• The Korea Journal of Herbology
• /
• v.28 no.6
• /
• pp.145-153
• /
• 2013

Objectives : Neuroinflammation is characterized by microglial activation and the expression of major inflammatory mediators. The present study investigated the inhibitory effect of ginsenoside Rg1 ($GRg_1$), a principle active ingredient in Panax ginseng, on pro-inflammatory cytokines and microglial activation induced by systemic lipopolysaccharide (LPS) treatment in the mouse brain tissue. Methods : Varying doses of $GRg_1$ was orally administered (10, 20, and 30 mg/kg) 1 h before the LPS injection (3 mg/kg, intraperitoneally). The mRNA expression of pro-inflammatory cytokines in the brain tissue was measured using the quantitative real-time PCR method at 4 h after the LPS injection, Microglial activation was evaluated using western blotting and immunohistochemistry against ionized calcium binding adaptor molecule 1 (Iba1) in the brain tissue. Cyclooxigenase-2 (COX-2) expressions also observed using western blotting and immunohistochemistry at 4 h after the LPS injection, In addition, double-immunofluorescent labeling of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and COX-2 with microglia and neurons was processed in the brain tissue. Results : $GRg_1$ (30 mg/kg) significantly attenuated the upregulation of TNF-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-6 mRNA in the brain tissue at 4 h after LPS injection. Morphological activation and Iba1 protein expression of microglia induced by systemic LPS injection were reduced by the $GRg_1$ (30 mg/kg) treatment. Upregulation of COX-2 protein expression in the brain tissue was also attenuated by the $GRg_1$ (30 mg/kg) treatment. Conclusion : The results suggest that $GRg_1$ is effective in the early stage of neuroinflammation which causes neurodegenerative diseases.

• Korean Journal of Remote Sensing
• /
• v.20 no.1
• /
• pp.39-46
• /
• 2004

The generalized Rayleigh-Gans (GRG) approximation is usually used to compute the scattering amplitudes of leaves smaller or comparable to a wavelength, while the physical optics (PO) approach with the resistive sheet approximation is commonly used for leaves larger or comparable to the wavelength. In this paper, the scattering amplitudes of an elliptical leaf are computed using those theoretical scattering models (GRG and PO) at different frequencies. The accuracies of the analytical models for microwave scattering from deciduous leaves are investigated by comparison with the precise estimation by the method of moment (MoM). It was found that both the PO approach and the GRG approximation can be used alternatively for computing the scattering matrices of natural deciduous leaves at P-, L-, C- and X-band frequencies.

• Journal of the Korean Data and Information Science Society
• /
• v.17 no.2
• /
• pp.421-436
• /
• 2006

Huang proposed a grey-based nearest neighbor approach to predict accurately missing attribute value in 2004. Our study proposes which way to decide the number of nearest neighbors using not only the deng's grey relational grade but also the wen's grey relational grade. Besides, our study uses not an arithmetic(unweighted) mean but a weighted one. Also, GRG is used by a weighted value when we impute missing values. There are four different methods - DU, DW, WU, WW. The performance of WW(Wen's GRG & weighted mean) method is the best of any other methods. It had been proven by Huang that his method was much better than mean imputation method and multiple imputation method. The performance of our study is far superior to that of Huang.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2002.04a
• /
• pp.140-145
• /
• 2002

At present, wind tunnel test or CFD is used for predicting aerodynamic drag coefficient in motor company. But, wind tunnel test requires much cost and time, and CFD has about 30% error. In this study a predicting program of the aerodynamic drag coefficient based on empirical techniques was developed. Also a mathematical optimization method using GRG method was added to the program. The program was applied to six cars. Aerodynamic drag coefficient values of six cars were Predicted with 4.857% average error. The optimization method was also applied to six cars. Three parameters selected from sensitivity analysis were determined to reduce the afterbody drag coefficient to the value established by a designer and when some parameters were changed for a developing automotive, optimal modifiable parameters were determined to preserve the same drag coefficient as the original automotive. It was verified that this program could predict the aerodynamic drag coefficient effectively and accurately, and this program with GRG method could determine optimal values of parameters.

• 한국데이터정보과학회:학술대회논문집
• /
• 2006.04a
• /
• pp.55-62
• /
• 2006

Huang proposed a grey-based nearest neighbor approach to predict accurately missing attribute value in 2004. Our study proposes which way to decide the number of nearest neighbors using not only the dong's grey relational grade but also the wen's grey relational grade. Besides, our study uses not an arithmetic(unweighted) mean but a weighted one. Also, GRG is used by a weighted value when we impute a missing values. There are four different methods - DU, DW, WU, WW. The performance of WW(wen's GRG & weighted mean) method is the best of my other methods. It had been proven by Huang that his method was much better than mean imputation method and multiple imputation method. The performance of our study is far superior to that of Huang.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.64 no.4
• /
• pp.297-302
• /
• 2015

Replacing a manual switch installed in a feeder for a distribution system with an automatic one increases the reliability of the electric power system. This is because the automatic switch can shorten the duration of a fault the customer experiences by splitting the faulty section faster than the manual one does. However, improving the reliability of the distribution system may increase investment costs. Here, the investment costs include automatic switch cost, replacement work cost and labor cost. For this reason, importance should be attached to the proper balance between the increase of the investment costs and the improvement of the reliability of the distribution system. This article analyzed reliability index and economics when manual switches installed in a feeder (RBTS Bus2 model) was replaced by automatic ones. In addition, it attempted to draw the optimum rate of automation of manual switches by automatic ones using the GRG optimization method, considering the current economic requirements.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.15 no.4
• /
• pp.675-691
• /
• 2002

The focus of this work is on the development of large-scale numerical optimization methods for optimal control of steady incompressible Navier-Stokes flows. The control is affected by the suction or injection of fluid on portions of the boundary, and the objective function of fluid on portions of the boundary, and the objective function represents the rate at which energy is dissipated in the fluid. We develop reduced Hessian sequential quadratic programming. Both quasi-Newton and Newton variants are developed and compared to the approach of eliminating the flow equations and variables, which is effectively the generalized reduced gradient method. Optimal control problems we solved for two-dimensional flow around a cylinder. The examples demonstrate at least an order-of-magnitude reduction in time taken, allowing the optimal solution of flow control problems in as little as half an hour on a desktop workstation.

• Korean Journal of Pharmacognosy
• /
• v.46 no.4
• /
• pp.279-282
• /
• 2015

In order to quantify compound K(CK), anticancer component of Panax ginseng C. A. Meyer, high titer rabbit polyclonal antibodies (pAbs) were raised against a conjugate of CK and bovine serum albumin coupled by a periodate oxidation method. Coating antigen (CK-OVA) was also prepared by the same method with OVA. As a result of optimization of antiserum dilution (2,000 fold), coating antigen ($25{\mu}g/ml$) and other condition (incubation time, temperature and washing method), ELISA method for the determination of CK was established. The measuring range extended from 0.5 ng/ml to 25 ng/ml of CK. The antibodies exhibited minor or even no cross reactivities with protopanaxatriol (1.56%) and other tested ginsenosides, $GRb_1$ (0.11%), $GRg_1$ (0.07%) except protopanaxadiol (87.2%) from the structural similarity. And the antibody showed good correlation (r=0.987) between the assay values obtained by this ELISA method and HPLC. Therefore, the ELISA method could be very useful tools for the determination of CK in biological fluids because of their high sensitivity and specificity.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.10 no.5
• /
• pp.223-227
• /
• 2002

Wind tunnel test or CFD is used for predicting aerodynamic drag coefficient in domestic motor companies. But, wind tunnel test requires much cost and time, and CFD has a relatively large error. In this study a predicting program of the aerodynamic drag coefficient based on empirical techniques was developed. Also GRG method was added to the program in order to decide optimal values of some parameters. The program was applied to 24 cars and the aerodynamic drag coefficients were predicted with 4.82% average error. Optimization was also accomplished to 6 cars. Some parameters to be modified were determined (1) to reduce the afterbody drag coefficient to the value established by a designer and (2) to preserve the same drag coefficient as the original automotive when some parameters have to be changed in the viewpoint of design. It was verified that the developed program can predict the aerodynamic drag coefficient appropriately and determine optimal values of some parameters.

• Journal of Biosystems Engineering
• /
• v.10 no.2
• /
• pp.55-62
• /
• 1985

박(朴)(1982, 1983, 1984 및 1985)이 개발(開發)한 배합사료공장(配合飼料工場)의 투자비용(投資費用) 및 운전비용(運轉費用)의 수학적모형(數學的模型)을 이용(利用)하여, 배합사료공장(配合飼料工場)의 적정(適正) 시스템의 설계(設計)를 예(例)를 들어 소개하였다. 적정(適正)시스템의 설계(設計)를 위(爲)하여 비선형(非線型) 프로그램의 "Single Objective Programming Problem(단일목적함수(單一目的函數))"와 "'Multiple Objective Decision Making Method(다목적함수(多目的函數))"의 2가지 방법(方法)을 적용(適用)하였다. Single Objective Programming Problem에서는 "Generalized Reduced Gradient(GRG) Method"를 이용(利用)하였고, Multiple Objective Decision Making Method(MODM)에서는 "Interactive Nonlinear Goal Program(INGP)"를 이용(利用)하였으며 그 결과(結果)는 다음의 몇가지로 요약(要約)할 수 있다. 1. 박(朴)이 개발(閒發)한 수학적(數學的) 모형(模型)들은 2 가지 방법(方法) 모두 사료공장(飼料工場)의 최적화(最適化) 설계(設計)에 효과적으로 이용(利用)할 수가 있었다. 2. MODM방법(方法)에 의(依)하여 얻어진 최적(最適)시스템은 Single Objective Program Problem에서 구(求)한 결과(結果)보다 균형(均衡)이 있는 시스템이었으며 장래(將來)의 사료원료(飼料原料), 사료구매시장(飼料購買市場), 기타 다른 조건(條件)들의 변화)에 대(對)해서 보다 탄력(彈力)이 있는 시스템으로 나타났다. 3. 엄밀한 의미(意味)에서 절대적(絶對的)인 최적사료공장(最適飼料工場)이란 있을 수 없으며, 주위의 조건(條件), 원료가격(原料價格), 사료가격(飼料價格), 공장주(工場主)의 취향 및 설계조건등(設計條件等)에 따라 최적(最適) 시스템은 각각(各各) 다르게 나타난다.