• 물과 미래
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• 제28권5호
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• pp.117-127
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• 1995

해상도를 고려하는 GIUH 모형에 대한 적용과 분석을 평창강 유역의 소유역인 이목정유역에 대하여 수행하였다. 모형의 적용과 Fractal 분석을 위해 1:25,000, 1:50,000 그리고 1:100,000 축척의 지도를 이용하였다. 따라서 축척간의 비율이 일정한 값을 갖는다. 링크의 길이는 해상도 1mm의 구장기를 이용하였고 Fractal 차원은 Richardson 방법을 사용하였다. 지도의 축척에 따라 매개변수들의 현저한 변화를 발견하였으며 이러한 경향은 매개변수의 물리적 의미를 상실하게 한다. 그런데 Fractal 변환과 의 Melton지형법칙은 이러한 규모문제를 효과적으로 조정해주는 역할을 할 수 있다. 그리고 이 방법은 하도망과 유역간의 연관성을 모형에 반영할 수 있는 장점이 있다. 이 연구에서 제안한 GIUH의 적용성을 검증하기 위해 지수형 GIUH 모형과 비교하였다. 그 결과 제안된 2모수 gamma GIUH 모형이 좋은 재현성을 보였다. 따라서 Fractal 이론을 도입한 2모수 gamma GIUH 모형은 축척을 고려하는 IUH를 유도하는데 있어서 적절하다고 할 수 있다.

• Biomolecules & Therapeutics
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• 제20권6호
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• pp.526-531
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• 2012

During our on-going studies to identify bioactive compounds in medicinal herbs, we found that saucerneol F (SF), a naturally occurring sesquilignan isolated from Saururus chinensis (S. chinensis), showed in vitro anti-inflammatory activity. In this study, we examined the effects of SF on the generation of 5-lipoxygenase (5-LO) dependent leukotriene $C_4$ ($LTC_4$), cyclooxygenase-2 (COX-2) dependent prostaglandin $D_2$ ($PGD_2$), and on phospholipase $C{\gamma}1$ ($PLC{\gamma}1$)-mediated degranulation in SCF-induced mouse bone marrow-derived mast cells (BMMCs). SF inhibited eicosanoid ($PGD_2$ and $LTC_4$) generation and degranulation dose-dependently. To identify the molecular mechanisms underlying the inhibition of eicosanoid generation and degranulation by SF, we examined the effects of SF on the phosphorylation of $PLC{\gamma}1$, intracellular $Ca^{2+}$ influx, the translocation of cytosolic phospholipase $A_2$ ($cPLA_2$) and 5-LO, and on the phosphorylation of MAP kinases (MAPKs). SF was found to reduce intracellular $Ca^{2+}$ influx by inhibiting $PLC{\gamma}1$ phosphorylation and suppressing the nuclear translocations of $cPLA_2$ and 5-LO via the phosphorylations of MAPKs, including extracellular signal-regulated protein kinase-1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38. Taken together, these results suggest that SF may be useful for regulating mast cell-mediated inflammatory responses by inhibiting degranulation and eicosanoid generation.

• 한국의학물리학회지:의학물리
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• 제28권2호
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• pp.54-60
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• 2017

This study was designed to measure transit dose with an electronic portal imaging device (EPID) in eight patients treated with intensity modulated radiotherapy (IMRT), and to verify the accuracy of dose delivery to patients. The calculated dose map of the treatment planning system (TPS) was compared with the EPID based dose measured on the same plane with a gamma index method. The plan for each patient was verified prior to treatment with a diode array (MapCHECK) and portal dose image prediction (PDIP). To simulate possible patient positioning errors during treatment, outcomes were evaluated after an anthropomorphic phantom was displaced 5 and 10 mm in various directions. Based on 3%/3 mm criteria, the $mean{\pm}SD$ passing rates of MapCHECK, PDIP (pre-treatment QA) for 47 IMRT were $99.8{\pm}0.1%$, $99.0{\pm}0.7%$, and, respectively. Besides, passing rates using transit dosimetry was $90.0{\pm}1.5%$ for the same condition. Setup errors of 5 and 10 mm reduced the mean passing rates by 1.3% and 3.0% (inferior to superior), 2.2% and 4.3% (superior to inferior), 5.9% and 10.9% (left to right), and 8.9% and 16.3% (right to left), respectively. These findings suggest that the transit dose-based IMRT verification method using EPID, in which the transit dose from patients is compared with the dose map calculated from the TPS, may be useful in verifying various errors including setup and/or patient positioning error, inhomogeneity and target motions.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.307.1-307.1
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• 2002

Inflammation is a frequent radiation-induced following therapeutic irradiation. Since the upregulation of adhesion molecules on endothelial cell surface has been known to be associated with inflammation. interfering with the expression of adhesion molecules is an important therapeutic target. We examined the effect of allicin. a major component of garlic. on the induction of intercellular adhesion molecule-1 (lCAM-1) by gamma-irradiation and the mechanisms of its effect in gamma-irradiated human umbilical vein endothelial cells (HUVECs). (omitted)

• 대한수학회지
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• 제38권4호
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• pp.697-709
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• 2001

Generalized forms of the von neumann-Sion type minimax theorem, the Fan-Ma intersection theorem, the Fan-a type analytic alternative, and the Nash-Ma equilibrium theorem hold for generalized convex spaces without having any linear structure.

• 대한수학회논문집
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• 제15권3호
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• pp.549-553
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• 2000

For a continuous map of the circle to itself, we give necessary and sufficient conditions for the $\omega$-limit set of each nonwandering point to be minimal.

• 지구물리와물리탐사
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• 제14권1호
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• pp.116-120
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• 2011

방사성원소 비는 방사성 특성의 미묘한 변화를 지도형태의 자료로 만드는데 유용하다. 그러나 방사성원소비를 계산하는 전통적인 방법은 만약 비를 구성하는 방사성원소 중 단 하나라도 평균값에 비해 적은 분산을 갖는 농축 추정치를 갖는다면 방사성원소비 지도 작성에 중요한 영향을 주지 못하게 되어 커다란 한계를 갖게 된다. 이와는 달리 만약 비를 구하기 전에 분자와 분모를 모두 거의 같은 평균과 분산으로 정규화 시켜준다면 방사성원소들은 지도가 작성되는 영역에서 원소들 사이의 차이를 부각시키는데 동일하게 기여하게 될 것이다.

• 대한수학회지
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• 제50권4호
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• pp.865-877
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• 2013

The disjoint union of mapping class groups of surfaces forms a braided monoidal category $\mathcal{M}$, as the disjoint union of the braid groups $\mathcal{B}$ does. We give a concrete and geometric meaning of the braidings ${\beta}_{r,s}$ in $\mathcal{M}$. Moreover, we find a set of elements in the mapping class groups which correspond to the standard generators of the braid groups. Using this, we can define an obvious map ${\phi}\;:\;B_g{\rightarrow}{\Gamma}_{g,1}$. We show that this map ${\phi}$ is injective and nongeometric in the sense of Wajnryb. Since this map extends to a braided monoidal functor ${\Phi}\;:\;\mathcal{B}{\rightarrow}\mathcal{M}$, the integral homology homomorphism induced by ${\phi}$ is trivial in the stable range.

• 대한방사선기술학회지:방사선기술과학
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• 제46권3호
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• pp.231-238
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• 2023

This study aimed to compare the results of delivery quality assurance (DQA) using MapCHECK and OCTAVIUS for radiation therapy. Thirty patients who passed the DQA results were retrospectively included in this study. The point dose difference (DD) and gamma passing rate (GPR) were analyzed to evaluate the agreement between the measured and planned data for all cases, Plan complexity was evaluated to analyze dosimetric accuracy by quantifying the degree of modulation according to each plan. We analyzed the monitor units (MUs) and total MUs for each plan to evaluate the correlation between the MUs and plan complexity. We used a paired t-test to compare the DD and GPRs that were obtained using the two devices. The DDs and GPRs were within the tolerance range for all cases. The average GPRs difference between the two devices was statistically significant for the brain, and head and neck for gamma criteria of 3%/3 mm and 2%/2 mm. There was no significant correlation between the modulation index and total MUs for any of the cases. These DQA devices can be used interchangeably for routine patient-specific QA in radiation therapy.

• 핵의학기술
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• 제17권2호
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• pp.10-14
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• 2013

Purpose: Due to developed simultaneous PET/MRI, it has become possible to obtain more anatomical image information better than conventional PET/CT. By the way, in the PET/CT, the linear absorption coefficient is measured by X-ray directly. However in case of PET/MRI, the value is not measured from MRI images directly, but is calculated by dividing as 4 segmentation ${\mu}-map$. Therefore, in this paper, we will evaluate the SUV's difference of attenuation correction PET images from PET/MRI and PET/CT. Materials and Methods: Biograph mCT40 (Siemens, Germany), Biograph mMR were used as a PET/CT, PET/MRI scanner. For a phantom study, we used a solid type $^{68}Ge$ source, and a liquid type $^{18}F$ uniformity phantom. By using VIBE-DIXON sequence of PET/MRI, human anatomical structure was divided into air-lung-fat-soft tissue for attenuation correction coefficient. In case of PET/CT, the hounsfield unit of CT was used. By setting the ROI at five places of each PET phantom images that is corrected attenuation, the maximum SUV was measured, evaluated %diff about PET/CT vs. PET/MRI. In clinical study, the 18 patients who underwent simultaneous PET/CT and PET/MRI was selected and set the ROI at background, lung, liver, brain, muscle, fat, bone from the each attenuation correction PET images, and then evaluated, compared by measuring the maximum SUV. Results: For solid $^{68}Ge$ source, SUV from PET/MRI is measured lower 88.55% compared to PET/CT. In case of liquid $^{18}F$ uniform phantom, SUV of PET/MRI as compared to PET/CT is measured low 70.17%. If the clinical study, the background SUV of PET/MRI is same with PET/CT's and the one of lung was higher 2.51%. However, it is measured lower about 32.50, 40.35, 23.92, 13.92, 5.00% at liver, brain, muscle, fat, femoral head. Conclusion: In the case of a CT image, because there is a linear relationship between 511 keV ${\gamma}-ray$ and linear absorption coefficient of X-ray, it is possible to correct directly the attenuation of 511 keV ${\gamma}-ray$ by creating a ${\mu}$map from the CT image. However, in the case of the MRI, because the MRI signal has no relationship at all with linear absorption coefficient of ${\gamma}-ray$, the anatomical structure of the human body is divided into four segmentations to correct the attenuation of ${\gamma}-rays$. Even a number of protons in a bone is too low to make MRI signal and to localize segmentation of ${\mu}-map$. Therefore, to develope a proper sequence for measuring more accurate attenuation coefficient is indeed necessary in the future PET/MRI.