• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제9권1호
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• pp.75-79
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• 2006

저자들은 장중첩증의 관장 정복 후 입원 관찰 기간 동안에 2차례 더 재발한 장중첩증을 가진 5세여 아에서 복부 CT 촬영으로 선두를 확인하고 복강경으로 치료한 이소성위점막과 췌조직을 동시에 가진 멕켈 게실에 의한 장중첩증 1예를 경험하였기에 문헌 고찰과 함께 보고한다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.261-272
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• 2021

Doxorubicin (Dox) is widely used to the treatment of cancer, however, it could cause damage to gastric mucosa. To investigate the protective effects and related mechanisms of coenzyme Q10 (CoQ10) and vitamin C (VC) on Dox-induced gastric mucosal injury, we presented the survey of the 4 groups of the rats with different conditions. The results showed Dox treatment significantly induced GES-1 apoptosis, but preconditioning in GES-1 cells with VC or CoQ10 significantly inhibited the Dox-induced decrease and other harm effects, including the expression and of IκKβ, IκBα, NF-κB/p65 and tumor necrosis factor (TNF-α) in GES-1 cells. Moreover, high-throughput sequencing results showed Dox treatment increased the number of harmful gut microbes, and CoQ10 and VC treatment inhibited this effect. CoQ10 and VC treatment inhibits Dox-induced gastric mucosal injury by inhibiting the activation of the IkKB/IκBα/NF-κB/p65/TNF-α pathway, promoting anti-inflammatory effects of gastric tissue and regulating the composition of the intestinal flora.

• Journal of Gastric Cancer
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• 제10권4호
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• pp.162-167
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• 2010

Purpose: The incidence of lymph node metastasis has been reported to range from 2.6 to 4.8% in early stage gastric cancer with mucosal invasion (T1a cancer). Lymph node metastasis in early stage gastric cancer is known as an important predictive factor. We analyzed the prediction factors of lymph node metastasis in T1a cancer. Materials and Methods: A total of 9,912 patients underwent radical gastrectomy due to gastric cancer from October 1994 to July 2006 in the Department Of Surgery at Samsung Medical Center. We did a retrospective analysis of 2,524 patients of these patients, ones for whom the cancer was confined within the mucosa. Results: Among the 2,524 patients, 57 (2.2%) were diagnosed with lymph node metastasis, and of these, cancer staging was as follows: 41 were N1, 8 were N2, and 8 were N3a. Univariate analysis of clinicopathological factors showed that the following factors were significant predictors of metastasis: tumor size larger than 4 cm, the presence of middle and lower stomach cancer, poorly differentiated adenocarcinoma and signet-ring cell carcinoma, diffuse type cancer (by the Lauren classification), and lymphatic invasion. Multivariate analysis showed that lymphatic invasion and tumor larger than 4 cm were significant factors with P<0.001 and P=0.024, respectively. Conclusions: The frequency of lymph node metastasis is extremely low in early gastric cancer with mucosal invasion. However, when lymphatic invasion is present or the tumor is larger than 4 cm, there is a greater likelihood of lymph node metastasis. In such cases, surgical treatments should be done to prevent disease recurrence.

• 한국식품과학회지
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• 제37권1호
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• pp.84-89
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• 2005

민들레 (Taraxacum mongolicum H.) 추출물에 대한 위장보호효과를 측정하기 위하여 민들레를 ethanol로 추출한 후 methylene chloride과 n-butanol을 이용하여 용매의 극성에 따라 순차적으로 추출물을 분획하여 각 분획물을 얻었다. 이들 분획물로 총플라보노이드 및 luteolin 함량을 측정하고 H. pylori 항균작용, urease 저해 효과, 프리라디칼소거작용, 세포막 보호 효과에 대해 시험하였다. 각 분획물의 총 플라보노이드와 luteolin 함량을 측정을 한 결과 n-butanol 분획에서 각각 27.75%, 1.14%로 다른 분획들보다 2가지 성분 모두 가장 많이 함유하고 있었다. 효능 시험에서도 n-butanol 분획은 위장 질환을 일으키는 직접적인 요인 중 하나인 H. pylori에 대한 항균 및 urease 저해 시험에서 다른 분획물 보다 좋은 결과를 보였다. 또한, 위장 장애의 간접적인 요인이 될 수 있는 라디칼의 소거 작용 및 활성산소로부터 세포막 보호에 대한 각 분획물의 시험에서도 n-butanol 분획물이 가장 우수한 효과를 나타내었으며 DPPH 라디칼소거능의 $SC_{50}$ 값은 $47{\mu}g/ml$, 세포막 보호실험에서 ${\tau}_{50}$=172min$(C=5.0{\mu}g/mL)$이었다. 따라서 각 분획물의 성분 분석과 수행되어진 효능 실험 결과들을 비교하여 볼 때 민들레 추출물의 n-butanol 분획물이 위점막 보호에 효과가 있음을 예측할 수 있었으며 위장 보호를 위한 조성물의 성분으로 사용될 수 있음을 시사하였다.

• 한국자원식물학회지
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• 제28권1호
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• pp.1-8
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• 2015

본 연구는 산약(Dioscorea Rhizoma)이 급성 위궤양을 유발한 흰쥐의 위장 장애에 미치는 효과를 조사하였다. 산약 분말사료를 섭이한 실험군과 산약 분말액을 투여한 실험군의 궤양성 출혈은 1 일 이상 진행되었으나 시간이 경과함에 따라 서서히 호전되었으며, 특히 산약즙을 처리한 실험군의 경우 급성 위궤양 유발직후에 국소적인 위점막 울혈만이 관찰되었다. 또한 산약분말액과 산약즙을 투여한 실험군에서는 급성 위괘양 유발 후 증가되는 gastrin과 histamine의 농도가 감소되어 산약이 위산의 과다 분비를 억제하는 것으로 조사되었으며, 산약을 투여한 모든 실험군에서 과도한 지질과산화물의 생성이 감소되었다. 이와 더불어 산약의 투여는 급성 위궤양에 의해 급격하게 증가된 SOD와 GPX의 활성을 감소시키는 반면, CAT의 활성은 높여주어 조직 내 항산화효소 활성을 정상 수준으로 회복시켜주는 것으로 나타났다. 따라서 산약은 급성 위궤양에 의한 위 조직의 손상을 감소시키고 혈장 성분과 항산화효소의 활성을 정상수준으로 회복시켜 위궤양으로부터 위장기능을 개선하는데 높은 효과가 있을 것으로 사료된다.

• 대한임상검사과학회지
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• 제37권3호
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• pp.190-196
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• 2005

Helicobacter pylori (H. pylori) infection is uncommon in developed countries, yet is common in underdeveloped and developing countries. Infection rate of H. pylori is minimally influenced by economic, environmental, and public health status and genetic factors. Korea is a developing country with a high incidence of H. pylori infection and gastric carcinoma, which is one of the leading causes of death. For this reason, accurate clinical and pathologic data on H. pylori-associated disease are very important. Intestinal metaplasia accompanies chronic gastritis and increases the risk of gastric carcinoma. For this reason, the relationship between H. pylori infection and intestinal metaplasia is very closely linked. Because of this, as the antecedent condition is guessed, it examines the relationship of the H. pylori and the intestinal metaplasia. Intestinal metaplasia is thought to be the basis in the development of intestinal type gastric carcinomas. Recent investigations showed that inflammatory reaction in the gastric fundus affect the development of gastric carcinogenesis. To verify neutrophilic activity in the gastric fundus and development of intestinal metaplasia in both gastric fundus and antral mucosa, their relationship was studied using 159 healthy patients who had undergone gastric endoscopic biopsies without any identifiable pathologic disesaes. When neutrophilic activity accompanied, incidence of intestinal metaplasia was significantly increased (p<0.05). H. pylori infection was statistically and significantly associated with the presence of intestinal metaplasia (p<0.05). These results suggest that H. pylori infection affected the development of intestinal metaplasia in the stomach. These results will help our understanding of H. pylori infection in the pathogenesis of intestinal metaplasia, a preneoplastic condition of the stomach. To reduce the incidence of gastric adenocarcinoma, eradication treatment of H. pylori is recommended when there's a neutrophilic activity in the gastric fundus.

• 대한한방내과학회지
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• 제34권4호
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• pp.362-374
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• 2013

Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice. Methods : Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution. Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p<0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p<0.05). Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.

• 대한이식학회지
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• 제32권4호
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• pp.104-107
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• 2018

Mucormycosis is an extremely rare but potentially life-threatening fungal infection. Gastrointestinal (GI) mucormycosis is very rare and occurs primarily in highly malnourished patients, especially in infants and children. A 55-year-old man with end-stage renal disease due to diabetic nephropathy, who had undergone deceased donor kidney transplantation 2 years prior, complained of abdominal pain and distension with a 3-day duration. Computed tomography revealed diffuse gastric wall thickening, and a huge amount of grey colored necrotic debris surrounded by erythematous erosive mucosa was observed at the antrum to upper body by GI endoscopy. The microscopic examination obtained from a GI endoscopic specimen demonstrated peptic detritus with numerous non-septate mucor hyphae in the mucosa and submucosa. Mucormycosis was diagnosed based on the clinical findings and morphological features. A total gastrectomy was performed and an antifungal agent was administered. A microscopic examination of the surgical specimen demonstrated invasive mucormycosis with numerous fungal hyphae with invasion into the mucosa to subserosa. The patient and graft were treated successfully by total gastrectomy and antifungal therapy.

• Radiation Oncology Journal
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• 제17권4호
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• pp.314-320
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• 1999

목적 : Paclitaxel(Toxol)은 미소관의 집합을 촉진시키고 분해를 방지하는 미소관 억제제로서 이 작용은 세포주기 중 방사선에 예민한 G2fM 시기에 일어나기 때문에 방사선조사와 병용할 경우 방사선감작제 가능성이 있다. Paclitaxel과 방사선조사를 병용하여 흰쥐의 위점막에서 paclitaxe이 방사선의 효과에 미치는 영향을 파악하기 위하여 본 연구를 시행하였다. 대상 및 방법 : 실험군은 paclitaxel 단독군, 방사선조사 단독군 및 paclitaxel과 방사선조사 병용군의 세 군으로 분류하여 paclltaxel 단독군은 paclitaxel (10 mg/kg)을 복강내 1회 주입하였고, 방사조사 단독군은 8 Gy를 전복부에 단일 조사하였으며, paclitaxel과 방사선조사 병용군은 paclitaxel (10 mg/kg)을 복강내 주입 후 24시간에 방사선조사 단독군과 동일한 방법으로 방사선조사하였다. 실험 완료 후 위점막 내 유사분열수, apoptosis와 기타 점막의 변화를 시간별로(6, 24시간, 3일 및 5일) 비교관찰하였다. 결과 : Paclitaxel 주입 후 위점막 내 유사분열은 증가하지 않았고 apoptosis는 6시간에 $5.75\%$였고 3일까지 비슷하게 지속되었다. Paclitaxel 주입 후 경미한 위선의 확장이 24시간에 관찰되었고, 세포의 비정형이 24시간과 3일에 보였으나 5일에는 정상으로 회복되었다. 방사선조사 단독군에서 apoptosis는 6시간에 $6.0\%$로 가장 많았으며 24시간에 $1.25\%$로 감소되었고 5일까지 지속되었다. 위선의 확장과 세포의 비정형은 방사선조사 후 6시간부터 5일까지 계속해서 경미하게 보였다. Paclltaxei과 방사선조사 병용군은 apoptosis가 6, 24시간, 3일 및 5일에 각각 5.5, 4.5, 4.0, $4.0\%$로 방사선조사 단독군에 비하여 24시간부터 많아졌고 3일에는 통계학적으로 유의한 차이가 있었다. 위선의 확장과 세포의 비정형은 Paclitaxel과 방사선조사 병용군에서 방사선조사 단독군에 비하여 증가되지 않았다. 결론 : 흰쥐의 위점막은 paclitaxel 주입 후 24시간에 방사선조사를 시행한 결과 apoptosis를 종말점으로 볼 때 paclitaxel의 첨가효과만을 보여 주었다.

• 동의생리병리학회지
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• 제18권1호
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• pp.187-193
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• 2004

Constipation is a common clinical problem that comprises of symptoms that include excessive straining, hard feces, feeling of incomplete evacuation and infrequent defecation. Although many conditions, such as metabolic problems, fiber deficiency, anorectal problem, an drug, can cause constipation. This study was examined the effects of Chilsun-Whan on intestinal mucosa and gastrointestinal transit time and plasma lipids in rats. Adult male rats were fed for weeks on diets containing no addition(basal diet group), 5% cellulose(cellulose group) and 2.5% . Chilsun-Whan group(Chilsun-Whan group). The results were as follows; 1. The fecal weght was significantly increased 2 times in Chilsun-Whan administrated group compare to basal diet group. 2. The gastrointestinal transit times was significantly decreased in Chilsun-Whan administrated group compare to basal diet. 3. Carmine red mixed with Chilsun-Whan, as a marker, was administered through a gastric tube for stomach or intracecally by a chronically implanted catheter for colon transit. Small intestinal transit and large intestinal transit time were significantly decreased in Chilsun-Whan administrated group compare to basal diet. 4. The height of jejunal villi was developed in Chilsun-Whan administrated group compare to basal diet The thickness of mucosa and muscle layer of colonic mucosa were significantly developed in Chilsun-Whan administrated group compare to basal diet group. 5. The change of goblet cell in colonic mucosa was increased acid mucin stained alcian blue in Chilsun-Whan administrated group compare to basal diet and cellulose group. 6. HDL-cholesterol of plasma lipid was increased in Chilsun-Whan administrated group compare to basal diet and cellulose groups. Theses results suggests that Chilsun-Whan may be used in prevention and treatment of constipation resulting in increase of fecal weight, decrease of gastrointestinal transit time. development of intestinal villi, intensify of stainability of acid mucin in colon.