• Journal of Advanced Navigation Technology
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• v.20 no.5
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• pp.482-489
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• 2016

Detection of gamma ray can be available using optical fiber scintillator under radiation environment. It monitors the transfer energies of these ions by photodiodes and then convertes into currents. The module which converts those currents into voltages and processes signals is named fine current module TIA, and it is essentially important to convert currents into voltages with high linearity. We have studied and developed the TIA, improving converting linearity and minimizing noises and off-set voltages. Also, we have made efforts to develop precise and accurate current module in compliance with concerned requirements. First of all, we established developing theory, developed related circuits, and then made the current module. And, we confirmed its stability and linearity to be more excellent than any other equipment proposed by other references. We tested the developed fine current modules in the real radiation environment under authorized supervising, confirmed them to meet related requirements.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1524-1531
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• 2020

The aim of this work is to develop a Geiger-Muller (GM) detector system for robot to look for a radioactive source in case of a nuclear emergency or in a high radiation environment. In order to find a radiation source easily, a detector system, including 3 detectors, was designed to search γ-ray radiation sources autonomously. First, based on GEANT4 simulation, radiation dose rates in 3 Geiger-Muller (GM) counters were simulated at different source-detector distances, distances between detectors and angles. Various sensitivity analyses were performed experimentally to verify the simulated designed detector system. A mono-energetic ¹³⁷Cs γ-ray source with energy 662 keV and activity of 1.11 GBq was used for the observation. The simulated results were compared with the experimental dose rate values and good agreements were obtained for various cases. Only based on the dose rates in three detectors, the radiation source with a specific source activity and angle was localized in the different location. A method was adopted with the measured dose rates and differences of distances to find the actual location of the lost γ-ray source. The corresponding angles of deviation and detection limits were calculated to determine the sensitivity and abilities of our designed detector system. The proposed system can be used to locate radiation sources in low and high radiation environments.

• Journal of Radiation Protection and Research
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• v.41 no.2
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• pp.87-91
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• 2016

Background: A hand-held detector for an emergency response was developed for nuclide identification and to estimate the information of the ambient dose rate in the scene of an accident as well as the radioactivity of the contaminants. Materials and Methods: To achieve this, the most suitable sensor was first selected as a cadmium zinc telluride (CZT) semiconductor and the signal processing unit from a sensor and the signal discrimination and storage unit were successfully manufactured on a printed circuit board. Results and Discussion: The performance of the developed signal processing unit was then evaluated to have an energy resolution of about 14 keV at 662 keV. The system control unit was also designed to operate the CZT detector, monitor the detector, battery, and interface status, and check and transmit the measured results of the ambient dose rate and radioactivity. In addition, a collimator, which can control the inner radius, and the airborne dust sampler, which consists of an air filter and charcoal filter, were developed and mounted to the developed CZT detector for the quick and efficient response of a nuclear accident. Conclusion: The hand-held CZT detector was developed to make the in-situ gamma-ray spectrometry and its performance was checked to have a good energy resolution. In addition, the collimator and the airborne dust sampler were developed and mounted to the developed CZT detector for a quick and efficient response to a nuclear accident.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.11
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• pp.1559-1564
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• 2012

Raisins (Thailand), dried mangos (Philippines), and dried figs (Iran) were gamma-irradiated (0~5 kGy), and their quality and detection characteristics were investigated. Microbiological characteristics were at safe levels when samples were irradiated at higher than 3 kGy. In color change after irradiation, dried mangoes were the most sensitive. Photostimulated luminescence (PSL) measurement was not applicable to dried fruits, showing negative or intermediate values for the irradiated samples. Thermoluminescence (TL) measurement was good for dried figs, exhibiting a glow curve in range of $150{\sim}200^{\circ}C$, where the signal intensity was dependent on the irradiation dose. Electron spin resonance (ESR) measurement was suitable for raisins and dried mangos, resulting in dose-dependent radiation-induced sugar radical signals.

• The Korean Journal of Nuclear Medicine
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• v.38 no.2
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• pp.152-160
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• 2004

Radioiodide uptake in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and effective radioiodide treatment for patients with invasive, recurrent, and/or metastatic thyroid cancers after total thyroidectomy. NIS gene transfer to tumor cells may significantly and specifically enhance internal radioactive accumulation of tumors following radioiodide administration, and result in better tumor control. NIS gene transfers have been successfully performed in a variety of tumor animal models by either plasmid-mediated transfection or virus (adenovirus or retrovirus)-mediated gene delivery. These animal models include nude mice xenografted with human melanoma, glioma, breast cancer or prostate cancer, rats with subcutaneous thyroid tumor implantation, as well as the rat intracranial glioma model. In these animal models, non-invasive imaging of in vivo tumors by gamma camera scintigraphy after radioiodide or technetium injection has been performed successfully, suggesting that the NIS can serve as an imaging reporter gene for gene therapy trials. In addition, the tumor killing effects of I-131, ReO4-188 and At-211 after NIS gene transfer have been demonstrated in in vitro clonogenic assays and in vivo radioiodide therapy studies, suggesting that NIS gene can also serve as a therapeutic agent when combined with radioiodide injection. Better NIS-mediated imaging and tumor treatment by radioiodide requires a more efficient and specific system of gene delivery with better retention of radioiodide in tumor. Results thus far are, however, promising, and suggest that NIS gene transfer followed by radioiodide treatment will allow non-invasive in vivo imaging to assess the outcome of gene therapy and provide a therapeutic strategy for a variety of human diseases.

• Journal of the Korean Chemical Society
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• v.38 no.1
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• pp.50-54
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• 1994

Spectrophotometric determination of some light lanthanide ions by flow injection method is described. Chromeazurol S forms water soluble complex with lanthanide ions in the presence of DTAB. The absorption maximum of the complexes are from 650 nm to 655 nm and the molar absorptivities were ca. $1.8{\times}10^5\;L mol^{-1}cm^{-1}$ on Tris buffer (pH 10.5). The calibration curves for Nd(III), Eu(III) and Sm(III) obtained by FIA are over the range of 0.1 to 0.6 ppm and the correlation coefficient were ca. 0.9993. The detection limits (S/N) were from 10 ppb for Nd(III) and Eu(III) to 20 ppb for Sm(III). The relative standard deviations was ${\pm}$.2% for 0.4 ppm sample. The samples throughput was ca. $50\;cm^{-1}$.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.1
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• pp.34.2-34.2
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• 2017

A small wide-field imaging telescope is a powerful instrument to survey the Universe: wide-field image can monitor the variability of many sources at a time, e.g. young stellar objects and active galactic nuclei, and it can be an effective way to locate transient sources without precise positional information such as gravitational wave sources or some gamma-ray bursts. In February 2017, we installed a 0.25 m f/3.6 telescope on the McDonald 0.8 m telescope as a piggyback system. With a $4k{\times}4k$ CCD camera, the telescope has a $2.35{\times}2.35deg$ field-of-view. Currently, it is equipped with Johnson UBVRI filters and 3 narrow-band filters: $H{\alpha}$, OIII and SII. We will present the installation process, and the telescope performance such as detection limit and image quality based on the data from commissioning observations. We will also discuss possible scientific projects with this system.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.65.2-65.2
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• 2018

Through MIRIS $Pa{\alpha}$ Galactic plane survey, a lot of $Pa{\alpha}$ blobs were detected along the plane. To reveal their characteristics, we are planning to collect NIR high-resolution spectroscopic data for them by using Immersion GRating INfrared Spectrograph (IGRINS). Here, we present the preliminary results of the IGRINS observations for a Herbig Be star, MWC 1080, which is one of the $Pa{\alpha}$ blobs detected in Cepheus. This Herbig Be star is known to possess a lot of young stellar objects (YSOs) and bright MIR ($10-20{\mu}m$) nebulosity in its vicinity. From IPHAS $H{\alpha}$ data, we revealed large extended $H{\alpha}$ features that correlate well with MIR and 13CO morphologies around MWC 1080. A part of the $H{\alpha}$ features shows a bow shock shape to the northeast of the primary star MWC 1080A, which seems to be due to an outflow from MWC 1080A. Through IGRINS observations, we detected faint [Fe II] ${\lambda}1.644{\mu}m$ and H2 1-0 S(1) ${\lambda}2.122{\mu}m$ emission lines around the bow shock feature. Interestingly, to the east region of MWC 1080A, we also detected strong [Fe II] and H2 emission lines with a couple of velocity components, which suggests the detection of a new outflow from another YSO. Broad $Br{\gamma}$ ${\lambda}2.1662{\mu}m$ line and H2 lines with various velocity components were detected around the bright MIR and $H{\alpha}$ nebulosity as well.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.747-752
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• 2013

Oncostatin M (OSM) is a multifunctional cellular regulator acting on a wide variety of cells, which has potential roles in the regulation of gene activation, cell survival, proliferation and differentiation. Previous studies have shown that OSM can induce morphological and/or functional differentiation and maturation of many tumor cells. However, the action of OSM on the induction of differentiation of human hepatocellular carcinoma (HCC) has not been reported. Here, we investigated the effects of different concentrations of OSM on human HCC cell line SMMC-7721 growth, proliferation, cell cycling, apoptosis and differentiation in vitro. Cell growth was determined via MTT assay, proliferation by cell cycle analysis, apoptosis by flow cytometry, morphology by transmission electronic microscopy, and cell function by detection of biochemical markers. Our results demonstrated that OSM strongly inhibited the growth of SMMC-7721 cells in a dose-dependent manner, associated with decreased clonogenicity. Cell cycle analysis revealed a decreased proportion of cells in S phase, with arrest at G0/G1. The apotosis rate was increased after OSM treatment compared to the control. These changes were associated with striking changes in cellular morphology, toward a more mature hepatic phenotype, accompanied by significant reduction of the expression of AFP and specific activity of ${\gamma}$-GT, with remarkable increase in secretion of albumin and ALP activity. Taken together, our findings indicate that OSM could induce the differentiation and reduce cell viability of SMMC-7721 cells, suggesting that differentiation therapy with OSM offers the opportunity for therapeutic intervention in HCC.

• Korean Journal of Veterinary Service
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• v.33 no.3
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• pp.223-231
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• 2010

A total of 191 samples collected from the commercial swine farms located in Chungnam province were investigated by PCR to estimate the prevalence of Lawsonia (L.) intracellularis infection. In the group of the pigs with proliferative enteritis, 14 (93.3%) of 15 intestinal samples and 12 (80.0%) of 15 feces were positive in PCR. In contrast, a relatively low positive rate (18.0%, 29 of 161 samples) was determined in the group of normal healthy pigs. The group of pigs over 120 days showed the highest positive rates (26.8%, 15 of 56 samples). In the comparison of the sequences of 210bp for species specific fragments and 301bp for outer membrane protein, the isolates (L1. L2) showed almost 100% identity with the reference L. intracellularis (L08049, USA). For the sequences of partial 16s rDNA, the homologies among the 5 isolates (L1-L5) were 97.4% to 99.3%, and those of 5 sequences (L1-L5) versus 5 overseas reference strains of L. intracellularis ranged from 98.6% to 99.8%. In the comparison of the nucleotide sequences among 5 isolates and other species in Desulfovibrionales showed 82.4 to 99.5% identities. The 5 isolates shared relatively low identities (76.9% to 84.4%) with the species of alpha-proteobacteria. In phylogenetic analysis based on the 16s rDNA sequences, all of the 5 isolates (L1-L5) were located in the same branch with the strains of L. intracellularis that were previously isolated from the pigs in USA and China. Seven strains of Desulfovibrio sp. were clustered in the neighboring branches, whereas alpha and gamma Proteobacteria showed distant relationship with L. intracellularis strains. The present findings suggest that L. intracellularis infection is endemic in the swine farms in the regions, and that the domestic isolates maintained very limited genetic variation.