• Proceedings of the KSMRM Conference
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• 2004.09a
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• pp.23-32
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• 2004

The chemotherapy sensitive Lewis lung carcinoma (LLC) and chemotherapy resistant Lewis lung carcinoma (CR-LLC) tumors concurrently implanted in mice, and compare these findings with histological macroscopic observations against 3D reconstruction of Fluorescence Molecular Tomography (FMT) preformed in vivo on the same animals. For the 3D image reconstruction we used 32 laser source images, a flat image and 3D surface rendering that confused for 3D Fluorescence Molecular Imaging (FMI). A minimum of ten tissue sections were analyzed per tumor for quantification of the TUNEL-positive cells, cell-associated Cy5.5-Annexin and vessel-associated Alexa Fluor-Lectin. These are useful apoptosis and angiogenesis markers, and they serve as validation experiments to data obtained in vivousing a Cy5.5-Annexin V conjugate injected intravenously in chemotherapy-treated animals carrying the tumors studied histologically. We detected higher levels of apoptosis and corresponding higher levels of Cy5.5 fluorescence in the LLC vs. the CR-LLC tumors according to tissue depth and these findings confirm that in vivo staining with the Cy5.5-Annexing conjugate correlates well with in vitro TUNEL staining and is consistent with the higher apoptotic index expected from the LLC line. There appeared to be 1.38% more apoptosis for LLC than CR-LLC. Consequently there is good correlation between the histology results and in vivo fluorescence-mediated optical imaging. In conclusion the apoptotic images of 3D FMI were validated by microscopic histological image analysis. This is a significant result for the continuous progress of fluorescence 3D imaging research.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2689-2694
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• 2016

Background: Most studies of human papilloma virus (HPV) are aimed at the natural history of the infection and its relation to cancer; however, there are few studies to assess knowledge of the general population. Our aim was analyze the degree of knowledge of Argentinians about HPV infection and its prevention. Materials and Methods: We conducted a voluntary, anonymous and non-binding survey with 27 multiple-choice items, in twelve private and public establishments, selected to include a broad population in terms of education, age and gender. The survey consisted of three sections: individual characteristics of the volunteer, HPV infection basic knowledge, its prevention and the virus relationship with other cancers. Results: One thousand two hundred ninety seven volunteers aged 18 to 80 participated. The total number of correct answers was 45.1%. The correct answers for relationship HPV and cervical cancer was 62.1%. Almost 55% did not know about types of HPV that the vaccines for protection. Statistical analysis showed that women, single people, workers, the better educated, those who have had a STDs or HPV and receiving information through medical or educational establishments had greater knowledge of the topic. Only 0.2% of participants answered all questions correctly. Conclusions: Knowledge plays an important role in health care and the deficiency found in our population could influence the success of the measures taken in the fight against cervical cancer. In this regard, we believe it would be appropriate, not only to emphasize early diagnosis and vaccine implementation, but also incorporate new communication strategies, facilitating reception of accurate and precise information by all strata of society.

• Journal of the Korean Chemical Society
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• v.53 no.1
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• pp.62-72
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• 2009

In this study, entropy definition and explanation in twelve general chemistry textbooks published in USA including what Korean universities select are analyzed. Analysis consists of two parts. One is diachronic analysis which focuses on the change between editions of same authors and the other is contents analysis composed of three sections‐ disorder in entropy definition and explanation, microstates number in entropy definition and explanation, possibility of alternative conception in learning statistical entropy and thermal entropy. As a result, the definition that entropy is the measure of disorder is denied and explanation using microstates number is introduced. Also, caution for the possibility of alternative conception that there are two different entropies is found. Reflecting the change in entropy explanation on new chemistry curriculum and reeducating teachers are meaningful on improvement of Korean chemistry education.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1391-1395
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• 2015

Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.

• Parasites, Hosts and Diseases
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• v.51 no.3
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• pp.343-347
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• 2013

Autochthonous human gnathostomiasis had never been reported in the Republic of Korea. We report here a case of Gnathostoma spinigerum infection in a 32-year-old Korean woman, presumed to have been infected via an indigenous route. The patient had experienced a painful migratory swelling near the left nasolabial fold area of the face for a year, with movement of the swelling to the mucosal area of the upper lip 2 weeks before surgical removal of the lesion. Histopathological examinations of the extracted tissue revealed inflammation with heavy eosinophilic infiltrations and sections of a nematode suggestive of a Gnathostoma sp. larva. The larva characteristically revealed about 25 intestinal cells with multiple (3-6) nuclei in each intestinal cell consistent with the 3rd-stage larva of G. spinigerum. The patient did not have any special history of travel abroad except a recent trip, 4 months before surgery, to China where she ate only cooked food. The patient is the first recorded autochthonous case of G. spinigerum infection in Korea.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.3
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• pp.192-197
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• 2014

Water analyses were conducted on 1,525 underground water laid in the western district of Korea's South Gyeongsang Province, from January 2007 until July 2010, according to sections, factors, fountainheads and inter-factor correlativities. The following are the results. 1. As a result of local incongruity rate, 18.2% in inland areas, coastal areas and 24.5% showed a high value comparatively. Costal areas showed high incongruity rate. 2. As a result of local incongruity rate, they were found that the total colony count and general bactria 39.9%, 42.6% showed a high in costal areas. 3. As a result of local factorial inspection, it was found that the turbidity content counted up to 0 to 0.2 NTU in 59.4% in inland areas, 60.2% in costal areas of sections, and in other 12.6%, 14.0%, it exceeded 0.5 NTU. As a result of local factorial inspection, it was found that the nitrate-nitrogen content counted up to 0 to 10 mg/L in 98.2% in inland areas, 97.6% in costal areas of sections, and in other 1.8%, 2.4%, it exceeded 10 mg/L. As regards chloride in coastal areas, water quality standards for chloride 250 mg/L exceeds the 1.4% higher then in inland areas. 4. Hardness in inland areas was closely correlated with total solids (r = 0.910), sulfate ion (r = 0.819). Also, total solids and boron (r = 0.600) showed high correlativities. On the other hand hardness in coastal areas was closely correlated with total solids (r = 0.919), chloride (r = 0.829). Also sulfate ion was closely correlated with hardness (r = 0.599), turbidity and aluminum (r = 0.635) showed high correlativities in this research.

• International Journal of Highway Engineering
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• v.13 no.3
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• pp.177-184
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• 2011

There are several differences between freeways and general national roads in terms of structures, conditions and limited speeds. Likewise, the characteristics of $CO_2$ emission in these roads differ depending on the road types. For these reasons, it is necessary to compare the two types of roads in terms of $CO_2$ emissions. The study was performed targeting Gyeongbu Expressway and National Highway 1. Firstly, the amount of $CO_2$ emission each car was compared in the whole sections of the both. Secondly, top 10 sections were picked out, and then $CO_2$ emission each section were compared. Lastly, two sections which were with the highest and lowest amount of $CO_2$ emission per car, were compared. As results, it were found that there were less amount of $CO_2$ emission on freeways. because cars are running on uniform velocity at relatively high speed, and that there were more amount of $CO_2$ emission on the national highway. because of frequent intersections and associated congestion. It may be concluded that the amount of $CO_2$ emission at the national highway could be reduced if signal coordination and intersection intervals are improved there.

• Journal of Korean Home Economics Education Association
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• v.24 no.3
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• pp.1-34
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• 2012

The objectives of this study are to introduce a critical perspective of the multicultural education in home economics education, to develop teaching-learning materials and to apply them in classes for the purpose of enhancing students' multicultural competence for a validity test. For these purposes, family life culture sections from six high school technology and home economics textbooks were analyzed based on the contents and elements of multicultural competence. After recomposing the family life culture sections, this study developed 12-session teaching-learning materials with an emphasis on media literacy. Among them, 4-session plans were taught in classrooms for 247 students in the 10th grades. To test the validity of the plans, a questionnaires was given to the students as a pre- and post-test. The data were analyzed with paired t-tests. The results showed significant pre and post differences in all sections of multicultural competence except the section of 'general cultural understanding'. This implied that the developed teaching-learning materials were effective in helping students overcome ethnocentrism and enhance the understanding of cultural differences.

• Journal of The Korean Association For Science Education
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• v.22 no.2
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• pp.276-285
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• 2002

In this study the concepts for science learning of physics and earth science presented in the seventh grade science textbooks for the seventh national curriculum of Korea approved by the ministry of education were analyzed in terms of the concrete and formal concept level. The parts of textbook analyzed for science learning consist of three sections in physics such as light, force, and waves, and three sections in earth science such as the structure of the earth, the substance of crust, and the movement and composition of the ocean. The analyzed results showed that the number of scientific concepts were differed from 54 to 74 in physics and from 86 to 120 in earth science depending upon publishers. In general, the concepts for science learning in the physics were found to be more in the formal level than the concrete level. However, the concepts for science learning in earth science were found to be more in the concrete level than the formal level. The analyzed results suggest that the concepts of science learning should be considered the learner's cognitive level and the sections should be disposed depending on the degree of difficulty for writing the science textbook. Therefore, it seems to be important to review carefully whether the textbook meets the object of the seventh curriculum of Korea during the process of the investigation for the science textbook.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.1
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• pp.49-56
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• 2021

The purpose of this study is to develop a methodology to select a cluster of night traffic accidents using CRP (Continuous Risk Profile) analysis. the other purpose of this study is to present the characteristics of the traffic accident cluster section selected at night using CRP analysis. The CRP analysis was performed considering traffic volume of target routes through traffic accident data. In addition, variables were set according to the freeway sections. the method of subtracting the daytime CRP from the nighttime CRP was used to analyze the nighttime traffic accident. As a result, Using the CRP analysis, the sections of hotspot were identified and plotted based on traffic accidents. Also, the sections where traffic accidents are frequent were those where IC or Tunnels were installed, and there was a deviation from the general section. In conclusion, CRP analysis could be used to calculate the frequent section of specialized traffic accidents at night, and it was selected as a point in need of improvement due to the frequent occurrence of specialized traffic accidents at night in the section where IC or tunnel facilities are installed. In addition, it is inferred that the number of specialized traffic accidents at night in the section where IC or tunnel facilities are installed is a factor in the problem of night visibility due to lighting facilities.