• Title/Summary/Keyword: GP5

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MDR1 C3435T and C1236T Polymorphisms: Association with High-risk Childhood Acute Lymphoblastic Leukemia

  • Pongstaporn, Wanida;Pakakasama, Samart;Chaksangchaichote, Panee;Pongtheerat, Tanett;Hongeng, Suradej;Permitr, Songsak
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2839-2843
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    • 2015
  • Background: MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. Materials and Methods: To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and outcome of ALL, 208 children with ALL (median age 5.0 yr) and 101 healthy Thai children were studied by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) assay. Results: C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR= 2.6, 95%CI =1.164-5.808; P=0.028 and OR= 2.231, 95%CI =1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.

Fracture Toughness Improvement of Graphite/Epoxy Composite by Intermittent Interlaminar Bonding (간헐적인 층간접착 을 이용한 Graphite/Epoxy 복합재료 의 파괴인성 개선)

  • 임승규;홍창선
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.8 no.5
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    • pp.425-434
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    • 1984
  • The concept of intermittent interlaminar bonding is investigated as a means of improving the fracture toughness of cross-ply Gr/Ep composites without significant loss of tensile strength and modulus. The concept of linear elastic fracture mechanics(LEFM)is used to study the effects of strong bonded area and bonding composites. The experimental results indicate that the fracture toughness and notch strength of intermittent interlaminar bonded composities are improved and the tensile strength only decreased by 3-8% in comparison to those of the fully bonded composites. Damage zones around the crack tip are detected by the modified X-Ray non-destructive testing technique and the fractography. The improvement of toughness is explained based on the damage zones. The mechanisms of damage zone are shown to be caused by subcrack along the fiber on the 0.deg. ply, matrix cracking along the fiber on the 90.deg. ply, interlaminar delamination, and ply pull-out of the 0.deg. ply.

Belongings Position Tracking System using RFID (RFID를 이용한 소지품 위치추적 시스템)

  • Kwun, Jungho;Kim, Jinsu;An, Beongku
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.12 no.5
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    • pp.75-81
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    • 2012
  • RFID is new recognition technology which can trace IC chip(built in information) with wireless frequency. The present RFID is used in parcel service, missing child potection system, bus card, and extensive areas. This paper proposes and designs a belongings position tracking system using RFID with GPS. The main features of the proposed system are as follows. First, the system can in real time track the lost belongings. Second, the system can provide lost belonging location information to the users. The performance evaluation of the proposed system is performed by using AVD(Android Virture Device).

Smart Message Service Platform for Mobile Environment (모바일용 스마트 메시지 서비스 플랫폼)

  • Kim, Nam-Yun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.11 no.5
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    • pp.73-79
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    • 2011
  • With increasing use of smartphone, users require a new message service to prevent security attack and provide integrated messages. Since smartphone uses data services such as 3G cell network and WiFi, it can provide reliable message transfer through various security policies. In addition, it can transfer various data collected using built-in camera and GPS. This paper proposes a smart message service platform which can provide security services such as authentication, confidentiality and integrity as well as transfer the integrated message including location, picture and text. To verity the functionality of the platform, this paper implements an iPhone app and message transfer server, and then shows the implementation results.

A Study on Horizontal Moment Flight Coefficient Estimation of a Flying Disc Using Miniaturized Inertial Measurement Module (초소형 관성측정모듈을 이용한 플라잉디스크의 수평축 모멘트 미계수 추정 연구)

  • Son, Hyunjin;Lee, Ju Hwan;Lee, Young Jae;Sung, Sangkyung
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.46 no.5
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    • pp.385-392
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    • 2018
  • This paper suggests a new method to estimate the roll and pitch damping moment coefficients of a flying disc through sensor data from the onboard IMU module. This method can be easily performed than wind tunnel or computational fluid dynamics methods because it estimates aerodynamic coefficients simply after accumulating the inertial data through several repeated flight experiments. Estimated coefficients are applied to a simulator which is based on the flight dynamics of a flying disc. Finally, the predicted flight trajectory is compared with the true position provided by GPS, which demonstrated the validity of the proposed estimation method.

The concentration differences of dental caries induced organic acids which are produced after intake of sucrose and carbonated drinks (자당 및 탄산음료 섭취 후 생성되는 구강 내 치아우식 유발성 유기산의 농도 차이)

  • Park, Jung-Eun;Jang, Jong-Hwa
    • Journal of Korean society of Dental Hygiene
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    • v.17 no.3
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    • pp.381-394
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    • 2017
  • Objectives: This study aims to evaluate carbonated drinks induced dental caries with qualitative analysis and to compare with oral organic acids including lactate, acetate, propionate, formate, butyrate, pyruvate and valerate which cause caries when taking either 10% sucrose drinks or carbonated drinks. Methods: Saliva was collected from six study subjects before and after (start, 5, 10, 30 minutes) taking water intake upon (A) 10% sucrose intake, (B) 10% sucrose intake, and (C) carbonated drink intake, then they were centrifuged at 1,200 rpm followed by removing bacteria and enzymes with syringe filtering, performing a qualitative analysis with HPLC conductivity detection (GP50 gradient pump, ED 50 detector) after saliva pre-treatment under isocratic 100 mM NaOH mobile phase. Results: Higher risk of dental caries was evaluated in order of C>B>A, with the results of total oral organic acids' concentration, lactates of organic acids and organic acids produced after 5 minutes from the 3 types of drinks intake. Conclusions: Carbonated beverages were estimated to develop higher dental caries induction than beverages containing 10% sucrose because of the high organic acid concentration in the mouth after its intake.

Study on diuretic activity and electrolytes excretion of methanol extract of Lippia nodiflora (Verbenaceae) in rats

  • D., Ashok Kumar;GP, Senthilkumar;V., Thamil selvan;UK, Mazumder;M., Gupta;SK, Ray
    • Advances in Traditional Medicine
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    • v.8 no.1
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    • pp.39-46
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    • 2008
  • In the Indian traditional medicine, Lippia nodiflora (Verbenaceae) whole plant is claimed to possess powerful diuretic activity. However, the diuretic potential of this plant is not yet investigated. The aim of this study was to evaluate the diuretic potential of methanol extract of Lippia nodiflora (MELN) in rats. Control (0.9% saline solution, 25 ml/kg, b.w) or urea (1 g/kg b.w) or frusemide (5 mg/kg b.w) and different concentrations of MELN (200 and 400 mg/kg b.w) were intraperitoneally administered (n = 6 per each treatment group) to hydrated rats and their urine output was monitored over a period of 5 h and 24 h after drug administration. The diuretic responses with its electrolyte excretion potency of the extract were highly remarkable in comparison with control animals. The extract at doses of 200 and 400 mg/kg shows a significant increase in volume of urine with increase in $Na^{+}$, $Ca^{2+}$ and $Cl^{-}$ excretion accompanied by the excretion of $K^{+}$ in dose dependent manner. This study suggests that the active component(s) in MELN had similar diuretic effect to that of frusemide. These results validate the traditional use of Lippia nodiflora as a diuretic agent.

Determination of Weight of Landslide Related Factors using GIS and Artificial Neural Network in the Kangneung Area (원격탐사, 지리정보시스템(GIS) 및 인공신경망을 이용한 강릉지역 산사태 발생 요인의 가중치 분석)

  • 이명진;이사로;원중선
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2004.03a
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    • pp.487-492
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    • 2004
  • 본 연구에서는 인공신경망 기법을 이용하여 산사태 발생원인에 대한 가중치를 구하였다. 여름철 집중호우시 산사태가 많이 발생하는 강원도 강릉시 사천면 사기막리 와 주문진읍 삼교리에 해당한다. 산사태가 발생할 수 있는 요인으로 지형도로부터 경사, 경사방향, 곡률, 수계추출을, 정밀토양도로부터 토질, 모재, 배수, 유효토심, 지형을, 임상도로부터 임상, 경급, 영급, 밀도를, 지질도로부터 암상을, Landsat TM 영상으로부터 토지이용도와 추출하여 격자화 하였으며, 아리랑1호 영상으로부터 선구조를 추출하여 l00m 간격으로 버퍼링 한 후 격자화 하였다. 이렇게 구축된 산사태 발생 위치 및 발생요인 데이터 베이스를 이용하여 인공신경망 기법을 적용하여 산사태 발생 원인에 대한 상대적인 가중치를 구하였다. 인공신경망의 역전파 알고리즘을 이용한 사기막리 지역과 삼교리 지역의 산사태 가중치를 보면 GPS를 이용한 현장조사와 위성영상을 이용한 변화탐지 기법모두의 경우모두와 훈련지역을 실제 산사태 발생 지역과 경사도가 0°인 지역, 실제 산사태 발생 지역과 Frequence ratio를 이용하여 작성한 취약성도에서 산사태 발생이 낮을 것으로 예상되는 지역, Frequence ratio를 이용한 취약성도에서 산사태 발생이 높을 것으로 예상되는 지역 과 낮을 것으로 예상되는 지역의 경우에서도 경사도는 1.5~2.5배정도 높은 상대적 가중치를 나타냈다. 이러한 가중치는 산사태 취약성도를 작성하는데 활용될 수 있다.

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Design of Spatio-temporal Indexing for searching location of RFID Objects (RFID 객체의 위치 검색을 위한 시공간 색인 설계)

  • Jun, Bong-Gi
    • Journal of the Korea Society of Computer and Information
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    • v.19 no.5
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    • pp.71-78
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    • 2014
  • The RFID-tag objects can be recognized by a distinct reader where it is installed. The RFID-tag objects are likely described as storages rather than the mobiles in the use of GPS. As RFID tags are large in number compared to moving objects, so the storing and retrieval costs are highly expensive. Here, two solutions for spatio-temporal model taking account of the feature in the tagged objects are proposed. First, the moving-tag objects are expressed by the terms "now" as well as "path location". Second, the size of storing index was noticeably reduced by not saving the tag information of palletizing products but mapping the tagged objects.

Orbital Parameters Modeling of High Resolution Satellite Imagery for Mapping Applications (매핑을 위한 고해상 위성영상의 궤도요소 모델링)

  • 유환희;성재열;김동규;진경혁
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.18 no.4
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    • pp.405-414
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    • 2000
  • A new generation of commercial satellites like IKONOS, SPOT-5 and OrbView-3,4 will have improved features, especially an higher geometric resolution with a better dynamic radiometric range. In addition high precision orbital position and attitude data will be provided by the on-board GPS receivers, IMU(Inertial Measurement Units) and star trackers. This additional information allows for reducing the number of ground control points. Furthermore this information enables direct georeferencing of imagery without ground control points. In our work mathematical models for calculating the satellite orbital parameters of SPOT-3 and KOMPSAT-1 were developed and can be easily extended to process images from other high resolution imaging systems as they become available.

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