• The Korea Journal of Herbology
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• v.38 no.2
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• pp.27-34
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• 2023

Objectives : Currently, the benign prostatic hyperplasia (BPH) is one of the most common urogenital disorder in old men. We were performed to determine the effects of abietic acid (AC), component of pine resin, in benign prostatic hyperplastic Sprague-Dawley rat (SD rat) induced by testosterone injection (IP). Methods : We monitored body weights in SD rat at start and end date of experiment. After end of experiment, the prostate weights were measured in SD rats. Glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels was performed in serum. And we determined the 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels in prostate tissue and serum using ELISA kit. Results : As results, the prostate wights were increased in BPH group compared to normal group and were decreased in fina, AC30, and AC 50 groups, respectively. Serum GOT levels were decreased in AC50 group compared to BPH group. And Serum GPT levels of AC30 and AC50 groups were lower than BPH group. In addition, the 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels were decreased the fina, AC10, AC30, and AC 50 groups contrast to the BPH group. Furthermore, 5-alpha reductase Ⅱ activity, testosterone levels, and dihydrotestosterone levels were decreased dose dependent in AC groups compared to BPH group. Conclusion : These results suggest that AC could be used as a potential material for the treatment of BPH by decreasing the androgen levels in benign prostatic hyperplasia model rats.

• Journal of the Institute of Convergence Signal Processing
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• v.24 no.1
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• pp.42-50
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• 2023

The development of technology has achieved digital innovation throughout the media industry, including production techniques and editing technologies, and has brought diversity in the form of consumer viewing through the OTT service and streaming era. The convergence of big data and deep learning networks automatically generated text in format such as news articles, novels, and scripts, but there were insufficient studies that reflected the author's intention and generated story with contextually smooth. In this paper, we describe the flow of pictures in the storyboard with image caption generation techniques, and the automatic generation of story-tailored scenarios through language models. Image caption using CNN and Attention Mechanism, we generate sentences describing pictures on the storyboard, and input the generated sentences into the artificial intelligence natural language processing model KoGPT-2 in order to automatically generate scenarios that meet the planning intention. Through this paper, the author's intention and story customized scenarios are created in large quantities to alleviate the pain of content creation, and artificial intelligence participates in the overall process of digital content production to activate media intelligence.

• Journal of Practical Engineering Education
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• v.16 no.5_spc
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• pp.663-676
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• 2024

This study, from the perspective of Learning with AI, aimed to explore the educational applicability of writing evaluation criteria generated by artificial intelligence. Specifically, it sought to systematically analyze the similarities and differences between AI-generated criteria and those developed by humans. The research questions for this study were set as follows: 1) What characteristics do the writing evaluation criteria generated by AI tools have? 2) What similarities and differences exist between the writing evaluation criteria generated by humans and AI tools? GPT and Claude were selected as representative AI tools, and they were tasked with generating writing evaluation criteria for undergraduate students. These AI-generated criteria were then compared with human-created criteria. The results showed a commonality: Both humans and AI-tools placed the highest importance on categories related to content. However, while humans evaluated based on three main categories - content, organization, and language usage - the AI tools included additional categories such as format and citations, original thinking, and overall impression. In general, human tended to include more detailed items within each evaluation category, while AI tools presented more concise items. Notably, differences were observed in language-related aspects and scoring systems, which were influenced by the AI tools being developed based on English. This study offers important insights into the development of collaborative evaluation models between humans and AI, and it explores the potential role of AI as a complementary tool in educational assessment in the future.

• The Korean Journal of Pharmacology
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• v.32 no.1
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• pp.13-21
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• 1996

Intracellular calcium concentration ($[Ca^{2+}]_i$) may play a crucial role in a variety of neuronal functions. Here we report that in primary culture of mouse cerebellar granule cells nicotinic acetylcholine receptors (nAChRs) are expressed in a specific developmental stage and involved in the regulation of intracellular calcium homeostasis. Nicotine-mediated calcium responses were measured using $^{45}Ca^{2+}$ or fluorometrically using the calcium-sensitive fluorescent dye fura-2. Maximal uptake of $^{45}Ca^{2+}$ evoked by nicotine in mouse cerebellar granule cells were revealed $8{\sim}12$ days in culture. In contrast, nicotine did not alter the basal $^{45}Ca^{2+}$ uptake in cultured glial cells. In cerebellar granule cells nicotine-evoked $^{45}Ca^{2+}$ uptake was largely blocked by the NMDA receptor antagonists. Glutamate pyruvate transaminase (GPT). which removes endogenous glutamate, also prevented nicotine effects, implying the indirect involvement of glutamate in nicotine-mediated calcium responses. Fluorometric studies using fura-2 showed two phases of nicotine-evoked $[Ca^{2+}]_i$ rises: the initial rising phase and the later plateau phase. Interestingly, the NMDA receptor antagonists and GPT appeared to inhibit only the later plateau phase of nicotine-evoked $[Ca^{2+}]_i$ rises. The present results imply that nicotine mediated $^{45}Ca^{2+}$ uptake and $[Ca^{2+}]_i$ rises are attributed to the calcium fluxes through both nAchRs and NMDA receptors in a time-dependent manner. Consequently, nAChRs may play an important role in neuronal development by being expressed in a specific developmental stage and regulating the intracellular calcium homeostasis.

• Annual Conference of KIPS
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• 2024.05a
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• pp.490-493
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• 2024

현재 다양한 분야에서 AI 가 사용되고 있다. 최근에는 소프트웨어공학 관점에서 요구 사항 분석에 Chat GPT 와 같은 LLM 모델을 적용하고 있다. 하지만 1) 대부분의 생성형 AI 는 불투명한 공정을 통해 3D 이미지가 생성하고, 3D 이미지를 생성할 때마다 다른 이미지를 생성한다. 이에 따라 동일한 인물이나 사물을 사용하고 싶은 사용자들은 동일한 객체가 들어간 그림을 일관성 있게 생성할 수 없다. 2) 또한 LLM 과 이미지 생성 AI 와의 결합이 시도 되고 있지만 문장 의미 분석 성능이 부족하다. 이를 해결하기 위해, 자연어 요구사항을 언어학적 기법을 통해 분석하고, 분석 결과를 기반으로 UML 시퀀스 다이어그램 및 3D 객체 생성 메커니즘을 제안한다. 즉 언어학적 분석 기법을 통해, 요구사항의 정확한 의미와 속성을 추출한다. 그런 다음 추출된 정보를 시퀀스 다이어그램과 매핑하여 3D 객체 이미지를 생성한다. 제안하는 방법을 통해 3D 객체 생성의 소프트웨어 개발 공정 사용으로 생산성을 높여 시간과 비용을 단축할 수 있을 것으로 기대한다.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.4
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• pp.12-26
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• 2012

Objectives: The purpose of this study is to examine the effects of Sagunjatang-Gami(SGJT) on uterine and ovarian function in the ovariectomized rat postmenopause model. Methods: SGJT was administered in ovariectomized Wister albino female rats for three month. After that, uterine weight, uterine index, serum estradiol-$17{\beta}$ levels and phosphorylation of ERK or AKT, and histological analysis of uterus were measured to assess the impact on uterine and ovarian function in ovariectomized rats. In addition, phosphorylation of $ER{\alpha}$, ERK, AKT by SGJT in MDA-MB-231 cells were measured. To identify safety of SGJT, the cell cytoxicity in MDA-MB-231 cells and serum GOT, GPT levels were measured in ovariectomized rats. Results: The results were as follows. 1. SGJT decreased the viability of MDA-MB-231 cells in a dose-dependent manner. 2. The level of serum GOT, GPT in SGJT-treated group showed significant decrease in comparison with control group. 3. Phosphorylation of $ER{\alpha}$, ERK, AKT by SGJT in MDA-MB-231 cells were increased. 4. Uterus index in SGJT-treated group showed significant increase in comparison with control group. The level of serum estradiol-$17{\beta}$ in SGJT-treated group showed significant increase in comparison with control group. Phosphorylation of ERK or AKT by SGJT in the uterus of ovariectomized rats was increased significantly. 5. Uterus index and the level of serum estradiol-$17{\beta}$ in SGJT-treated group increased at higher rates in comparison with estrogen-treated group. Conclusions: Taken together, we suggest that SGJT has been shown to be effective in preventing postmenopausal uterine and ovarian degeneration and curing postmenopausal low estrogen related symptoms.

• The Journal of the Convergence on Culture Technology
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• v.7 no.2
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• pp.427-436
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• 2021

The purpose of this study is to implement a machine learning language model that learns literary texts. Literary texts have an important characteristic that pairs of question-and-answer are not frequently clearly distinguished. Also, literary texts consist of pronouns, figurative expressions, soliloquies, etc. They hinder the necessity of machine learning using literary texts by making it difficult to learn algorithms. Algorithms that learn literary texts can show more human-friendly interactions than algorithms that learn general sentences. For this goal, this paper proposes three text correction tasks that must be preceded in researches using literary texts for machine learning language model: pronoun processing, dialogue pair expansion, and data amplification. Learning data for artificial intelligence should have clear meanings to facilitate machine learning and to ensure high effectiveness. The introduction of special genres of texts such as literature into natural language processing research is expected not only to expand the learning area of machine learning, but to show a new language learning method.

• Korean Journal of Plant Resources
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• v.27 no.4
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• pp.271-278
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• 2014

Rubus coreanus has been used as a traditional medicine in Asia because of its various pharmacological properties. This study examined the effects of protocatechuic acid (PCA), one of phenolic compounds derived from R. coreanus on the lipid metabolism in high cholesterol diet-induced mice. A total of 30 male C57BL/6 mice were divided into 5 groups with 6 mice in each group as follows: (1) Control mice received normal diet (ND). (2) Mice received high-cholesterol diet (HCD) plus water, 10% sucrose solution and treated daily oral phosphate-buffered-saline (PBS) of equal volumes through gavage. (3) Mice received HCD and treated daily with 25 mg/kg b.w./day of PCA (4) with 50 mg/kg b.w./day or (5) with 10 mg/kg b.w./day of simvastatin via oral gavage for 12 weeks. Body weights were measured weekly for a period of experiment. After treatment, liver, thymus, spleen and kidney were harvested and weighed, and the lipid metabolite profiles (total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c) and liver-damaging markers (GOT and GPT) in serum were examined. PCA significantly reduced the total cholesterol, TG, LDL-c level and increased the HDL-c level. PCA administration also significantly reduced the levels of GOT and GPT. These results indicate that the PCA could be used as a functional material for lowering lipid and an adjuvant for the treatment of hyperlipemia.

• Journal of the Korea Society of Computer and Information
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• v.28 no.8
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• pp.195-204
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• 2023

In this study, prompt engineering that improves prompts was explored to improve the performance of teaching and learning materials recommendations using generative artificial intelligence such as GPT and Stable Diffusion. Picture materials were used as the types of teaching and learning materials. To explore the impact of the prompt composition, a Zero-Shot prompt, a prompt containing learning target grade information, a prompt containing learning goals, and a prompt containing both learning target grades and learning goals were designed to collect responses. The collected responses were embedded using Sentence Transformers, dimensionalized to t-SNE, and visualized, and then the relationship between prompts and responses was explored. In addition, each response was clustered using the k-means clustering algorithm, then the adjacent value of the widest cluster was selected as a representative value, imaged using Stable Diffusion, and evaluated by 30 elementary school teachers according to the criteria for evaluating teaching and learning materials. Thirty teachers judged that three of the four picture materials recommended were of educational value, and two of them could be used for actual classes. The prompt that recommended the most valuable picture material appeared as a prompt containing both the target grade and the learning goal.

• Journal of Sasang Constitutional Medicine
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• v.19 no.2
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• pp.155-169
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• 2007

1. Objectives This study aimed to investigate the anti-oxidative effect of Nocyongdaebo-tang (NYD) decoction in oxidized rats induced by AAPH. 2. Methods AAPH (2.2-azobis-2 aminodinopropane-hydrochloride) was injected intraperitoneally to induce oxidization and NYD was orally administered to the rats. To observe the anti-oxidative effect of NYD, we performed blood chemistry analysis, histological analysis, and evaluated the levels of SOD, catalase, glutathione, NO and MDA in liver. 3. Results & Conclusions 1) Serum Albumin level was increased significantly in the NYD group as compared with the control group and the saline group. 2) Serum LDL-cholesterol level was reduced significantly in the NYD group as compared with the control group. 3) GPT level in liver was reduced significantly in the NYD group as compared with the control group. 4) SOD, catalase activity and glutathione levels were increased significantly in the NYD group as compared with the control group and the saline group. 5) The levels of NO and MDA were reduced significantly in the NYD group as compared with the control group. 6) The degenerative change of liver tissue of NYD group was decreased in comparison with the control group. In conclusion, NYD decoction is considered to have an anti-oxidative effect in rats.