• Journal of Astronomy and Space Sciences
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• v.30 no.2
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• pp.83-85
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• 2013

Anomalous X-ray pulsars (AXPs) are thought to be magnetars which are young isolated neutron stars with extremely strong magnetic fields of > $10^{14}$ Gauss. Their tremendous magnetic fields inferred from the spin parameters provide a huge energy reservoir to power the observed X-ray emission. High-energy emission above 0.3 MeV has never been detected despite intensive search. Here, we present the possible Fermi Large Area Telescope (LAT) detection of ${\gamma}$-ray pulsations above 200 MeV from the AXP, 1E 2259+586, which puts the current theoretical models of ${\gamma}$-ray emission mechanisms of magnetars into challenge. We speculate that the high-energy ${\gamma}$-rays originate from the outer magnetosphere of the magnetar.

• BMB Reports
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• v.42 no.8
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• pp.516-522
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• 2009

SH2D4A, comprising a single SH2 domain, is a novel protein of the SH2 signaling protein family. We have previously demonstrated SH2D4A is expressed ubiquitously in various tissues and is located in the cytoplasm. In this study we investigated the function of SH2D4A in human embryonic kidney (HEK) 293 cells using interaction analysis, cell proliferation assays, and kinase activity detection. SH2D4A was found to directly bind to estrogen receptor $\alpha$ (ER$\alpha$), and prevent the recruitment of phospholipase C-$\gamma$ (PLC-$\gamma$) to ER$\alpha$. Moreover, we observed its inhibitory effects on estrogen-induced cell proliferation, involving the protein kinase C (PKC) signaling pathway. Together, these findings suggested that SH2D4A inhibited cell proliferation by suppression of the ER$\alpha$/PLC-$\gamma$/PKC signaling pathway. SH2D4A may be useful for the development of a new anti-cancer drug acting as an ER signaling modulator.

• Journal of the Korean Chemical Society
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• v.8 no.2
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• pp.85-87
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• 1964

In order to stabilze alloxan as a reagent for detection of amino acids by spot test, sugars and other reductants were added to the aqueous alloxan solution. It was found that lactose was the best for the purpose. The alloxan reagent containing lactose did not give color change on blank test and was very stable that there was no color change even it was allowed to stand in room temperature for several months. The color reaction with amino acids and some amines was not affected by lactose. This spot test for amino acids is in sensitivity as comparable to that of the previously reported methods and gave color reaction with proline and hydroxyproline to 1${\gamma}$ and 5${\gamma}$ respectively.

• Preventive Nutrition and Food Science
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• v.2 no.2
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• pp.89-95
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• 1997

The comparative effects of gamma irradiation an ozone treatment on the microbiological and physicochemical qualities were investigated for the improvement of hygienic quality of aloe powder and bee pollen. Gamma irradiation at 7.5~10kGy could reduce total aerobic bacteria, molds and coliforms below detection levels, but ozone treatment up to 18 ppm for 8hr was not sufficient to eliminate the microorganisms from aloe powder and bee pollen. The physicochemical properties such as fatty acid an amino acid compositions, mineral content, TBA value, barbaloin and pigment contents were not significantly changed by gamma irradiation, whereas ozone treatment caused significant changes in fatty acid composition, lipid oxidation and destruction of barbaloin and natural pigments.

• Nuclear Engineering and Technology
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• v.53 no.10
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• pp.3431-3437
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• 2021

In this study, one-dimensional gamma ray source positions are estimated using a plastic scintillating optical fiber, two photon counters and via data processing with a machine learning algorithm. A nonlinear regression algorithm is used to construct a machine learning model for the position estimation of radioactive sources. The position estimation results of radioactive sources using machine learning are compared with the theoretical position estimation results based on the same measured data. Various tests at the source positions are conducted to determine the improvement in the accuracy of source position estimation. In addition, an evaluation is performed to compare the change in accuracy when varying the number of training datasets. The proposed one-dimensional gamma ray source position estimation system with plastic scintillating fiber using machine learning algorithm can be used as radioactive leakage scanners at disposal sites.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1718-1733
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• 2023

The virtual Frisch-grid method for room-temperature radiation detectors has been widely used because of its simplicity and high performance. Recently, side electrodes were separately attached to each surface of the detectors instead of covering the entire detector surface with a single electrode. The side-electrode structure enables the measurement of the three-dimensional (3D) gamma-ray interaction in the detector. The positional information of the interaction can then be utilized to precisely calibrate the response of the detector for gamma-ray spectroscopy and imaging. In this study, we developed a 3D position-sensitive 5 × 5 × 12 mm³ cadmium-zinc-telluride (CZT) detector and applied a flattening method to correct detector responses. Collimated gamma-rays incident on the surface of the detector were scanned to evaluate the positional accuracy of the detection system. Positional distributions of the radiation interactions with the detector were imaged for quantitative and qualitative evaluation. The energy spectra of various radioisotopes were measured and improved by the detector response calibration according to the calculated positional information. The energy spectra ranged from 59.5 keV (emitted by ²⁴¹Am) to 1332 keV (emitted by ⁶⁰Co). The best energy resolution was 1.06% at 662 keV when the CZT detector was voxelized to 20 × 20 × 10.

• Nuclear Engineering and Technology
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• v.55 no.11
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• pp.4246-4251
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• 2023

The optimized design of a Neutron Activation Analysis (NAA) system, including Delayed Gamma NAA (DGNAA) and Prompt Gamma NAA (PGNAA), has been proposed in this research based on Mevex Linac with 5 MeV electron energy and 50 kW power as a neutron source. Based on the MCNPX 2.6 simulation, the optimized configuration contains; tungsten as an electron-photon converter, BeO as a photoneutron target, BeD₂ and plexiglass as moderators, and graphite as a reflector and collimator, as well as lead as a gamma shield. The obtained thermal neutron flux at the beam port is equal to 2.06 × 10⁹ (# /cm².s). In addition, using the optimized neutron beam, the detection limit has been calculated for some elements such as H-1, B-10, Na-23, Al-27, and Ti-48. The HPGe Coaxial detector has been used to measure gamma rays emitted by nuclides in the sample. By the results, the proposed system can be an appropriate solution to measure the concentration and toxicity of elements in different samples such as food, soil, and plant samples.

• Korean Journal of Food Science and Technology
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• v.30 no.3
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• pp.498-501
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• 1998

It was determined whether photostimulated luminescence (PSL) is applicable to the detection of post-irradiation of foods by measuring PSL photon counts for unirradiated and irradiated pepper powder, dried herbs, fresh shrimp, potato, soybean, dried fig, chestnut, dried squid, and dried cod. The samples were irradiated with $^{60}Co\;{\gamma}-ray$ source and PSL photon counts were measured for them. The photon counts of unirradiated samples were lower than 2,000 for potatoes and less than 1,000 for the others. The photon counts of the irradiated samples except dried figs (0.5 kGy), chestnuts (0.2 kGy), and dried squid (0.5 kGy) were higher than 1,000, and the photon counts increased with dose. Thus, PSL might be applied to the primary detection of irradiated foods.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2662-2669
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• 2023

For the precise measurements of special nuclear materials (SNM) including Pu and Am isotopes, we have used phoswich detector combination of two single crystal scintillators of Gd₃Ga₃Al₂O₁₂:Ce and CsI:Tl. High detection efficiency and sensitivity along with high figure of merit for the discrimination of these phoswich detectors ensures the detection and discrimination of thermal neutrons and gammas from spontaneous fission of Pu and other isotopes in presence of high gamma background. Using this detector, the low energy gammas, which is stopped completely in 1mm thick disc of GGAG, can be also discriminated from high energies gamma and shows linearity in wide range of sample quantities. By changing only the appropriate shielding, the similar setup was used for thermal neutron detection and shows a very good linearity over wide range. The quantity of a test sample was also calculated accurately by using the measured calibrated plot.

• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.67.1-67.1
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• 2000