YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antigastritic and Antiulcerative Effects of Cirsium japonicum var. ussuriense Extract and Fractions

엉겅퀴(Cirsium japonicum var. ussuriense)추출물 및 분획물의 항위염 및 항위궤양 효과에 대한 연구

  • Received : 2011.03.14
  • Accepted : 2011.04.19
  • Published : 2011.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Cirsium japonicum var. ussuriense (CJ) is used as a folk medicine for diuretic, arthritis, dyspepsia, and bleeding in Korea. Until now, more than fifteen kinds of CJ were identified and among them, Cirsium japonicum var. nakaianum Nakai was selected as experimental material. Both that from The Medical Herb Garden of Seoul National University located at Gayang-dong, Koyang city and native that from a hillock near Dangjin, Chungnam were collected and analyzed to determine whether it is varied in efficacy on their habitats. Extracts and fractions of CJ had a strong effect of antibacterial activity on H. pylori and antioxidant effects. And the CJ from Garden and Dangjin were showed to be more efficient in acute gastritis through the HCl${\cdot}$ethanol-induced gastric lesion test and chronic gastritis through the indomethacin-induced gastric lesion test, respectively. This study proved that the effects of CJ are varied by their habitats. Also, these results suggest that the CJ has potentials for use as functional food and medicine.

Keywords

References

  1. Galbraith, R. A. : Sexual side effects of drugs. Drug Ther (NY) 21, 38 (1991).
  2. Pietrangelo, A., Borella, F., Casalgrandi, G., Montosi, G., Ceccarelli, D., Gallesi, D., Giovannini, F., Gasparetto, A. and Masini, A. : Antioxidant activity of silybin in vivo during longterm iron overload in rats. Gastroenterology 109, 1941 (1995). https://doi.org/10.1016/0016-5085(95)90762-9
  3. Itoh, M. and Guth, P. H. : Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 88, 1162 (1985). https://doi.org/10.1016/S0016-5085(85)80075-5
  4. Yoshikawa, T., Ueda, S., Naito, Y., Takahashi, S., Oyamada, H., Morita, Y., Yoneta, T. and Kondo, M. : Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun. 7, 285 (1989). https://doi.org/10.3109/10715768909087953
  5. Naito, Y., Yoshikawa, T., Kaneko, T., Iinuma, S., Nishimura, S., Takahashi, S. and Kondo, M. : Role of oxygen radicals in indomethacin-induced gastric mucosal microvascular injury in rats. J. Clin. Gastroenterol. 17, 99 (1993). https://doi.org/10.1097/00004836-199312001-00018
  6. Hiraishi, H., Terano, A., Ota, S., Ivey, K. J. and Sugimoto, T. : Oxygen metabolite-induced cytotoxicity to cultured rat gastric mucosal cells. Am. J. Physio. 253, 40 (1987).
  7. Wadhwa, S. S. and Perry, M. A. : Gastric injury induced by hemorrhage, local ischemia, and oxygen radical generation. Am. J. Physiol. 253, 129 (1987).
  8. Hahm, K. B., Park, I. S., Kim, Y. S., Kim, J. H., Cho, S. W., Lee, S. I. and Youn, J. K. : Role of rebamipide on induction of heatshock proteins and protection against reactive oxygen metabolite-mediated cell damage in cultured gastric mucosal cells. Free Radic. Biol. Med. 22, 711 (1997). https://doi.org/10.1016/S0891-5849(96)00406-6
  9. EliaKim, R., Karmeli, F., Okon, E. and Rachmilewitz, D. : Ketotofen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats. Dig. Dis. Sci. (United States) 40, 1140 (1995). https://doi.org/10.1007/BF02064212
  10. Shay, H., Komarov, S. A., Fels, S. S., Meranz, D., Gruenstein, M. and Siplet, H. : A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 4, 43 (1945).
  11. Kim, J. M., Shin, J. E., Han, M. J., Baek, N. I. and Kim, D. H. : Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori. Natural Product Science 9, 158 (2003).
  12. Choi, C. H., Cha, Y. J., An, C. S., Kim, K. J., Kim, K. C., Moon, S. P., Lee, Z. H. and Min, Y. D. : Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein. Cancer. Cell. Int. 4, 6 (2004). https://doi.org/10.1186/1475-2867-4-6
  13. Mizui, T. and Dodeuchi, M. : Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol. 33, 939 (1983). https://doi.org/10.1254/jjp.33.939
  14. Kasuya, Y., Urushidani, T. and Okabe, S. : Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat. Jpn. J. Pharmacol. 29, 670 (1979). https://doi.org/10.1254/jjp.29.670
  15. Kitagawa, H., Takeda, F. and Kohe, H. : A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats. Arzneimittelforschung 36, 1240 (1986).
  16. Uchiyama, M., Suzuki, Y. and Fukuzawa, K. : Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi 88, 678 (1968). https://doi.org/10.1248/yakushi1947.88.6_678
  17. Oyaizu, M. : Studied on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr. 44, 307 (1986). https://doi.org/10.5264/eiyogakuzashi.44.307
  18. Nishimiki, M., Rao, N. A., Appaji, N. and Yagi, K. : The occurrence of superoxide anion in the reaction of reduced henazine methosulfate and molecular oxygen. Biochemical and Biophysical Research Communications. 46, 849 (1972). https://doi.org/10.1016/S0006-291X(72)80218-3
  19. Ito, M., Shii, D., Segami, T., Kojima, R. and Suzuki, Y. : Preventive actions of Z-103 through increase in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol induced gastric mucosal damage in rats. Jpn. J. Pharmacol. 59, 267 (1992). https://doi.org/10.1254/jjp.59.267
  20. Ayasolla, K., Khan, M., Singh, A. K. and Singh, I. : Inflammatory mediator -and amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic. Biol. Med. 37, 325 (2004). https://doi.org/10.1016/j.freeradbiomed.2004.04.007
  21. Ayasolla, K. R., Giri, S., Singh, A. K. and Singh, I. : 5- Aminoimidazole-4-carboxamide-I-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Apeptide-induced inflammatory mediators in astroglia. J. Neuroinflammation 2, 21 (2005). https://doi.org/10.1186/1742-2094-2-21