• Journal of Advanced Navigation Technology
• /
• v.17 no.4
• /
• pp.396-403
• /
• 2013

Recently, GNSS users can utilize various navigation satellite thanks to GPS modernization, renewal of GLONASS, and development of Galileo and Beidou. And availability performance of users is expected to be improved because these new navigation satellites transmit L5 signal as well as L1 signal, and users can directly estimate the ionospheric delays. In accordance with these changes existing Satellite Based Augmentation System (SBAS) which considers only GPS L1 signal is being developed to support dual frequency and multi-constellation GNSS users. This paper describes the main features of dual-frequency, multi-constellation SBAS algorithms and estimates the performance in Korean region by simulation.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.21 no.3
• /
• pp.127-137
• /
• 2018

Recently, UAVs and Drones have been used for various applications. In particular, in the field of surveying, there are studies on the technology for monitoring the terrain based on the high resolution image data obtained by using the UAV-equipped digital camera or various sensors, or for generating high resolution orthoimage, DSM, and DEM. In this study, we analyzed the accuracy of GCP(Ground control point) matching using UAV and VRS-GPS. First, we used VRS-GPS to pre-empt the ground reference point, and then imaged at a base altitude of 150m using UAV. To obtain DSM and orthographic images of 646 images, RMSE was analyzed using pix4d mapper version As a result, even if the number of GCP matches is more than five, the error range of the national basic map(scale : 1/5,000) production work regulations is observed, and it is judged that the digital map revision and gauging work can be utilized sufficiently.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3305-3308
• /
• 2013

Background: The role of inflammation in prostate diseases is suggested by the presence of inflammatory cells within the prostate in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) patients. In addition, bacterial and viral infection may lead to chronic and recurrent inflammation of the prostate. The human papillomaviruses (HPVs) are a family of sexually transmitted viruses which have been implicated in the aetiology of cervical cancer and several other malignancies. This study evaluated the frequency of HPV infection in individuals with prostatic disease in Iran. Materials and Methods: The study included formalin fixed paraffin- embedded tissue samples of 196 primary prostate cases, including 29 PCa and 167 BPH samples. HPV DNA was purified and amplified through MY09/MY11 and GP5+/GP6+ primers with nested PCR. All patients were interviewed using a questionnaire to collect demographic information. Results: Nested PCR showed that HPV DNA was found in 17.2 percent of PCa samples and 4.8 percent of BPH samples (not significant). Conclusions: Our data do not support a significant role of HPV infection in prostatic disease in Iranian patients, but demographic data indicated a probable association between presence of HPV DNA and risk of inflammation in prostate tissue which might lead to prostate carcinoma. Further studies are required to elucidate any roles of HPV infection in prostatic disease.

• Fisheries and Aquatic Sciences
• /
• v.6 no.3
• /
• pp.125-129
• /
• 2003

Effects of synthetic oligodeoxynucleotides (ODNs) containing cytidine-phosphate-guanosine(CpG) motif(s) on nonspecific immune responses of olive flounder (Paralichthys olivaceus) and on protection against lethal infection with Edwardsiella tarda were investigated. Respiratory bunt activities of the head kidney phagocytes in the fish injected either 0.25 or 0.5 ${\mu}g/fish$of ODNs containing CpG motifs (ODN 1826 and ODN 1670) were significantly higher than those injected with an ODN containing a guanosine-phosphate-cytidine (GpC) motif (ODN 1720) or with hanks balanced salt solution (HBSS, control) at 3, 5 and 7 days after injection. The serum lysozyme activities of fish injected with 0.25${\mu}g$ of ODN 1826 were significantly higher than those injected with ODN 1720 or HBSS at 1 and 7 days after injection. At 7 days after injection, the group of fish injected with CpG ODNs showed higher serum lysozyme activities than fish injected with ODN 1720 or control. The group of fish injected 0.25 or 0.5${\mu}g$ of CpG ODNs showed higher survival rates than those treated with GpC ODN and the control group after challenge with Edwardsiella tarda. The present study proved the ability of synthetic CpG ODN to increase nonspecific immune responses and disease resistance in olive flounder.

• Journal of the Korean Chemical Society
• /
• v.30 no.1
• /
• pp.90-100
• /
• 1986

Along with synthesizing a model oligodeoxyribonuclotide GpApApTpTpCp which had the EcoRI recognition site according to "Phosphotriester Method", reported methods for protecting functions, condensation, deprotection, purifying products, quantification and identification were evaluated and modified. It was realized that oligomers were efficiently synthesized by elongating by dimer unit per step of the condensation and the condensation yields were decreased with increased numbers of the residues. The problems of quantification/identification involved in the oligonucleotide synthesis using small amount of the reactants were solved by employing UV/IR spectrophotometry and hplc/tlc. It was also proved that a nucleotide having the exposed 5'-OH function was well synthesized by condensing a 5'-OH nucleotide and a phosphodiester nucleotide whose molar ratio was intendedly made to be 1 : 1.2 and then detritylating followed by washing with an aqueous solution of sodium bicarbonate. Spectrophotometric and chromatographic data of the nucleotides and their derivatives concerned in this synthetic work were prepared.

• Biomolecules & Therapeutics
• /
• v.19 no.4
• /
• pp.493-497
• /
• 2011

The aim of this study was to investigate the effect of amlodipine on the pharmacokinetics of warfarin after oral and intravenous administration of warfarin in rats. Warfarin was administered orally (0.2 mg/kg) or intravenously (0.05 mg/kg) without or with oral administration of amlodipine (0.1 or 0.4 mg/kg) in rats. The effect of amlodipine on the P-glycoprotein (P-gp) as well as cytochrome P450 (CYP) 3A4 activity was also evaluated. Amlodipine inhibited CYP3A4 enzyme activity with 50% inhibition concentration ($IC_{50}$) of 9.1 ${\mu}M$. Compared to those animals in the oral control group (warfarin without amlodipine), the area under the plasma concentration-time curve (AUC) of warfarin was significantly greater (0.1 mg/kg, p<0.05; 0.4 mg/kg, p<0.01) by 26.5-53.5%, and the peak plasma concentration ($C_{max}$) was significantly higher (0.4 mg/kg, p<0.05) by 26.2% after oral administration of warfarin with amlodipine, respectively. Consequently, the relative bioavailability of warfarin increased by 1.26- to 1.53-fold and the absolute bioavailability of warfarin with amlodipine was significantly greater by 61.7-72.5% compared to that in the control group (47.4%). In contrast, amlodipine had no effect on any pharmacokinetic parameters of warfarin given intravenously. Therefore, the enhanced oral bioavailability of warfarin may be due to inhibition of CYP 3A4-mediated metabolism in the intestine and/or liver rather than renal elimination and P-gp by amlodipine.

• Journal of Veterinary Science
• /
• v.21 no.1
• /
• pp.5.1-5.12
• /
• 2020

The major glycoproteins of bovine gammaherpesvirus 4 (BoHV-4) are gB, gH, gM, gL, and gp180 with gB, gH, and gp180 being the most glycosylated. These glycoproteins participate in cell binding while some act as neutralization targets. Glycosylation of these envelope proteins may be involved in virion protection against neutralization by antibodies. In infected cattle, BoHV-4 induces an immune response characterized by low neutralizing antibody levels or an absence of such antibodies. Therefore, virus seroneutralization in vitro cannot always be easily demonstrated. The aim of this study was to evaluate the neutralizing capacity of 2 Argentine BoHV-4 strains and to associate those findings with the gene expression profiles of the major envelope glycoproteins. Expression of genes coding for the envelope glycoproteins occurred earlier in cells infected with isolate 10/154 than in cells infected with strain 07/435, demonstrating a distinct difference between the strains. Differences in serological response can be attributed to differences in the expression of antigenic proteins or to post-translational modifications that mask neutralizing epitopes. Strain 07/435 induced significantly high titers of neutralizing antibodies in several animal species in addition to bovines. The most relevant serological differences were observed in adult animals. This is the first comprehensive analysis of the expression kinetics of genes coding for BoHV-4 glycoproteins in 2 Argentine strains (genotypes 1 and 2). The results further elucidate the BoHV-4 life cycle and may also help determine the genetic variability of the strains circulating in Argentina.

• Korean Journal of Poultry Science
• /
• v.44 no.1
• /
• pp.51-57
• /
• 2017

Subsequent to the introduction of the "Laws on Consumption Promotion of Livestock Products" in 2002, a mandatory check-off system for the egg industry was introduced in June 2009. Unlike other livestock products, the check-off on eggs is financed not from the sale of the egg-the end product-but from the spent hen. Variables such as the falling price of spent hens lead to a low financing rate; The present farm allotment rate of 14%, introduced in 2015, is much higher than the 0.2% to 0.3% check-off rate in other types of business, thus placing a huge burden on farms. When check-off is financed from the egg, it is expected that 6.5 billion won will be raised using a rate of 0.3% of sale proceeds, Therefore, it is urgent for the government to establish infrastructure to enable producers and merchants to do business through Grade & Packing centers. This can be achieved by the staged construction of local Grade & Packing centers. Check-off should continue to be financed from the present spent hen until this infrastructure is established, and an institutional strategy should be provided by the government to raise the financing rate accurately and transparently using statistical treatment of supply data for spent hens as a short-term alternative.

• Journal of the military operations research society of Korea
• /
• v.5 no.1
• /
• pp.37-72
• /
• 1979

This paper presents the FORTRAN program for expected damage by surface-to-surface weapons. One of the methods can be used to determine the effectiveness of general purpose (GP) bombs and cluster weapons against single unitary targets, linear targets, area targets, and areas of unitary target elements, The effectiveness index is in terms of fractional damage ($F_D$) or the number of volleys ($N_V$).

• Information and Communications Magazine
• /
• v.28 no.5
• /
• pp.3-9
• /
• 2011

위치정보에 기반한 다양한 서비스들이 IT융합을 통해 급속히 발전하면서 스마트 폰 시장의 활성화와 맞물려 일반 대중에게 깊이 자라를 잡고 있다. 통신 단말기 제조 업체뿐만 아니라 일반 산업체 및 통신 사업자들에게도 IT융합 기술을 활용한 위치인식 솔루션 및 시스템에 대한 관심이 급속도로 높아지고 있다. 본고에서는 기존의 GPS를 통한 위치인식 기술뿐만 아니라 통신 네트워크와 기타 여러 전파원을 활용한 위치 인식 기술 및 네트워크 기반의 기술과 단말기 기반기술과의 혼합방식을 통한 위치인식 기술들을 소개하고자한다.