• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.993-1000
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• 2023

Recently, enviromentally friendly natural substances derived from plants have been attracting attention as cosmetic materials, and research on various physiological activities of natural substances is being actively conducted. This study investigated the antioxidant, anti-inflammatory, moisturizing, and antibacterial effects of three types of extracts of mixtures containing different mixing ratios, Polygala tenuifolia, Angelica dahurica, and Elsholtzia splendens, known to have various physiological activities. The mixing ratio is 7 conditions (M1, 1:1:1; M2, 0.5:1.5:1; M3, 1.5:0.5:1; M4, 0.1:0.95:0.95; M5, 0.5:0.5:2; M6, 0.95 :1.95:0.1; M7, 1.45:0.1:1.45), and the optimal mixing ratio was confirmed for use as a cosmetic material. DPPH and ABTS radical scavenging activities showed scavenging abilities of 75.37% and 99.19%, respectively, at 1,000 ㎍/mL of M6. At a concentration of 200 ㎍/mL of M6, it showed 50% of nitric oxide production inhibition compared to the lipopolysaccharide-treated that induced an inflammatory response. It was confirmed that M3 and M6 produced hyaluronic acid 1.47 and 1.49 times higher than the control at a concentration of 50 ㎍/mL, respectively. Through the disc diffiusion test, the clear zone was 9.75 mm at 8 ㎍/mL of M6, confirming the inhibition of growth of staplylococcus aureus strain. Based on the above results, it is believed that the mixed extract of Polygala tenuifolia, Angelica dahurica, and Elsholtzia splendens can be used as a functional natural material for cosmetics.

• Journal of The Korean Association For Science Education
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• v.31 no.6
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• pp.864-875
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• 2011

The purpose of this study was to investigate high school students' understanding of acid-base related concepts using three different titration technologies. The test population was composed of 209 students from three classes in the 10th grade. The different titration experiments using indicator, or pH-meter or MBL were performed in each class unit, respectively. The analyses of the effect on the understanding of different titration technologies were carried out by comparing the mean scores of the concept test taken before and after the titration for the three groups. The results of the acid-base related concept test indicated that statistically significant effects on the understanding of the concepts were shown by all groups. Comparing the effect on the comprehension of the three groups, the MBL group showed the most significant effect, while the pH-meter group showed the least significant. It was also attempted to analyze the effect on comprehension of the concepts by the cognitive and the motivational levels of students. This study revealed that the students in the formal operation stage showed higher understanding of the acidbase related concepts, while those in the concrete operation stage showed lower comprehension. It was also shown that the students at the active motivational level scored higher in comprehension than those who had a low score. The results of this study implied that each group showed differently enhanced comprehension of concepts by titration technologies. Therefore, teachers need to promote an appropriate experiment technology for the cognitive and motivational levels of students as well as try to help students express freely their own perspectives.

• Clinical and Experimental Reproductive Medicine
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• v.11 no.1
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• pp.17-32
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• 1984

There are numerous reports on the relative risk of pelvic inflammatory disease among the users versus the nonusers of intrauterine device. Reported relative risk varied from no difference between the two groups to 3-9 fold increase in the users. In an attempt to define this relative risk of pelvic inflammatory disease and related microorganisms ,pelvic organ observation and bacteriological study were done through laparoscopy. Specimens for microbiologic culture were obtained simultaneously from the fallopian tubes via laparoscopy and from the endocervix via regular pelvic examination method. The study population was consisted of 30 I.U.D.users and 35 J.U.D.nonusers who visited the Yonsei University Severance Hospital and the Sung-Ga Hospital for laparoscopic sterilization. The results obtained were as follows: 1. There was no difference in age distribution, economic status and numbers of parity and abortion between I.U.D. users and I.U.D. nonusers. 2. The pelvic inflammatory findings were noted on laparoscopy in 2 cases of I.U.D. users, with an incidence of 6.6%. And no pelvic inflammatory finding was noted in any of the nonusers,but this difference was not statistically significant (p>0.005). 3. All the bacteriologic culture of the specimens from the fallopian tubes of both groups yielded negative results. 4. The bacteriologic culture of the spec imens f rom the endocervix revealed more frequent isolation of possible pathogen such as Hem ophilus ,alpha-Streptococcus ,Corynebacteria, Bacteroides in the I.U.D.users than in the nonusers.But,this difference was also not statistically significant (p>0.005).

• The Korean Journal of Nuclear Medicine Technology
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• v.26 no.1
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• pp.27-32
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• 2022

Purpose When performing a whole-body bone scan, many patients are experiencing psychological difficulties due to the close distance to the detector. Recently, in the medical field, there is a report that using virtual reality (VR) equipment can give pain relief to pediatric patients with weak concentration or patients receiving severe treatment through a distraction method. Therefore, in this paper, VR equipment was used to provide psychological stability to patients during nuclear medicine tests, and it is intended to evaluate whether it can be used in clinical practice. Materials and Methods As VR equipment, ALLIP Z6 VR (ALLIP, Korea) was used and the experiment was conducted after connecting to a mobile phone. The subjects were 30 patients who underwent whole-body bone examination from September 1, 2021 to September 30, 2021. After intravenous injection of 99mTc-HDP, 3 to 6 hours later, VR equipment was put on and whole body images were obtained. After the test, a survey was conducted, and a Likert scale of 5 points was used for psychological anxiety and satisfaction with VR equipment. Hypothesis verification and reliability of the survey were analyzed using SPSS Statistics 25 (IBM, Corp., Armonk, NY, USA). Results Anxiety about the existing whole-body bone test was 3.03±1.53, whereas that of anxiety after wearing VR equipment was 2.0±1.21, indicating that anxiety decreased to 34%. When regression analysis of the effect of the patient's concentration on VR equipment on anxiety about the test, the B value was 0.750 (P<0.01) and the t value was 6.181 (P<0.01). decreased and showed an influence of 75%. In addition, overall satisfaction with VR equipment was 3.76±1.28, and the intention to reuse was 66%. The Cronbach α value of the reliability coefficient of the questionnaire was 0.901. Conclusion When using VR equipment, patients' attention was dispersed, anxiety was reduced, and psychological stability was found. In the future, as VR equipment technology develops, it is thought that if the equipment can be miniaturized and the resolution of VR content images is increased, it can be used in various clinical settings if it provides more realistic stability to the patient.

• Journal of Korean Society of Forest Science
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• v.106 no.2
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• pp.249-257
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• 2017

This study was conducted to analyze the relationship between tree-ring growth of Pinus densiflora and climate factors based on national forest inventory(NFI) data. Annual tree-ring growth data of P. densiflora collected by the $5^{th}$ NFI were first organized to analyze yearly growth patterns of the species. Yearly growing degree days and standard precipitation index based on daily mean temperature and precipitation data from 1951 to 2010 were calculated. Using the information, yearly temperature effect index(TEI) and precipitation effect index(PEI) were estimated to analyze the effect of climate conditions on the tree-ring growth of the species. A tree-ring growth estimation equation appropriate for P. densiflora was then developed by using the TEI and PEI as independent variables. The tree-ring growth estimation equation was finally applied to the climate change scenarios of RCP 4.5 and RCP 8.5 for predicting the changes in tree-ring growth of P. densiflora from 2011 to 2100. The results indicate that tree-ring growth of P. densiflora is predicted to be decreased over time when the tree-ring growth estimation equation is applied to the climate change scenarios of RCP 4.5 and RCP 8.5. It is predicted that the decrease of tree-ring growth over time is relatively small when RCP 4.5 is applied. On the other hand, the steep decrease of tree-ring growth was found in the application of RCP 8.5, especially after the year of 2050. The results of this study are expected to provide valuable information necessary for estimating local growth characteristics of P. densiflora and for predicting changes in tree-ring growth patterns caused by climates change.

• Food Science of Animal Resources
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• v.30 no.2
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• pp.277-285
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• 2010

The objective of this study was to manufacture spent layer chicken meat products by natural freeze-drying. The spent layers of chickens that were slaughtered at 80 wk were obtained from a local slaughter house and separated into two halves of carcasses. The samples were divided into the following groups: 1) control (non-curing), 2) curing, and 3) curing with 2% trehalose before drying. The cured meats were placed at $2^{\circ}C$ for 7 d and then transferred to a natural drying spot located in Injae City, Gangwondo, Korea. The experiment was conducted from January to March in 2008. The average temperature, RH, and wind speed were $-1.5^{\circ}C$, 63%, and 1.8 m/sec, respectively. The cured treatments showed higher pH, lower Aw and lower shear force value compared with the control. Based on the results of TBARS (2-thiobarbituric acid reactive substances) level and volatile basic nitrogen value, lipid oxidation and protein deterioration were inhibited in curing treatments during drying. Trehalose acted as a humectant because it maintained a lower water activity despite the relatively higher moisture content during drying. The polyunsaturated fatty acids content and sensory attributes were higher in cured treatments than in the control during drying. Most of the bacterial counts in the treated groups were lower by 2 Log CFU/g after 1 mon of drying, and Salmonella spp. and Listeria spp. were not found in any treatment. There was also no microbial safety problem associated with dried meat products. Based on the results of this experiment, dried meat products could be manufactured from precured spent layer chickens by natural freeze-drying during winter.

• Sleep Medicine and Psychophysiology
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• v.7 no.2
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• pp.88-95
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• 2000

Objectives: The object of this experiment was to evaluate the effect of sleep deprivation on mood states of normal adults using a subjective scale and an objective scale, minimizing the effect of other factors other than that of sleep deprivation. Methods: Seventy volunteers were first participated in this sleep deprivation schedule, and 36 of them completed this experiment. The subjects and the control group members were all in their early 20's (mean $age=20.8{\pm}1.35$ vs $20.6{\pm}1.10$) and in good health. A log was checked by these subjects from a week before the laboratory study started. Drugs, alcohol and beverages containing any caffeine had been prohibited for a week before and during sleep deprivation periods. The study was performed only in summer to control other factors like sunlight, temperature and moisture. Before this experiment, the subjects had slept adequately for a week at least. On day 1 of the experiment the subjects got up at 6 a.m. and stayed in a sleep laboratory without sunlight or external noises. They could only go about their daily routines. They were forbidden to have a nap and be drowsy. GVA (Global Vigor and Affect) and MADRS (Montgomery-Asberg Depression Rating Scale) were checked 11 times. The data was analysed focusing on the changing mood states. Results: The mood during sleep deprivation became worse as the sleep deprivation time progressed. Especially 20 hours ($GA=59.25{\pm}8.06$, $MADRS=3.43{\pm}1.25$) and 40 hours ($GA=38.83{\pm}9.22$, $MADRS=6.08{\pm}1.46$) after sleep deprivation, there were significant changes compared to the control group ($MADRS=6.08{\pm}1.46$ vs $1.07{\pm}1.18$, p<0.001). Conclusions: While controlling factors other than sleep deprivation might have had some influence on mood changes, significant mood changes during sleep deprivation were observed. The mood states became worse as the sleep deprivation progressed.

• Clinical and Experimental Pediatrics
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• v.49 no.1
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• pp.34-39
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• 2006

Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. However, its metabolic basis has not been clearly explained. The UDP-glucuronosyltransferase gene(UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 1828G>A(rs 10929303) polymorphism of the UGT1A1 gene, which encodes for a key enzyme of bilirubin metabolism. Methods : The genomic DNA was isolated from 80 Korean full term neonates who had greater than a 12 mg/dL level of serum bilirubin with no obvious cause, and the genomic DNA was also isolated from 164 Korean neonates of the control population. We studied a single nucleotide polymorphism (SNP) of 1828G>A in the untranslated region of the UGT1A1 gene by direct sequencing. Results : Three of the 80 neonates with a serum bilirubin level above 12 mg/dL had homozygous mutations and 10 of the 80 neonates with a serum bilirubin level above 12 mg/dL had heterozygous mutations. Thirteen of the 164 neonates of the control group had homozygous mutations and 16 neonates of the control group had heterozygous mutations. The allele frequency of 1828G>A polymorphism of UGT1A1 in the hyperbilirubinemia group was 10.0 percent, which was not significantly different from the allele frequency of 12.8 percent in the control group. Conclusion : In this study, the 1828G>A polymorphism of the UGT1A1 gene was detected in the Korean neonates with neonatal hyperbilirubinemia. Our results indicated that this SNP is not associated with the prevalence of hyperbilirubinemia in Koreans.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.3
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• pp.435-443
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• 2012

This study investigated soil carbon storage and microbial activities influenced by different management practices in rice paddies and pastures. Soils under a single-crop farming of rice (CON) and rice-Italian ryegrass rotation farming (IRG) were compared in Jangheung, Jeollanam-do, Seocheon and Cheonan, Chungcheongnam-do. Soils from pastures were analyzed to investigate the effect of duration period (P1, P2, P3) in Namwon, Jeollabuk-do and Seosan, Chungcheongnam-do. In rice paddy, total and particulate carbon (PC) concentrations in the IRG soils were significantly higher than those in the CON soils both in Jangheung and Seocheon where the IRG has been established for three years, whereas carbon concentrations were not significantly different in Cheonan where IRG planting history is only one year. In rice paddy soils, PC was suggested as an early indicator to monitor changes in soil carbon storage followed by adopting different management practices. In pasture, total and PC concentrations increased with duration period especially in the 0-5 cm soils. Contrary to the rice paddy soils, the magnitude of change in PC concentration is not as great as that in total carbon concentration, implying that there is a need to develop a new early indicator other than PC using different fractionation scheme. The soil carbon storage in pasture also increased with years since establishment and the increasing rate was significantly greater in the early stage (0-5 yrs) than the later one (> 5 yrs). Microbial activities measured from fluorescein diacetate (FDA) hydrolysis analysis were significantly lower in the IRG soils than CON soils, whereas no difference was observed in the pastures of different ages. This shows that FDA activity is not a sensitive indicator to differentiate soil qualities influenced by management practices if it is used by itself.

• Journal of The Korean Society of Grassland and Forage Science
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• v.30 no.1
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• pp.25-34
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• 2010

Although whole crop barley (Hordeum vulgare L.) is now widely grown as a silage crop in Korea, forage production and silage quality of that for organic farm have not been published. Therefore, this experiment was conducted to evaluate the effect of harvest stage on forage production and quality of organic barley, and effect of field wilting and crushed rice for shortening of harvest date and improvement of forage quality. The experiment was split-plot design with three replications. Main plots were heading, milking and yellow stages, and sub-plot were field wilting for I day, crushed rice 10% (CR10%) and 15% (CR15%) treatments. The dry matter (DM) contents of heading, milking and yellow stages were 12.8%, 21.9% and 29.8%, respectively. The DM yields of heading, milking and yellow stages were 10,346, 15,819 and 18,336 kg/ha, respectively, and the total digestible nutrients (TDN) of these were 6,288, 9,550 and 10,178 kg/ha, respectively. The pH of milking stage showed low 4.00 pH values. The crude protein, ether extract, crude ash, non-fiber carbohydrate (NFC) and TDN contents were decreased as harvest stage progressed, while neutral detergent fiber (NDF) and acid detergent fiber (ADF) were increased. The crude ash (CA) of milking stage showed the lowest among harvest stages. Field wilting and crushed rice treatments decreased CA, NDF and ADF contents, and increased NFC and TDN contents. In vitro dry matter digestibility (IVDMD) decreased with progressed harvest stage, while field wilting and crushed rice treatments increased that of barley silage. Lactic acid and total organic acid contents of milking stage were the highest, and butyric acid of milking stage was the lowest among harvest stage. The good effect of field wilting and crushed rice was observed in heading stage. The experiment results indicate that optimum harvest stage of barley silage for organic was milking stage. The field wilting and crushed rice additive could be recommended as effective method for shortening harvest date and increasing forage quality of organic barley silage