• 수산해양기술연구
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• 제13권2호
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• pp.21-26
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• 1977

대서양(大西洋) Africa 연안어장(沿岸漁場)에서 조업중(操業中)인 태창수산(太倉水産) 소속(所屬) Stern trawl 선(船) No. 85 PARTO(499S)에서 사용(使用)하고 있는 PT-4 형(型) 어구(漁具)의 조정한계(調整限界) 및 적정(適正)한 예망속도(曳網速度)와 주기(主機)의 운전상태(運轉狀態)를 판단(判斷)하기 위(爲)하여 warp에 작용(作用)하는 장력(張力)을 측정(測定)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 어구조정(漁具調整)의 한계(限界)는 warp에 작용(作用)하는 장력(張力)의 크기가 약(約) 7,500kg, 강약(强弱)의 범위(範圍)가 약(約) 1,000kg을 초과(超過)하지 않는 것이 효과적으로 판단(判斷)했다. 2. 예망속도(曳網速度)는 주기(主機)의 효과적인 운전상태(運轉狀態)와 어획성능(漁獲性能)을 고려(考慮)하여 $3.6{\sim}4.0$ knot로 판단(判斷)했다. 3. 주기(主機)의 운전상태(運轉狀態)는 유량소모(油量消耗)가 급증(急增)하는 r. p. m. 290, propeller pitch 각도(角度) 13.8를 초과(超過)하지 아니하고 $13.5^{\circ}{\sim}13.8^{\circ}$를 사용(使用)하는 것이 효과적으로 판단(判斷)했다.

• 한국수산과학회지
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• 제14권4호
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• pp.260-264
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• 1981

어선에서 발생되는 수중소음을 측정하기 위하여 선미식 트롤어선인 새바다호가 수심 100m인 제주도남쪽 해역에서 운항중일 때의 구중소음을 녹음 분석한 결과를 요약하면 다음과 같다. 1) 새바다호가 운항중일 때 주된 주파수대는 $100\sim500Hz$이며 최대음압은 121dB였다. 2) 항주중의 수중소음은 속도가 증가함에 따라 음압준위가 높아진다. 3) 후진할 때의 소음은 전진할 매와 소음 spectrum도 다르고 음경준위도 높았다. 4) 기관만을 운전할 때보다 항주중일 때의 수중소음이 10dB이상 높았다. 5) 어이에서 발생되는 수중소음의 주음원은 기사소음과 프로펠라의 회전 및 선체의 진동때문인 것으로 생각된다. 6) 거리에 따른 음압의 감쇠는 주파수가 높아짐에 따라 커지고 주파수 제곱에 비례하여 감쇠하였다.

• 한국게임학회 논문지
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• 제11권2호
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• pp.151-159
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• 2011

노년시대를 대비하는 기능성 게임의 교과목을 개발하기 위하여 인문대학과 공과대학의 관련학과 학생들을 대상으로 연구진의 교과 항목들에 대해 중요성과 필요성에 대한 설문을 조사하였다. 양 대학의 학생들의 인지에 대한 공통점과 차이점을 분석하여 이를 토대로 융합 학제간 신 교과목을 개발하였다. 노인용 기능성 게임의 인식을 학생들에게 확산시키고자 본 교과목을 양대학의 교과과정에 포함시켜 시행하였다.

• 한국지반환경공학회 논문집
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• 제10권6호
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• pp.79-88
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• 2009

본 연구에서는 상부 토피고가 낮거나 지반조건이 불량한 터널의 경우 기존 터널의 보강공법과 다른 선지보네일 보강공법을 적용한 터널의 설계 및 시공사례를 조사하였다. 신기술 신공법인 선지보네일 보강공법을 대단면 터널 상부지반에 보강하여 기존 터널 보강공법들에 비하여 보강효과 및 안정성 측면의 실효성을 확인하였다. 선지보네일 공법에 대한 설계, 현장시공 사례 및 계측 데이타를 조사하여 그 보강 결과를 확인하였으며, 터널 상부지반 선지보네일 보강에 따른 대단면 터널의 아칭 특성에 대하여 유한요소 수치해석 프로그램인 MIDAS/GTS를 이용하여 연구하였다. 이와 더불어 터널 상부지반에 선지보네일 공법을 적용함에 있어서 적절한 설치간격과, 적용시 공법의 보강효과를 극대화하기 위한 방법을 제시하였다.

• Animal cells and systems
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• 제15권3호
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• pp.227-233
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• 2011

The Nramp1/Slc11a1 locus encodes a proton-coupled divalent cation transporter, expressed in late endosomes/lysosomes of macrophages, that constitutes a component of the innate immune response to combat intracellular pathogens and it was shown to play an important role in regulating inherent immunity. The previously identified Z-DNA forming polymorphic repeat(GT)n in the promoter region of the human Nramp1 gene does act as a functional polymorphism influencing gene expression. Research has shown that INF-${\gamma}$, TNF-${\alpha}$, IL-$1{\beta}$ and bacteria LPS increase the level of Nramp1 expression. However, the molecular mechanism for Nramp1 gene regulation is unclear. In this research, bovine Nramp1 5'-flanking region (-1748~+769) was cloned and analyzed by bioinformatics. Then to find the core promoter and the cis-acting elements, deletion analysis of promoter was performed using a set of luciferase reporter gene constructs containing successive deletions of the bovine Nramp1 5'-flanking regions. Promoter activity analysis by the dual luciferase reporter assay system showed that the core promoter of Nramp1 was located at +58~-89 bp. Some positive regulatory elements are located at -89~-205 bp and -278~-1495 bp. And the repressor elements were in region -205~-278 bp, intron1 and -1495~-1748 bp. LPS-responsive regions were located at -1495~-1748 bp and -278~-205 bp. The present study provides an initial effort to explore the molecular mechanism of transcriptional activation of the bovine Nramp1 gene and should facilitate further studies to decode the complex regulatory process and for molecular breeding for disease resistance in bovines.

• Journal of Ginseng Research
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• 제28권1호
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• pp.11-17
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• 2004

Earlier studies have demonstrated that chromium (Cr) Ⅵ compounds have been shown to be more toxic and carcinogenic than other chromium compounds. The aim of the present work was to evaluate the antioxidant effects of red ginseng against chromium Ⅵ-induced toxicity and free radical generation. Sixty adult male rats were divided into six equal groups include: control group, group received Cr Ⅵ alone (50 mg/kg b.w.), group treated with Korean ginseng (K. ginseng) alone (20 mg/kg b.w), group treated with Cr Ⅵ for 15 days then received K. ginseng for other 15 days, group treated with Cr Ⅵ and K. ginseng at the same time for 15 days, and group treated with K. ginseng for 15 days then Cr Ⅵ for other 15 days. The results revealed that Cr Ⅵ caused significant increase in ALT, AST, ALP, G-GT, urea, creatinine, and acid phosphatase. Whereas, it caused significant decrease in TP, albumin, testosterone, GPX, and SOD indicating a stress for liver, kidney and testes. K. ginseng alone caused significant increase in GPX and SOD activities in healthy animals and this result suggests a prophylactic role for this herb in protection against the damaging impact induced by free radical species. Furthermore, the other biochemical parameters measured after K. ginseng administration were comparable to the control values. Treatment with Cr Ⅵ followed by K. ginseng, Cr Ⅵ and K. ginseng or K. ginseng followed by Cr Ⅵ resulted in significant improvement in all tested parameters towards the normal values of the controls. However, this improvement was pronounced in the group pre-treated with K. ginseng for 15 days before Cr Ⅵ administration. It could be concluded that K. ginseng exhibited a protective action against the toxic effects of Cr Ⅵ and it had the ability to scavenge free radicals resulted from Cr Ⅵ intoxication.

• 약학회지
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• 제60권3호
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• pp.118-127
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• 2016

A growing number of studies have demonstrated that ABCB1 gene polymorphisms are associated with the variability of responses to imatinib. However, the effects of ABCB1 polymorphisms on imatinib response in chronic myeloid leukemia (CML) are inconsistent. The aim of the present study was to clarify the associations between ABCB1 polymorphisms and imatinib response in CML. A systematic literature review was performed. The databases of PubMed, Embase, and Cochrane Library were searched for all published studies from inception to December 2015. The following terms were used with functions of 'AND' and 'OR': 'chronic myeloid leukemia', 'CML', 'ABCB1', 'MDR1', 'polymorphism', 'SNP', and 'imatinib'. Using the Review Manager 5, odds ratios (ORs) were pooled to estimate the effect of ABCB1 polymorphisms on imatinib response in CML. The pooled analysis showed that ABCB1 2677 G allele was significantly associated with poor response to imatinib in African and Asian patients (GG vs TT, OR: 0.32, p<0.0001; GG+GT vs TT, OR: 0.44, p=0.0005). In subgroup analyses, African patients carrying ABCB1 1236 C allele exhibited higher risk for worse response, whereas Asian patients with 1236 C allele showed better response (CC+CT vs TT, OR: 0.41, p=0.008 for African; OR: 1.65, p=0.03 for Asian). There was no association between C3435T polymorphisms and imatinib response in African, Asian, and Caucasian CML patients.

• 플랜트 저널
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• 제9권4호
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• pp.31-36
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• 2013

국내 A 복합발전소에서 운전 중인 150 MW급 가스터빈 저압 1단 회전익의 교체주기 연장가능성을 다각적으로 모색하였다. 제작사가 추천한 24,000 등가운전시간 이상을 사용한 저압 1단 회전익의 외관검사, 열차폐코팅 제거 후 모재의 표면검사 및 균열검사를 각각 실시하였다. 또한 제작사별 150 MW급 가스터빈의 교체주기를 비교 분석하였다. 제작사가 추천한 24,000 등가운전시간 이상이 경과하여 27,000 등가운전시간을 운전한 저압의 외관을 검사한 결과 냉각홀 부위에 다수의 균열이 관찰되었다. 그러나 열차폐코팅을 제거한 상태에서 실시한 모재의 표면검사에서는 균열이 거의 관찰되지 않았으며, 모재까지 진행된 일부 미세 균열에 대해서는 절단면 검사를 통하여 균열깊이가 기능에 영향을 미치지 않는 수준임을 확인하였다. 따라서 본 연구대상 가스터빈 저압 1단 회전익의 교체정비주기는 현행 24,000 등가운전시간에서 3,000 등가운전시간의 연장이 가능할 것으로 보인다. 또한 연구대상 저압 1단 회전익에 대하여 제작사가 추천한 교체주기는 타제작사 1단 회전익 교체주기의 2/3 수준으로 짧게 설정되어 있어 교체주기 연장이 가능할 것으로 판단된다.

• Environmental Analysis Health and Toxicology
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• 제18권3호
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• pp.209-217
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• 2003

To investigate the effects of low dosed microcystin -LR (MCLR) on the initial stage of subacute hepatotoxicity in vivo, male Sprague-Dawley rats after weanling were divided in four groups. The orally treated group (OG) was administered orally by 1 $\mu\textrm{g}$/kg B.W. at an interval of three days. The free group (FG) has taken the drinking water including 1 $\mu\textrm{g}$/L freely and the control group (CC) was only treated with 0.9％ saline solution All groups were treated for a period of 3 weeks. There was a significant correlation in body growth rate between OG and FC and especially, a deterioration of the growth of spleen was observed in the FG after 5 days. The protein levels were also decreased in OG and FG after 9 days. Level of total fat was increased to the 9th day but again decreased up to the initial level. High hemolysis of the isolated erythrocytes occurred only in OG. Activities of ${\gamma}$-G7 of 0G and FG were higher twice-fold than CG, but the values of OG were already higher at the first treatment day. No significant change in aspartate aminotransferase (AST) activity was shown in all groups, but the activity of alanine aminotransferase (ALT) was slightly increased at the beginning state. There were much similarities in the results of OG and FG. except the growth inhibition of spleen in FG. It may be concluded that long -term effects of the low doses of mycrocystins in animals including human being can lead to serious health problems, especially to liver and spleen.

• Restorative Dentistry and Endodontics
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• 제24권4호
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• pp.633-638
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• 1999

The purpose of our study is to evaluate the ability of nickel-titanium(NiTi) files in maintaining the original curvature of a curved root canal during canal preparation. Curved canals on translucent resin blocks were prepared with Profiles and stainless steel files and they were placed at the platform which can reproduce the same position. The unprepared and prepared canal forms were accurately compared by double exposure technique of photography. The results were as follows : 1 NiTi files made a canal comparatively taper, but stainless steel files didn't make a canal taper, wicest at midportion and comparatively wide at a apical portion. 2. Canals preparations with no. 25 Profile.06 up to the working length were most excellent in taperness and in maintaining the original curvature. Canals prepared with no 30 Profile.06 up to the working length made a little outer transportation at a apical portion, but not severe. 3. Canal preparations with Profile GT were excellent in taperness and in maintaining the original curvature, but made more enlargement toward the inner side at the starting portion of the curvature. 4. Canal preparations with stainless steel files were not tapered and provided the largest transportation.