• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2004년도 한국우주과학회보 제13권1호
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• pp.44-44
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• 2004

GPS를 이용하여 대기 수증기의 3차원 분포도를 구하기 위하여, 관측소와 GPS 위성 간 시선방향으로의 수증기에 의한 GPS 신호지연 정도를 결정할 필요가 있다. 이 때 정확성 향상을 위하여 반드시 고려해야하는 위상중심변화(phase center variations)와 조석하중에 의한 지각변위(ocean loading displacements) 등 수직방향 좌표 결정 오차를 유발하는 요인들을 소개한다. 타 연구를 통해 위상중심변화는 크게는 l0cm 이상의 오차를, 그리고 조석하중에 의한 지각변위는 한반도의 경우 최대 3-4cm 정도의 오차를 보임을 알았지만, 이들 오차가 시선방향 습윤지연 결정에 미치는 영향은 규명되지 않았다. (중략)

• Restorative Dentistry and Endodontics
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• 제46권2호
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• pp.25.1-25.12
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• 2021

Objectives: This study used micro-computed tomography (µCT) to compare voids and interfaces in single-cone obturation among AH Plus, EndoSequence BC, and prototype surface pre-reacted glass ionomer (S-PRG) sealers and to determine the percentage of sealer contact at the dentin and gutta-percha (GP) interfaces. Materials and Methods: Fifteen single-rooted human teeth were shaped using ProTaper NEXT size X5 rotary files using 2.5% NaOCl irrigation. Roots were obturated with a single-cone ProTaper NEXT GP point X5 with AH Plus, EndoSequence BC, or prototype S-PRG sealer (n = 5/group). Results: The volumes of GP, sealer, and voids were measured in the region of 0-2, 2-4, 4-6, and 6-8 mm from the apex, using image analysis of sagittal µCT scans. GP volume percentages were: AH Plus (75.5%), EndoSequence BC (87.3%), and prototype S-PRG (94.4%). Sealer volume percentages were less: AH Plus (14.3%), EndoSequence BC (6.8%), and prototype S-PRG (4.6%). Void percentages were AH Plus (10.1%), EndoSequence BC (5.9%), and prototype S-PRG (1.0%). Dentin-sealer contact ratios of AH Plus, EndoSequence BC, and prototype S-PRG groups were 82.4% ± 6.8%, 71.6% ± 25.3%, and 70.2% ± 9.4%, respectively. GP-sealer contact ratios of AH Plus, EndoSequence BC, and prototype S-PRG groups were 65.6% ± 29.1%, 80.7% ± 25.8%, and 87.0% ± 8.6%, respectively. Conclusions: Prototype S-PRG sealer created a low-void obturation, similar to EndoSequence BC sealer with similar dentin-sealer contact (> 70%) and GP-sealer contact (> 80%). Prototype S-PRG sealer presented comparable filling quality to EndoSequence BC sealer.

• 통합자연과학논문집
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• 제5권2호
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• pp.72-78
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• 2012

Multidrug resistance is a major obstacle in cancer chemotherapy. Cancer cells efflux chemotherapeutic drug out of cell by means of transporter and reduce the active concentration of it inside cell. Such transporters are member of the ATP binding cassettes (ABC) protein. It includes P-gp, multiple resistant protein (MRP), and breast cancer resistant protein (BCRP). These proteins are widely distributed in the human cells such as kidney, lung, endothelial cells of blood brain barrier etc. However, there are number of drugs developed for it, but most of them are getting transported by it. So, still there is necessity of a good modulator, which could effectively combat the transport of chemotherapeutic agents. Natural products origin modulators were found to be effective against transporter such as flavonoids, which belongs to third generation modulators. They have advantage over synthetic inhibitor in the sense that they have simple structure and abundant in nature. This review focuses on the P-gp structure its architecture, efflux mechanism, herbal inhibitors and their mechanism of action.

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.216-220
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• 1999

A chemosensitivity assay with small replicate Mm5mt/cl C3H mammary tumor cell cultures was developed to determine whether changes in viral antigen expression and release into culture fluids could be utilized as an in vitro measure of modulating drug effect. The 52,000 MW viral envelope glycoprotein (gp52) of the mouse mammary tumor virus (MMTV) was measured in culture fluids of control and drug-treated cultures while cell density was simultaneously determined by cell staining and OD 664 nm determination. While extra-cellular gp52 levels and cell density progressively increased over 72 hours for control cultures, declines in both parameters provided dual measures of effect for combination [N(phophonacetyl-L-aspartic acid)+5-fluorouracil], combination 〔N(phophonacetyl-L-aspartic acid )+5-fluoro-5'-deoxyuridine〕and single component treatment of this combination. At each treated time point, thesecombinations begin to produce a greater decline in both cell density and gp52 levels as compared to single drug treatments. These results indicate that N(phopho-nacetyl-L-aspartic acid) in combination can enhance the effectiveness of single drug.

• 한국측량학회지
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• 제17권3호
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• pp.283-292
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• 1999

본 논문에서는 대축척 항공 사진(1/5,000)을 촬영할 때 수신한 GPS 자료를 처리하여 결정한 항공 사진 카메라의 투영중심 위치를 이용한 항공삼각측량에 대해서 연구하였다. 항공삼각측량에 적용 가능성을 검토하기 위해 GPS자료를 처리하여 모델 조정법으로 결정한 투영중심의 위치와 비교하여 정확도 및 오차를 분석하였다. 또한, GPS 자료로 결정한 투영중심의 위치를 광속 조정법에 적용하였다. 기준국으로부터 30 km이내인 경우 L1 반송파 자료를 이용하여 결정한 투영중심 위치의 정확도는 일정하고, 4개의 기준점으로 평면(XY) 정확도(RMS)는 13 cm, 높이(Z) 정확도(RMS)는 15 cm로 수치지도 제작에 필요한 정확도를 얻을 수 있었다. 따라서, GPS를 항공삼각측량에 이용함으로써 경제적인 지도 제작 방안을 제시하였다.

• KASI NEWSLETTER
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• 통권55호
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• pp.14-15
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• 2006

지난 해 한국천문연구원은 세계 4번째,아시아에서는 첫 번째로 IGS(International GNSS Service)국제 글로벌 테이터 센터(Global Data center)를 유치하였다.이번 사업을 진두 지휘한 이는 1989년부터 GPS와 동고동락한 박필호박사이다.

• Steel and Composite Structures
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• 제33권3호
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• pp.319-332
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• 2019

This study is aimed to predict the behaviour of channel shear connectors in composite floor systems at different temperatures. For this purpose, a soft computing approach is adopted. Two novel intelligence methods, including an Extreme Learning Machine (ELM) and a Genetic Programming (GP), are developed. In order to generate the required data for the intelligence methods, several push-out tests were conducted on various channel connectors at different temperatures. The dimension of the channel connectors, temperature, and slip are considered as the inputs of the models, and the strength of the connector is predicted as the output. Next, the performance of the ELM and GP is evaluated by developing an Artificial Neural Network (ANN). Finally, the performance of the ELM, GP, and ANN is compared with each other. Results show that ELM is capable of achieving superior performance indices in comparison with GP and ANN in the case of load prediction. Also, it is found that ELM is not only a very fast algorithm but also a more reliable model.

• 융합정보논문지
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• 제10권4호
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• pp.98-103
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• 2020

본 연구에서는 KTAS(Korean Triage and Acuity Scale) 결과가 분류를 시행한 주체의 직종에 따른 차이가 있는지를 알아보고자 한다. 2016년 1월 1일부터 2017년 12월 31일까지의 응급의료기관으로 내원한 환자 자료 중, 국가응급진료정보망으로 전송된 자료 총 10,960,359건을 분석하였다. 분류자 직종은 전문의, 전공의, 인턴, 일반의, 간호사, 응급구조사였다. 최초 중증도 분류와 최종 중증도 분류 결과의 일치율은 일반의가 98.9%로 가장 높았고, 인턴이 80.2%로 가장 낮았다. 과대 분류에서는 일반의가 0.6%로 가장 낮았고, 인턴은 16.0%로 가장 높았다. 또한 과소 분류는 전문의와 응급구조사가 0.4%로 가장 낮았고, 인턴이 3.8%로 가장 높았다. 중증도 분류 결과는 직종별 유의미한 차이가 있었다(p<0.001). 중증도 분류는 환자의 예후에 영향을 미치는 요인 중 하나로 직종별, 숙련도에 따라 그 결과가 달라져서는 안 된다. 때문에 정확한 중증도 분류를 위한 분류자의 역량 강화가 필요하다.

• BMB Reports
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• 제34권1호
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• pp.66-72
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• 2001

To investigate the mechanism of adriamycin (ADM) resistance in the ADM resistant subline PC-14/ADM, we examined the expressions of p-glycoprotein (P-gp), topoisomerase I (Topo I) and II (Topo II), glutathione-S-transferases (GSTs), tissue transglutaminase (t-TG), epidermal growth factor receptor (EGFR), and E-cadherin and the activity of superoxide dismutase (SOD) in PC-14 and PC-14/ADM cells. There was no change in the cellular levels of P-gp, Topo I, Topo II, and the two isoforms of GSTs. However, SOD activity in PC-14/ADM cells was 2.38 fold higher than that in PC-14 cells. A marked induction of the t-TG expression was also observed in PC-14/ADM cells. In addition to those changes, expressions of EGFR and E-cadherin were down regulated in PC-14/ADM cells. Therefore, molecular modifications such as an increase in SOD activity, induction of the t-TG expression, and down regulation of EGFR and E-cadherin expressions may play important roles in PC-14/ADM cells during the development of ADM resistance.

• 전기전자학회논문지
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• 제23권1호
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• pp.181-187
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• 2019

In this paper, we demonstrated a power amplifier monolithic microwave integrated circuit (MMIC) for X-band radar applications. It utilizes commercial $0.25{\mu}m$ GaN-based high electron mobility transistor (HEMT) technology and delivers more than 20 W of output power. The developed GaN-based power amplifier MMIC has small signal gain of over 22 dB and saturated output power of over 43.3 dBm (21.38 W) in a pulse operation mode with pulse width of $200{\mu}s$ and duty cycle of 4% over the entire band of 9 to 10 GHz. The chip dimensions are $3.5mm{\times}2.3mm$, generating the output power density of $2.71W/mm^2$. Its power added efficiency (PAE) is 42.6-50.7% in the frequency bandwidth from 9 to 10 GHz. The developed GaN-based power amplifier MMIC is expected to be applied in a variety of X-band radar applications.