer on the friction surfaces. The oxide layers on the friction surfaces are confirmed to Fe₂O₃ by x-ray diffraction (XRD) and scanning electron microscope-energy dispersive spectroscopy (SEM-EDS) analysis.

• 정보과학회 논문지
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• 제44권2호
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• pp.124-131
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• 2017

고성능 컴퓨팅 환경을 위해서 최근 등장한 차세대 매니코어 프로세서는 전통적인 구조의 메모리와 함께 고대역 온-패키지 메모리를 장착하고 있다. Intel Xeon Phi Knights Landing(KNL) 프로세서의 온-패키지 메모리인 Multi-Channel DRAM(MCDRAM)은 기존의 DDR4 메모리보다 이론적으로 네 배 높은 대역폭을 제공한다. 본 논문에서는 MCDRAM을 이용하여 MPI 노드 내 통신 성능을 향상시키기 위한 방안을 제안한다. 실험 결과, 제안된 기법을 사용할 경우 DDR4를 사용하는 경우와 비교해서 MPI 노드 내 통신 성능을 최대 272% 향상시킬 수 있음을 보인다. 또한 MCDRAM 활용 방법에 따른 성능 영향뿐만 아니라 프로세스의 코어 친화도에 따른 성능 영향을 보인다.