• BMB Reports
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• v.51 no.5
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• pp.255-260
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• 2018

Wntless/GPR177 functions as WNT ligand carrier protein and activator of $WNT/{\beta}$-catenin signaling, however, its molecular role in gastric cancer (GC) has remained elusive. We investigated the role of GPR177 in gastric tumorigenesis and provided the therapeutic potential of a clinical development of anti-GPR177 monoclonal antibodies. GPR177 mRNA expression was assessed in GC transcriptome data sets (GSE15459, n = 184; GSE66229, n = 300); protein expression was assessed in independent patient tumor tissues (Yonsei TMA, n = 909). GPR177 expression were associated with unfavorable prognosis [log-rank test, GSE15459 (P = 0.00736), GSE66229 (P = 0.0142), and Yonsei TMA (P = 0.0334)] and identified as an independent risk predictor of clinical outcomes: GSE15459 [hazard ratio (HR) 1.731 (95% confidence interval; CI; 1.103-2.715), P = 0.017], GSE66229 [HR 1.54 (95% CI, 1.10-2.151), P = 0.011], and Yonsei TMA [HR 1.254 (95% CI, 1.049-1.500), P = 0.013]. Either antibody treatment or GPR177 knockdown suppressed proliferation of GC cells and sensitized cells to apoptosis. And also inhibition of GPR177 suppresses in vitro and in vivo tumorogenesis in GC cells and inhibits $WNT/{\beta}$-catenin signaling. Finally, targeting and inhibition of GPR177 with antibody suppressed tumorigenesis in PDX model. Together, these results suggest GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of GC patients.

• Journal of the Korean Recycled Construction Resources Institute
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• v.5 no.2
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• pp.177-184
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• 2017

Many ground subsidence accidents have happened in Korea. The accident was caused by the subsidence and leakage of the deteriorated sewage pipe. This study aims to establish the empirical data of the ground penetration radar(GPR) detection for ground subsidence. A test bed was also manufactured for the same purpose. The GPR detection variables are embedment depth and horizontal distance of embedded cast iron pipe and expanded polystyrene(EPS). From the detection results, the EPS embedded by a depth of 1.5m was difficult for detection. The EPS closely embedded to the cast iron pipe within a 0.5m distance had a very strong cast iron pipe signal. Therefore, the detection was impossible. This study developed an image processing program, called the GPR image processing program(GPRiPP), to process the GPR detection results. Its major function is the gain function, which amplifies the wiggle wave signal. Compared to the existing programs, the GPRiPP is capable of showing a similar image processing performance.

• Journal of the Korea institute for structural maintenance and inspection
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• v.7 no.2
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• pp.177-184
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• 2003

A series of experimental work has been conducted to evaluate the capability of Ground Penetrating Radar (GPR) system in detecting delamination inside concrete. Three antenna at 900 MHz, 1000 MHz, and 1500 MHz frequency are used in the experiments for laboratory size specimens, and 400 MHz antenna has been used for a large size specimen. The laboratory size specimens have the dimensions of 1,000 mm (length) ${\times}$ 600 mm (width) ${\times}$ 140 mm (thickness) with a delamination of 200 mm (length) ${\times}$ 600 mm (width) ${\times}$ 140 mm (thickness). The cover depth of the delamination is varied as follows: 20 mm, 30 mm, 60 mm, and 70 mm. In all cases, the delamination has been successfully identified. The property of three frequencies was seized about detecting delamination. Also, it was shown that the image results in GPR were improved by signal processing.

• Proceedings of the IEEK Conference
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• 2001.06a
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• pp.177-180
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• 2001

A decoupled, wide-band, perfectly magnetically conductor(PMC)-backed air waveguide antenna is designed and constructed for the use of the continuous electromagnetic wave ground penetrating radar in the frequency range from 200MHz to 600MHz. Two planar dipoles are located inside air slab covered by PMC on the top side and separated by an air gap from the bottom ground interface. The coupling between the transmitting and the receiving dipoles is calculated by less than -60dB over the frequency from 200MHz to 600MHz.

• Journal of the Korean Geophysical Society
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• v.6 no.3
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• pp.165-177
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• 2003

The purpose of this paper is to analyze the behavior and to study the safety evaluation of the Unmun Dam located in Cheongdo-Gun of GyeongBuk Province, Korea. For this purpose, soil analyses including boring data, geophysical surveys were conducted. In this paper, especially many geophysical methods were adopted to configure out the subsurface situation of dam. Applied geophysical methods were: 1) electric resistivity survey, 2) high frequency magnetotelluric (HFMT) survey, 3) ground penetrating radar (GPR) survey, 4) seismic refraction survey, 5) seismic cross-hole tomography survey, and 6) high frequency impedance (ZHF) survey. Each of geophysical surveys were analyzed and joint analyses between geophysical surveys were also performed to deduce the more reliable subsurface information of Dam by using the features and characteristics of each geophysical survey. Since many defects, such as gravel and weathered rock blocks in the dam core, and lots of amounts of leakage, by boring analyses were found, reinforcement by compaction grouting system (CGS) has been conducted in some range of dam. Some geophysical data and data of geotechnical gauges were also used to confirm the effects of reinforcement. Electric resistivity, EM, GPR, ZHF, seismic refraction and seismic tomography surveys show that left side of dam is weak, which means the possibility of existence of gravel, rock block, water and cavities in the core of dam. This result coincides with the boring data. Especially, electric survey after reinforcement shows that even the right side of the dam has been deformed by the strong pressure during the reinforcement itself. As a conclusion, some problems in the dam found. Especially, the dam near spillway shows the high possibility of leakage. It should be pointed out that only the left side of he dam has not a leakage problem. As a whole, the dam has problems of weakness, because of unsatisfactory construction. It is strongly recommended that highly intensive monitoring is required.