• 동의생리병리학회지
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• 제22권6호
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• pp.1390-1396
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• 2008

The aim of this study is to analyze literatures researching changes of liver function parameters after administration of herbal medicine and the safety of herbal medicine on hepato-biliary system. Eight Korean databases were searched for researches on the safety of oriental herbal medicine. According to inclusion criteria, nineteen studies were selected and analyzed. As a result, seventy outcomes in five parameters(aspartate transaminase, alanine transaminase, gamma(${\gamma}$)-glutamyl transferase, alkaline Phosphatase, total bilirubin) were obtained. After administration, parameters decreased or sustained in fifty seven outcomes. In thirteen outcomes, parameters slightly increased. In two outcomes, parameters increased but not severely. The change of liver function parameters after administration of herbal medicine is expected to be harmless. But it requires additional large scale studies and modification in method to corroborate the safety of herbal medicine.

• 생물정신의학
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• 제13권4호
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• pp.273-278
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• 2006

Objectives : Biochemical markers can provide an objective evidence of heavy alcohol drinking. The purpose of this study was to compare and evaluate the usefulness of biological markers detecting alcohol dependence, such as mean corpuscular volume(MCV), gamma-glutamyl transferase(GGT), and carbohydrate-deficient transferrin(CDT) in the patients of an alcohol counseling center. Methods : This study was done with 64 patients with alcohol dependence and 36 healthy subjects. Relative values(%) of CDT were determined in their sera with turbidimetric immunoassay(Bio-Rad %CDT assay, Axis-Shield ASA, Oslo, Norway), and were compared with conventional markers of alcohol consumption, GGT and MCV. Results : Among the patients with alcohol dependence, 78.1% showed abnormal %CDT levels compared with GGT(61.9%) and MCV(20.7%). The areas under the receiver operating characteristic(ROC) curves(95% confidence interval) for %CDT, GGT, and MCV were 0.934(0.866-0.973), 0.871(0.789-0.930), and 0.575 (0.472-0.673), respectively. Conclusion : %CDT seems to be the most reliable biological marker for the detection and monitoring of alcohol consumption in the patients with alcohol dependence of the alcohol counseling center.

• Journal of Preventive Medicine and Public Health
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• 제26권2호
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• pp.179-191
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• 1993

Generally fatty liver is attributed either to chronic alcoholism, diabetes mellitus, or obesity. Based upon this commonly held clinical brief, this study was conducted to investigate the contributing factors of fatty liver and odds ratio (OR) of known contributing factors. A sample of 310 male participants, who visited at Seoul Paik Automated Multiphasic Health Testing System from November 1991 to December 1991, was separated into 112 cases and 198 controls by ultrasonographic fin ding. There were statistically significant difference between fatty liver and normal in triglyceride (TG), body mass index (BMI), alanine aminotransferase (ALT), high density lipoprotein cholesterol (HDL-C), fasting blood sugar (FBS), alcohol consumption, low density lipoprotein cholesterol (LDL-C), total cholesterol, gamma-glutamyl transferase ($\gamma$-GT), duration of alcohol intake and alkaline phosphatase (Alk.P)(P<0.01, P<0.05). The statistically significant elevated odds ratio were noted for TG (4.48, confidence interval (CI) 2.66-7.55, P=0.000), alcohol consumption(3.24, CI 1.56-6.23, P=0.002), BMI(3.05, CI 1.87-4.97, P=0.000), and FBS (2.59, CI 1.53-4.40, P=0,000). In summary, it is suggested that the fatty liver could be preventive by avoiding such deleterious factors as high fat diet, alcohol and obesity.

• Journal of Preventive Medicine and Public Health
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• 제31권4호
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• pp.728-739
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• 1998

To improve wellness and quality of life by recognizing the health efforts of stress, the author estimated the relationships between stress, subjective symptoms and clinical diagnosis through a questionnaire and a battery of specified laboratory tests; electrocardiography, blood pressure, cholesterol, aspartate aminotransferase(AST), alanine aminotransferase(ALT), gamma glutamyl transferase$(\gamma-GTP)$, fasting blood sugar, gastro-endoscopy or UGI, abdominal sonography, etc. The data was gathered from 337 clients who were undergoing multiphasic screening program at a University Hospital from January to March 1998. The mean age of subjects was $46.5{\pm}11.2$ years and the mean of body mass index was $24.0{\pm}3.7kg/m^2$. The mean vol of stress was $18.5{\pm}6.0$ expressed as the score out of 40. By general characteristics and lift style among male, mean level of stress was significantly higher in case of lower socioeconomic status, habitual drug use, longer daily working time(>10 hours), no regular exercise, drinkers, irregular meal, skip-ping breakfast(p<0.05). In case of female, that was significantly higher in case of lower education, lowe. socioeconomic status, longer daily working time(>10 hours), no regular exercise, drinkers, smokers, irregular meal, skipping breakfast(p<0.05). Significant correlations were observed between stress and subjective symptoms in all kinds of organ system (p<0.01). Correlation coefficients of stress among male were relatively high with neuro-psychiatric symptom$(\gamma=0.476)$ and cardio-vascular symptom$(\gamma=0.361)$ in order, and correlation coefficients of stress among female was highest with neuro-psychiatric symptom$(\gamma=0.371)$. The prevalence of the diagnosis through the battery of laboratory tests was high in upper gastrointestinal disorders and hypercholesterolemia in order in both sex group. Among male the mean score of stress was significantly high in ulcerative peptic disorder of upper gastrointestine and hepatopathy in order (p<0.05) . Among female that was significantly high in diabetes mellitus. In summary, it is likely that there are associations between stress, subjective symptoms and clinical diagnosis. To promote wellness and quality of life it would be of value that periodic stress evaluation program and stress management including apropriate control of smoking and drinking, regular exercise and meal.

• Journal of Nutrition and Health
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• 제49권2호
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• pp.80-87
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• 2016

본 연구에서는 건강한 여대생 10명을 대상으로 하여 오리육에 농도를 달리한 울금을 첨가하여 섭취한 후 30분, 60분, 120분, 180분 후 혈액을 채취하여 울금 농도에 따른 혈중 지질농도의 변화를 살펴보았다. 연구결과는 다음과 같다. 1) 조사대상자는 병적 질환이 없고 신체조건이 한국인 기준에 해당되는 여대생 10명을 대상으로 하여 연구를 시행하였으며 대상자는 $159.6{\pm}2.6cm$, $51.3{\pm}3.5kg$이었으며, BMI는 $20.1{\pm}1.0$으로 정상 범위에 해당하였다. 공복시 혈당과 지질농도, GGT, GPT, GOT, CRP, 헤모글로빈 농도는 모두 정상 수준이었다. 2) 식후 혈중 포도당의 공복 시 혈당에 비해 증가된 ${\Delta}-AUC$값에서 유의적인 차이가 없었다. 3) 식후 혈중 총콜레스테롤은 울금 0.2%, 0.4% 첨가하였을 때 공복 시에 비한 ${\Delta}-AUC$값에서 대조군에 비해 유의적으로 낮았다. 4) 혈중 중성지방의 농도는 식후 90분 까지 0.4% 첨가군에서만 대조군에 비해 유의적으로 낮았다. 5) 식후 LDL의 공복 시에 비한 ${\Delta}-AUC$값은 울금 0.2%, 0.4% 첨가하였을 때 대조군에 비해 유의적으로 낮았다. 6) 식후 HDL의 공복 시에 비한 ${\Delta}-AUC$값은 울금 0.2%, 0.4% 첨가하였을 때 대조군에 비해 유의적으로 높았다. 본 연구는 혈중 지질상태가 정상인 여대생을 대상으로한 인체실험으로 0.2% 이상의 울금 첨가가 고지방식인 훈제오리육가공품의 섭취 시 혈중 지질농도에 영향을 미치고 있음을 밝힌 연구로 그 의미가 있다 할 것이다. 그러나 이의 기전을 보다 명확히 제시할 수 있는 다양한 조건에서의 추후 연구가 필요하다.

• Journal of Animal Science and Technology
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• 제45권6호
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• pp.1031-1038
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• 2003

본 연구는 축사 내에서 집약적으로 사육되고 있는 꽃사슴의 녹용 성장기간 중의 혈액성분변화와 녹용성장과의 관련성 해석을 위한 기초자료를 제공하고자 수행하였다. 녹용성장기간 중 혈액성분의 변화를 측정하기 위하여 우리 내에서 사육 중인 4${\sim}$6년 생 꽃사슴 웅록 25두를 무작위로 선별하여, 낙각 직후부터 10일 간격으로 절각일(50일)까지 혈액을 채취하여 미네랄과 효소 활성치를 측정하였다. 칼슘과 인의 농도는 녹용성장기간 중 커다란 변동이 없었으며 나트륨, 칼륨, 염소의 농도는 낙각 직후와 녹용성장에 따른 경시적인 유의차가 나타났다. AST, ALT, amylase, CK, GGT 및 LDH의 농도는 낙각 직후와 녹용성장에 따른 유의차는 인정되지 않았으나, ALK-P의 농도는 녹용성장이 진행되면서 계속 증가하여 낙각 후 50일 경에는 최고치를 나타내어 낙각시의 농도와 유의차가 나타났으며(p〈0.01), CK와 LDH의 활성은 다른 동물들보다 높게 나타났다.

• 대한의생명과학회지
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• 제22권1호
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• pp.9-17
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• 2016

Unfortunately, the five-year survival rate of lung cancer is relatively low compared with other cancers. Therefore, better predictors are need for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer. Recently, increasing data suggest that Glasgow Prognostic Score (GPS) and procalcitonin levels are useful predictor cancer prognosis. In this study, we retrospectively investigated the correlation of GPS or procalcitonin to clinical variables in patients with pretreatment lung cancer. In 135 patients with pretreatment lung cancer, GPS, procalcitonin, demographic characteristics, hematological, coagulation, biochemical, inflammatory and cardiac markers were measured. Monocyte, eosinophil, basophil, neutrophil to lymphocyte ratio, red cell distribution width (RDW), platelet to lymphocyte ratio, mean platelet volume to platecrit ratio, D-dimer and prothrombin time (PT) levels were higher, whereas mean platelet volume was lower than their normal ranges. Glucose and sodium levels were low, whereas gamma glutamyl transferase (GGT), total bilirubin, creatinine and inorganic phosphorus concentrations were increase compared their normal ranges. Procalcitonin, high sensitivity C-reactive protein and troponin-I concentrations were elevated compared with their normal ranges. GPS had significantly positive or negative relations to cancer stage, hematological, coagulation, biochemical, inflammatory and troponin-I. Based on the data, we suggest that GPS may be a potent and useful predictor for prognosis, therapeutic strategy, risk stratification and predicting long-term mortality of lung cancer.

• 대한한방내과학회지
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• 제38권2호
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• pp.164-171
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• 2017

Objectives: The purpose of this case report is to describe the efficacy of Saenggan-tang-gagam treatment in a patient with immune-tolerant chronic hepatitis B who converted to the immune active phase during hospitalization for Intracerebral hemorrhage. Methods: A 61-year-old male patient with chronic hepatitis B was hospitalized from July 21, 2016 to October 24, 2016. On September 5, the patient showed fatigue and dyspepsia, and his urine was dark. These symptoms were accompanied by a dramatic elevation of aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) levels. Saenggan-tang-gagam was administered three times a day until the patient was discharged from the hospital. Results: After the Saenggan-tang-gagam treatment, AST and ALP levels decreased significantly, below the upper limit level. In addition, the levels of ALT and GG were significantly decreased. In addition, the fatigue, dyspepsia, and dark urine induced by hepatitis improved after the Saenggan-tang-gagam treatment. Conclusion: This case report suggests that traditional Korean medicine has a beneficial effect on the immune active phase of chronic hepatitis B.

• 한국임상수의학회지
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• 제28권4호
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• pp.431-434
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• 2011

7년령의 중성화된 수컷 코커 스파니엘이 왼쪽복부종괴, 식욕부진, 체중감소로 경북대학교 부속동물병원에 내원하였다. 혈액학적, 생화학적 검사로 중증의 백혈구증가증, 경도의 저알부민혈증, GGT의 급격한 증가를 나타내었다. 방사선학적 검사시 왼쪽신장의 거대한 종괴가 관찰되었으며, 폐전이는 관찰되지 않았다. 조직병리학적 소견에서 종괴는 신장세포암종으로 확진되었다. 편측성 신장요관절제술을 실시하였다. 추시 결과 수술 6개월 후 환축이 폐사되었음을 확인 할 수 있었다.

• 보건의료산업학회지
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• 제7권3호
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• pp.71-82
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• 2013

Arterial stiffness(AS) is an important pathologic state of vascular injury. This study was carried out to elucidate the effect of physiological variables on brachial-ankle pulse wave velocity(BAPWV), index of AS. Four hundred adults(volunteers) participated in this study. Body indices, biochemical, cardiac and inflammatory markers, and right(Rt)- and left(Lt)-BAPWV were measured. Body mass index(BMI), Rt- and Lt-BAPWV, glucose, triglyceride, alkaline phosphatase(ALP), gamma-glutamyl transferase(GGT), creatinine, uric acid, troponin-I(TNI), NT-proBNP and high sensitivity C-reactive protein(hs-CRP) levels were higher than the reference value of each variable. Rt- and Lt-BAPWV were directly correlated with age, body weight, BMI, glucose, ketone, aspartate aminotransferase, alanine aminotransferase, ALP, GGT, total cholesterol, low density lipoprotein, lipoprotein(a), apolipoprotein-B, blood urea nitrogen, heart rate, TNI, creatine kinase, CK-MB, lactic dehydrogenase, myoglobin, hs-CRP, lipase, reumatoid factor, fibrinogen and D-dimer (P<0.05, P<0.01, P<0.001 or P<0.000, respectively), but inversely associated with total bilirubin, uric acid, apolipoprotein-A1 and GFR (P<0.05). These observations suggest that a variety of physiological variables may influence BAPWV, resulting in increased risk or prevention of cardiovascular and/or cerebrovascular attacks. Therefore, physiological variables affecting BAPWV should be regularly controlled.