• 제목/요약/키워드: Gastric bleeding

검색결과 149건 처리시간 0.029초

위 사구종양 1예 (A Case of Gastric Glomus Tumor)

  • 이진성;최선택;이현욱;권병진;이지은;이시형
    • Journal of Yeungnam Medical Science
    • /
    • 제28권2호
    • /
    • pp.165-172
    • /
    • 2011
  • Gastric glomus tumor is a rare mesenchymal tumor that originates from modified smooth muscle cells of the glomus body. Glomus tumors are commonly observed in peripheral soft tissue, such as dennis or subungal region, but rarely in the gastrointestinal tract. A 39-year-old woman was admitted due to epigastric soreness. Upper gastrointestinal endoscopy revealed a subepithelial mass measuring 3.5 cm with central ulceration at the lesser curvature-posterior wall of the antrum. Characteristically, contrast enhanced abdominal computed tomography scan demonstrated high enhancement of the submucosal mass up to the same level of the abdominal aorta in the arterial phase; this enhancement persisted to delayed phase. Due to the risk of bleeding and malignancy, wedge resection of the submucosal tumor was performed. Histologic findings were compatible with a glomus tumor.

  • PDF

엉겅퀴(Cirsium japonicum var. ussuriense)추출물 및 분획물의 항위염 및 항위궤양 효과에 대한 연구 (Antigastritic and Antiulcerative Effects of Cirsium japonicum var. ussuriense Extract and Fractions)

  • 이유미;황인영;이은방;정춘식
    • 약학회지
    • /
    • 제55권2호
    • /
    • pp.160-167
    • /
    • 2011
  • Cirsium japonicum var. ussuriense (CJ) is used as a folk medicine for diuretic, arthritis, dyspepsia, and bleeding in Korea. Until now, more than fifteen kinds of CJ were identified and among them, Cirsium japonicum var. nakaianum Nakai was selected as experimental material. Both that from The Medical Herb Garden of Seoul National University located at Gayang-dong, Koyang city and native that from a hillock near Dangjin, Chungnam were collected and analyzed to determine whether it is varied in efficacy on their habitats. Extracts and fractions of CJ had a strong effect of antibacterial activity on H. pylori and antioxidant effects. And the CJ from Garden and Dangjin were showed to be more efficient in acute gastritis through the HCl${\cdot}$ethanol-induced gastric lesion test and chronic gastritis through the indomethacin-induced gastric lesion test, respectively. This study proved that the effects of CJ are varied by their habitats. Also, these results suggest that the CJ has potentials for use as functional food and medicine.

Pancreatic Arteriovenous Malformation as an Unusual Cause of Chronic Gastrointestinal Bleeding in a Patient with Early Gastric Cancer: Multimodality Imaging Spectrum with Pathologic Correlation

  • Lee, Borahm;Lee, Jeong Eun;Cho, June Sik;Shin, Kyung Sook;You, Sun Kyoung;Cheon, Kwang Sik;Song, In Sang;Kim, Kyung Hee
    • Investigative Magnetic Resonance Imaging
    • /
    • 제19권4호
    • /
    • pp.241-247
    • /
    • 2015
  • Arteriovenous malformation (AVM) of the pancreas is extremely rare, although it may be increasingly diagnosed due to the widespread use of cross-sectional imaging of the abdomen. Early diagnosis of this disease is important to prevent delay of treatment and resulting fatal complications. We report a rare case of pancreatic AVM in a 48-year-old man who presented with severe chronic anemia and early gastric cancer, which made diagnosis challenging. Imaging findings, including ultrasound, computed tomography, and magnetic resonance imaging, are shown, as well as the pathologic features.

Correlation Study Between Anemias with Higher MCV and Lower MCHC

  • Choi, Woo-Soon;Kim, Hee-Sang
    • 대한임상검사과학회지
    • /
    • 제43권1호
    • /
    • pp.12-18
    • /
    • 2011
  • The purpose of this study was to evaluate the significance of higher than normal mean corpuscular volume (MCV) and lower than normal mean corpuscular hemoglobin concentration (MCHC) in 20 patients. The hemoglobin (Hb), red blood cell indices (MCV, MCH, MCHC,), red cell distribution width (RDW), serum ferritin, serum iron (Fe) and total iron binding capacity (TIBC) were measured and the transferrin saturation were calculated. 18 (90.0%) cases were categorized as chronic diseases. Chronic renal failure, malignancy, and bleeding were all related to the cases. The mean values of hemoglobin was $9.5{\pm}2.14g/dL$; the MCV was $29.0{\pm}2.8fL$; the MCH was $30.9{\pm}1.0pg$; the MCHC was $31.2{\pm}0.5%$; the RDW was $17.0{\pm}3.6%$; serum Fe was $39{\pm}21{\mu}g/dL$; the TIBC was $219.7{\pm}108.8{\mu}g/dL$; transferrin saturation was $19.2{\pm}9.9%$ and ferritin was $445.5{\pm}499.6{\mu}g/L$ in the patients. The WHO criteria for hemoglobin of patients confirms anemia in 18 of the 20 (90.0%) cases. Anemia of chronic disease was shown in 11 (73.3%) cases; acute gastric ulcer with hemorrhage in 1 (6.7%) case; iron deficiency anemia in 1 (6.7%) case; 2 patients (13.3%) were of normal cases. There were changes in the baseline Hb level results of the 19 (95.0%) cases while no change was shown in 1 case. As a result, diseases associated with anemia and bleeding where the MCV is higher than the normal range and MCHC is lower than normal range are considered relevant findings.

  • PDF

조기위암으로 진단된 환자에서의 전복강경하 위전절제술의 초기 경험 (Totally Laparoscopic Total Gastrectomy for Early Gastric Cancer: An Initial Experience)

  • 이정선;이한홍;김진조;박승만
    • Journal of Gastric Cancer
    • /
    • 제10권1호
    • /
    • pp.26-33
    • /
    • 2010
  • 목적: 전복강경하 위전절제술(TLTG)의 방법을 보고하고 그 기술적 용이성 및 안전성을 확인하기 위하여 본 연구를 진행하게 되었다. 대상 및 방법: 2005년 2월부터 2009년 9월까지 가톨릭대학교 의과대학 인천성모병원에서 조기위암으로 진단 받은 후 TLTG를 시행 받은 11명의 환자들의 의무기록부를 후향적으로 조사하여 환자들의 임상적 특징과 수술 결과 그리고 병리학적 소견들을 분석하였다. 결과: 수술 시간은 평균 $385.6{\pm}94.1$분이었고 복강 내 문합에 소요된 시간은 평균 $97.5{\pm}60.0$분이었고 절제된 림프절의 개수는 평균 47개였다. 유동식 섭취 개시 시기는 수술 후 평균 $6.1{\pm}7.6$일이었고 수술 후 재원 기간은 평균 $14.2{\pm}11.9$일이었다. 개복 수술로의 전환 예는 없었고 수술 중 합병증이 2예, 수술 후 합병증이 3예에서 발생하였으며 한 예의 수술 사망 예가 있었는데 환자는 수술 후 4일째 혈소판 수혈에 반응하지 않는 원인불명의 혈소판 감소증이 발생하여 수술 후 6일째 복강 내 출혈에 의해 사망하였다. 결론: TLTG는 기술적으로 용이하였고 비교적 안전하였다. 그러나 긴 복강 내 문합 시간과 수술 시간은 향후 해결해야 할 과제이다.

위에 발생한 원발성 융모막암 (Primary Gastric Choriocarcinoma)

  • 전경화;정지한;진형민;김욱;박조현;전해명;박승만;임근우;박우배;김승남
    • Journal of Gastric Cancer
    • /
    • 제8권1호
    • /
    • pp.47-52
    • /
    • 2008
  • 융모막암은 임신과 연관되어 발생하는 악성 종양으로 주로 자궁에서 발생한다. 위장관에서도 융모막암이 발생할 수 있는데 매우 드물고 다른 장기의 융모암과 다른 발생 기전을 가진다. 원발성 위융모암은 치료 성적이 나쁘고 전이 속도가 빨라서 예후가 매우 나쁘다. 저자들은 혈변, 상복부 통증을 주소로 내원한 69세 여자 환자에서 수술전 진행성 저분화형 위선암으로 진단되어 위아전절제술을 시행하였으나 수술 후 위 전정부의 원발성 융모막암으로 진단된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 융모막암 치료 원칙은 수술적 절제술과 보조적 항암 화학치료이지만 생존율 증가가 입증된 치료 방법은 아직 없는 실정이다. 그러므로 저분화도를 보이거나 출혈 경향을 보이는 위암인 경우에는 융모막암의 가능성도 염두에 두고 적극적인 검사가 이루어져야 할 것으로 생각된다.

  • PDF

알코올성 위염에 대한 조구등(釣鉤藤)의 항염증 효과 (Anti-inflammatory effect of Uncariae Ramulus et Uncus on alcohol-induced gastritis)

  • 이진아;이태종;김진영;신미래;박해진;노성수
    • 대한본초학회지
    • /
    • 제37권5호
    • /
    • pp.63-74
    • /
    • 2022
  • Objective : Gastritis refers to an inflammatory disease of the gastric mucosa. Alcohol is one of the main aggression factors, causing bleeding and inflammation in the gastric mucosa and it is known to not only increase lipid peroxide levels, but also deplete key antioxidant factors. The purpose of this study was to determine the effect of Uncariae Ramulus et Uncus water extract (URW) in alcohol-induced gastritis. Methods : The total polyphenol and flavonoid contents of URW were confirmed through an in vitro experiment. Also, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) activity were confirmed. For in vivo experiments, mice were divided into 4 groups (n=8). Also, 1 hr after oral administration of each drug, 50% ethanol was orally administered to induce gastritis. Results : As a result of in vitro experiments, URW showed excellent antioxidant activity. In alcohol-induced gastritis, URW alleviated the damage to the gastric mucosa caused by alcohol. Also, URW decreased reactive oxygen species (ROS) and malondialdehyde (MDA) levels in serum and gastric tissues, and significantly decreased the expression of NADPH oxidases in gastric tissues. In addition, it significantly modulated the nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and nuclear factor-𝜅B p65 (NF-𝜅B) pathways as well as significantly increased the expression of anti-inflammatory proteins. Conclusions : These results suggest that URW not only reduces oxidative stress through excellent antioxidant activity but also relieves gastric mucosal inflammation as a regulator of Nrf2 and NF-𝜅B pathways.

Effect of Route of Preoperative Biopsy on Endoscopic Submucosal Dissection for Patients with Early Gastric Cancer

  • Jiang, Hui;Tu, Hui-Ming;Qiao, Qiao;Xu, Ke-Bin;Li, Jie;Qi, Xiao-Wei;Ge, Xiao-Song
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제15권20호
    • /
    • pp.8917-8921
    • /
    • 2014
  • Objective: To observe and compare the effects of multi-patch biopsy under conventional white light imaging endoscopy (C-WLI) and precise targeted biopsy under magnifying narrow-band imaging endoscopy (M-NBI) on the endoscopic submucosal dissection (ESD) of early gastric cancers and intraepithelial neoplasias. Methods: According to the way of selecting biopsy specimens, patients were divided into C-WLI and M-NBI groups, 20 cases. The ESD operations of the 2 groups were compared quantitively. Results: The mean frequency of biopsy in M-NBI group was ($1.00{\pm}0.00$), obviously lower than in the C-WLI group ($4.78{\pm}1.02$) (P<0.01).The average total number of selected biopsy specimens was also fewer ($1.45{\pm}0.12$ and $7.82{\pm}2.22$, respectively, P<0.01). There was no significant difference in the time of determining excision extension, marking time and the time of specimen excision of 2 groups during the ESD (P>0.05), whereas submucosal injection time, mucosal dissection time, stopping bleeding time, wound processing time in the M-NBI group were significantly shorter than in the C-WLI group (P<0.01). Conclusion: Precise targeted biopsy under M-NBI can obviously shorten the time of ESD operation, with small quantity of tissues but high pathological positive rate.

육군자탕의 정제 개발과 성분함량 및 약리효과 평가 (Development of tablets and evaluation of ingredient content and pharmacological effects of Yukgunja-tang)

  • 김명진;최혜민;유병우;홍영주;라채숙;김민주;김정옥
    • 대한본초학회지
    • /
    • 제36권1호
    • /
    • pp.67-76
    • /
    • 2021
  • Objective : Yukgunja-tang is one of the herbal prescriptions widely used for functional indigestion. In this study, we evaluated the pharmacological effect through the Yukgunja-tang formulation development. Methods : The RAW 264.7 cells were pretreated with Yukgunja-tang tablet (YGJT-T : 50, 100 and 200 ㎍/㎖) and then stimulated with lipopolysaccharide (LPS : 500 ng/㎖). Cell viability, inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) and inflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured. Also, ICR mice induced acute gastritis by oral administration of 150 mM HCl in 60% ethanol. The YGJT-T (30 mg/kg) was pretreated for 3 days, and 150 mM HCl in 60% ethanol was orally administered 1 hour after the last drug treatment. Mice were sacrificed 1 hour after oral administration of 150 mM HCl in 60% ethanol. The gastric mucosa was observed, and inflammatory cytokines in the gastric tissue were measured. Results : The marker components of YGJT-T were determined by simultaneous analysis using HPLC. In RAW 264.7 cells, pretreatment of YGJT-T was non-toxic and inhibited the production of inflammatory mediators such as NO and PGE2 and suppressed inflammatory cytokines. In addition, pretreatment of YGJT-T improved bleeding and edema due to gastric lesions caused by acute gastritis and suppressed inflammatory cytokines. Conclusion : In summary, our results confirmed that treatment with YGJT-T has anti-inflammatory and anti-gastritis effects in vitro and in vivo. Therefore, in this study, YGJT-T could support a potential strategy for the prevention and treatment of gastritis.

만성 소화성 궤양에 합병된 위출구 폐색의 수술적 치료 (Surgical Treatment for Chronic Peptic Ulcer with Gastric Outlet Obstruction)

  • 이제희;양시준;전영웅;박세혁;김종흥;박종민
    • Journal of Gastric Cancer
    • /
    • 제8권3호
    • /
    • pp.160-165
    • /
    • 2008
  • 목적: 소화성 궤양의 급만성 합병증으로 대표되는 천공, 출혈, 협착의 수술적 치료에서 Helicobacter pylori (H. pylori) 제균요법과 proton pump inhibitor의 도입, 중재적 내시경 치료와 같은 비수술적 치료의 발달로 천공, 출혈 등의 급성기 합병증의 수술은 점차 감소되고 있다. 그러나 내과적 소화성 궤양의 협착, 폐색에 대한 비수술적 치료의 결과는 만족스럽지 못한 상태로 수술의 역할이 중요하다. 이에 저자들은 만성 소화성 궤양으로 위출구 폐색을 동반한 환자들의 수술적 치료 후 임상결과를 분석하고자 하였다. 대상 및 방법: 1994년 1월부터 2007년 12월까지 국립의료원 외과에서 소화성 궤양 폐색으로 수술한 31명의 환자를 후향적으로 분석하였고, 이전의 궤양 수술로 인한 유착성 폐색 및 천공이나 출혈로 인한 응급수술시 발견된 폐색동반의 예는 제외하였다. 각 임상병리학적 결과를 수술방법에 따라 우회수술군과 절제수술군으로 분류하였고, 수술결과의 평가는 Visick score를 이용하였다. 수술 후 재발의 기준은 소화성 궤양의 임상증상이 나타나 내시경으로 확진된 경우만을 포함하였다. 결과: 우회수술군이 6명(19.4%), 절제수술군이 25명(80.6%)이었다. 평균 연령은 57.5세(25~81세)이었고, 남자 29명(93.5%), 여자 2명(6.5%)이었다. 평균 증상 지속기간 29.6개월이었고, 흡연자가 19명(61.3%), NSAID 복용자가 6명(19.4%), H. pylori 양성환자가 7명(22.6%) 있었다. 수술 전 내시경적 확장술은 2명에서 시도되었으며, 주병변의 위치는 위, 십이지장이 각각 9명, 20명, 양쪽이 2명이었다. 수술 후 합병증은 13명 (41.9%)에서, 궤양의 재발은 2명(6.5%)에서 있었고, 재수술이 4명(12.9%)에서 필요하였다. 평균 Visick score는 1.8 (1~4)이었다. 우회수술군과 절제수술군의 비교에서 두 군의 임상병리학적 차이는 없었으며, 두 군에서 각각 1명이 재발되었고 합병증은 각각 5명(83.3%), 8명(32%)으로 우회수술군에서 많았으나 통계적 유의성은 없었다(P=0.175). 평균 Visick score는 각각 3.0점, 1.6점으로 절제수술군에서 좋은 결과를 보였다(P=0.001). 결론: 만성 소화성 궤양으로 배출구 폐색을 동반한 환자의 치료에 있어서 내시경적 확장술 등의 비수술적 치료가 비교적 좋은 결과를 보고하고 있지만 여전히 수술은 중요한 치료 방법이다. 궤양 폐색의 수술적 치료시 악성 궤양과의 감별이 용이하지 않고 수술 후 환자의 만족도를 고려한다면 우회수술보다는 절제수술이 바람직한 술식으로 생각된다.

  • PDF